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The map label for this gene is pcaR [H]

Identifier: 78045943

GI number: 78045943

Start: 440741

End: 441649

Strand: Reverse

Name: pcaR [H]

Synonym: XCV0387

Alternate gene names: 78045943

Gene position: 441649-440741 (Counterclockwise)

Preceding gene: 78045946

Following gene: 78045933

Centisome position: 8.53

GC content: 69.64

Gene sequence:

>909_bases
ATGGCGCGAGCGCTTACCATGCACGGACCTGTCCGCTGCCGCACTCCTATGCCCGAGCCCGCCTCCAGCCGCCGCAAACG
TCCCGCCACCGTGGTAGCGGCCGGCAGCGATCGCGGCCTGCCGCATGAGCTGATGCAGCAGATCGCCGCCGCCCAGGGCG
ATCCGGACTTCATGACCTCGCTGGGGCGCGGGCTGGTGGTGCTGAGCGTGTTCGCGCAGCACGCGCGCGAAGTGACGATG
TCGCAGATCAGCCTGGAAACCGGTATCTCGCGCGCAGCCGTCCGGCGCGTGCTGCATACGCTGGCCAAGCTGGGCTATGT
GGGCGAGCAAGGACGTGGCTACGTGTTGCTGCCGCGCGTGCTGGGCATCGGCGGCGCGTACGCGGCGTCTTCATCGATGA
CCGCGGCCGCACAGCCGGTCCTGGACGGGCTGCGCGACCAACTGCACGAATCGTGTTCGCTGGGCGTGCTGGATGGCGAC
GATCTGCTGTACGTGGCGCGGTCGGAAACGGTGCGCATCATGTCGATCGGGCTGCGCCCGGGGACGCGGCTGCCGGCCTA
CTGCACCTCGATGGGGCGGGTGTTGCTGGCCGCCCTGCCCGGCGACACCTTGCAGGCGTATCTGGAACGCACCACCTTGC
GTCCGCGGACCGACCGCACGGTGACCCAGGCCTCGGCGCTGCTGGAGGTGCTGGCGCGCACGCGCCGCGAAGGCATGTGC
CTGACCGATCAGGAACTGGAAATCGGCCTGCGCTCGATCGCCGTGCCGGTGCGCAACCTGCGCGGCGAGGTGATCGCCGC
GCTCAACATCGGCGCCCAGGCCGGGCGGGTGAGCCTGCAGACGATGCAAACGCAGTTGCTGGAACCGCTGAAGCAGGCGG
CGCAGCGGCTGGGAACCTTGCTGAGTTAG

Upstream 100 bases:

>100_bases
GGACTAAGAGCACCGATCCGTCACAAACCAGCGGCGATTATGCGGCAAGCAGGGTGAAGCGCTTACATGCCCACGCACAG
AGTGTGAGCCGGGGCATGCC

Downstream 100 bases:

>100_bases
TGCAGCACCTTGCGTTGGCGCGGGCGTCGCCCGCGGGGCATCTGACCTGCCCCTGTGCTGCATAAGCGCTAGTGGCGCAG
CGGTGGCTGGCAGAGGTCAA

Product: IclR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MARALTMHGPVRCRTPMPEPASSRRKRPATVVAAGSDRGLPHELMQQIAAAQGDPDFMTSLGRGLVVLSVFAQHAREVTM
SQISLETGISRAAVRRVLHTLAKLGYVGEQGRGYVLLPRVLGIGGAYAASSSMTAAAQPVLDGLRDQLHESCSLGVLDGD
DLLYVARSETVRIMSIGLRPGTRLPAYCTSMGRVLLAALPGDTLQAYLERTTLRPRTDRTVTQASALLEVLARTRREGMC
LTDQELEIGLRSIAVPVRNLRGEVIAALNIGAQAGRVSLQTMQTQLLEPLKQAAQRLGTLLS

Sequences:

>Translated_302_residues
MARALTMHGPVRCRTPMPEPASSRRKRPATVVAAGSDRGLPHELMQQIAAAQGDPDFMTSLGRGLVVLSVFAQHAREVTM
SQISLETGISRAAVRRVLHTLAKLGYVGEQGRGYVLLPRVLGIGGAYAASSSMTAAAQPVLDGLRDQLHESCSLGVLDGD
DLLYVARSETVRIMSIGLRPGTRLPAYCTSMGRVLLAALPGDTLQAYLERTTLRPRTDRTVTQASALLEVLARTRREGMC
LTDQELEIGLRSIAVPVRNLRGEVIAALNIGAQAGRVSLQTMQTQLLEPLKQAAQRLGTLLS
>Mature_301_residues
ARALTMHGPVRCRTPMPEPASSRRKRPATVVAAGSDRGLPHELMQQIAAAQGDPDFMTSLGRGLVVLSVFAQHAREVTMS
QISLETGISRAAVRRVLHTLAKLGYVGEQGRGYVLLPRVLGIGGAYAASSSMTAAAQPVLDGLRDQLHESCSLGVLDGDD
LLYVARSETVRIMSIGLRPGTRLPAYCTSMGRVLLAALPGDTLQAYLERTTLRPRTDRTVTQASALLEVLARTRREGMCL
TDQELEIGLRSIAVPVRNLRGEVIAALNIGAQAGRVSLQTMQTQLLEPLKQAAQRLGTLLS

Specific function: Positive regulator of all genes within the pca regulon, pcaBDC, pcaIJ and pcaF. Also required for the chemotactic response to aromatic compounds [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI1788131, Length=231, Percent_Identity=31.6017316017316, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1789999, Length=261, Percent_Identity=26.0536398467433, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1786468, Length=241, Percent_Identity=32.3651452282158, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87082359, Length=224, Percent_Identity=26.3392857142857, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1788581, Length=184, Percent_Identity=26.6304347826087, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1786715, Length=228, Percent_Identity=23.6842105263158, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI145693096, Length=221, Percent_Identity=28.9592760180996, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012794
- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 32424; Mature: 32293

Theoretical pI: Translated: 10.39; Mature: 10.39

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARALTMHGPVRCRTPMPEPASSRRKRPATVVAAGSDRGLPHELMQQIAAAQGDPDFMTS
CCCEEECCCCEEECCCCCCCCHHHCCCCCEEEECCCCCCCCHHHHHHHHHCCCCHHHHHH
LGRGLVVLSVFAQHAREVTMSQISLETGISRAAVRRVLHTLAKLGYVGEQGRGYVLLPRV
HCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEHHH
LGIGGAYAASSSMTAAAQPVLDGLRDQLHESCSLGVLDGDDLLYVARSETVRIMSIGLRP
HCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEECCCCEEEEECCCEEEEEEECCCC
GTRLPAYCTSMGRVLLAALPGDTLQAYLERTTLRPRTDRTVTQASALLEVLARTRREGMC
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
LTDQELEIGLRSIAVPVRNLRGEVIAALNIGAQAGRVSLQTMQTQLLEPLKQAAQRLGTL
CCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LS
CC
>Mature Secondary Structure 
ARALTMHGPVRCRTPMPEPASSRRKRPATVVAAGSDRGLPHELMQQIAAAQGDPDFMTS
CCEEECCCCEEECCCCCCCCHHHCCCCCEEEECCCCCCCCHHHHHHHHHCCCCHHHHHH
LGRGLVVLSVFAQHAREVTMSQISLETGISRAAVRRVLHTLAKLGYVGEQGRGYVLLPRV
HCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEHHH
LGIGGAYAASSSMTAAAQPVLDGLRDQLHESCSLGVLDGDDLLYVARSETVRIMSIGLRP
HCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEECCCCEEEEECCCEEEEEEECCCC
GTRLPAYCTSMGRVLLAALPGDTLQAYLERTTLRPRTDRTVTQASALLEVLARTRREGMC
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
LTDQELEIGLRSIAVPVRNLRGEVIAALNIGAQAGRVSLQTMQTQLLEPLKQAAQRLGTL
CCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LS
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8083169 [H]