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The map label for this gene is trxB [H]

Identifier: 77748566

GI number: 77748566

Start: 1347289

End: 1348998

Strand: Direct

Name: trxB [H]

Synonym: XAC1182

Alternate gene names: 77748566

Gene position: 1347289-1348998 (Clockwise)

Preceding gene: 21241935

Following gene: 21241937

Centisome position: 26.03

GC content: 68.3

Gene sequence:

>1710_bases
ATGTCTTTGGACCAGACCCGCCACCATCAGATGTTTCCCGAGCTGGACGCGGGCCAGTTGTCGATCACCCGGCGCTTCGC
CAGCGGGCCGGCGCAACGGTTCGGCGCGGGCGATACCGTATTTGAGGTCGGCGATGCCCATGCGCCGGTGTGGGTGGTGC
TGGAGGGCGCCATCGAAGTGGTGCGCCGCGATGGATTGGGCAACGAAAAGCCGATCACCCGGCACACGCCCGGCCAGTTC
ACCGGCGAGGTGAGTCAGCTGGCCGGGCGCGCGTCGCTGGCGGCTGGACGTGCCGGGCCGGACGGCTGCCTGGCGCTGCC
GTTCGATACCGCGCATCTGCGCGCGCTGATGATCAGTTCGGCCGAAGTGGGCGAAGTGGTGATGCGTGCATTGATCCTGC
GCCGCGTCGGGCTGATCGAGGGCGATGCGTCGGGTTCGGTGCTGATCGGCGAGCCGGACGACCCGCATCTGACCCGGTTG
CAGGGCTTTTTGACCCGTAACGGCTACCCCAACACGGTGATGGATGTCTCCGACGACGAAGGCCGCGCGTTGGTGCAGCG
CCTGGGTATCCAGGAGCACGATCTACCGGTGATGGTATGCCCGAGCGGGCGCGTGCTGCGCCAGCCCAGCGATGCCGAAG
CCGCGCATTGCCTGGGCATGACGCCGGACATCGACCCGGACAAACGCTACGACGTGGCGATCGTGGGCGCCGGCCCCGCC
GGCCTGGCGACGGCGGTGTATGCCGCATCCGAAGGCTTGTCGGTGCTGGTGCTGGACCAGCGCGCCATCGGCGGGCAGGC
CGGTGCCTCGGCGCGTATCGAAAATTATCTCGGCTTTCCCACCGGCATTTCCGGGCAGGCGCTGGCCGGGCGCGCGTACA
ACCAGGCGCTGAAATTCGGCGCGGAACTGGCGATTCCGATCGAAGCGGCCATGCTGGAATGCGGCCGCGACGATGGCGCG
CTGAAGCTGGATCTTGCCGATGGCAAACAGTTGCTGGCCAGCACGGTGGTGATCGCGTCGGGTGCGCGTTACCGGCGCCC
GGAGATCGAGGGCCTGGATCGCTTCGAAGGCCACGGTGTGTCCTACTGGGCCTCGCCGGTGGAAGCGCGCCTGTGCGAAG
GCGGCGTGGTGGCGCTGGTGGGCGGCGGCAATTCTGCAGGGCAGGCGGTGGCGTTCCTGGCGCCGCGGGTCAAGGAGCTG
CACCTGATCATTCGCGGCGACGGGTTGGAGAGCTCGATGTCGCAATATCTCATCGAACGTATCGCCGCGTTGCCGAACGT
GCAGCTGCACACCGGCACCGAAGTGGCCGCGCTGGAAGGCGACCCCGAGCGCGGCTTGCAGGCCGCGGTGTTGCGCACCC
GCAAGGACGGTGCAACCGCGCGCGTGGAGTTGCGGCACCTGTTCCTGTTCGTCGGCGCAGACCCCAACACCGGTTGGCTG
CAGGACTGCGTGGACACCGACAAGCGCGGCTTTGTCATGACCGGCACCGCGCGTGGCGACGGCGTACCGGCGTGCCTGCC
GCTGGAAACCAATCGCCCTGGCGTGTTCGCCATCGGCGATGTGCGTGCGGGCTCGGTCAAGCGCGTGGCCGCTGCAGTGG
GCGAGGGCGCCGCCGTGGTCGCGCAGATCCATCAGTACCTCGCCCATCAGGCCAACCCAGTGCCGGTCTCCGAACTTGCC
AGCGCCACCCAGGAGTCCACCAGCGCATGA

Upstream 100 bases:

>100_bases
CTGCGCGCTGTCGTGGCCATCAGTGACCATTTCGGGTGATTGCCATTGCCGTCACCACTGCCCATGCTTGCATGTGATCC
CCTAGCTGCGTCGTCCCTCC

Downstream 100 bases:

>100_bases
GCCAACGCTGCCGCCATACCGATCAAATCCATGCGGTCACGCCCAGTGCGCGTGGCTGCGAAGAATGTCTGGCCATCGAC
AGCGAATGGGTGCATCTGCG

Product: thioredoxin reductase

Products: NA

Alternate protein names: TRXR [H]

Number of amino acids: Translated: 569; Mature: 568

Protein sequence:

>569_residues
MSLDQTRHHQMFPELDAGQLSITRRFASGPAQRFGAGDTVFEVGDAHAPVWVVLEGAIEVVRRDGLGNEKPITRHTPGQF
TGEVSQLAGRASLAAGRAGPDGCLALPFDTAHLRALMISSAEVGEVVMRALILRRVGLIEGDASGSVLIGEPDDPHLTRL
QGFLTRNGYPNTVMDVSDDEGRALVQRLGIQEHDLPVMVCPSGRVLRQPSDAEAAHCLGMTPDIDPDKRYDVAIVGAGPA
GLATAVYAASEGLSVLVLDQRAIGGQAGASARIENYLGFPTGISGQALAGRAYNQALKFGAELAIPIEAAMLECGRDDGA
LKLDLADGKQLLASTVVIASGARYRRPEIEGLDRFEGHGVSYWASPVEARLCEGGVVALVGGGNSAGQAVAFLAPRVKEL
HLIIRGDGLESSMSQYLIERIAALPNVQLHTGTEVAALEGDPERGLQAAVLRTRKDGATARVELRHLFLFVGADPNTGWL
QDCVDTDKRGFVMTGTARGDGVPACLPLETNRPGVFAIGDVRAGSVKRVAAAVGEGAAVVAQIHQYLAHQANPVPVSELA
SATQESTSA

Sequences:

>Translated_569_residues
MSLDQTRHHQMFPELDAGQLSITRRFASGPAQRFGAGDTVFEVGDAHAPVWVVLEGAIEVVRRDGLGNEKPITRHTPGQF
TGEVSQLAGRASLAAGRAGPDGCLALPFDTAHLRALMISSAEVGEVVMRALILRRVGLIEGDASGSVLIGEPDDPHLTRL
QGFLTRNGYPNTVMDVSDDEGRALVQRLGIQEHDLPVMVCPSGRVLRQPSDAEAAHCLGMTPDIDPDKRYDVAIVGAGPA
GLATAVYAASEGLSVLVLDQRAIGGQAGASARIENYLGFPTGISGQALAGRAYNQALKFGAELAIPIEAAMLECGRDDGA
LKLDLADGKQLLASTVVIASGARYRRPEIEGLDRFEGHGVSYWASPVEARLCEGGVVALVGGGNSAGQAVAFLAPRVKEL
HLIIRGDGLESSMSQYLIERIAALPNVQLHTGTEVAALEGDPERGLQAAVLRTRKDGATARVELRHLFLFVGADPNTGWL
QDCVDTDKRGFVMTGTARGDGVPACLPLETNRPGVFAIGDVRAGSVKRVAAAVGEGAAVVAQIHQYLAHQANPVPVSELA
SATQESTSA
>Mature_568_residues
SLDQTRHHQMFPELDAGQLSITRRFASGPAQRFGAGDTVFEVGDAHAPVWVVLEGAIEVVRRDGLGNEKPITRHTPGQFT
GEVSQLAGRASLAAGRAGPDGCLALPFDTAHLRALMISSAEVGEVVMRALILRRVGLIEGDASGSVLIGEPDDPHLTRLQ
GFLTRNGYPNTVMDVSDDEGRALVQRLGIQEHDLPVMVCPSGRVLRQPSDAEAAHCLGMTPDIDPDKRYDVAIVGAGPAG
LATAVYAASEGLSVLVLDQRAIGGQAGASARIENYLGFPTGISGQALAGRAYNQALKFGAELAIPIEAAMLECGRDDGAL
KLDLADGKQLLASTVVIASGARYRRPEIEGLDRFEGHGVSYWASPVEARLCEGGVVALVGGGNSAGQAVAFLAPRVKELH
LIIRGDGLESSMSQYLIERIAALPNVQLHTGTEVAALEGDPERGLQAAVLRTRKDGATARVELRHLFLFVGADPNTGWLQ
DCVDTDKRGFVMTGTARGDGVPACLPLETNRPGVFAIGDVRAGSVKRVAAAVGEGAAVVAQIHQYLAHQANPVPVSELAS
ATQESTSA

Specific function: Serves To Protect The Cell Against DNA Damage By Alkyl Hydroperoxides. It Can Use Either NADH Or NADPH As Electron Donor For Direct Reduction Of Redox Dyes Or Of Alkyl Hydroperoxides When Combined With The Ahpc Protein. [C]

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081763, Length=321, Percent_Identity=31.7757009345794, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1787114, Length=323, Percent_Identity=27.2445820433437, Blast_Score=106, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6321898, Length=334, Percent_Identity=25.748502994012, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6320560, Length=330, Percent_Identity=26.6666666666667, Blast_Score=104, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.8.1.9 [H]

