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The map label for this gene is yugH [H]

Identifier: 78043844

GI number: 78043844

Start: 97746

End: 98924

Strand: Direct

Name: yugH [H]

Synonym: CHY_0115

Alternate gene names: 78043844

Gene position: 97746-98924 (Clockwise)

Preceding gene: 78042949

Following gene: 78043815

Centisome position: 4.07

GC content: 48.18

Gene sequence:

>1179_bases
GTGAACCTTGAAGAAAAAATAAACCCGGTTTTACGGCAGATACCCCCTTCGGGGATCAGAAAATTTTTTGACCTGGTAGC
CAATACCAAAGGCGTTATCTCCCTCGGGGTAGGGGAACCGGATTTTGTTACACCCTGGTATATCCGGGAAGAGGGGATTT
ATTCCCTGGAAAAGGGCTACACCATGTACACATCCAATCAGGGGCTTTTGGAACTTAGGGAAGAAATTAGCCGCTACCTC
TTACGGCTTACGGGGGTAGCTTATGACCCGGTCCAGGAAGTTTTGGTGACCGTTGGGGTCAGCGAAGGGGTCGATTTAGC
CCTGAGGGCTCTTGTCTCTCCCGGGGATGAGGTGCTTATTCCCGAGCCCTCCTATGTTTCTTACGGGCCAACGACGATGC
TGGCGGGAGGGAAGCCGGTTTACATCCGGACGCGGCCGGAAAACGGCTTTAAATTAACGCCGGAGCTTTTAGAAGAAGCA
ATAACTCCGAAGTCGAAAATCTTGCTTCTCTGTTATCCCAATAACCCGACCGGAGCGGTGATGACCGCCGATGACCTGGC
CAAACTCCTGCCGGTTATTGCCGAACACGACCTTCTCGTAATTTCCGATGAGATTTATGCGGAACTTACTTATGAAGGGA
AGCACGTTTCCGTTGCTTCTTTTCCGGGAATGAAAGAGCGTACGGTGATTTTAAATGGCTTTTCCAAAGCTTTCGCCATG
ACCGGCTGGCGGCTTGGTTATGCGGCCGGTCCTAAAGAAATCATAGCGGCGATGACCAAAATACACCAGTACACCATGCT
TTGCGCTCCGATTACGGCGCAAAAAGCAGCGATAGAAGCTTTGAAAAATCAAAACGATGCGGTAAAAAAGATGGTGGAAG
AGTATAATTACCGGAGAAGAATTTTAGTGGAAGCTTTTAGCGAAATGGGGCTCTGGCTTTTTGAACCCAAAGGAGCCTTT
TATGCTTTCCCGGATATTTCGGCAACCGGCTTATCCAGTGAAGAGTTTGCCGAAAGGCTTTTATTTGAAGAAAAGGTAGC
GGTGGTACCCGGGTCGGCTTTTGGACCTTCTGGAGAGGGCTTTATCCGGATTTCCTATGCTACCGCCCGGAAAGATTTAA
TTGAAGCTTTAAAGAGAATAAAAAGATTTGTGCGGAAAAAATCTTTAAAAAAGCAGTAA

Upstream 100 bases:

>100_bases
GAGTGCAAAGCTGTGCTACCCACTTTATCTTAAAAACCTACAAGCATGAAGGAGTTATTTTGGACGATGAAGAGGAAGAT
AGAAGGCTGGTGATAACGCC

Downstream 100 bases:

>100_bases
AAACCCCTTTGACGGGTTTTTTCTTTTTTTACCCTAAAATTACCTTGCAAATTAGAGCTTTTGGCATTAAAATATTATTC
GAGATACGTATTATACGAAA

Product: putative aspartate aminotransferase

Products: N-succinyl-2-L-amino-6-oxoheptanedioate; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MNLEEKINPVLRQIPPSGIRKFFDLVANTKGVISLGVGEPDFVTPWYIREEGIYSLEKGYTMYTSNQGLLELREEISRYL
LRLTGVAYDPVQEVLVTVGVSEGVDLALRALVSPGDEVLIPEPSYVSYGPTTMLAGGKPVYIRTRPENGFKLTPELLEEA
ITPKSKILLLCYPNNPTGAVMTADDLAKLLPVIAEHDLLVISDEIYAELTYEGKHVSVASFPGMKERTVILNGFSKAFAM
TGWRLGYAAGPKEIIAAMTKIHQYTMLCAPITAQKAAIEALKNQNDAVKKMVEEYNYRRRILVEAFSEMGLWLFEPKGAF
YAFPDISATGLSSEEFAERLLFEEKVAVVPGSAFGPSGEGFIRISYATARKDLIEALKRIKRFVRKKSLKKQ

