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The map label for this gene is thlA [H]

Identifier: 78046957

GI number: 78046957

Start: 1581204

End: 1582379

Strand: Reverse

Name: thlA [H]

Synonym: XCV1401

Alternate gene names: 78046957

Gene position: 1582379-1581204 (Counterclockwise)

Preceding gene: 78046959

Following gene: 78046956

Centisome position: 30.56

GC content: 64.37

Gene sequence:

>1176_bases
ATGTCCGACATCGTCATCGTTGCTGCCAAACGTACTGCCATCGGCTCGTTCCTCGGCCAATTCAATGCGGTGCCGGCACC
CACGCTCGCCGCGGCTGCTATCCAGGGCGCACTCGCGCAATCGGGCATCGCGCCTGCCGATATTTCCGAAGTCATCGTCG
GCTGCGTGCTGCCGGCCAATCTGGGCCAGGCACCTGCGCGTCAGGCCGCGATCGCCGCAGGCATTCCTACCTCGACCGGC
GCCACCACCATCAACAAGGTGTGCGGCTCGGGAATGAAGGCGATCATGTTGGGGCACGACCTGATCAAGGCCGGCTCGGC
CAGCATCGTGGTGGCCGGCGGCATGGAGTCGATGAGCAATGCCCCGCATCTGCTGCCCAACTCGCGCACCGGCAACCGCT
ACGGCAATTTTCAGGCGGTCGATCACATGGCCTGGGACGGTCTGACGAATCCGTATGACGGCCAGGCCATGGGCGTGTTC
GGCGAAGCCACTGCGGAGAAGTTCGGCTTCAGCCGCGCCGACCAGGATGCGTTCGCCATCGCCTCGGTGGAACGCGCGCA
GGCGGCGCAGCGCAGCGGCGCGTTTGCCGACGAAATCGTGCCGGTGACGGTGACCACGCGCAAGGGCGACGTCGTCGTCG
ACAGCGATGAGCAGCCGGGCAAGTCCGACGTGGCCAAGATTCCGACGCTGAAGCCAGCCTTCAAGAAAGACGGCAGCGTG
ACCGCGGCCAGTTCCTCGAGTATTTCCGATGGAGCGGCAATCACCGTGCTAATGAGCGCGGACGACGCGCAACGCCGTGG
CGTGACGCCGCTGGCACGCATCGTTGGCCATGTCACCCACGCTCAGGAACCGGAGTGGTTCACCACCGCACCGGTCGCTG
CGATCCAGTCGCTGGTCAGCAAGCTCGGCTGGCGATTGGACGATGTGGATCTGTTCGAAATCAACGAAGCCTTCGCCGTC
GTGGCGATGGCACCGATCAGGCAACTCGGCATCGCGCACGATAAGGTCAATGTGCATGGCGGCGCCTGCGCATTGGGTCA
TCCGATCGGTGCATCCGGCGCGCGTTTGGTGGTGACATTGGTGAACGCGTTGCGCAGCCGCGGAGGCAAGCGCGGAATCG
CCACGCTGTGCATCGGCGGCGGCGAAGCCACTGCCATTGCTATCGAATTGATTTAA

Upstream 100 bases:

>100_bases
GCTTTGCTTACTTTAAATCGGAAAGCGTGCGCGTGGGGCGCGCGCTGGCGCGGCGCCGCCATGAGGCAGATAATCGTTTC
ACTTTAAACGGTATCTGCTC

Downstream 100 bases:

>100_bases
TTATCTTTAACGGCGATTTTGCAAAACTGAATGCGCGTGCGCTTGACACTTGTCTTGTGGCCGTCATCATGTCGGGGGCG
CGCAATAGCGCGTTGCCTAA

Product: acetyl-CoA C-acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MSDIVIVAAKRTAIGSFLGQFNAVPAPTLAAAAIQGALAQSGIAPADISEVIVGCVLPANLGQAPARQAAIAAGIPTSTG
ATTINKVCGSGMKAIMLGHDLIKAGSASIVVAGGMESMSNAPHLLPNSRTGNRYGNFQAVDHMAWDGLTNPYDGQAMGVF
GEATAEKFGFSRADQDAFAIASVERAQAAQRSGAFADEIVPVTVTTRKGDVVVDSDEQPGKSDVAKIPTLKPAFKKDGSV
TAASSSSISDGAAITVLMSADDAQRRGVTPLARIVGHVTHAQEPEWFTTAPVAAIQSLVSKLGWRLDDVDLFEINEAFAV
VAMAPIRQLGIAHDKVNVHGGACALGHPIGASGARLVVTLVNALRSRGGKRGIATLCIGGGEATAIAIELI

Sequences:

>Translated_391_residues
MSDIVIVAAKRTAIGSFLGQFNAVPAPTLAAAAIQGALAQSGIAPADISEVIVGCVLPANLGQAPARQAAIAAGIPTSTG
ATTINKVCGSGMKAIMLGHDLIKAGSASIVVAGGMESMSNAPHLLPNSRTGNRYGNFQAVDHMAWDGLTNPYDGQAMGVF
GEATAEKFGFSRADQDAFAIASVERAQAAQRSGAFADEIVPVTVTTRKGDVVVDSDEQPGKSDVAKIPTLKPAFKKDGSV
TAASSSSISDGAAITVLMSADDAQRRGVTPLARIVGHVTHAQEPEWFTTAPVAAIQSLVSKLGWRLDDVDLFEINEAFAV
VAMAPIRQLGIAHDKVNVHGGACALGHPIGASGARLVVTLVNALRSRGGKRGIATLCIGGGEATAIAIELI
>Mature_390_residues
SDIVIVAAKRTAIGSFLGQFNAVPAPTLAAAAIQGALAQSGIAPADISEVIVGCVLPANLGQAPARQAAIAAGIPTSTGA
TTINKVCGSGMKAIMLGHDLIKAGSASIVVAGGMESMSNAPHLLPNSRTGNRYGNFQAVDHMAWDGLTNPYDGQAMGVFG
EATAEKFGFSRADQDAFAIASVERAQAAQRSGAFADEIVPVTVTTRKGDVVVDSDEQPGKSDVAKIPTLKPAFKKDGSVT
AASSSSISDGAAITVLMSADDAQRRGVTPLARIVGHVTHAQEPEWFTTAPVAAIQSLVSKLGWRLDDVDLFEINEAFAVV
AMAPIRQLGIAHDKVNVHGGACALGHPIGASGARLVVTLVNALRSRGGKRGIATLCIGGGEATAIAIELI

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4557237, Length=391, Percent_Identity=47.3145780051151, Blast_Score=347, Evalue=1e-95,
Organism=Homo sapiens, GI148539872, Length=389, Percent_Identity=48.586118251928, Blast_Score=346, Evalue=2e-95,
Organism=Homo sapiens, GI167614485, Length=388, Percent_Identity=38.659793814433, Blast_Score=266, Evalue=2e-71,
Organism=Homo sapiens, GI4501853, Length=397, Percent_Identity=37.0277078085642, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI4504327, Length=401, Percent_Identity=31.1720698254364, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI194353979, Length=393, Percent_Identity=31.2977099236641, Blast_Score=137, Evalue=2e-32,
Organism=Escherichia coli, GI87082165, Length=390, Percent_Identity=45.3846153846154, Blast_Score=324, Evalue=7e-90,
Organism=Escherichia coli, GI1788554, Length=391, Percent_Identity=46.5473145780051, Blast_Score=305, Evalue=2e-84,
Organism=Escherichia coli, GI1787663, Length=403, Percent_Identity=36.7245657568238, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI48994986, Length=403, Percent_Identity=35.9801488833747, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1788683, Length=416, Percent_Identity=28.8461538461538, Blast_Score=139, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI25147385, Length=384, Percent_Identity=42.96875, Blast_Score=310, Evalue=7e-85,
Organism=Caenorhabditis elegans, GI17535921, Length=393, Percent_Identity=41.9847328244275, Blast_Score=291, Evalue=3e-79,
Organism=Caenorhabditis elegans, GI133906874, Length=389, Percent_Identity=38.560411311054, Blast_Score=279, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17535917, Length=398, Percent_Identity=35.678391959799, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17551802, Length=424, Percent_Identity=29.9528301886792, Blast_Score=164, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6325229, Length=395, Percent_Identity=46.5822784810127, Blast_Score=328, Evalue=8e-91,
Organism=Saccharomyces cerevisiae, GI6322031, Length=391, Percent_Identity=35.2941176470588, Blast_Score=195, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24655093, Length=390, Percent_Identity=46.6666666666667, Blast_Score=347, Evalue=8e-96,
Organism=Drosophila melanogaster, GI24640423, Length=391, Percent_Identity=46.5473145780051, Blast_Score=328, Evalue=5e-90,
Organism=Drosophila melanogaster, GI17648125, Length=390, Percent_Identity=37.1794871794872, Blast_Score=238, Evalue=7e-63,
Organism=Drosophila melanogaster, GI17137578, Length=422, Percent_Identity=30.0947867298578, Blast_Score=155, Evalue=6e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 39875; Mature: 39744

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00098 THIOLASE_1 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDIVIVAAKRTAIGSFLGQFNAVPAPTLAAAAIQGALAQSGIAPADISEVIVGCVLPAN
CCCEEEEEECHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCC
LGQAPARQAAIAAGIPTSTGATTINKVCGSGMKAIMLGHDLIKAGSASIVVAGGMESMSN
CCCCCHHHHHHCCCCCCCCCHHHHHHHHCCCCEEEHHHHHHHHCCCCEEEEECCHHHHCC
APHLLPNSRTGNRYGNFQAVDHMAWDGLTNPYDGQAMGVFGEATAEKFGFSRADQDAFAI
CCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEECHHHHHHHCCCCCCCCHHHH
ASVERAQAAQRSGAFADEIVPVTVTTRKGDVVVDSDEQPGKSDVAKIPTLKPAFKKDGSV
HHHHHHHHHHHCCCCHHCEEEEEEEECCCCEEECCCCCCCCCHHHHCCCCCHHHCCCCCE
TAASSSSISDGAAITVLMSADDAQRRGVTPLARIVGHVTHAQEPEWFTTAPVAAIQSLVS
EECCCCCCCCCCEEEEEEECCCHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
KLGWRLDDVDLFEINEAFAVVAMAPIRQLGIAHDKVNVHGGACALGHPIGASGARLVVTL
HHCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCEEEECCCEEECCCCCCCCCHHHHHHH
VNALRSRGGKRGIATLCIGGGEATAIAIELI
HHHHHHCCCCCCEEEEEECCCCEEEEEEEEC
>Mature Secondary Structure 
SDIVIVAAKRTAIGSFLGQFNAVPAPTLAAAAIQGALAQSGIAPADISEVIVGCVLPAN
CCEEEEEECHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCC
LGQAPARQAAIAAGIPTSTGATTINKVCGSGMKAIMLGHDLIKAGSASIVVAGGMESMSN
CCCCCHHHHHHCCCCCCCCCHHHHHHHHCCCCEEEHHHHHHHHCCCCEEEEECCHHHHCC
APHLLPNSRTGNRYGNFQAVDHMAWDGLTNPYDGQAMGVFGEATAEKFGFSRADQDAFAI
CCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEECHHHHHHHCCCCCCCCHHHH
ASVERAQAAQRSGAFADEIVPVTVTTRKGDVVVDSDEQPGKSDVAKIPTLKPAFKKDGSV
HHHHHHHHHHHCCCCHHCEEEEEEEECCCCEEECCCCCCCCCHHHHCCCCCHHHCCCCCE
TAASSSSISDGAAITVLMSADDAQRRGVTPLARIVGHVTHAQEPEWFTTAPVAAIQSLVS
EECCCCCCCCCCEEEEEEECCCHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
KLGWRLDDVDLFEINEAFAVVAMAPIRQLGIAHDKVNVHGGACALGHPIGASGARLVVTL
HHCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCEEEECCCEEECCCCCCCCCHHHHHHH
VNALRSRGGKRGIATLCIGGGEATAIAIELI
HHHHHHCCCCCCEEEEEECCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]