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The map label for this gene is fadA [H]

Identifier: 78047619

GI number: 78047619

Start: 2351883

End: 2353088

Strand: Reverse

Name: fadA [H]

Synonym: XCV2063

Alternate gene names: 78047619

Gene position: 2353088-2351883 (Counterclockwise)

Preceding gene: 78047620

Following gene: 78047615

Centisome position: 45.44

GC content: 65.34

Gene sequence:

>1206_bases
ATGAGCAAGCAGATTCAAGAAGCCTACATCGTTGCCGCCACGCGTACGCCGGTGGGCAAGGCGCCGAAGGGCGTGTTCCG
CAATACCCGTCCCGACGACATGCTGGCGCATGTGCTGCGCGCCGTGGTCGCGCAGGCGCCGGGCATCGATACCTCGCGCA
TCGACGACGCCATCATCGGCTGCGCCATGCCCGAAGGCGAGCAAGGCATGAACGTGGCGCGCATCGGCGTGTTGCTGGCG
GGCCTGCCCAATTCGGTGGCCGGCCAGACCATCAACCGCTTCTGTTCGTCCGGCATCCAGGCCATCGCCATGGCCGCCGA
CCAGATCCGGCTGGGCAATGCCGACCTGATGCTGGCCGGCGGTACCGAGTCGATGTCGATGGTGCCGATGATGGGCAACA
AGGTGGCGATGTCGCCAAGCGTGTTCGCCGACGACCATGTGGCCATTGCCTATGGCATGGGCATCACTGCCGAGAAGGTC
GCAGAAGAGTGGAAGGTGTCGCGCGAAGACCAGGACGCTTTTGCGCTGGCCTCCCATCAAAAGGCGATCGCCGCAATTGC
CGCCGGCGAGTTCCGCGACGAAATCACTCCGTACGAAATCCATTCGCACCAGCCCGATCTGGCAGGCAACGTCATCGCGC
TGCGCAAGCGCCTGGTCGACACCGACGAAGGCCCGCGTCCGGACAGCTCGCTCGAGGGCCTGGCCAAGCTGCGCCCGGTG
TTCCGCAACGGCCAGTTCGGCGGCAGCGTCACCGCCGGTAATTCCTCGCAGATGAGCGATGGCGCCGGTGCCGTGCTGCT
GGCCTCCGAGCAGGCGATCAAGGATTACGGCCTCACACCGCTTGCGCGTTTTGTCAGCTTCTCGGTGGCCGGCGTGCGCC
CGGAAGTCATGGGCATTGGACCGATCGCCGCCATTCCCAAGGCGCTCAAGCAGGCCGGGCTGACCAAGGATCAACTCGAC
TGGATCGAGCTCAACGAAGCCTTCGCCGCACAGGCGTTGGCCGTGATCCGCGACAGCGAACTGGATCCATCCAAAGTCAA
TCCGCTGGGTGGCGCAATCGCCCTTGGTCACCCGCTGGGCGCCACCGGCGCGATCCGTGCCGCCACGCTGGTGCATGGCC
TGCGCCGTCGTCAGCAGAAGTACGGCATGGTCACCATGTGCATCGGTACCGGCATGGGCGCTGCTGGCATCATCGAAGCG
CTGTGA

Upstream 100 bases:

>100_bases
TCTCGCTTCCACCAAATTCATCCGCCGGGCAGGAACATTCGGGCACGCGGATTCGCTTTGACGAATCCCAAATCCCGAAT
CCCGGCTATCGGAGATAGCC

Downstream 100 bases:

>100_bases
GGCGCGTGGAGCGCCGGGTCGGCCTTCCGGGTCGGTCTGGTGTTTCCATCTGTGTCATCCATCCGCGGAGATCAGGTGTT
AACGATCACATCGCGATGCT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MSKQIQEAYIVAATRTPVGKAPKGVFRNTRPDDMLAHVLRAVVAQAPGIDTSRIDDAIIGCAMPEGEQGMNVARIGVLLA
GLPNSVAGQTINRFCSSGIQAIAMAADQIRLGNADLMLAGGTESMSMVPMMGNKVAMSPSVFADDHVAIAYGMGITAEKV
AEEWKVSREDQDAFALASHQKAIAAIAAGEFRDEITPYEIHSHQPDLAGNVIALRKRLVDTDEGPRPDSSLEGLAKLRPV
FRNGQFGGSVTAGNSSQMSDGAGAVLLASEQAIKDYGLTPLARFVSFSVAGVRPEVMGIGPIAAIPKALKQAGLTKDQLD
WIELNEAFAAQALAVIRDSELDPSKVNPLGGAIALGHPLGATGAIRAATLVHGLRRRQQKYGMVTMCIGTGMGAAGIIEA
L

Sequences:

>Translated_401_residues
MSKQIQEAYIVAATRTPVGKAPKGVFRNTRPDDMLAHVLRAVVAQAPGIDTSRIDDAIIGCAMPEGEQGMNVARIGVLLA
GLPNSVAGQTINRFCSSGIQAIAMAADQIRLGNADLMLAGGTESMSMVPMMGNKVAMSPSVFADDHVAIAYGMGITAEKV
AEEWKVSREDQDAFALASHQKAIAAIAAGEFRDEITPYEIHSHQPDLAGNVIALRKRLVDTDEGPRPDSSLEGLAKLRPV
FRNGQFGGSVTAGNSSQMSDGAGAVLLASEQAIKDYGLTPLARFVSFSVAGVRPEVMGIGPIAAIPKALKQAGLTKDQLD
WIELNEAFAAQALAVIRDSELDPSKVNPLGGAIALGHPLGATGAIRAATLVHGLRRRQQKYGMVTMCIGTGMGAAGIIEA
L
>Mature_400_residues
SKQIQEAYIVAATRTPVGKAPKGVFRNTRPDDMLAHVLRAVVAQAPGIDTSRIDDAIIGCAMPEGEQGMNVARIGVLLAG
LPNSVAGQTINRFCSSGIQAIAMAADQIRLGNADLMLAGGTESMSMVPMMGNKVAMSPSVFADDHVAIAYGMGITAEKVA
EEWKVSREDQDAFALASHQKAIAAIAAGEFRDEITPYEIHSHQPDLAGNVIALRKRLVDTDEGPRPDSSLEGLAKLRPVF
RNGQFGGSVTAGNSSQMSDGAGAVLLASEQAIKDYGLTPLARFVSFSVAGVRPEVMGIGPIAAIPKALKQAGLTKDQLDW
IELNEAFAAQALAVIRDSELDPSKVNPLGGAIALGHPLGATGAIRAATLVHGLRRRQQKYGMVTMCIGTGMGAAGIIEAL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=395, Percent_Identity=45.0632911392405, Blast_Score=298, Evalue=5e-81,
Organism=Homo sapiens, GI167614485, Length=405, Percent_Identity=41.4814814814815, Blast_Score=281, Evalue=1e-75,
Organism=Homo sapiens, GI148539872, Length=402, Percent_Identity=38.5572139303483, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI4557237, Length=408, Percent_Identity=36.0294117647059, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI4504327, Length=446, Percent_Identity=31.1659192825112, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI194353979, Length=247, Percent_Identity=35.6275303643725, Blast_Score=124, Evalue=1e-28,
Organism=Escherichia coli, GI1787663, Length=412, Percent_Identity=44.9029126213592, Blast_Score=306, Evalue=1e-84,
Organism=Escherichia coli, GI48994986, Length=400, Percent_Identity=43, Blast_Score=286, Evalue=2e-78,
Organism=Escherichia coli, GI87082165, Length=406, Percent_Identity=41.1330049261084, Blast_Score=268, Evalue=5e-73,
Organism=Escherichia coli, GI1788554, Length=410, Percent_Identity=41.7073170731707, Blast_Score=261, Evalue=8e-71,
Organism=Escherichia coli, GI1788683, Length=452, Percent_Identity=32.0796460176991, Blast_Score=166, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI133906874, Length=406, Percent_Identity=38.6699507389163, Blast_Score=243, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI25147385, Length=405, Percent_Identity=34.0740740740741, Blast_Score=204, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI17535921, Length=406, Percent_Identity=32.512315270936, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17551802, Length=443, Percent_Identity=28.6681715575621, Blast_Score=160, Evalue=9e-40,
Organism=Caenorhabditis elegans, GI17535917, Length=409, Percent_Identity=29.5843520782396, Blast_Score=145, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6322031, Length=404, Percent_Identity=41.0891089108911, Blast_Score=270, Evalue=3e-73,
Organism=Saccharomyces cerevisiae, GI6325229, Length=412, Percent_Identity=36.6504854368932, Blast_Score=225, Evalue=1e-59,
Organism=Drosophila melanogaster, GI24655093, Length=407, Percent_Identity=39.5577395577396, Blast_Score=268, Evalue=6e-72,
Organism=Drosophila melanogaster, GI17648125, Length=418, Percent_Identity=38.9952153110048, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24640423, Length=409, Percent_Identity=34.4743276283619, Blast_Score=213, Evalue=1e-55,
Organism=Drosophila melanogaster, GI17137578, Length=442, Percent_Identity=31.447963800905, Blast_Score=164, Evalue=7e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41944; Mature: 41813

