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The map label for this gene is phoR [H]

Identifier: 78046627

GI number: 78046627

Start: 1202643

End: 1203971

Strand: Reverse

Name: phoR [H]

Synonym: XCV1071

Alternate gene names: 78046627

Gene position: 1203971-1202643 (Counterclockwise)

Preceding gene: 78046628

Following gene: 78046626

Centisome position: 23.25

GC content: 67.42

Gene sequence:

>1329_bases
ATGCCTCAACACATCCGTTCCGCCTGGCTCAAGACGCTCGGCACTCTCGCGCTGTTGTTGGGCGCTGCCGTCGTCGTCGG
CGTGCTGATCGGGCATGTGTGGATGGCGCTGACGCTCACCGCTCTGGGCGTGCTGGCCTGGCATTACTGGCGGCTGCGCC
AGGTGCTGCGGCGGCTGACTGCACGCCAGCGTGCCGAGCCTGCGGCCGGGATCGGGGCCTGGAACGAACTGGACCGGCTG
CTGTATCGCAGCCAGGACGAAATGCGCGCGCGCAAGCGGCGCCTGATCGAAATGTTGCGCACCTACCGCGCCGCGGCGCA
GGCGCTGCCGGATGCAGTGGTGGTCGTGGATCGCAACAGCCAGCGCGTGCAGTGGTTCAACAAGGCGGCCGGCGGTTTGC
TCGGCCTGCACCATCCCGGCGACATGGGCGTGTCGATCGTGGAGCGGCTGCAGCCGTTGCCGCTGGCGCATTGGCTGGCG
GCCGGGCGCAACGCCGAGCCGATGCTGGATGCCGCCTCGCCGGCAGACCCGGATCTTCGCCTGAATCTGCGCCTGATCCC
CTACTCCGACGACTACTGGCTGCTGGTGGCGCGCGATGTCAGCAAGCTGCTGCGGCTGGAACAGGTGCGCCGCGATTTCG
TGGCCAACGTCTCGCATGAACTGCGTACCCCGCTGACGGTGGTGCACGGTTATCTGGACATGCTCGACCCGGAAGACTTC
CCCGATTCGGGTCCGATGCTGGCGGAAATGCGCAAGCAATCCCAGCGCATGGCGCAGCTGGTCGAAGACCTGCTGACGCT
GTCGCGGCTGGAATCGCAGGAAGAACTCGGCGAAGAACACGTGGCGATGGCGCCGATGCTGTCGACCTTGCGCCGCGAGG
CCGAGGCGCACAGCCAGGGCCGCCACACCGTGGAGGTGATCGACGAGGCCGGCGTGGATCTGCTCGGCTCCAACAAGGAG
CTGCACAGTGCGTTTTCCAACCTGGTGACCAATGCGGTGCGCTACACGCCCGGCGGCGGCACGGTGACGATCCGTTTCGT
GCGCGAAGGCGATGGTGCGGCGCTGGCCGTGCGCGACACCGGCTATGGCATTCCCGCCTCGCACCTGCCGCGCATCACCG
AACGCTTCTACCGTGTGTCCAGCAGCCGCTCGCGCGAGAGCGGCGGCACCGGGCTGGGGCTGTCGATCGTCAAGCACATC
CTGGGGCTGCATCAGGCGCGCCTGGACATCGAAAGCGAAGTGGGACGCGGCAGCGAATTCTCGTGTCATTTCGTGCCTGC
GCGCGTCGTGCAGCGCGAGCAATCGGTGCCACTGTCACGCTCGGCGTGA

Upstream 100 bases:

>100_bases
GGCTATCGTTTTTCCTCGGCGACCTGACGTGCCGCAAAGCCGCCCCGGCCGCAGTCCGGCCGGGTGGCTGCCTACCTGAC
GCTTCGTGGTAACGCCTTCC

Downstream 100 bases:

>100_bases
TATGTAGTCAGTGCGCGCCGCAGCGCGCTGCGATGGACGCGTCTGCCACGCGCCGCATTGCCTGCGTTGCGCGCCCCAGG
CAATTACACAACCCGTCTTG

Product: two-component system sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MPQHIRSAWLKTLGTLALLLGAAVVVGVLIGHVWMALTLTALGVLAWHYWRLRQVLRRLTARQRAEPAAGIGAWNELDRL
LYRSQDEMRARKRRLIEMLRTYRAAAQALPDAVVVVDRNSQRVQWFNKAAGGLLGLHHPGDMGVSIVERLQPLPLAHWLA
AGRNAEPMLDAASPADPDLRLNLRLIPYSDDYWLLVARDVSKLLRLEQVRRDFVANVSHELRTPLTVVHGYLDMLDPEDF
PDSGPMLAEMRKQSQRMAQLVEDLLTLSRLESQEELGEEHVAMAPMLSTLRREAEAHSQGRHTVEVIDEAGVDLLGSNKE
LHSAFSNLVTNAVRYTPGGGTVTIRFVREGDGAALAVRDTGYGIPASHLPRITERFYRVSSSRSRESGGTGLGLSIVKHI
LGLHQARLDIESEVGRGSEFSCHFVPARVVQREQSVPLSRSA

Sequences:

