Click here to switch to the map view.

The map label for this gene is mtaD [H]

Identifier: 78043497

GI number: 78043497

Start: 612338

End: 613672

Strand: Direct

Name: mtaD [H]

Synonym: CHY_0698

Alternate gene names: 78043497

Gene position: 612338-613672 (Clockwise)

Preceding gene: 78045001

Following gene: 78044033

Centisome position: 25.5

GC content: 46.37

Gene sequence:

>1335_bases
ATGTCAATTTTAATTAAAAACGGAACAATTGTAACAATGAACGAAAAACGGGAAATTTTAAAAGGCGATTTATACATCGA
GGGAAATATCATTAAGGATATTGGCCCTTCTTTAGATGTTCAGACGGACAAAGTTATCGATGCTGCCGGCAAAGTGGTGA
TTCCAGGTCTAATCCAGACCCACATTCACCTCTGCCAAACCCTTTTCCGGGGGCAAGCGGATGATCTGGAACTTTTGGAT
TGGTTGAAACTCCGGATCTGGCCTTTAGAAGGAGGACACGATCCCGAATCTCTGTATTATTCGGCAATGCTCGGAATTGG
CGAACTGTTTAAAGGCGGAACCACTGCAATTGTCGATATGGCAACGGTTAACCATACCGATTCTAACTTCCAGGCCATTT
ATGATAGCGGGATTCGGGCGATTTCCGGAAAGTGCATGATGGATTACGGGACGGAAGTACCCAAGTCCATGCAGGATACT
ACCGAAAATGCCATTGATGAAAGCGTGCAGCTCCTGGAAAAATGGCACGGCAAGGACAACGGCCGCATCTTGTACGCGTT
TACTCCGCGCTTTGCGGTTTCCTGCACCGAAGATTTATTAAAAGAAGTTGTCAAGTTAGCTGAGCAGTACAAAGTAAGGG
TTCACACCCATGCTTCCGAAAATAAAGGAGAAGTGGAGCTTGTCTTAAAGGAAAGAGGCATGAGAAACGTTCTGTACTTA
GAAAAGTTAGGGATGACGGCTCCAAACCTGATCCTTGCCCATTGTATTCATTTAGACGAACGGGAAATGAAGGTCTTGGC
TGAGTCCAAAACCAAAATTGCCCACTGCCCCTCTTCCAACTTAAAATTAGCATCGGGCATTGCCAAAATTCCCGAGCTTT
TAGAAATGGGCGCGGAAATTTCCATCGCCGCCGATGGCGCTCCGTGCAACAATAACCTGGATGCCTTTATTGAGATGCGG
ATGGCCGCACTGATTCAAAAGCCGTTCTACGGTCCAACTTCAATGCCTGCCCAGAAAGTTTTTGAATTAGCTACCATTGG
CGGTGCCCGGGCTATGGGTCTGGAAGACCAAATTGGCAGCCTGGAAGTGGGTAAAAAAGCAGACGTGGTCATTGTAGACC
TGGATGAAATGAGAACGACCCCAAACGAAGGGGTAAATATATACACCCAGCTCGTTTATCAAGCCCAGAGCAGTAATGTT
TTAACGACCATTGTTGACGGTAAAATCGTAATGGAGAACCGGGTCTTAAAGACCATGGATGAGGTGGAAGTACGCCGGAA
AGCCAACGAAAGCTTAAAACGAGTAGCTGACCGGGTTGGGGTTAGCTTAGAATAG

Upstream 100 bases:

>100_bases
GAAAGGCCAGGCGTAATGCCTGGTCTTTAATCCTTGTGAGAAAAGTTGCAAATTTAATTTACAATGCCAGGCCCAAACTG
TTTTCAAGGGAGTGACTGCC

Downstream 100 bases:

>100_bases
GTGAGAGCGATGAAACCGATAAAGGATTTGGTGGAAGTAGCGTTGGGGAAAAAGCCTGCGGACCTGGTTTTAAAAAATGC
TCAAGTGTTTAATAGCTTTA

Product: N-ethylammeline chlorohydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase [H]

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MSILIKNGTIVTMNEKREILKGDLYIEGNIIKDIGPSLDVQTDKVIDAAGKVVIPGLIQTHIHLCQTLFRGQADDLELLD
WLKLRIWPLEGGHDPESLYYSAMLGIGELFKGGTTAIVDMATVNHTDSNFQAIYDSGIRAISGKCMMDYGTEVPKSMQDT
TENAIDESVQLLEKWHGKDNGRILYAFTPRFAVSCTEDLLKEVVKLAEQYKVRVHTHASENKGEVELVLKERGMRNVLYL
EKLGMTAPNLILAHCIHLDEREMKVLAESKTKIAHCPSSNLKLASGIAKIPELLEMGAEISIAADGAPCNNNLDAFIEMR
MAALIQKPFYGPTSMPAQKVFELATIGGARAMGLEDQIGSLEVGKKADVVIVDLDEMRTTPNEGVNIYTQLVYQAQSSNV
LTTIVDGKIVMENRVLKTMDEVEVRRKANESLKRVADRVGVSLE

Sequences:

>Translated_444_residues
MSILIKNGTIVTMNEKREILKGDLYIEGNIIKDIGPSLDVQTDKVIDAAGKVVIPGLIQTHIHLCQTLFRGQADDLELLD
WLKLRIWPLEGGHDPESLYYSAMLGIGELFKGGTTAIVDMATVNHTDSNFQAIYDSGIRAISGKCMMDYGTEVPKSMQDT
TENAIDESVQLLEKWHGKDNGRILYAFTPRFAVSCTEDLLKEVVKLAEQYKVRVHTHASENKGEVELVLKERGMRNVLYL
EKLGMTAPNLILAHCIHLDEREMKVLAESKTKIAHCPSSNLKLASGIAKIPELLEMGAEISIAADGAPCNNNLDAFIEMR
MAALIQKPFYGPTSMPAQKVFELATIGGARAMGLEDQIGSLEVGKKADVVIVDLDEMRTTPNEGVNIYTQLVYQAQSSNV
LTTIVDGKIVMENRVLKTMDEVEVRRKANESLKRVADRVGVSLE
>Mature_443_residues
SILIKNGTIVTMNEKREILKGDLYIEGNIIKDIGPSLDVQTDKVIDAAGKVVIPGLIQTHIHLCQTLFRGQADDLELLDW
LKLRIWPLEGGHDPESLYYSAMLGIGELFKGGTTAIVDMATVNHTDSNFQAIYDSGIRAISGKCMMDYGTEVPKSMQDTT
ENAIDESVQLLEKWHGKDNGRILYAFTPRFAVSCTEDLLKEVVKLAEQYKVRVHTHASENKGEVELVLKERGMRNVLYLE
KLGMTAPNLILAHCIHLDEREMKVLAESKTKIAHCPSSNLKLASGIAKIPELLEMGAEISIAADGAPCNNNLDAFIEMRM
AALIQKPFYGPTSMPAQKVFELATIGGARAMGLEDQIGSLEVGKKADVVIVDLDEMRTTPNEGVNIYTQLVYQAQSSNVL
TTIVDGKIVMENRVLKTMDEVEVRRKANESLKRVADRVGVSLE

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=336, Percent_Identity=33.6309523809524, Blast_Score=168, Evalue=1e-41,
Organism=Escherichia coli, GI1789249, Length=390, Percent_Identity=33.0769230769231, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI87082177, Length=464, Percent_Identity=24.7844827586207, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17540282, Length=421, Percent_Identity=23.2779097387173, Blast_Score=92, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6319963, Length=378, Percent_Identity=27.7777777777778, Blast_Score=138, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24643849, Length=387, Percent_Identity=26.3565891472868, Blast_Score=143, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 49042; Mature: 48911

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSILIKNGTIVTMNEKREILKGDLYIEGNIIKDIGPSLDVQTDKVIDAAGKVVIPGLIQT
CEEEEECCEEEEECCCHHHHCCCEEEECCCHHHCCCCCCCCHHHHHHCCCCEEECHHHHH
HIHLCQTLFRGQADDLELLDWLKLRIWPLEGGHDPESLYYSAMLGIGELFKGGTTAIVDM
HHHHHHHHHCCCCCCHHHHHEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEE
ATVNHTDSNFQAIYDSGIRAISGKCMMDYGTEVPKSMQDTTENAIDESVQLLEKWHGKDN
EEECCCCCCHHHHHHCCCHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
GRILYAFTPRFAVSCTEDLLKEVVKLAEQYKVRVHTHASENKGEVELVLKERGMRNVLYL
CEEEEEECCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCEEEEEECCCCCHHHHH
EKLGMTAPNLILAHCIHLDEREMKVLAESKTKIAHCPSSNLKLASGIAKIPELLEMGAEI
HHHCCCCHHHHHHHHHCCCHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCE
SIAADGAPCNNNLDAFIEMRMAALIQKPFYGPTSMPAQKVFELATIGGARAMGLEDQIGS
EEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCC
LEVGKKADVVIVDLDEMRTTPNEGVNIYTQLVYQAQSSNVLTTIVDGKIVMENRVLKTMD
CCCCCCCCEEEEEHHHHCCCCCCCHHHHHHHHHHHCCCCEEEEEECCEEEECCHHHHHHH
EVEVRRKANESLKRVADRVGVSLE
HHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SILIKNGTIVTMNEKREILKGDLYIEGNIIKDIGPSLDVQTDKVIDAAGKVVIPGLIQT
EEEEECCEEEEECCCHHHHCCCEEEECCCHHHCCCCCCCCHHHHHHCCCCEEECHHHHH
HIHLCQTLFRGQADDLELLDWLKLRIWPLEGGHDPESLYYSAMLGIGELFKGGTTAIVDM
HHHHHHHHHCCCCCCHHHHHEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEE
ATVNHTDSNFQAIYDSGIRAISGKCMMDYGTEVPKSMQDTTENAIDESVQLLEKWHGKDN
EEECCCCCCHHHHHHCCCHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
GRILYAFTPRFAVSCTEDLLKEVVKLAEQYKVRVHTHASENKGEVELVLKERGMRNVLYL
CEEEEEECCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCEEEEEECCCCCHHHHH
EKLGMTAPNLILAHCIHLDEREMKVLAESKTKIAHCPSSNLKLASGIAKIPELLEMGAEI
HHHCCCCHHHHHHHHHCCCHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCE
SIAADGAPCNNNLDAFIEMRMAALIQKPFYGPTSMPAQKVFELATIGGARAMGLEDQIGS
EEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCC
LEVGKKADVVIVDLDEMRTTPNEGVNIYTQLVYQAQSSNVLTTIVDGKIVMENRVLKTMD
CCCCCCCCEEEEEHHHHCCCCCCCHHHHHHHHHHHCCCCEEEEEECCEEEECCHHHHHHH
EVEVRRKANESLKRVADRVGVSLE
HHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA