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The map label for this gene is cobDQ [H]

Identifier: 78043446

GI number: 78043446

Start: 680321

End: 681427

Strand: Direct

Name: cobDQ [H]

Synonym: CHY_0773

Alternate gene names: 78043446

Gene position: 680321-681427 (Clockwise)

Preceding gene: 78044196

Following gene: 78042950

Centisome position: 28.33

GC content: 39.48

Gene sequence:

>1107_bases
ATGCTTGAACACGGAGGAAATAAGCAACTTTTTTACGAAAAATACGGGGTTTTACCGCGTTACGATTTTAGCGCCAATTT
AAACCCCCTGGGTCCACCCAGAGACGCTCTTAAACTTTTGCGGGAAAACTTAAAGGAGTTAATTTCTACCTATCCCGATT
ATCGGTACCGGGAGTTAGAAAAGGCGGCTTACGGGTATTTTCAAAAGGAAGAAGTAGTTCTGGGAAACGGGGCTTCGTCC
CTTTTAAACTATTTACTTTTTTATCTAAAACCTTCCCGGGGGTTAATTATCGGACCTACTTTTAACCTTTACGAAAAAAC
GCTAAGAAATCGCGAGATACCGGTAGAAAAGCTGGACTGTGCTTTAGAGGAGAAAGGGTATAGTAATGCCAGGGCTTATC
TTTTGCAAAAAGGCCGGAAGGGAGATTTATTGTTGATTTGCCGGCCAAACAACCCCGATGGCTCTGCCTGGCCCGTAAGT
GAATTATTTAAATTAATTGCTTTATGTCAGGAAAAAGGGATAAAGCTTCTTTTAGATGAAAGTTTTGCCGATTTTATGGA
AGATGAGAGGGAAATCTTTTGGCGAAATTCCGGAAAGTTAAAAGATGTCTATATCTTAATTTCCCTTACCAAAATTTTTG
CCATTCCCGGTTTAAGGCTTGGAGCTTTAATCTTACCGGAAAAGGATTATAAAGATTTTAAAAAATTTTTACCGGAGTGG
GAGATAAATAATCTGGCAGCGGAGATAGGGCCGGTACTTTTTGCCCAGAGGGATTATCTGTTAAAAACCAGAGCTTTAAT
AAAAAAAGAAAGGGAGTATTTAAGCCAAAATCTTTTTCGTCTTGGCTTTCAGGTTTTGCCGTCTAAAGCAAATTTTTTAA
TGGCTTATCTTCCTGAAAGTATCAGCTCAGAACAGCTTCTTTCTGAACTGGCAAAATACCGGATAGCTGTAAGACCGCTC
CAAAATTTTGGCTTGAAACGGGAAGCGGTGCGGATTGCGGTAAAAACCCGGAAAGAAAACCGGGTGCTTATAAATACCTT
AAAAAATATTTTATTCAAGACTCACGGTAAAAAGTCAAGGACCAAGAAATGGAAATTAGAAAAGTAG

Upstream 100 bases:

>100_bases
TGGTCGCAGGAAAAAGAAGAAATCTTAAGAAAAGAGTTTTCTTCCTATACATGCCGGGTATTAACCCTGGTGGATGGAGG
AATTACTTTGGAGGTTCATG

Downstream 100 bases:

>100_bases
GGGCTAAAAAAGGCAATAATAACCCTCTCCAACTATATGGTAATAGTTGGAAAATAGCAGAGAAGAGAAAAGGTTTTATT
CAAGAACTATTTCATCACCG

Product: putative cobalamin biosynthesis protein CobD

Products: NA

Alternate protein names: Putative threonine-phosphate decarboxylase; L-threonine-O-3-phosphate decarboxylase; Cobyric acid synthase [H]

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MLEHGGNKQLFYEKYGVLPRYDFSANLNPLGPPRDALKLLRENLKELISTYPDYRYRELEKAAYGYFQKEEVVLGNGASS
LLNYLLFYLKPSRGLIIGPTFNLYEKTLRNREIPVEKLDCALEEKGYSNARAYLLQKGRKGDLLLICRPNNPDGSAWPVS
ELFKLIALCQEKGIKLLLDESFADFMEDEREIFWRNSGKLKDVYILISLTKIFAIPGLRLGALILPEKDYKDFKKFLPEW
EINNLAAEIGPVLFAQRDYLLKTRALIKKEREYLSQNLFRLGFQVLPSKANFLMAYLPESISSEQLLSELAKYRIAVRPL
QNFGLKREAVRIAVKTRKENRVLINTLKNILFKTHGKKSRTKKWKLEK

Sequences:

>Translated_368_residues
MLEHGGNKQLFYEKYGVLPRYDFSANLNPLGPPRDALKLLRENLKELISTYPDYRYRELEKAAYGYFQKEEVVLGNGASS
LLNYLLFYLKPSRGLIIGPTFNLYEKTLRNREIPVEKLDCALEEKGYSNARAYLLQKGRKGDLLLICRPNNPDGSAWPVS
ELFKLIALCQEKGIKLLLDESFADFMEDEREIFWRNSGKLKDVYILISLTKIFAIPGLRLGALILPEKDYKDFKKFLPEW
EINNLAAEIGPVLFAQRDYLLKTRALIKKEREYLSQNLFRLGFQVLPSKANFLMAYLPESISSEQLLSELAKYRIAVRPL
QNFGLKREAVRIAVKTRKENRVLINTLKNILFKTHGKKSRTKKWKLEK
>Mature_368_residues
MLEHGGNKQLFYEKYGVLPRYDFSANLNPLGPPRDALKLLRENLKELISTYPDYRYRELEKAAYGYFQKEEVVLGNGASS
LLNYLLFYLKPSRGLIIGPTFNLYEKTLRNREIPVEKLDCALEEKGYSNARAYLLQKGRKGDLLLICRPNNPDGSAWPVS
ELFKLIALCQEKGIKLLLDESFADFMEDEREIFWRNSGKLKDVYILISLTKIFAIPGLRLGALILPEKDYKDFKKFLPEW
EINNLAAEIGPVLFAQRDYLLKTRALIKKEREYLSQNLFRLGFQVLPSKANFLMAYLPESISSEQLLSELAKYRIAVRPL
QNFGLKREAVRIAVKTRKENRVLINTLKNILFKTHGKKSRTKKWKLEK

Specific function: Catalyzes two activities which are involved in the adenosylcobalamin biosynthesis:decarboxylates L-threonine-O-3- phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cob

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=318, Percent_Identity=23.8993710691824, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2; PF01656 CbiA; PF07685 GATase_3 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 42727; Mature: 42727

Theoretical pI: Translated: 10.06; Mature: 10.06

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEHGGNKQLFYEKYGVLPRYDFSANLNPLGPPRDALKLLRENLKELISTYPDYRYRELE
CCCCCCCCCEEHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHH
KAAYGYFQKEEVVLGNGASSLLNYLLFYLKPSRGLIIGPTFNLYEKTLRNREIPVEKLDC
HHHHCCCCCCCEEECCCHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHCCCCCCHHHHHH
ALEEKGYSNARAYLLQKGRKGDLLLICRPNNPDGSAWPVSELFKLIALCQEKGIKLLLDE
HHHHCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEHH
SFADFMEDEREIFWRNSGKLKDVYILISLTKIFAIPGLRLGALILPEKDYKDFKKFLPEW
HHHHHHHHHHHHHCCCCCCCEEEEEEEEHHHHHHCCCCCCCEEECCCCCHHHHHHHCCCC
EINNLAAEIGPVLFAQRDYLLKTRALIKKEREYLSQNLFRLGFQVLPSKANFLMAYLPES
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEECCCCC
ISSEQLLSELAKYRIAVRPLQNFGLKREAVRIAVKTRKENRVLINTLKNILFKTHGKKSR
CCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEEEECCCCCHHHHHHHHHHHHHCCCCCCC
TKKWKLEK
CCCCCCCC
>Mature Secondary Structure
MLEHGGNKQLFYEKYGVLPRYDFSANLNPLGPPRDALKLLRENLKELISTYPDYRYRELE
CCCCCCCCCEEHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHH
KAAYGYFQKEEVVLGNGASSLLNYLLFYLKPSRGLIIGPTFNLYEKTLRNREIPVEKLDC
HHHHCCCCCCCEEECCCHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHCCCCCCHHHHHH
ALEEKGYSNARAYLLQKGRKGDLLLICRPNNPDGSAWPVSELFKLIALCQEKGIKLLLDE
HHHHCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEHH
SFADFMEDEREIFWRNSGKLKDVYILISLTKIFAIPGLRLGALILPEKDYKDFKKFLPEW
HHHHHHHHHHHHHCCCCCCCEEEEEEEEHHHHHHCCCCCCCEEECCCCCHHHHHHHCCCC
EINNLAAEIGPVLFAQRDYLLKTRALIKKEREYLSQNLFRLGFQVLPSKANFLMAYLPES
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEECCCCC
ISSEQLLSELAKYRIAVRPLQNFGLKREAVRIAVKTRKENRVLINTLKNILFKTHGKKSR
CCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEEEECCCCCHHHHHHHHHHHHHCCCCCCC
TKKWKLEK
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12712204 [H]