>Translated_442_residues
MPQHIRSAWLKTLGTLALLLGAAVVVGVLIGHVWMALTLTALGVLAWHYWRLRQVLRRLTARQRAEPAAGIGAWNELDRL
LYRSQDEMRARKRRLIEMLRTYRAAAQALPDAVVVVDRNSQRVQWFNKAAGGLLGLHHPGDMGVSIVERLQPLPLAHWLA
AGRNAEPMLDAASPADPDLRLNLRLIPYSDDYWLLVARDVSKLLRLEQVRRDFVANVSHELRTPLTVVHGYLDMLDPEDF
PDSGPMLAEMRKQSQRMAQLVEDLLTLSRLESQEELGEEHVAMAPMLSTLRREAEAHSQGRHTVEVIDEAGVDLLGSNKE
LHSAFSNLVTNAVRYTPGGGTVTIRFVREGDGAALAVRDTGYGIPASHLPRITERFYRVSSSRSRESGGTGLGLSIVKHI
LGLHQARLDIESEVGRGSEFSCHFVPARVVQREQSVPLSRSA
>Mature_441_residues
PQHIRSAWLKTLGTLALLLGAAVVVGVLIGHVWMALTLTALGVLAWHYWRLRQVLRRLTARQRAEPAAGIGAWNELDRLL
YRSQDEMRARKRRLIEMLRTYRAAAQALPDAVVVVDRNSQRVQWFNKAAGGLLGLHHPGDMGVSIVERLQPLPLAHWLAA
GRNAEPMLDAASPADPDLRLNLRLIPYSDDYWLLVARDVSKLLRLEQVRRDFVANVSHELRTPLTVVHGYLDMLDPEDFP
DSGPMLAEMRKQSQRMAQLVEDLLTLSRLESQEELGEEHVAMAPMLSTLRREAEAHSQGRHTVEVIDEAGVDLLGSNKEL
HSAFSNLVTNAVRYTPGGGTVTIRFVREGDGAALAVRDTGYGIPASHLPRITERFYRVSSSRSRESGGTGLGLSIVKHIL
GLHQARLDIESEVGRGSEFSCHFVPARVVQREQSVPLSRSA

Specific function: Member of the two-component regulatory system phoR/phoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates phoB in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=432, Percent_Identity=38.6574074074074, Blast_Score=282, Evalue=2e-77,
Organism=Escherichia coli, GI145693157, Length=226, Percent_Identity=31.4159292035398, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1788393, Length=262, Percent_Identity=30.1526717557252, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1786783, Length=269, Percent_Identity=29.368029739777, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790346, Length=214, Percent_Identity=30.3738317757009, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1789149, Length=227, Percent_Identity=29.0748898678414, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790551, Length=218, Percent_Identity=33.0275229357798, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI48994928, Length=267, Percent_Identity=27.7153558052434, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1790861, Length=205, Percent_Identity=30.2439024390244, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI87082128, Length=219, Percent_Identity=26.9406392694064, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1789403, Length=201, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI87081816, Length=231, Percent_Identity=27.7056277056277, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787894, Length=218, Percent_Identity=29.3577981651376, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1788549, Length=248, Percent_Identity=27.4193548387097, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790436, Length=231, Percent_Identity=25.5411255411255, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789808, Length=202, Percent_Identity=28.2178217821782, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR021766
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR014310 [H]

Pfam domain/function: PF11808 DUF3329; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49170; Mature: 49039

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQHIRSAWLKTLGTLALLLGAAVVVGVLIGHVWMALTLTALGVLAWHYWRLRQVLRRLT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARQRAEPAAGIGAWNELDRLLYRSQDEMRARKRRLIEMLRTYRAAAQALPDAVVVVDRNS
HHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
QRVQWFNKAAGGLLGLHHPGDMGVSIVERLQPLPLAHWLAAGRNAEPMLDAASPADPDLR
HHHHHHHHHCCCEEECCCCCCHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCCCCEE
LNLRLIPYSDDYWLLVARDVSKLLRLEQVRRDFVANVSHELRTPLTVVHGYLDMLDPEDF
EEEEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCC
PDSGPMLAEMRKQSQRMAQLVEDLLTLSRLESQEELGEEHVAMAPMLSTLRREAEAHSQG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RHTVEVIDEAGVDLLGSNKELHSAFSNLVTNAVRYTPGGGTVTIRFVREGDGAALAVRDT
CHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHEECCCCCEEEEEEEEECCCCEEEEECC
GYGIPASHLPRITERFYRVSSSRSRESGGTGLGLSIVKHILGLHQARLDIESEVGRGSEF
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHCCCCCCC
SCHFVPARVVQREQSVPLSRSA
EEEECHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PQHIRSAWLKTLGTLALLLGAAVVVGVLIGHVWMALTLTALGVLAWHYWRLRQVLRRLT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARQRAEPAAGIGAWNELDRLLYRSQDEMRARKRRLIEMLRTYRAAAQALPDAVVVVDRNS
HHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
QRVQWFNKAAGGLLGLHHPGDMGVSIVERLQPLPLAHWLAAGRNAEPMLDAASPADPDLR
HHHHHHHHHCCCEEECCCCCCHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCCCCEE
LNLRLIPYSDDYWLLVARDVSKLLRLEQVRRDFVANVSHELRTPLTVVHGYLDMLDPEDF
EEEEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCC
PDSGPMLAEMRKQSQRMAQLVEDLLTLSRLESQEELGEEHVAMAPMLSTLRREAEAHSQG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RHTVEVIDEAGVDLLGSNKELHSAFSNLVTNAVRYTPGGGTVTIRFVREGDGAALAVRDT
CHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHEECCCCCEEEEEEEEECCCCEEEEECC
GYGIPASHLPRITERFYRVSSSRSRESGGTGLGLSIVKHILGLHQARLDIESEVGRGSEF
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHCCCCCCC
SCHFVPARVVQREQSVPLSRSA
EEEECHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2556368 [H]