Molecular weight: Translated: 59727; Mature: 59596

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS50042 CNMP_BINDING_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLDQTRHHQMFPELDAGQLSITRRFASGPAQRFGAGDTVFEVGDAHAPVWVVLEGAIEV
CCCCCCHHHHCCCCCCCCCEEEEHHHHCCCHHHCCCCCCEEECCCCCCCEEEEEHHHHHH
VRRDGLGNEKPITRHTPGQFTGEVSQLAGRASLAAGRAGPDGCLALPFDTAHLRALMISS
HHHCCCCCCCCCCCCCCCCCCCHHHHHHCHHHHHCCCCCCCCEEEECCCHHHHHHHHHCC
AEVGEVVMRALILRRVGLIEGDASGSVLIGEPDDPHLTRLQGFLTRNGYPNTVMDVSDDE
CHHHHHHHHHHHHHHHCCEECCCCCCEEECCCCCCHHHHHHHHHHCCCCCCCEEECCCCC
GRALVQRLGIQEHDLPVMVCPSGRVLRQPSDAEAAHCLGMTPDIDPDKRYDVAIVGAGPA
HHHHHHHCCCCCCCCCEEECCCCCEECCCCCCCHHHHCCCCCCCCCCCCEEEEEEECCCH
GLATAVYAASEGLSVLVLDQRAIGGQAGASARIENYLGFPTGISGQALAGRAYNQALKFG
HHHHHHHHHCCCCEEEEEECHHCCCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHCC
AELAIPIEAAMLECGRDDGALKLDLADGKQLLASTVVIASGARYRRPEIEGLDRFEGHGV
CCEEEEHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCC
SYWASPVEARLCEGGVVALVGGGNSAGQAVAFLAPRVKELHLIIRGDGLESSMSQYLIER
EEECCCHHHHHCCCCEEEEEECCCCCCCCHHHHCCCCEEEEEEEECCCCHHHHHHHHHHH
IAALPNVQLHTGTEVAALEGDPERGLQAAVLRTRKDGATARVELRHLFLFVGADPNTGWL
HHHCCCCEEECCCEEEEECCCHHHCHHHHHHHHCCCCCEEEEEEEEEEEEEECCCCCCHH
QDCVDTDKRGFVMTGTARGDGVPACLPLETNRPGVFAIGDVRAGSVKRVAAAVGEGAAVV
HHHHCCCCCCEEEEECCCCCCCCEEEEECCCCCCEEEEECCCCCCHHHHHHHHCCCHHHH
AQIHQYLAHQANPVPVSELASATQESTSA
HHHHHHHHHCCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
SLDQTRHHQMFPELDAGQLSITRRFASGPAQRFGAGDTVFEVGDAHAPVWVVLEGAIEV
CCCCCHHHHCCCCCCCCCEEEEHHHHCCCHHHCCCCCCEEECCCCCCCEEEEEHHHHHH
VRRDGLGNEKPITRHTPGQFTGEVSQLAGRASLAAGRAGPDGCLALPFDTAHLRALMISS
HHHCCCCCCCCCCCCCCCCCCCHHHHHHCHHHHHCCCCCCCCEEEECCCHHHHHHHHHCC
AEVGEVVMRALILRRVGLIEGDASGSVLIGEPDDPHLTRLQGFLTRNGYPNTVMDVSDDE
CHHHHHHHHHHHHHHHCCEECCCCCCEEECCCCCCHHHHHHHHHHCCCCCCCEEECCCCC
GRALVQRLGIQEHDLPVMVCPSGRVLRQPSDAEAAHCLGMTPDIDPDKRYDVAIVGAGPA
HHHHHHHCCCCCCCCCEEECCCCCEECCCCCCCHHHHCCCCCCCCCCCCEEEEEEECCCH
GLATAVYAASEGLSVLVLDQRAIGGQAGASARIENYLGFPTGISGQALAGRAYNQALKFG
HHHHHHHHHCCCCEEEEEECHHCCCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHCC
AELAIPIEAAMLECGRDDGALKLDLADGKQLLASTVVIASGARYRRPEIEGLDRFEGHGV
CCEEEEHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCC
SYWASPVEARLCEGGVVALVGGGNSAGQAVAFLAPRVKELHLIIRGDGLESSMSQYLIER
EEECCCHHHHHCCCCEEEEEECCCCCCCCHHHHCCCCEEEEEEEECCCCHHHHHHHHHHH
IAALPNVQLHTGTEVAALEGDPERGLQAAVLRTRKDGATARVELRHLFLFVGADPNTGWL
HHHCCCCEEECCCEEEEECCCHHHCHHHHHHHHCCCCCEEEEEEEEEEEEEECCCCCCHH
QDCVDTDKRGFVMTGTARGDGVPACLPLETNRPGVFAIGDVRAGSVKRVAAAVGEGAAVV
HHHHCCCCCCEEEEECCCCCCCCEEEEECCCCCCEEEEECCCCCCHHHHHHHHCCCHHHH
AQIHQYLAHQANPVPVSELASATQESTSA
HHHHHHHHHCCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11353084 [H]