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The map label for this gene is lon2 [H]

Identifier: 78043822

GI number: 78043822

Start: 30884

End: 32782

Strand: Direct

Name: lon2 [H]

Synonym: CHY_0040

Alternate gene names: 78043822

Gene position: 30884-32782 (Clockwise)

Preceding gene: 78043341

Following gene: 78043236

Centisome position: 1.29

GC content: 47.45

Gene sequence:

>1899_bases
GTGAAATTTTTTCTACTGCCTAACGAGCGGCGCGAATTGGAAAAAAAAGTCGAACTAATCGGAAATGTATTAACCAATTT
ATACGGTCCGGATAAACTTATTTTAAAAGCTGCCAAGGTGGAAGCCTTAAATCTCATTCAATCGGAGAAGTTAGAAGAAA
AGGTTTTGGGCTATCAGAAAATCGTCTTAGAGGATCCCTCCCTGACCCGGGTACCGGCGGCAGGTGAACTTGCCGAAATT
TTAGCAACCATTGAAGACCATATAGCGGATATTTTAGCCCGCCGGACGGTAGAGGAAGACCTGGAGCGCAAAGTAGAGCG
GAAGATGCAGGAACGGCATGAGGAGTATTTAGAGGAAATCCGGCGGCAGGTTTTAAAAGAATCCGGCAACGTGGAAAACG
CTCAAACCTTAAAAAAACTCGCCCGCCTGGAAAAATTAGAAGAAACCAAAATTGCTGCCACGGCTATGTCTTTTCTCCGT
CCCCGGAGTTTTTCCGAAATCGTCGGGCAGGAGCGGGCCATTCGGGCACTTTTAGCAAAACTTTCATCACCTTTTCCCCA
GCACATCCTCTTATATGGACCGCCGGGGGTGGGGAAGACCACCGCTGCCCGTTTGTGTTTGGAAGAGGCCAAAAAGCGTA
AAGGCTCACCCTTTGCTCCGGATGCTCCTTTTGTGGAAGTGGATGGCACTACATTGCGCTGGGACCCACGGGAAGTTACC
AATCCCCTTTTGGGTTCGGTGCATGATCCCATTTATCAGGGAGCCCGCCGGGATTTAGCGGAAACGGGAGTGCCGGAACC
AAAACTCGGACTTGTTACCGAAGCCCACGGTGGGATATTATTTATCGATGAAATTGGGGAGTTGGACCCTTTATTACAAA
ATAAGCTTTTAAAAGTTTTGGAAGATAAACGGGTATATTTTGATTCGGCCTATTACGACCCCGATGACCCCAATGTACCG
CAGTACATTAAAAAAATCTTTGAAGAAGGGGCGCCGGCGGACTTTATTTTAATCGGTGCTACCACCCGCTCGCCGGAAGA
AATAAATCCGGCCTTAAGGTCACGCTGCGCGGAAATCTTTTTTGAGCCGTTGGGGCCGGCGGAAATAAAAGAGATAGTTT
TAAAAGCGGCGCAAAAGTTAAATGTCAAACTTGCTCCGGATGTACCGGAGCTAATTGCCGGTTATACGGTGGAAGGACGG
AAGGCCGTTAATATTTTAGCCGATGGATATGCAATAGCCCGGTTTAAAAATCCCGAAGGGGATGCTTTAACCATTACCGC
CGATGATATTTTAGAGGTGGTTAATGTCAGCCGGATTTCGCCCAATAACCTGGTTAGGGGTAGCGATACTTATGAAATTG
GCAAAGTGTTTGGCTTAGGGGTTTATCAGTATTTGGGGTCGGTATTAGAAATTGAGGGAATAGCCTTTGATGCTAAAACT
CCCGGTCAGGGAACGGTTCGTTTTAACGATACTGCCGGTTCTATGGCAAAAGATTCGGTGTTTAATGCTTTGTCGTCTAT
CCGAAAAATTACCGGCATCGATCCCCATAACTATGACCTGCATGTAAACGTAGTAGGCGGAGGTAATATTGACGGTCCTT
CTGCCGGGGCAGCGCTGTTTTTGGTGATGTACTCGGCAATTACCAGGACTCCTTTGCGCCAGGACATTGCTATTACCGGT
GAGATTTCCGTGCACGGAAGGATTAAGCCCGTAGGCGGAATTCCGGAAAAAATTTACGGCGCTAAACAGGCGGGGATTTC
TACGGTACTGATTCCCTTTGATAATTTAAAAGACGTACCCCGGGGTCATTTGGGGATAAAGGTTGTGCCGGTAAAGACGG
TAGAAGAAGTAGTGGAAATTGCTACCCAAAAACCCCTTTTAACCACCAGGGCGGTGTAG

Upstream 100 bases:

>100_bases
ACATTAAAGCCCTTGGAGTGTATACGGTAGAAGTAAAGCTTCATCCGGAGGTAACAGCAAAACTCAAGGTAGCGGTTAAA
GAAGAAGGAAGGGGTTAAAG

Downstream 100 bases:

>100_bases
GAGGATTTTTTTATGAACGAGCTTTTAATGCTACCTCCGCATAATATTGATGCCGAACAGGCGGTTCTTGGGACCATATT
AAGTAATGGTGAAAGCCTTT

Product: putative ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La 2 [H]

Number of amino acids: Translated: 632; Mature: 632

Protein sequence:

>632_residues
MKFFLLPNERRELEKKVELIGNVLTNLYGPDKLILKAAKVEALNLIQSEKLEEKVLGYQKIVLEDPSLTRVPAAGELAEI
LATIEDHIADILARRTVEEDLERKVERKMQERHEEYLEEIRRQVLKESGNVENAQTLKKLARLEKLEETKIAATAMSFLR
PRSFSEIVGQERAIRALLAKLSSPFPQHILLYGPPGVGKTTAARLCLEEAKKRKGSPFAPDAPFVEVDGTTLRWDPREVT
NPLLGSVHDPIYQGARRDLAETGVPEPKLGLVTEAHGGILFIDEIGELDPLLQNKLLKVLEDKRVYFDSAYYDPDDPNVP
QYIKKIFEEGAPADFILIGATTRSPEEINPALRSRCAEIFFEPLGPAEIKEIVLKAAQKLNVKLAPDVPELIAGYTVEGR
KAVNILADGYAIARFKNPEGDALTITADDILEVVNVSRISPNNLVRGSDTYEIGKVFGLGVYQYLGSVLEIEGIAFDAKT
PGQGTVRFNDTAGSMAKDSVFNALSSIRKITGIDPHNYDLHVNVVGGGNIDGPSAGAALFLVMYSAITRTPLRQDIAITG
EISVHGRIKPVGGIPEKIYGAKQAGISTVLIPFDNLKDVPRGHLGIKVVPVKTVEEVVEIATQKPLLTTRAV

Sequences:

>Translated_632_residues
MKFFLLPNERRELEKKVELIGNVLTNLYGPDKLILKAAKVEALNLIQSEKLEEKVLGYQKIVLEDPSLTRVPAAGELAEI
LATIEDHIADILARRTVEEDLERKVERKMQERHEEYLEEIRRQVLKESGNVENAQTLKKLARLEKLEETKIAATAMSFLR
PRSFSEIVGQERAIRALLAKLSSPFPQHILLYGPPGVGKTTAARLCLEEAKKRKGSPFAPDAPFVEVDGTTLRWDPREVT
NPLLGSVHDPIYQGARRDLAETGVPEPKLGLVTEAHGGILFIDEIGELDPLLQNKLLKVLEDKRVYFDSAYYDPDDPNVP
QYIKKIFEEGAPADFILIGATTRSPEEINPALRSRCAEIFFEPLGPAEIKEIVLKAAQKLNVKLAPDVPELIAGYTVEGR
KAVNILADGYAIARFKNPEGDALTITADDILEVVNVSRISPNNLVRGSDTYEIGKVFGLGVYQYLGSVLEIEGIAFDAKT
PGQGTVRFNDTAGSMAKDSVFNALSSIRKITGIDPHNYDLHVNVVGGGNIDGPSAGAALFLVMYSAITRTPLRQDIAITG
EISVHGRIKPVGGIPEKIYGAKQAGISTVLIPFDNLKDVPRGHLGIKVVPVKTVEEVVEIATQKPLLTTRAV
>Mature_632_residues
MKFFLLPNERRELEKKVELIGNVLTNLYGPDKLILKAAKVEALNLIQSEKLEEKVLGYQKIVLEDPSLTRVPAAGELAEI
LATIEDHIADILARRTVEEDLERKVERKMQERHEEYLEEIRRQVLKESGNVENAQTLKKLARLEKLEETKIAATAMSFLR
PRSFSEIVGQERAIRALLAKLSSPFPQHILLYGPPGVGKTTAARLCLEEAKKRKGSPFAPDAPFVEVDGTTLRWDPREVT
NPLLGSVHDPIYQGARRDLAETGVPEPKLGLVTEAHGGILFIDEIGELDPLLQNKLLKVLEDKRVYFDSAYYDPDDPNVP
QYIKKIFEEGAPADFILIGATTRSPEEINPALRSRCAEIFFEPLGPAEIKEIVLKAAQKLNVKLAPDVPELIAGYTVEGR
KAVNILADGYAIARFKNPEGDALTITADDILEVVNVSRISPNNLVRGSDTYEIGKVFGLGVYQYLGSVLEIEGIAFDAKT
PGQGTVRFNDTAGSMAKDSVFNALSSIRKITGIDPHNYDLHVNVVGGGNIDGPSAGAALFLVMYSAITRTPLRQDIAITG
EISVHGRIKPVGGIPEKIYGAKQAGISTVLIPFDNLKDVPRGHLGIKVVPVKTVEEVVEIATQKPLLTTRAV

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG1067

COG function: function code O; Predicted ATP-dependent protease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S16 family [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=447, Percent_Identity=26.6219239373602, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI31377667, Length=160, Percent_Identity=31.25, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1786643, Length=488, Percent_Identity=27.8688524590164, Blast_Score=123, Evalue=4e-29,
Organism=Escherichia coli, GI1789828, Length=118, Percent_Identity=41.5254237288136, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17556486, Length=498, Percent_Identity=26.9076305220884, Blast_Score=94, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17505831, Length=178, Percent_Identity=33.7078651685393, Blast_Score=76, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24666867, Length=227, Percent_Identity=31.7180616740088, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI221513036, Length=227, Percent_Identity=31.7180616740088, Blast_Score=92, Evalue=1e-18,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR020568
- InterPro:   IPR014251 [H]

Pfam domain/function: PF00004 AAA; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 69454; Mature: 69454

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS00676 SIGMA54_INTERACT_2 ; PS50045 SIGMA54_INTERACT_4 ; PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFFLLPNERRELEKKVELIGNVLTNLYGPDKLILKAAKVEALNLIQSEKLEEKVLGYQK
CEEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
IVLEDPSLTRVPAAGELAEILATIEDHIADILARRTVEEDLERKVERKMQERHEEYLEEI
EEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRQVLKESGNVENAQTLKKLARLEKLEETKIAATAMSFLRPRSFSEIVGQERAIRALLAK
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LSSPFPQHILLYGPPGVGKTTAARLCLEEAKKRKGSPFAPDAPFVEVDGTTLRWDPREVT
HCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCEEEECHHHHC
NPLLGSVHDPIYQGARRDLAETGVPEPKLGLVTEAHGGILFIDEIGELDPLLQNKLLKVL
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCEEEEECCCCCCHHHHHHHHHHH
EDKRVYFDSAYYDPDDPNVPQYIKKIFEEGAPADFILIGATTRSPEEINPALRSRCAEIF
HHCCEEEECCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCHHCCHHHHHHHHHHH
FEPLGPAEIKEIVLKAAQKLNVKLAPDVPELIAGYTVEGRKAVNILADGYAIARFKNPEG
HCCCCHHHHHHHHHHHHHHCCCEECCCCHHHHCCCCCCCCCEEEEEECCEEEEEECCCCC
DALTITADDILEVVNVSRISPNNLVRGSDTYEIGKVFGLGVYQYLGSVLEIEGIAFDAKT
CEEEEEHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEECCEEEECCC
PGQGTVRFNDTAGSMAKDSVFNALSSIRKITGIDPHNYDLHVNVVGGGNIDGPSAGAALF
CCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCCHHHHHH
LVMYSAITRTPLRQDIAITGEISVHGRIKPVGGIPEKIYGAKQAGISTVLIPFDNLKDVP
HHHHHHHHCCCCCCCEEEEEEEEECEEEECCCCCCHHHHCHHHCCCEEEEEECCCCCCCC
RGHLGIKVVPVKTVEEVVEIATQKPLLTTRAV
CCCCCEEEEEHHHHHHHHHHHCCCCCHHCCCC
>Mature Secondary Structure
MKFFLLPNERRELEKKVELIGNVLTNLYGPDKLILKAAKVEALNLIQSEKLEEKVLGYQK
CEEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
IVLEDPSLTRVPAAGELAEILATIEDHIADILARRTVEEDLERKVERKMQERHEEYLEEI
EEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRQVLKESGNVENAQTLKKLARLEKLEETKIAATAMSFLRPRSFSEIVGQERAIRALLAK
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LSSPFPQHILLYGPPGVGKTTAARLCLEEAKKRKGSPFAPDAPFVEVDGTTLRWDPREVT
HCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCEEEECHHHHC
NPLLGSVHDPIYQGARRDLAETGVPEPKLGLVTEAHGGILFIDEIGELDPLLQNKLLKVL
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCEEEEECCCCCCHHHHHHHHHHH
EDKRVYFDSAYYDPDDPNVPQYIKKIFEEGAPADFILIGATTRSPEEINPALRSRCAEIF
HHCCEEEECCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCHHCCHHHHHHHHHHH
FEPLGPAEIKEIVLKAAQKLNVKLAPDVPELIAGYTVEGRKAVNILADGYAIARFKNPEG
HCCCCHHHHHHHHHHHHHHCCCEECCCCHHHHCCCCCCCCCEEEEEECCEEEEEECCCCC
DALTITADDILEVVNVSRISPNNLVRGSDTYEIGKVFGLGVYQYLGSVLEIEGIAFDAKT
CEEEEEHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEECCEEEECCC
PGQGTVRFNDTAGSMAKDSVFNALSSIRKITGIDPHNYDLHVNVVGGGNIDGPSAGAALF
CCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCCHHHHHH
LVMYSAITRTPLRQDIAITGEISVHGRIKPVGGIPEKIYGAKQAGISTVLIPFDNLKDVP
HHHHHHHHCCCCCCCEEEEEEEEECEEEECCCCCCHHHHCHHHCCCEEEEEECCCCCCCC
RGHLGIKVVPVKTVEEVVEIATQKPLLTTRAV
CCCCCEEEEEHHHHHHHHHHHCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377; 7961402; 11325926 [H]