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The map label for this gene is beta [H]

Identifier: 78046330

GI number: 78046330

Start: 884442

End: 886112

Strand: Reverse

Name: beta [H]

Synonym: XCV0774

Alternate gene names: 78046330

Gene position: 886112-884442 (Counterclockwise)

Preceding gene: 78046331

Following gene: 78046329

Centisome position: 17.11

GC content: 64.93

Gene sequence:

>1671_bases
ATGCAACGCGAATACGACTACATCATCATCGGCGCCGGCTCGGCAGGCAACGTGCTGGCGGCACGCCTGACCGAAGATCC
CGGCGTGACCGTGCTGCTGCTCGAAGCGGGCGGGCCGGATTACCGCCTGGATTTCCGCACGCAGATGCCGGCAGCACTGG
CCTTTCCGTTGCAGGGACGTCGCTACAACTGGGCCTATGAAACCGAGCCGGAACCCTACATGGACAACCGGCGCATGGAA
TGCGGTCGCGGCAAGGGCCTGGGCGGTTCGTCGCTGATCAACGGCATGTGCTACATCCGCGGCAATGCACTGGACTTCGA
TCATTGGGCCAAGCGCCCCGGCCTGGAGGACTGGAGCTACCGCGATGTCCTGCCGTACTTCCGCAAGGCAGAGACGCGCG
ACATCGGCGCCAACGATTACCACGGCGGCGACGGCCCGGTGAGCGTGGCAACGCCGAAGAACGACAACAACGTGTTGTTC
CATGCCATGGTCGAGGCAGGCGTACAGGCAGGCTACCCGCGTACCGACGATCTCAATGGCTACCAGCAGGAAGGCTTCGG
ACCGATGGACCGCACGGTGACGCCACGCGGGCGCCGCGCCAGCACCGCGCGCGGTTACCTGGACATGGCCAAGCCGCGCG
ACGGCCTGCATATCGTCACCCACGCCACCACCGACCGCATTTTGTTTGCAGGCAAGCGTGCCATCGGCGTGCATTACCTG
GTGGGCAACAGCAGCGAAGGAATCGATGCGCATGCACGCCGCGAAGTACTGGTGTGCGCGGGTGCGATCGCCTCGCCGCA
GCTGCTGCAACGCTCCGGCGTAGGCGCACCCGATCTGCTGCGCGCACTGGATGTGCAACTGGTGCACGACCTGCCCGGCG
TCGGCCAGAACCTGCAGGACCACCTGGAGGTGTATATCCAGTACGCATGCACCAAGCCGGTGTCCTTGTATCCGGCATTG
CAGTGGTGGAACCAGCCTGCGATCGGCGCGGAATGGTTATTCGCCGGTACCGGCACCGGCGCCAGCAATCAGTTCGAAGC
CGGCGGCTTCATCCGCACGCGCGAGGAATTCGACTGGCCCAACATCCAGTACCACTTCCTTCCGGTGGCCATCAATTACA
ACGGCAGCAATGCCGTCAAGGAGCACGGCTTCCAAGCGCACGTCGGCTCGATGCGCACACCCAGCCGCGGGCGTGTGCAC
GCCAAATCGCGCGACCCGCGCCAGCATCCTTCGATCCTGTTCAACTACCAATCCACCGACCAGGACTGGCAGGAATTCCG
CGACGCGATCCGCATCACCCGCGAGATCATCGCGCAACCGGCGCTAGACCCCTACCGCGGCCGCGAGATCAGCCCCAGTG
CGGACTGCAAGACCGATGCGGAGCTGGACGCATTCGTCCGCTCTCGCGCTGAAACCGCCTATCACCCCTCCTGCTCCTGC
GCGATGGGCACCGACGACATGGCGGTGGTGGACGGCCAGGGCCGCGTGCACGGCATGGAGGGCCTGCGCGTGATCGATGC
CTCGATCATGCCGCGCATCATCACCGGCAACCTCAACGCCACCACCATCATGATTGCCGAGAAAATCGCCGACCGCATGC
GCGGTCGCCCCCCATTGCCGCGCAGCACCGCCGATTACTACATCGCTGGCGATGCACCTGTGCGCGGGTGA

Upstream 100 bases:

>100_bases
TGGTGGCAATAACGCGCCGCTATCGCTCCCCGGGAGCACGCTTGCGTCTGTGCCGTATGCCTTGACCGCCACCGCACCGT
TATCGCATCAGGAGAACACC

Downstream 100 bases:

>100_bases
CCTTTTCTCCGGGTCGAGCGTGCGGTGCCCTAACCCTTCTTGCATGTACCGTGAACCCTTCCATGAGCGCGTTGGCGGCG
TCCTCGCCGCCGGTGGTCCC

Product: choline dehydrogenase

Products: NA

Alternate protein names: CDH; CHD [H]

Number of amino acids: Translated: 556; Mature: 556

Protein sequence:

>556_residues
MQREYDYIIIGAGSAGNVLAARLTEDPGVTVLLLEAGGPDYRLDFRTQMPAALAFPLQGRRYNWAYETEPEPYMDNRRME
CGRGKGLGGSSLINGMCYIRGNALDFDHWAKRPGLEDWSYRDVLPYFRKAETRDIGANDYHGGDGPVSVATPKNDNNVLF
HAMVEAGVQAGYPRTDDLNGYQQEGFGPMDRTVTPRGRRASTARGYLDMAKPRDGLHIVTHATTDRILFAGKRAIGVHYL
VGNSSEGIDAHARREVLVCAGAIASPQLLQRSGVGAPDLLRALDVQLVHDLPGVGQNLQDHLEVYIQYACTKPVSLYPAL
QWWNQPAIGAEWLFAGTGTGASNQFEAGGFIRTREEFDWPNIQYHFLPVAINYNGSNAVKEHGFQAHVGSMRTPSRGRVH
AKSRDPRQHPSILFNYQSTDQDWQEFRDAIRITREIIAQPALDPYRGREISPSADCKTDAELDAFVRSRAETAYHPSCSC
AMGTDDMAVVDGQGRVHGMEGLRVIDASIMPRIITGNLNATTIMIAEKIADRMRGRPPLPRSTADYYIAGDAPVRG

Sequences:

>Translated_556_residues
MQREYDYIIIGAGSAGNVLAARLTEDPGVTVLLLEAGGPDYRLDFRTQMPAALAFPLQGRRYNWAYETEPEPYMDNRRME
CGRGKGLGGSSLINGMCYIRGNALDFDHWAKRPGLEDWSYRDVLPYFRKAETRDIGANDYHGGDGPVSVATPKNDNNVLF
HAMVEAGVQAGYPRTDDLNGYQQEGFGPMDRTVTPRGRRASTARGYLDMAKPRDGLHIVTHATTDRILFAGKRAIGVHYL
VGNSSEGIDAHARREVLVCAGAIASPQLLQRSGVGAPDLLRALDVQLVHDLPGVGQNLQDHLEVYIQYACTKPVSLYPAL
QWWNQPAIGAEWLFAGTGTGASNQFEAGGFIRTREEFDWPNIQYHFLPVAINYNGSNAVKEHGFQAHVGSMRTPSRGRVH
AKSRDPRQHPSILFNYQSTDQDWQEFRDAIRITREIIAQPALDPYRGREISPSADCKTDAELDAFVRSRAETAYHPSCSC
AMGTDDMAVVDGQGRVHGMEGLRVIDASIMPRIITGNLNATTIMIAEKIADRMRGRPPLPRSTADYYIAGDAPVRG
>Mature_556_residues
MQREYDYIIIGAGSAGNVLAARLTEDPGVTVLLLEAGGPDYRLDFRTQMPAALAFPLQGRRYNWAYETEPEPYMDNRRME
CGRGKGLGGSSLINGMCYIRGNALDFDHWAKRPGLEDWSYRDVLPYFRKAETRDIGANDYHGGDGPVSVATPKNDNNVLF
HAMVEAGVQAGYPRTDDLNGYQQEGFGPMDRTVTPRGRRASTARGYLDMAKPRDGLHIVTHATTDRILFAGKRAIGVHYL
VGNSSEGIDAHARREVLVCAGAIASPQLLQRSGVGAPDLLRALDVQLVHDLPGVGQNLQDHLEVYIQYACTKPVSLYPAL
QWWNQPAIGAEWLFAGTGTGASNQFEAGGFIRTREEFDWPNIQYHFLPVAINYNGSNAVKEHGFQAHVGSMRTPSRGRVH
AKSRDPRQHPSILFNYQSTDQDWQEFRDAIRITREIIAQPALDPYRGREISPSADCKTDAELDAFVRSRAETAYHPSCSC
AMGTDDMAVVDGQGRVHGMEGLRVIDASIMPRIITGNLNATTIMIAEKIADRMRGRPPLPRSTADYYIAGDAPVRG

Specific function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=543, Percent_Identity=49.5395948434622, Blast_Score=511, Evalue=1e-145,
Organism=Escherichia coli, GI1786503, Length=552, Percent_Identity=78.0797101449275, Blast_Score=914, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17532301, Length=563, Percent_Identity=44.582593250444, Blast_Score=460, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24642048, Length=592, Percent_Identity=36.1486486486487, Blast_Score=292, Evalue=5e-79,
Organism=Drosophila melanogaster, GI24642042, Length=572, Percent_Identity=35.6643356643357, Blast_Score=277, Evalue=1e-74,
Organism=Drosophila melanogaster, GI45551458, Length=580, Percent_Identity=33.6206896551724, Blast_Score=273, Evalue=3e-73,
Organism=Drosophila melanogaster, GI45549471, Length=580, Percent_Identity=33.6206896551724, Blast_Score=272, Evalue=4e-73,
Organism=Drosophila melanogaster, GI24642059, Length=570, Percent_Identity=35.2631578947368, Blast_Score=267, Evalue=2e-71,
Organism=Drosophila melanogaster, GI24642055, Length=585, Percent_Identity=34.7008547008547, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI17137792, Length=564, Percent_Identity=34.9290780141844, Blast_Score=259, Evalue=3e-69,
Organism=Drosophila melanogaster, GI24642039, Length=573, Percent_Identity=34.0314136125654, Blast_Score=242, Evalue=4e-64,
Organism=Drosophila melanogaster, GI18859995, Length=571, Percent_Identity=34.3257443082312, Blast_Score=242, Evalue=4e-64,
Organism=Drosophila melanogaster, GI24650267, Length=571, Percent_Identity=32.2241681260946, Blast_Score=241, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24642035, Length=576, Percent_Identity=33.5069444444444, Blast_Score=238, Evalue=1e-62,
Organism=Drosophila melanogaster, GI24642037, Length=577, Percent_Identity=32.9289428076257, Blast_Score=237, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24642051, Length=571, Percent_Identity=30.9982486865149, Blast_Score=228, Evalue=7e-60,
Organism=Drosophila melanogaster, GI18859993, Length=577, Percent_Identity=32.9289428076257, Blast_Score=214, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24645930, Length=580, Percent_Identity=26.551724137931, Blast_Score=158, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24642057, Length=583, Percent_Identity=28.1303602058319, Blast_Score=126, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011533
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.1 [H]

