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The map label for this gene is copZ [H]

Identifier: 78042694

GI number: 78042694

Start: 828483

End: 828734

Strand: Direct

Name: copZ [H]

Synonym: CHY_0939

Alternate gene names: 78042694

Gene position: 828483-828734 (Clockwise)

Preceding gene: 78043699

Following gene: 78044857

Centisome position: 34.5

GC content: 46.83

Gene sequence:

>252_bases
ATGTGTGAACATTGCGGAGCTCACAATCATGCGGCAGAGCAAACTGTGGTTTTAAAAGTCGATGGGATGACCTGCAACCA
CTGCAAAATGTCTGTGGAAAAAGCCCTTTATACAGTTAACGGGGTAAAAATGGCTGCTGTCAATCTTGCTGAAGGTCTGG
CTACCGTTTTATACGACCCGAACCTGGCCACTGTTGAACAAATGAAAGCGGCCGTAGAAAAAGCGGGCTATGAAGTGGTA
GGCGTACAGTAA

Upstream 100 bases:

>100_bases
GGGTGTGTTAAGAGGGCGATTAAAACCGGTGAAGAAGAACCGGTAATCAAAGAACTTTTAGAGGTTTTGGATAAATTTAT
ACGATAAGGGGGAATTTAAA

Downstream 100 bases:

>100_bases
AAAGGGGGAGTAATCCCCTTTTTTTAACACCAAAATCAGGGATGGTTATTGCTACCTGCGACTAAACGCCAAAAAATCTA
AGTTTGGCGTTGGGATGCGC

Product: heavy metal-binding domain-containing protein

Products: ADP; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 83; Mature: 83

Protein sequence:

>83_residues
MCEHCGAHNHAAEQTVVLKVDGMTCNHCKMSVEKALYTVNGVKMAAVNLAEGLATVLYDPNLATVEQMKAAVEKAGYEVV
GVQ

Sequences:

>Translated_83_residues
MCEHCGAHNHAAEQTVVLKVDGMTCNHCKMSVEKALYTVNGVKMAAVNLAEGLATVLYDPNLATVEQMKAAVEKAGYEVV
GVQ
>Mature_83_residues
MCEHCGAHNHAAEQTVVLKVDGMTCNHCKMSVEKALYTVNGVKMAAVNLAEGLATVLYDPNLATVEQMKAAVEKAGYEVV
GVQ

Specific function: Chaperone that serves for the intracellular sequestration and transport of Cu(+). Delivers Cu(+) to the copper-exporting P-type ATPase A (CopA) [H]

COG id: COG2608

COG function: function code P; Copper chaperone

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743073, Length=64, Percent_Identity=42.1875, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001757
- InterPro:   IPR006122
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR001802 [H]

Pfam domain/function: PF00403 HMA [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 8835; Mature: 8835

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS01047 HMA_1 ; PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.8 %Cys     (Translated Protein)
6.0 %Met     (Translated Protein)
10.8 %Cys+Met (Translated Protein)
4.8 %Cys     (Mature Protein)
6.0 %Met     (Mature Protein)
10.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCEHCGAHNHAAEQTVVLKVDGMTCNHCKMSVEKALYTVNGVKMAAVNLAEGLATVLYDP
CCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCEEEEHHHHHHHHEEEEECC
NLATVEQMKAAVEKAGYEVVGVQ
CCHHHHHHHHHHHHCCEEEEECC
>Mature Secondary Structure
MCEHCGAHNHAAEQTVVLKVDGMTCNHCKMSVEKALYTVNGVKMAAVNLAEGLATVLYDP
CCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCEEEEHHHHHHHHEEEEECC
NLATVEQMKAAVEKAGYEVVGVQ
CCHHHHHHHHHHHHCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA