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The map label for this gene is ubiA [H]

Identifier: 78045961

GI number: 78045961

Start: 458096

End: 459001

Strand: Reverse

Name: ubiA [H]

Synonym: XCV0405

Alternate gene names: 78045961

Gene position: 459001-458096 (Counterclockwise)

Preceding gene: 78045962

Following gene: 78045959

Centisome position: 8.86

GC content: 67.99

Gene sequence:

>906_bases
ATGAGCAAGCATGGTGTCGAACAACTGCCCGCAGCGCGCGCGCTGACGTGGCCGCAGCGATTGGGCCAGTACTGGAAGCT
GGTCCGTGGCGACCGCCCGATCGGGAGCCTGCTGCTGCTCTGGCCCACCTGGTGGGCGTTGTGGCTGGCTGCCGATGGCC
TGCCGCCGCTGTGGACGCTGTTGGTGTTCACCGCCGGGGTGTGGCTGACCCGCTCGGCCGGCTGCGTGATCAACGATTAC
GCAGACCGCTGGCTAGATCCGCACGTGGAGCGCACCAAATCGCGTCCGCTGGCCACCGGCGCGGTCTCCGGGCGCGAGGC
GCTGTGGGTCTTCGTGGTGCTGATGCTGGTGGCCTTCGCGCTGGTGCTCACGCTCAACTGGCTCACCGTGGCGCTGAGCG
TGCCCGGCGTGTTCCTGGCCGCCAGCTACCCCTATCTCAAGCGCCATACCCACCTGCCGCAGGTCTATCTGGGCATGGCG
TTCGGCTGGGGCATCCCGATGGCCTTCGCCGCCGTGCAAGGCCGCGTGCCGTTGCTGGGCTGGCTGCTGTATGCCGCCAA
CATCCTGTGGGCCACCGCCTACGACACCTGGTACGCCATGGTCGACCGCGACGACGATATCCGCATGGGCAGCAAATCCA
CCGCCATCCTGTTCGGCAGATTCGATCTGATCGCACAAGGCATCTTGTATGCGCTGATGGCCGCGACGCTGGTGCTGGTC
GGCCTGCGCGCCGATCTCGGTGTGGCGTACTGGGCCGGTCTGGCCGTTGCGGCGCTGCTGGTCGCCTACGAATTCCGCAT
CGCCCGCCACCGCGAGCGTGGCCCCTGCTTCCGCGCCTTCCTGCACAACAACTGGGTCGGCCTGGCGATCTTCGTCGGCA
TCGCCGTGGCGGTGGCGGGGCGTTAG

Upstream 100 bases:

>100_bases
GCCATCATGGATGGCAGGGCATTGCCAGGATTGCCGCCCGCACAGCGCCCACCCCGCGCCCACATGACCACGGCCGAGCC
GCGCTGCTACCCTTTGCCGC

Downstream 100 bases:

>100_bases
ATTCGGGAATCGGGAATCGGGAATCGGGAATCGGGAATCCGTCGATTACAGACCAGATGTTGGGATGACGGGTGAGGGTT
CGAAGCATGCGCGCATCTTT

Product: 4-hydroxybenzoate octaprenyltransferase

Products: NA

Alternate protein names: 4-HB polyprenyltransferase [H]

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MSKHGVEQLPAARALTWPQRLGQYWKLVRGDRPIGSLLLLWPTWWALWLAADGLPPLWTLLVFTAGVWLTRSAGCVINDY
ADRWLDPHVERTKSRPLATGAVSGREALWVFVVLMLVAFALVLTLNWLTVALSVPGVFLAASYPYLKRHTHLPQVYLGMA
FGWGIPMAFAAVQGRVPLLGWLLYAANILWATAYDTWYAMVDRDDDIRMGSKSTAILFGRFDLIAQGILYALMAATLVLV
GLRADLGVAYWAGLAVAALLVAYEFRIARHRERGPCFRAFLHNNWVGLAIFVGIAVAVAGR

Sequences:

>Translated_301_residues
MSKHGVEQLPAARALTWPQRLGQYWKLVRGDRPIGSLLLLWPTWWALWLAADGLPPLWTLLVFTAGVWLTRSAGCVINDY
ADRWLDPHVERTKSRPLATGAVSGREALWVFVVLMLVAFALVLTLNWLTVALSVPGVFLAASYPYLKRHTHLPQVYLGMA
FGWGIPMAFAAVQGRVPLLGWLLYAANILWATAYDTWYAMVDRDDDIRMGSKSTAILFGRFDLIAQGILYALMAATLVLV
GLRADLGVAYWAGLAVAALLVAYEFRIARHRERGPCFRAFLHNNWVGLAIFVGIAVAVAGR
>Mature_300_residues
SKHGVEQLPAARALTWPQRLGQYWKLVRGDRPIGSLLLLWPTWWALWLAADGLPPLWTLLVFTAGVWLTRSAGCVINDYA
DRWLDPHVERTKSRPLATGAVSGREALWVFVVLMLVAFALVLTLNWLTVALSVPGVFLAASYPYLKRHTHLPQVYLGMAF
GWGIPMAFAAVQGRVPLLGWLLYAANILWATAYDTWYAMVDRDDDIRMGSKSTAILFGRFDLIAQGILYALMAATLVLVG
LRADLGVAYWAGLAVAALLVAYEFRIARHRERGPCFRAFLHNNWVGLAIFVGIAVAVAGR

Specific function: Synthesis of 3-octaprenyl-4-hydroxybenzoate [H]

COG id: COG0382

COG function: function code H; 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI260656052, Length=284, Percent_Identity=35.5633802816901, Blast_Score=159, Evalue=4e-39,
Organism=Escherichia coli, GI1790473, Length=279, Percent_Identity=56.2724014336918, Blast_Score=306, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI17553718, Length=302, Percent_Identity=35.0993377483444, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI32565247, Length=303, Percent_Identity=34.983498349835, Blast_Score=158, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17553720, Length=359, Percent_Identity=30.6406685236769, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI32565245, Length=161, Percent_Identity=41.6149068322981, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI32565243, Length=160, Percent_Identity=41.25, Blast_Score=108, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6324370, Length=294, Percent_Identity=33.3333333333333, Blast_Score=116, Evalue=5e-27,
Organism=Drosophila melanogaster, GI21355567, Length=278, Percent_Identity=36.6906474820144, Blast_Score=173, Evalue=1e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006370
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 33431; Mature: 33300

Theoretical pI: Translated: 10.06; Mature: 10.06

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKHGVEQLPAARALTWPQRLGQYWKLVRGDRPIGSLLLLWPTWWALWLAADGLPPLWTL
CCCCCCHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHH
LVFTAGVWLTRSAGCVINDYADRWLDPHVERTKSRPLATGAVSGREALWVFVVLMLVAFA
HHHHHHHHHCCCCCCEEEHHHHHCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
LVLTLNWLTVALSVPGVFLAASYPYLKRHTHLPQVYLGMAFGWGIPMAFAAVQGRVPLLG
HHHHHHHHHHHHHCCCHHHHCCCHHHHHHCCCCHHHHHHHHHCCHHHHHHHHCCCHHHHH
WLLYAANILWATAYDTWYAMVDRDDDIRMGSKSTAILFGRFDLIAQGILYALMAATLVLV
HHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHH
GLRADLGVAYWAGLAVAALLVAYEFRIARHRERGPCFRAFLHNNWVGLAIFVGIAVAVAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCC
R
C
>Mature Secondary Structure 
SKHGVEQLPAARALTWPQRLGQYWKLVRGDRPIGSLLLLWPTWWALWLAADGLPPLWTL
CCCCCHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHH
LVFTAGVWLTRSAGCVINDYADRWLDPHVERTKSRPLATGAVSGREALWVFVVLMLVAFA
HHHHHHHHHCCCCCCEEEHHHHHCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
LVLTLNWLTVALSVPGVFLAASYPYLKRHTHLPQVYLGMAFGWGIPMAFAAVQGRVPLLG
HHHHHHHHHHHHHCCCHHHHCCCHHHHHHCCCCHHHHHHHHHCCHHHHHHHHCCCHHHHH
WLLYAANILWATAYDTWYAMVDRDDDIRMGSKSTAILFGRFDLIAQGILYALMAATLVLV
HHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHH
GLRADLGVAYWAGLAVAALLVAYEFRIARHRERGPCFRAFLHNNWVGLAIFVGIAVAVAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]