Molecular weight: Translated: 61438; Mature: 61438

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00623 GMC_OXRED_1 ; PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQREYDYIIIGAGSAGNVLAARLTEDPGVTVLLLEAGGPDYRLDFRTQMPAALAFPLQGR
CCCCCCEEEEECCCCCCEEEEEECCCCCCEEEEEECCCCCEEEEECCCCCCEEECCCCCC
RYNWAYETEPEPYMDNRRMECGRGKGLGGSSLINGMCYIRGNALDFDHWAKRPGLEDWSY
EECCEECCCCCCCCCCCCCCCCCCCCCCHHHHHCCEEEEECCCCCHHHHHCCCCCCCCCH
RDVLPYFRKAETRDIGANDYHGGDGPVSVATPKNDNNVLFHAMVEAGVQAGYPRTDDLNG
HHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCEEEEEEHHHHHHCCCCCCCCCCC
YQQEGFGPMDRTVTPRGRRASTARGYLDMAKPRDGLHIVTHATTDRILFAGKRAIGVHYL
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEECCCEEEEEEE
VGNSSEGIDAHARREVLVCAGAIASPQLLQRSGVGAPDLLRALDVQLVHDLPGVGQNLQD
ECCCCCCCCHHHHCEEEEEECCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHH
HLEVYIQYACTKPVSLYPALQWWNQPAIGAEWLFAGTGTGASNQFEAGGFIRTREEFDWP
HHHHHHHHHCCCCCEECHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCEEEEHHHCCCC
NIQYHFLPVAINYNGSNAVKEHGFQAHVGSMRTPSRGRVHAKSRDPRQHPSILFNYQSTD
CEEEEEEEEEEEECCCCHHHHCCCEEECCCCCCCCCCEEECCCCCCCCCCCEEEEECCCC
QDWQEFRDAIRITREIIAQPALDPYRGREISPSADCKTDAELDAFVRSRAETAYHPSCSC
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCE
AMGTDDMAVVDGQGRVHGMEGLRVIDASIMPRIITGNLNATTIMIAEKIADRMRGRPPLP
ECCCCCEEEECCCCCEECCCCEEEECCCCCCEEEECCCCEEEEHHHHHHHHHHCCCCCCC
RSTADYYIAGDAPVRG
CCCCCEEEECCCCCCC
>Mature Secondary Structure
MQREYDYIIIGAGSAGNVLAARLTEDPGVTVLLLEAGGPDYRLDFRTQMPAALAFPLQGR
CCCCCCEEEEECCCCCCEEEEEECCCCCCEEEEEECCCCCEEEEECCCCCCEEECCCCCC
RYNWAYETEPEPYMDNRRMECGRGKGLGGSSLINGMCYIRGNALDFDHWAKRPGLEDWSY
EECCEECCCCCCCCCCCCCCCCCCCCCCHHHHHCCEEEEECCCCCHHHHHCCCCCCCCCH
RDVLPYFRKAETRDIGANDYHGGDGPVSVATPKNDNNVLFHAMVEAGVQAGYPRTDDLNG
HHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCEEEEEEHHHHHHCCCCCCCCCCC
YQQEGFGPMDRTVTPRGRRASTARGYLDMAKPRDGLHIVTHATTDRILFAGKRAIGVHYL
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEECCCEEEEEEE
VGNSSEGIDAHARREVLVCAGAIASPQLLQRSGVGAPDLLRALDVQLVHDLPGVGQNLQD
ECCCCCCCCHHHHCEEEEEECCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHH
HLEVYIQYACTKPVSLYPALQWWNQPAIGAEWLFAGTGTGASNQFEAGGFIRTREEFDWP
HHHHHHHHHCCCCCEECHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCEEEEHHHCCCC
NIQYHFLPVAINYNGSNAVKEHGFQAHVGSMRTPSRGRVHAKSRDPRQHPSILFNYQSTD
CEEEEEEEEEEEECCCCHHHHCCCEEECCCCCCCCCCEEECCCCCCCCCCCEEEEECCCC
QDWQEFRDAIRITREIIAQPALDPYRGREISPSADCKTDAELDAFVRSRAETAYHPSCSC
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCE
AMGTDDMAVVDGQGRVHGMEGLRVIDASIMPRIITGNLNATTIMIAEKIADRMRGRPPLP
ECCCCCEEEECCCCCEECCCCEEEECCCCCCEEEECCCCEEEEHHHHHHHHHHCCCCCCC
RSTADYYIAGDAPVRG
CCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]