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The map label for this gene is mrdB [H]

Identifier: 78043340

GI number: 78043340

Start: 306934

End: 308067

Strand: Direct

Name: mrdB [H]

Synonym: CHY_0358

Alternate gene names: 78043340

Gene position: 306934-308067 (Clockwise)

Preceding gene: 78044121

Following gene: 78043247

Centisome position: 12.78

GC content: 43.83

Gene sequence:

>1134_bases
ATGCAATTTCGCCGGATGTTAAAGGAACTTGACTGGGGAGTGCTGGCCAATGTTTTTTTAATTATTATTTTAGGACTTGT
GTTAATCGCCAGCGCTACCCGGGCAACTTCTCCCGATGATGTTCTTGGTTTAGCTAAAACCCAGCTACTCTGGGTTTTTT
CTGGTCTTCTTTTAATGTTTGGTAGTTTGTACATTCCTTATGATGACTTTCCGCGCTATGCCAAATTCCTCTATCTTTTT
AACCTTGTTATGTTGGTGACCGTATTATTTGCCGGGAGGGAAGCTTTAGGGGCGCAGCGCTGGATTAAAATAGGCCCCTT
TTCCTTGCAACCCTCGGAGTTTGCAAAAGATATCATAACTATAACTCTGGCCAATTATTTAGCTGCCCGTCAGGGACAGA
TTGATAAACTTAGCGATTTTATCCGGGTGTTTGTCCATATTGGTGTCCCTATGCTGTTAATTTTAAAGCAGCCGGATTTA
GGTACTTCGCTGGTTTTTGTCGCCATTACTTTTGCTCAGCTTTATGTAGCGGGGGCAAACCGTAAACTCTTATTTAGTCT
CTTTGGCGGGGGCCTGGTTTTGGCCATTGGCTGGATTGCTCTCCATCTTCACTTTCCCCAAATCTGGATTCCTTTAAAAG
AATACCAGTTAAATCGGTTAATTATTTTTTTAGACCCGTGGAAGGATATGCAGGGAGCGGGTTACCACGTGATTCAGTCA
CAGATTGCCATTGGTTCGGGAGGTTTTTGGGGGAAAGGACTTTTTCGGGGAAGTCAAAATCAGCTGAACTTTCTGCCCGA
GCAGCACACCGATTTTATTTTTTCCGTGTTAGGGGAAGAACTGGGCTTTATCGGTGCTTCGGTGCTACTGGTACTATATT
TGACTCTTTTTTGGCAGTTGATTCGCATTGGCCAGCAGGCCAAGGATTTACTGGGAAGTTTACTGGTAGCCGGAGTTGTG
GCCAAGCTTGCTTTTCACACTTTTATTAATATTGGGATGACCTGCGGGATTATGCCCGTAACCGGTATACCCTTACCTTT
TGTAAGTTACGGAGGAAGTGCTATGTGGTCCAATTTATTATCGGTGGGCCTGGCGCTTAATGTTTACTTAAGGAGGAAAA
AATTATCGTTTTAG

Upstream 100 bases:

>100_bases
GATTTGGCTTCTAAATAAATTACGGCTTTTAGGCCGTTTCTTTTTTTATGAGCAAAAGTTTGGTATAATTAAACGCGAAC
AAGACGTGGGAGTGGAGCAT

Downstream 100 bases:

>100_bases
GTTTTAAGGGAAATAGTTAAATTTTCAAAAAATTCTCTTAACAAAGAAAACAAATTTAAGTATAATGGAGAAAAATTAAT
TACGGGTTTTCCAGGAGGAG

Product: FtsW/RodA/SpoVE family peptidoglycan biosynthesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MQFRRMLKELDWGVLANVFLIIILGLVLIASATRATSPDDVLGLAKTQLLWVFSGLLLMFGSLYIPYDDFPRYAKFLYLF
NLVMLVTVLFAGREALGAQRWIKIGPFSLQPSEFAKDIITITLANYLAARQGQIDKLSDFIRVFVHIGVPMLLILKQPDL
GTSLVFVAITFAQLYVAGANRKLLFSLFGGGLVLAIGWIALHLHFPQIWIPLKEYQLNRLIIFLDPWKDMQGAGYHVIQS
QIAIGSGGFWGKGLFRGSQNQLNFLPEQHTDFIFSVLGEELGFIGASVLLVLYLTLFWQLIRIGQQAKDLLGSLLVAGVV
AKLAFHTFINIGMTCGIMPVTGIPLPFVSYGGSAMWSNLLSVGLALNVYLRRKKLSF

Sequences:

>Translated_377_residues
MQFRRMLKELDWGVLANVFLIIILGLVLIASATRATSPDDVLGLAKTQLLWVFSGLLLMFGSLYIPYDDFPRYAKFLYLF
NLVMLVTVLFAGREALGAQRWIKIGPFSLQPSEFAKDIITITLANYLAARQGQIDKLSDFIRVFVHIGVPMLLILKQPDL
GTSLVFVAITFAQLYVAGANRKLLFSLFGGGLVLAIGWIALHLHFPQIWIPLKEYQLNRLIIFLDPWKDMQGAGYHVIQS
QIAIGSGGFWGKGLFRGSQNQLNFLPEQHTDFIFSVLGEELGFIGASVLLVLYLTLFWQLIRIGQQAKDLLGSLLVAGVV
AKLAFHTFINIGMTCGIMPVTGIPLPFVSYGGSAMWSNLLSVGLALNVYLRRKKLSF
>Mature_377_residues
MQFRRMLKELDWGVLANVFLIIILGLVLIASATRATSPDDVLGLAKTQLLWVFSGLLLMFGSLYIPYDDFPRYAKFLYLF
NLVMLVTVLFAGREALGAQRWIKIGPFSLQPSEFAKDIITITLANYLAARQGQIDKLSDFIRVFVHIGVPMLLILKQPDL
GTSLVFVAITFAQLYVAGANRKLLFSLFGGGLVLAIGWIALHLHFPQIWIPLKEYQLNRLIIFLDPWKDMQGAGYHVIQS
QIAIGSGGFWGKGLFRGSQNQLNFLPEQHTDFIFSVLGEELGFIGASVLLVLYLTLFWQLIRIGQQAKDLLGSLLVAGVV
AKLAFHTFINIGMTCGIMPVTGIPLPFVSYGGSAMWSNLLSVGLALNVYLRRKKLSF

Specific function: This is one of the proteins responsible for the rod shape of the cell. It is required for the expression of the enzymatic activity of PBP2, which is thought to synthesize peptidoglycan in the step of initiation of cell elongation [H]

COG id: COG0772

COG function: function code D; Bacterial cell division membrane protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ftsW/rodA/spoVE family [H]

Homologues:

Organism=Escherichia coli, GI1786853, Length=336, Percent_Identity=39.2857142857143, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1786277, Length=339, Percent_Identity=30.9734513274336, Blast_Score=172, Evalue=3e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001182
- InterPro:   IPR018365
- InterPro:   IPR011923 [H]

Pfam domain/function: PF01098 FTSW_RODA_SPOVE [H]

EC number: NA

Molecular weight: Translated: 41963; Mature: 41963

Theoretical pI: Translated: 10.01; Mature: 10.01

Prosite motif: PS00428 FTSW_RODA_SPOVE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFRRMLKELDWGVLANVFLIIILGLVLIASATRATSPDDVLGLAKTQLLWVFSGLLLMF
CCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
GSLYIPYDDFPRYAKFLYLFNLVMLVTVLFAGREALGAQRWIKIGPFSLQPSEFAKDIIT
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHCHHHCEEECCCCCCHHHHHHHHHH
ITLANYLAARQGQIDKLSDFIRVFVHIGVPMLLILKQPDLGTSLVFVAITFAQLYVAGAN
HHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCC
RKLLFSLFGGGLVLAIGWIALHLHFPQIWIPLKEYQLNRLIIFLDPWKDMQGAGYHVIQS
CCEEHHHHCCHHHHHHHHHHHHHCCCHHEEEHHHHCCCEEEEEEECCCCCCCCCHHHHHH
QIAIGSGGFWGKGLFRGSQNQLNFLPEQHTDFIFSVLGEELGFIGASVLLVLYLTLFWQL
HHEECCCCCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IRIGQQAKDLLGSLLVAGVVAKLAFHTFINIGMTCGIMPVTGIPLPFVSYGGSAMWSNLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCHHHHHHHH
SVGLALNVYLRRKKLSF
HHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQFRRMLKELDWGVLANVFLIIILGLVLIASATRATSPDDVLGLAKTQLLWVFSGLLLMF
CCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
GSLYIPYDDFPRYAKFLYLFNLVMLVTVLFAGREALGAQRWIKIGPFSLQPSEFAKDIIT
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHCHHHCEEECCCCCCHHHHHHHHHH
ITLANYLAARQGQIDKLSDFIRVFVHIGVPMLLILKQPDLGTSLVFVAITFAQLYVAGAN
HHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCC
RKLLFSLFGGGLVLAIGWIALHLHFPQIWIPLKEYQLNRLIIFLDPWKDMQGAGYHVIQS
CCEEHHHHCCHHHHHHHHHHHHHCCCHHEEEHHHHCCCEEEEEEECCCCCCCCCHHHHHH
QIAIGSGGFWGKGLFRGSQNQLNFLPEQHTDFIFSVLGEELGFIGASVLLVLYLTLFWQL
HHEECCCCCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IRIGQQAKDLLGSLLVAGVVAKLAFHTFINIGMTCGIMPVTGIPLPFVSYGGSAMWSNLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCHHHHHHHH
SVGLALNVYLRRKKLSF
HHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]