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The map label for this gene is dosC [H]

Identifier: 78046954

GI number: 78046954

Start: 1578368

End: 1580077

Strand: Reverse

Name: dosC [H]

Synonym: XCV1398

Alternate gene names: 78046954

Gene position: 1580077-1578368 (Counterclockwise)

Preceding gene: 78046955

Following gene: 78046953

Centisome position: 30.51

GC content: 66.43

Gene sequence:

>1710_bases
ATGTCCTCTTCTTTTACGTCGCGCCGGCGCAACCAGCTGGCGCTGATTTTTTCTGCGCTGATCTTCGTCGTCATCGGAAT
CGGCATCTTCGTGGGTGCCCGCCGTTCGCTGGCCGACGCTGCGCTGGTGTCGCACACCCACGAGGTGATCGGGCGGGTGG
ACGAGATCCAGGCGCGCGTGCTCGATGCCGAATCGGCGCAGCGCGGCTTCCTGCTTACCGGCAACGACGCCTACCTGCTG
GACTACCAGACCAGTGTCGAACGTCTGCCGATCCTGCTGGACAACCTGCGCCGCCTGATCGTCGACAACCCCGCACAGGA
GCAGCACCTGGCGCAGTTGCAACGGCTGGTGGAAACCCGCCTGCGGCAGATTCAGCACGTGCTCGACCTCTATGCGCAAG
GTGGGCTGGAGCCGGCACGTGCCGACATCCGGCAGAGCGCATTCCGCACTACCAGCGCCATCCGCGAGCAGGCATTGACG
ATGGTGCAGCGCGAACAGGAGCTGCTGGCACAACGCGCGCGAAGCAGCGAACAAAGCGCCAACCTGTTGCTGGCACTGGC
ATTGGCCGGCATTCCGTTCGGGCTGTTGGTGGTGGGCATGGTCTATGCGCTGTTGATGCGCGAACTGCGCCACCGCGCGC
AGGCAGAACAGCTGGCGGCGCAGGCCAATCGCGAGTTGGGCGAGAGCATCGAGGCACTGCAGCGCAGTACCGCCGATCTC
AACCTGCTCAGCCGTTACACCGGCCTGCTGCAGAGCTGCATCAGTGCCGAAGAAGCGTTGATGGTCAGCAGCCGTACCCT
GGCCGGCCTGCTGCCGGGCGTGGCGGGAAGCGTGTACCTGCTGCGCGCCTCGCAGGACCGCGCCGAGGCGATCAGCCACT
GGGGCGAGCCGCTGGTGCGCAGCGCGCCGCATCTGTCGCCCGAGCAGTGCTGGGCGCTGCGCCGCGGCCAGCCGCATATC
GTCCAAGACCTGGGCCGGGATGCGCTGTGTGCGCATATCGAAGAACCCGCACACGATGCATCCGTCACCACCGCGTGCCT
GCCGATGTCGGCGCAAGGCACCCAGCTCGGGTTTCTGTTCCTGTCTGCCGCCGGCCCGGGGCCGATGCCGCGGCTGGAAA
TCGCCGAGGCGGCCGCCGAACAGTTGTCGTTGGCGCTGAGCAACCTGCGTCTGCGCGAGTCGCTGCGCCGGCAGTCGATC
CGCGATGCGCTGACGGGGCTGTATAACCGCCGCTATCTGGAAGAATCGCTGAGCCACGAGTTGGCGCGGTGCGCACGGCG
TGGTCTGCCGTTGTCGGTCTTGATGCTGGACGTGGACCATTTCAAGCAGTTCAACGACAGCCAGGGCCATGCCGGCGGCG
ACCTGTTGCTGGCAGCGGTGGGCGAATTGCTGCTGACCCGCCTGCGCGCCGAGGACGTGGCATGCCGCTACGGCGGTGAG
GAATTCACCGTCCTTCTGCCCGAAGCCGATGGCGAAGAAGCCATGCGCGTGGCCGAGCAGATTCGCAGTTACATCGCCGC
GCTGGCGGTCAGCGACGGTGCGCGCGCCTTGCCGAAGGTGACTGCCTCGATCGGCGTGGCCAGCTTCCCTGCCGATGGCG
AACAGGGTGCGAGCCTGATCCAGAAAGCCGACGCAGCGCTGTATCGTGCCAAGCATGCTGGGCGCAACCGGGTCGAGCGA
TACGGTGCTGCTACGGACAGTGCGGACTGA

Upstream 100 bases:

>100_bases
CCCTCTCGCAGCACCCGCAACGCGCCGGCCATGTGCCGGCGCGCTTGTCTCGGCCGACGGGTGGCTCGTGTTGTCGAGGC
CGGCAGGCTAGCATTCGCAT

Downstream 100 bases:

>100_bases
AGGCAGCGGACGAGGCCACGGCGGGCAGCCAGGCGCGGCTGCGCACGAAGCCGGGAGGTAGCACGCGGAGACTGCGGCCC
TGGTGCGCCGCGCGCACCCA

Product: putative sensor protein

Products: NA

Alternate protein names: DGC [H]

Number of amino acids: Translated: 569; Mature: 568

Protein sequence:

>569_residues
MSSSFTSRRRNQLALIFSALIFVVIGIGIFVGARRSLADAALVSHTHEVIGRVDEIQARVLDAESAQRGFLLTGNDAYLL
DYQTSVERLPILLDNLRRLIVDNPAQEQHLAQLQRLVETRLRQIQHVLDLYAQGGLEPARADIRQSAFRTTSAIREQALT
MVQREQELLAQRARSSEQSANLLLALALAGIPFGLLVVGMVYALLMRELRHRAQAEQLAAQANRELGESIEALQRSTADL
NLLSRYTGLLQSCISAEEALMVSSRTLAGLLPGVAGSVYLLRASQDRAEAISHWGEPLVRSAPHLSPEQCWALRRGQPHI
VQDLGRDALCAHIEEPAHDASVTTACLPMSAQGTQLGFLFLSAAGPGPMPRLEIAEAAAEQLSLALSNLRLRESLRRQSI
RDALTGLYNRRYLEESLSHELARCARRGLPLSVLMLDVDHFKQFNDSQGHAGGDLLLAAVGELLLTRLRAEDVACRYGGE
EFTVLLPEADGEEAMRVAEQIRSYIAALAVSDGARALPKVTASIGVASFPADGEQGASLIQKADAALYRAKHAGRNRVER
YGAATDSAD

Sequences:

>Translated_569_residues
MSSSFTSRRRNQLALIFSALIFVVIGIGIFVGARRSLADAALVSHTHEVIGRVDEIQARVLDAESAQRGFLLTGNDAYLL
DYQTSVERLPILLDNLRRLIVDNPAQEQHLAQLQRLVETRLRQIQHVLDLYAQGGLEPARADIRQSAFRTTSAIREQALT
MVQREQELLAQRARSSEQSANLLLALALAGIPFGLLVVGMVYALLMRELRHRAQAEQLAAQANRELGESIEALQRSTADL
NLLSRYTGLLQSCISAEEALMVSSRTLAGLLPGVAGSVYLLRASQDRAEAISHWGEPLVRSAPHLSPEQCWALRRGQPHI
VQDLGRDALCAHIEEPAHDASVTTACLPMSAQGTQLGFLFLSAAGPGPMPRLEIAEAAAEQLSLALSNLRLRESLRRQSI
RDALTGLYNRRYLEESLSHELARCARRGLPLSVLMLDVDHFKQFNDSQGHAGGDLLLAAVGELLLTRLRAEDVACRYGGE
EFTVLLPEADGEEAMRVAEQIRSYIAALAVSDGARALPKVTASIGVASFPADGEQGASLIQKADAALYRAKHAGRNRVER
YGAATDSAD
>Mature_568_residues
SSSFTSRRRNQLALIFSALIFVVIGIGIFVGARRSLADAALVSHTHEVIGRVDEIQARVLDAESAQRGFLLTGNDAYLLD
YQTSVERLPILLDNLRRLIVDNPAQEQHLAQLQRLVETRLRQIQHVLDLYAQGGLEPARADIRQSAFRTTSAIREQALTM
VQREQELLAQRARSSEQSANLLLALALAGIPFGLLVVGMVYALLMRELRHRAQAEQLAAQANRELGESIEALQRSTADLN
LLSRYTGLLQSCISAEEALMVSSRTLAGLLPGVAGSVYLLRASQDRAEAISHWGEPLVRSAPHLSPEQCWALRRGQPHIV
QDLGRDALCAHIEEPAHDASVTTACLPMSAQGTQLGFLFLSAAGPGPMPRLEIAEAAAEQLSLALSNLRLRESLRRQSIR
DALTGLYNRRYLEESLSHELARCARRGLPLSVLMLDVDHFKQFNDSQGHAGGDLLLAAVGELLLTRLRAEDVACRYGGEE
FTVLLPEADGEEAMRVAEQIRSYIAALAVSDGARALPKVTASIGVASFPADGEQGASLIQKADAALYRAKHAGRNRVERY
GAATDSAD

Specific function: Overexpression leads to an increased level of c-di-GMP, which leads to changes in the cell surface, to abnormal cell division, increased biofilm formation and decreased swimming (the latter 2 in strain W3110). In a strain able to produce cellulose (strain

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GGDEF domain [H]

Homologues:

Organism=Escherichia coli, GI145693134, Length=165, Percent_Identity=43.6363636363636, Blast_Score=128, Evalue=8e-31,
Organism=Escherichia coli, GI87082007, Length=175, Percent_Identity=42.2857142857143, Blast_Score=115, Evalue=9e-27,
Organism=Escherichia coli, GI1786584, Length=175, Percent_Identity=37.1428571428571, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1787262, Length=159, Percent_Identity=38.3647798742138, Blast_Score=113, Evalue=4e-26,
Organism=Escherichia coli, GI87081881, Length=169, Percent_Identity=39.6449704142012, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI1788381, Length=173, Percent_Identity=36.9942196531792, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1787816, Length=163, Percent_Identity=36.8098159509202, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1787802, Length=216, Percent_Identity=30.5555555555556, Blast_Score=91, Evalue=3e-19,
Organism=Escherichia coli, GI1788085, Length=163, Percent_Identity=30.0613496932515, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI87081974, Length=128, Percent_Identity=32.03125, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1787541, Length=172, Percent_Identity=33.1395348837209, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI87081977, Length=166, Percent_Identity=32.5301204819277, Blast_Score=72, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR012292
- InterPro:   IPR009050 [H]

Pfam domain/function: PF00990 GGDEF [H]

EC number: =2.7.7.65 [H]

Molecular weight: Translated: 62026; Mature: 61894

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSFTSRRRNQLALIFSALIFVVIGIGIFVGARRSLADAALVSHTHEVIGRVDEIQARV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDAESAQRGFLLTGNDAYLLDYQTSVERLPILLDNLRRLIVDNPAQEQHLAQLQRLVETR
HCCCCCCCCEEEECCCEEEEECHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LRQIQHVLDLYAQGGLEPARADIRQSAFRTTSAIREQALTMVQREQELLAQRARSSEQSA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
NLLLALALAGIPFGLLVVGMVYALLMRELRHRAQAEQLAAQANRELGESIEALQRSTADL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLLSRYTGLLQSCISAEEALMVSSRTLAGLLPGVAGSVYLLRASQDRAEAISHWGEPLVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHCCCHHHH
SAPHLSPEQCWALRRGQPHIVQDLGRDALCAHIEEPAHDASVTTACLPMSAQGTQLGFLF
CCCCCCHHHHHHHHCCCCHHHHHCCCHHHHHHHCCCCCCCCHHHHHCCCCCCCCEEEEEE
LSAAGPGPMPRLEIAEAAAEQLSLALSNLRLRESLRRQSIRDALTGLYNRRYLEESLSHE
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LARCARRGLPLSVLMLDVDHFKQFNDSQGHAGGDLLLAAVGELLLTRLRAEDVACRYGGE
HHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
EFTVLLPEADGEEAMRVAEQIRSYIAALAVSDGARALPKVTASIGVASFPADGEQGASLI
EEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHH
QKADAALYRAKHAGRNRVERYGAATDSAD
HHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SSSFTSRRRNQLALIFSALIFVVIGIGIFVGARRSLADAALVSHTHEVIGRVDEIQARV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDAESAQRGFLLTGNDAYLLDYQTSVERLPILLDNLRRLIVDNPAQEQHLAQLQRLVETR
HCCCCCCCCEEEECCCEEEEECHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LRQIQHVLDLYAQGGLEPARADIRQSAFRTTSAIREQALTMVQREQELLAQRARSSEQSA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
NLLLALALAGIPFGLLVVGMVYALLMRELRHRAQAEQLAAQANRELGESIEALQRSTADL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLLSRYTGLLQSCISAEEALMVSSRTLAGLLPGVAGSVYLLRASQDRAEAISHWGEPLVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHCCCHHHH
SAPHLSPEQCWALRRGQPHIVQDLGRDALCAHIEEPAHDASVTTACLPMSAQGTQLGFLF
CCCCCCHHHHHHHHCCCCHHHHHCCCHHHHHHHCCCCCCCCHHHHHCCCCCCCCEEEEEE
LSAAGPGPMPRLEIAEAAAEQLSLALSNLRLRESLRRQSIRDALTGLYNRRYLEESLSHE
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LARCARRGLPLSVLMLDVDHFKQFNDSQGHAGGDLLLAAVGELLLTRLRAEDVACRYGGE
HHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
EFTVLLPEADGEEAMRVAEQIRSYIAALAVSDGARALPKVTASIGVASFPADGEQGASLI
EEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHH
QKADAALYRAKHAGRNRVERYGAATDSAD
HHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]