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The map label for this gene is hemN [H]

Identifier: 78044379

GI number: 78044379

Start: 353479

End: 354609

Strand: Direct

Name: hemN [H]

Synonym: CHY_0411

Alternate gene names: 78044379

Gene position: 353479-354609 (Clockwise)

Preceding gene: 78044431

Following gene: 78043787

Centisome position: 14.72

GC content: 39.88

Gene sequence:

>1131_bases
TTGATAATAACAAATAAAGCTCAGGCCCTTTACCTGCATATGCCTTTTTGTCTTAAGAAGTGCCATTACTGTGCTTTTAC
CTCTTTTCCCGCGCCGGCGGGTGAAGGGGTATTTTCGTATTTAAGCTTAATAAAGAAAGAATTGGAATGGCGAAAAGATT
TTTTAGCGCCTCTTAAGACCATTTATGTGGGCGGGGGAACGCCAACTTCCCTTTCGCTGAACGCTTTAGAAAAACTGGGG
GAAATTATCTCGCCGTATATTTCCGATAAGCTTTTGGAGTTTACCGTTGAAGCCAATCCGGGAACGTTAAATAGGGAAAA
AATTCGCCTTTTAAAAGATTTAGGAGTCAATCGTGTAAGCCTTGGGGCCCAATCTTTTAATGATGAGATTCTTTTAAAAA
TGGGTAGAGCCCATACTGCTGCTCAAACGTTGGAAGCGTACAATTTATTGAGGGAAGAGGGCATAAACAATTTAAACCTG
GACTTAATTATCGGTTATCCCGAGGGGCGCGAAAGCTTTATAAACACTGTAAAAACGGCCATAAGCTTAAAGCCGGAACA
TATTTCTTTATACGATTTAAAGGTAGAAGAAAATACCCGCCTTTATGAAGAAGTAGCAAAGGGTGAAATAATACTTCCGG
AAGAGGATGAAGTAGTTTTATATTGGGAGGAAGCGATTAATCTTTTAGAGGAAAACGGTTACGAACGGTACGAAATTGCT
AACTTTGCTCGAAACCAGCAGTATTCCCGTCACAACCTTACTTACTGGGAAAATAAACCTTATCTTGGCATTGGCCTAGC
TGCCCATAGCAAGGTAGGCCTGTACCGGTTCTGGAATCCGAATACGATGCTGGAGTACCGGGAAATGCTTTTAACAGGAA
AAAATTATGGCGAGGAAAAATTAACTTTAGAAGAAGATGCCAAAGAAGAAATAATTTTAAGATTAAGGTTAAAAACCGGG
CTAAATCTTCAGGAGTTTCAAAAAAAATACCGGCGGGACTTTATGGCAGAGTTTGGCGATAAAATCCAAAAATTTATCGA
ACTTGGCCTGCTTTTCCTTGAAGATGATAGGCTTTTTTTAACCCGCAAGGGGAGTTTTGTAGCCAACACTGTATTAATTG
AGTTTATCTAA

Upstream 100 bases:

>100_bases
AAGAAAAAGCTTTTGGAAAAGCAGAAAGAAGGTAAAAAGCGAATGAAACAAATTGGCAGGGTGGAAATTCCCCAGGAAGC
TTTTATGGCGGTGTTGAAAA

Downstream 100 bases:

>100_bases
ACTTGACAAAAAATGCTTGACAGTGCTATTTTTAATTTGAAGTTAGCACTCAACAAAAGAGAGTGCTAACAAAAAGGGGT
GAAGCGGTATGATTGATGAG

Product: putative oxygen-independent coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MIITNKAQALYLHMPFCLKKCHYCAFTSFPAPAGEGVFSYLSLIKKELEWRKDFLAPLKTIYVGGGTPTSLSLNALEKLG
EIISPYISDKLLEFTVEANPGTLNREKIRLLKDLGVNRVSLGAQSFNDEILLKMGRAHTAAQTLEAYNLLREEGINNLNL
DLIIGYPEGRESFINTVKTAISLKPEHISLYDLKVEENTRLYEEVAKGEIILPEEDEVVLYWEEAINLLEENGYERYEIA
NFARNQQYSRHNLTYWENKPYLGIGLAAHSKVGLYRFWNPNTMLEYREMLLTGKNYGEEKLTLEEDAKEEIILRLRLKTG
LNLQEFQKKYRRDFMAEFGDKIQKFIELGLLFLEDDRLFLTRKGSFVANTVLIEFI

Sequences:

>Translated_376_residues
MIITNKAQALYLHMPFCLKKCHYCAFTSFPAPAGEGVFSYLSLIKKELEWRKDFLAPLKTIYVGGGTPTSLSLNALEKLG
EIISPYISDKLLEFTVEANPGTLNREKIRLLKDLGVNRVSLGAQSFNDEILLKMGRAHTAAQTLEAYNLLREEGINNLNL
DLIIGYPEGRESFINTVKTAISLKPEHISLYDLKVEENTRLYEEVAKGEIILPEEDEVVLYWEEAINLLEENGYERYEIA
NFARNQQYSRHNLTYWENKPYLGIGLAAHSKVGLYRFWNPNTMLEYREMLLTGKNYGEEKLTLEEDAKEEIILRLRLKTG
LNLQEFQKKYRRDFMAEFGDKIQKFIELGLLFLEDDRLFLTRKGSFVANTVLIEFI
>Mature_376_residues
MIITNKAQALYLHMPFCLKKCHYCAFTSFPAPAGEGVFSYLSLIKKELEWRKDFLAPLKTIYVGGGTPTSLSLNALEKLG
EIISPYISDKLLEFTVEANPGTLNREKIRLLKDLGVNRVSLGAQSFNDEILLKMGRAHTAAQTLEAYNLLREEGINNLNL
DLIIGYPEGRESFINTVKTAISLKPEHISLYDLKVEENTRLYEEVAKGEIILPEEDEVVLYWEEAINLLEENGYERYEIA
NFARNQQYSRHNLTYWENKPYLGIGLAAHSKVGLYRFWNPNTMLEYREMLLTGKNYGEEKLTLEEDAKEEIILRLRLKTG
LNLQEFQKKYRRDFMAEFGDKIQKFIELGLLFLEDDRLFLTRKGSFVANTVLIEFI

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=271, Percent_Identity=29.8892988929889, Blast_Score=148, Evalue=8e-36,
Organism=Escherichia coli, GI1789325, Length=272, Percent_Identity=34.9264705882353, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI87082341, Length=388, Percent_Identity=23.4536082474227, Blast_Score=103, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 43408; Mature: 43408

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIITNKAQALYLHMPFCLKKCHYCAFTSFPAPAGEGVFSYLSLIKKELEWRKDFLAPLKT
CEECCCCCEEEEECHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHE
IYVGGGTPTSLSLNALEKLGEIISPYISDKLLEFTVEANPGTLNREKIRLLKDLGVNRVS
EEECCCCCCCEEHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHCCCCEEE
LGAQSFNDEILLKMGRAHTAAQTLEAYNLLREEGINNLNLDLIIGYPEGRESFINTVKTA
CCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHH
ISLKPEHISLYDLKVEENTRLYEEVAKGEIILPEEDEVVLYWEEAINLLEENGYERYEIA
HCCCCCEEEEEEEEECCCHHHHHHHHCCCEECCCCCCEEEEHHHHHHHHHHCCCCHHHHH
NFARNQQYSRHNLTYWENKPYLGIGLAAHSKVGLYRFWNPNTMLEYREMLLTGKNYGEEK
HHHHCCCCCCCCCEEECCCCEEEEEEECCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCC
LTLEEDAKEEIILRLRLKTGLNLQEFQKKYRRDFMAEFGDKIQKFIELGLLFLEDDRLFL
CEECCCCHHEEEEEEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCEEEE
TRKGSFVANTVLIEFI
EECCCEEEEEEEEEEC
>Mature Secondary Structure
MIITNKAQALYLHMPFCLKKCHYCAFTSFPAPAGEGVFSYLSLIKKELEWRKDFLAPLKT
CEECCCCCEEEEECHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHE
IYVGGGTPTSLSLNALEKLGEIISPYISDKLLEFTVEANPGTLNREKIRLLKDLGVNRVS
EEECCCCCCCEEHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHCCCCEEE
LGAQSFNDEILLKMGRAHTAAQTLEAYNLLREEGINNLNLDLIIGYPEGRESFINTVKTA
CCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHH
ISLKPEHISLYDLKVEENTRLYEEVAKGEIILPEEDEVVLYWEEAINLLEENGYERYEIA
HCCCCCEEEEEEEEECCCHHHHHHHHCCCEECCCCCCEEEEHHHHHHHHHHCCCCHHHHH
NFARNQQYSRHNLTYWENKPYLGIGLAAHSKVGLYRFWNPNTMLEYREMLLTGKNYGEEK
HHHHCCCCCCCCCEEECCCCEEEEEEECCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCC
LTLEEDAKEEIILRLRLKTGLNLQEFQKKYRRDFMAEFGDKIQKFIELGLLFLEDDRLFL
CEECCCCHHEEEEEEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCEEEE
TRKGSFVANTVLIEFI
EECCCEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]