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQIQEAYIVAATRTPVGKAPKGVFRNTRPDDMLAHVLRAVVAQAPGIDTSRIDDAIIG
CCCCCCEEEEEEEECCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHC
CAMPEGEQGMNVARIGVLLAGLPNSVAGQTINRFCSSGIQAIAMAADQIRLGNADLMLAG
CCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEC
GTESMSMVPMMGNKVAMSPSVFADDHVAIAYGMGITAEKVAEEWKVSREDQDAFALASHQ
CCCCCEEEECCCCEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHHH
KAIAAIAAGEFRDEITPYEIHSHQPDLAGNVIALRKRLVDTDEGPRPDSSLEGLAKLRPV
HHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
FRNGQFGGSVTAGNSSQMSDGAGAVLLASEQAIKDYGLTPLARFVSFSVAGVRPEVMGIG
HHCCCCCCEEECCCCCCCCCCCCEEEEECHHHHHHCCCHHHHHHHHHHHCCCCCHHEECC
PIAAIPKALKQAGLTKDQLDWIELNEAFAAQALAVIRDSELDPSKVNPLGGAIALGHPLG
HHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCC
ATGAIRAATLVHGLRRRQQKYGMVTMCIGTGMGAAGIIEAL
CCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHCC
>Mature Secondary Structure 
SKQIQEAYIVAATRTPVGKAPKGVFRNTRPDDMLAHVLRAVVAQAPGIDTSRIDDAIIG
CCCCCEEEEEEEECCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHC
CAMPEGEQGMNVARIGVLLAGLPNSVAGQTINRFCSSGIQAIAMAADQIRLGNADLMLAG
CCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEC
GTESMSMVPMMGNKVAMSPSVFADDHVAIAYGMGITAEKVAEEWKVSREDQDAFALASHQ
CCCCCEEEECCCCEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHHH
KAIAAIAAGEFRDEITPYEIHSHQPDLAGNVIALRKRLVDTDEGPRPDSSLEGLAKLRPV
HHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
FRNGQFGGSVTAGNSSQMSDGAGAVLLASEQAIKDYGLTPLARFVSFSVAGVRPEVMGIG
HHCCCCCCEEECCCCCCCCCCCCEEEEECHHHHHHCCCHHHHHHHHHHHCCCCCHHEECC
PIAAIPKALKQAGLTKDQLDWIELNEAFAAQALAVIRDSELDPSKVNPLGGAIALGHPLG
HHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCC
ATGAIRAATLVHGLRRRQQKYGMVTMCIGTGMGAAGIIEAL
CCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]