Sequences:

>Translated_392_residues
MNLEEKINPVLRQIPPSGIRKFFDLVANTKGVISLGVGEPDFVTPWYIREEGIYSLEKGYTMYTSNQGLLELREEISRYL
LRLTGVAYDPVQEVLVTVGVSEGVDLALRALVSPGDEVLIPEPSYVSYGPTTMLAGGKPVYIRTRPENGFKLTPELLEEA
ITPKSKILLLCYPNNPTGAVMTADDLAKLLPVIAEHDLLVISDEIYAELTYEGKHVSVASFPGMKERTVILNGFSKAFAM
TGWRLGYAAGPKEIIAAMTKIHQYTMLCAPITAQKAAIEALKNQNDAVKKMVEEYNYRRRILVEAFSEMGLWLFEPKGAF
YAFPDISATGLSSEEFAERLLFEEKVAVVPGSAFGPSGEGFIRISYATARKDLIEALKRIKRFVRKKSLKKQ
>Mature_392_residues
MNLEEKINPVLRQIPPSGIRKFFDLVANTKGVISLGVGEPDFVTPWYIREEGIYSLEKGYTMYTSNQGLLELREEISRYL
LRLTGVAYDPVQEVLVTVGVSEGVDLALRALVSPGDEVLIPEPSYVSYGPTTMLAGGKPVYIRTRPENGFKLTPELLEEA
ITPKSKILLLCYPNNPTGAVMTADDLAKLLPVIAEHDLLVISDEIYAELTYEGKHVSVASFPGMKERTVILNGFSKAFAM
TGWRLGYAAGPKEIIAAMTKIHQYTMLCAPITAQKAAIEALKNQNDAVKKMVEEYNYRRRILVEAFSEMGLWLFEPKGAF
YAFPDISATGLSSEEFAERLLFEEKVAVVPGSAFGPSGEGFIRISYATARKDLIEALKRIKRFVRKKSLKKQ

Specific function: Unknown

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI95147551, Length=358, Percent_Identity=30.1675977653631, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI169881279, Length=358, Percent_Identity=30.1675977653631, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI56713256, Length=403, Percent_Identity=30.272952853598, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI56713254, Length=403, Percent_Identity=30.272952853598, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI169881281, Length=264, Percent_Identity=29.1666666666667, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI4507369, Length=379, Percent_Identity=25.3298153034301, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI187936925, Length=401, Percent_Identity=25.9351620947631, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI14211921, Length=401, Percent_Identity=25.9351620947631, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI19263340, Length=368, Percent_Identity=25.2717391304348, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI215599424, Length=368, Percent_Identity=25.2717391304348, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI149944424, Length=297, Percent_Identity=28.2828282828283, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI4885351, Length=393, Percent_Identity=25.1908396946565, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1786816, Length=384, Percent_Identity=31.7708333333333, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1788722, Length=376, Percent_Identity=32.7127659574468, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1788627, Length=376, Percent_Identity=27.9255319148936, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1790797, Length=320, Percent_Identity=27.5, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1787909, Length=386, Percent_Identity=24.6113989637306, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1788332, Length=223, Percent_Identity=28.2511210762332, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787710, Length=190, Percent_Identity=27.8947368421053, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71994476, Length=418, Percent_Identity=29.9043062200957, Blast_Score=158, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI71994472, Length=380, Percent_Identity=31.5789473684211, Blast_Score=158, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17567369, Length=405, Percent_Identity=26.4197530864197, Blast_Score=144, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI17567663, Length=402, Percent_Identity=25.1243781094527, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71981209, Length=344, Percent_Identity=24.4186046511628, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322401, Length=320, Percent_Identity=29.375, Blast_Score=133, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6320317, Length=339, Percent_Identity=25.6637168141593, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6323118, Length=338, Percent_Identity=24.8520710059172, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI28573069, Length=387, Percent_Identity=26.0981912144703, Blast_Score=144, Evalue=9e-35,
Organism=Drosophila melanogaster, GI24646114, Length=387, Percent_Identity=26.0981912144703, Blast_Score=144, Evalue=9e-35,
Organism=Drosophila melanogaster, GI28573067, Length=387, Percent_Identity=26.0981912144703, Blast_Score=144, Evalue=9e-35,
Organism=Drosophila melanogaster, GI28573065, Length=387, Percent_Identity=26.0981912144703, Blast_Score=144, Evalue=9e-35,
Organism=Drosophila melanogaster, GI18859735, Length=383, Percent_Identity=24.8041775456919, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24641770, Length=393, Percent_Identity=25.9541984732824, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24641760, Length=393, Percent_Identity=25.9541984732824, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24641768, Length=393, Percent_Identity=25.9541984732824, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24641766, Length=393, Percent_Identity=25.9541984732824, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24641764, Length=393, Percent_Identity=25.9541984732824, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45551451, Length=393, Percent_Identity=25.9541984732824, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001176
- InterPro:   IPR004839
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: 2.6.1.17

Molecular weight: Translated: 43575; Mature: 43575

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLEEKINPVLRQIPPSGIRKFFDLVANTKGVISLGVGEPDFVTPWYIREEGIYSLEKGY
CCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCEEEECCCCEEHHCCE
TMYTSNQGLLELREEISRYLLRLTGVAYDPVQEVLVTVGVSEGVDLALRALVSPGDEVLI
EEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEE
PEPSYVSYGPTTMLAGGKPVYIRTRPENGFKLTPELLEEAITPKSKILLLCYPNNPTGAV
CCCCCCCCCCEEEECCCCEEEEEECCCCCCEECHHHHHHHCCCCCCEEEEEECCCCCCCE
MTADDLAKLLPVIAEHDLLVISDEIYAELTYEGKHVSVASFPGMKERTVILNGFSKAFAM
EEHHHHHHHHHHHHCCCEEEEECCEEEEEEECCCEEEEECCCCCCCCEEEEECHHHHHHH
TGWRLGYAAGPKEIIAAMTKIHQYTMLCAPITAQKAAIEALKNQNDAVKKMVEEYNYRRR
CCCEECCCCCHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
ILVEAFSEMGLWLFEPKGAFYAFPDISATGLSSEEFAERLLFEEKVAVVPGSAFGPSGEG
HHHHHHHHCCEEEECCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHEECCCCCCCCCCCC
FIRISYATARKDLIEALKRIKRFVRKKSLKKQ
EEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNLEEKINPVLRQIPPSGIRKFFDLVANTKGVISLGVGEPDFVTPWYIREEGIYSLEKGY
CCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCEEEECCCCEEHHCCE
TMYTSNQGLLELREEISRYLLRLTGVAYDPVQEVLVTVGVSEGVDLALRALVSPGDEVLI
EEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEE
PEPSYVSYGPTTMLAGGKPVYIRTRPENGFKLTPELLEEAITPKSKILLLCYPNNPTGAV
CCCCCCCCCCEEEECCCCEEEEEECCCCCCEECHHHHHHHCCCCCCEEEEEECCCCCCCE
MTADDLAKLLPVIAEHDLLVISDEIYAELTYEGKHVSVASFPGMKERTVILNGFSKAFAM
EEHHHHHHHHHHHHCCCEEEEECCEEEEEEECCCEEEEECCCCCCCCEEEEECHHHHHHH
TGWRLGYAAGPKEIIAAMTKIHQYTMLCAPITAQKAAIEALKNQNDAVKKMVEEYNYRRR
CCCEECCCCCHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
ILVEAFSEMGLWLFEPKGAFYAFPDISATGLSSEEFAERLLFEEKVAVVPGSAFGPSGEG
HHHHHHHHCCEEEECCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHEECCCCCCCCCCCC
FIRISYATARKDLIEALKRIKRFVRKKSLKKQ
EEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-succinyl-L-2,6-diaminoheptanedioate; 2-oxoglutarate

Specific reaction: N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-succinyl-2-L-amino-6-oxoheptanedioate + L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9274030; 9384377 [H]