Click here to switch to the map view.

The map label for this gene is sirC [H]

Identifier: 78043790

GI number: 78043790

Start: 664575

End: 665189

Strand: Direct

Name: sirC [H]

Synonym: CHY_0754

Alternate gene names: 78043790

Gene position: 664575-665189 (Clockwise)

Preceding gene: 78044696

Following gene: 161594525

Centisome position: 27.67

GC content: 43.9

Gene sequence:

>615_bases
GTGTATCCTATCAGTTTAAATTTAAGGGGGACCCCCGTGTTAGTAGTAGGGGGTGGTCGGGTTGCCCTTCGAAAGGTGCA
AAATCTTCTCCGAGAAGGTGCAAAAATTACCGTAGTTGCCCCGAAAACTCTTCCGGAATTAATGAGTCTGGCCCAGAGCG
GGCAAATTAAACTTTATCTGCGGGAATTTCAGGAAGAAGATTTATCCGGCCCCAAGTTAGTCTTTGCTGCCACCGATAAT
TCAGAGCTTAATAAAAGAATAGCTAATCTTTGTCAAAGACTGGGGATTTGGGTCAACGTAGCCGACAATCCCGAGGAGTC
CAATTTTATTGTTCCAGCGGTTTGGCGCCGGGGAGGTTGGGAAATAGCTGTGGGGACCTCAGGGTTATCTCCCCTGGCGG
CCCGCCTTTTAAAAGAAGAGCTTTCCTGGTTAATTGATCCTGCCTGGGATGATTACCTGAAATTTTGGGGGGAATTACGT
AAAGCCTTAAAGGAAAGCAATATTGAGAAAAATAGGAGGGAAGAAATTTTAAAAGAAGTAGCCAAGATTTATGATTACCG
GAAGTTTTGCCGGGAAAAACCTTCGGTAAAATTAATCTTGGAAAAATTTAAATAA

Upstream 100 bases:

>100_bases
GGAAAATCTTCCCTATTATTTGGGACTTGTTTTGGTTGCTGGACTTTTTGGCTACTATATCTTTTTACGGTACATTAAAA
AGAAGTAAGGAGAGTTTACC

Downstream 100 bases:

>100_bases
AAATATTTTCACAAAGCAGGATTTACGAAAAATTTTACGAATTATCTTAATAAAAATTGAATATTGTAACTTTAAGGTGC
CTTTACGGCTTAAAAGGGAA

Product: siroheme synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 204; Mature: 204

Protein sequence:

>204_residues
MYPISLNLRGTPVLVVGGGRVALRKVQNLLREGAKITVVAPKTLPELMSLAQSGQIKLYLREFQEEDLSGPKLVFAATDN
SELNKRIANLCQRLGIWVNVADNPEESNFIVPAVWRRGGWEIAVGTSGLSPLAARLLKEELSWLIDPAWDDYLKFWGELR
KALKESNIEKNRREEILKEVAKIYDYRKFCREKPSVKLILEKFK

Sequences:

>Translated_204_residues
MYPISLNLRGTPVLVVGGGRVALRKVQNLLREGAKITVVAPKTLPELMSLAQSGQIKLYLREFQEEDLSGPKLVFAATDN
SELNKRIANLCQRLGIWVNVADNPEESNFIVPAVWRRGGWEIAVGTSGLSPLAARLLKEELSWLIDPAWDDYLKFWGELR
KALKESNIEKNRREEILKEVAKIYDYRKFCREKPSVKLILEKFK
>Mature_204_residues
MYPISLNLRGTPVLVVGGGRVALRKVQNLLREGAKITVVAPKTLPELMSLAQSGQIKLYLREFQEEDLSGPKLVFAATDN
SELNKRIANLCQRLGIWVNVADNPEESNFIVPAVWRRGGWEIAVGTSGLSPLAARLLKEELSWLIDPAWDDYLKFWGELR
KALKESNIEKNRREEILKEVAKIYDYRKFCREKPSVKLILEKFK

Specific function: Catalyzes the dehydrogenation of precorrin-2 to form sirohydrochlorin used as precursor in both siroheme biosynthesis and in the anaerobic branch of adenosylcobalamin biosynthesis [H]

COG id: COG1648

COG function: function code H; Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789768, Length=163, Percent_Identity=37.4233128834356, Blast_Score=104, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR006367 [H]

Pfam domain/function: NA

EC number: =1.3.1.76 [H]

Molecular weight: Translated: 23249; Mature: 23249

Theoretical pI: Translated: 9.92; Mature: 9.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYPISLNLRGTPVLVVGGGRVALRKVQNLLREGAKITVVAPKTLPELMSLAQSGQIKLYL
CCEEEEECCCCEEEEECCCHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHCCCCEEEHH
REFQEEDLSGPKLVFAATDNSELNKRIANLCQRLGIWVNVADNPEESNFIVPAVWRRGGW
HHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEECCCCCCCCEEEEHHCCCCCE
EIAVGTSGLSPLAARLLKEELSWLIDPAWDDYLKFWGELRKALKESNIEKNRREEILKEV
EEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
AKIYDYRKFCREKPSVKLILEKFK
HHHHHHHHHHHCCCCHHHHHHHCC
>Mature Secondary Structure
MYPISLNLRGTPVLVVGGGRVALRKVQNLLREGAKITVVAPKTLPELMSLAQSGQIKLYL
CCEEEEECCCCEEEEECCCHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHCCCCEEEHH
REFQEEDLSGPKLVFAATDNSELNKRIANLCQRLGIWVNVADNPEESNFIVPAVWRRGGW
HHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEECCCCCCCCEEEEHHCCCCCE
EIAVGTSGLSPLAARLLKEELSWLIDPAWDDYLKFWGELRKALKESNIEKNRREEILKEV
EEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
AKIYDYRKFCREKPSVKLILEKFK
HHHHHHHHHHHCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA