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The map label for this gene is ampC [H]

Identifier: 77465753

GI number: 77465753

Start: 874559

End: 875701

Strand: Direct

Name: ampC [H]

Synonym: RSP_3749

Alternate gene names: 77465753

Gene position: 874559-875701 (Clockwise)

Preceding gene: 77465751

Following gene: 77465758

Centisome position: 92.74

GC content: 63.17

Gene sequence:

>1143_bases
ATGAAGCACCTTTCCCCCCTCTCCATCCTGCTCATGGTGGGCGCGCTGACGCCCGCGCTTGCGCAAGACACCACGCCGTC
GTTCGAGAGCGCCGCCGCCGCGGCCTTCGAGAGCGTCATCGAGGAGCATGACATTCCCGGTCTGGTGGTGGGCGTGACCC
ACGGCGGACGGCACAGTTTCTATCAGACAGGCTTGGCCTCACGGGAAGATCAGCAGCCGGTAACCCCTGACACGCTTTTT
GAGCTCGGTTCGATCAGCAAGATCTTCAACGTGACGCTGGCGGCCTTGGCAGAGGAGCGGGGCGCGCTGTCGCTCGATGC
GCCGGTCGCCGACTATCTTCCCTCCCTGCGAGGTTCTCCTGCAGGAGAGCTGACGCTGATCGATCTGGCGACGCACCATA
CCGGCGGCCTCCCGTTGCAGGTGCCGGACGAAGTTGCAGATGTAGATCGCCTGGTCGACTGGCTACGGAGTTGGCGACCG
CCCGAGCCCGGTACGCGCAGCTATTCCAACATCAGCATCGGCCTATTGGGGCACATCACCGCGGGCGTGCTGGGCATGAG
CTATGCTGATGCGTCCCAGACGGTTATCTTCCCGGCGCTCGGATTGAAGAGCACGTGGATCGACGTCCCCACCGATGCGA
TGGGACGCTACGCCTTCGGCTATGACCGCAAGACAGACGCGCCAACCCGGGTTACGCCCGGCGTGCTGGACGATGAAGCG
TACGGGGTAAAATCCTCCGCTCGCGACATGCTGACGCTGCTCGACCTCGAGCTTGGAACCGGCACTGCCTCGCCCGAAGT
TCAAACGGCGGTGGCCACCACGCAGGAGGGCCGGTTCCAGACCCGCCTGTACACGCAGGCCATGATATGGGAGGCCTATC
CTTGGCCTGTCGACCCAGAGCGTCTGGTGGAGGGGAACGGGTATGACTTCATCCTCCAGCCTCAGCCTGTGGACGAGGTG
GACACGACACCCGATCGGAGGGTCATCCTGAACAAGACAGGTTCCACGAACGGCTTCGGTGGGTACATCGCGATCGTGCC
AAGCGAGGATCTGGGCGTCGTCGTCCTTGCCAACCGCAACTACCCCAACGAGGCGCGGGTTCGAGCCACTTACGACCTGA
TCACTCACATCTTGGCCGAATAA

Upstream 100 bases:

>100_bases
TCTGGCATGAGATCTACTTATGTGCAGTCCAACCCTTTGTCGTCTGCCTCGTGCAGTCGGCGCGGTCTATCCCGGCTCCG
ATGATCACATAGGACCGGAC

Downstream 100 bases:

>100_bases
GTTCGACACGCTCGGGGGGGACCGCCAAACGGCCGAAGCATCCGCTTCACGGCCCCCCGGAATTCCGGGCGGCAAAGGTC
TGCTGGCAGCCCTTTCTCAG

Product: beta-lactamase

Products: NA

Alternate protein names: Cephalosporinase [H]

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MKHLSPLSILLMVGALTPALAQDTTPSFESAAAAAFESVIEEHDIPGLVVGVTHGGRHSFYQTGLASREDQQPVTPDTLF
ELGSISKIFNVTLAALAEERGALSLDAPVADYLPSLRGSPAGELTLIDLATHHTGGLPLQVPDEVADVDRLVDWLRSWRP
PEPGTRSYSNISIGLLGHITAGVLGMSYADASQTVIFPALGLKSTWIDVPTDAMGRYAFGYDRKTDAPTRVTPGVLDDEA
YGVKSSARDMLTLLDLELGTGTASPEVQTAVATTQEGRFQTRLYTQAMIWEAYPWPVDPERLVEGNGYDFILQPQPVDEV
DTTPDRRVILNKTGSTNGFGGYIAIVPSEDLGVVVLANRNYPNEARVRATYDLITHILAE

Sequences:

>Translated_380_residues
MKHLSPLSILLMVGALTPALAQDTTPSFESAAAAAFESVIEEHDIPGLVVGVTHGGRHSFYQTGLASREDQQPVTPDTLF
ELGSISKIFNVTLAALAEERGALSLDAPVADYLPSLRGSPAGELTLIDLATHHTGGLPLQVPDEVADVDRLVDWLRSWRP
PEPGTRSYSNISIGLLGHITAGVLGMSYADASQTVIFPALGLKSTWIDVPTDAMGRYAFGYDRKTDAPTRVTPGVLDDEA
YGVKSSARDMLTLLDLELGTGTASPEVQTAVATTQEGRFQTRLYTQAMIWEAYPWPVDPERLVEGNGYDFILQPQPVDEV
DTTPDRRVILNKTGSTNGFGGYIAIVPSEDLGVVVLANRNYPNEARVRATYDLITHILAE
>Mature_380_residues
MKHLSPLSILLMVGALTPALAQDTTPSFESAAAAAFESVIEEHDIPGLVVGVTHGGRHSFYQTGLASREDQQPVTPDTLF
ELGSISKIFNVTLAALAEERGALSLDAPVADYLPSLRGSPAGELTLIDLATHHTGGLPLQVPDEVADVDRLVDWLRSWRP
PEPGTRSYSNISIGLLGHITAGVLGMSYADASQTVIFPALGLKSTWIDVPTDAMGRYAFGYDRKTDAPTRVTPGVLDDEA
YGVKSSARDMLTLLDLELGTGTASPEVQTAVATTQEGRFQTRLYTQAMIWEAYPWPVDPERLVEGNGYDFILQPQPVDEV
DTTPDRRVILNKTGSTNGFGGYIAIVPSEDLGVVVLANRNYPNEARVRATYDLITHILAE

Specific function: This protein is a serine beta-lactamase with a substrate specificity for cephalosporins [H]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-C beta-lactamase family [H]

Homologues:

Organism=Escherichia coli, GI1790593, Length=344, Percent_Identity=39.5348837209302, Blast_Score=242, Evalue=4e-65,
Organism=Escherichia coli, GI1786574, Length=379, Percent_Identity=22.9551451187335, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001586
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: =3.5.2.6 [H]

Molecular weight: Translated: 40986; Mature: 40986

Theoretical pI: Translated: 4.35; Mature: 4.35

Prosite motif: PS00336 BETA_LACTAMASE_C

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHLSPLSILLMVGALTPALAQDTTPSFESAAAAAFESVIEEHDIPGLVVGVTHGGRHSF
CCCCCHHHHHHHHHHHCHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHH
YQTGLASREDQQPVTPDTLFELGSISKIFNVTLAALAEERGALSLDAPVADYLPSLRGSP
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHCCCC
AGELTLIDLATHHTGGLPLQVPDEVADVDRLVDWLRSWRPPEPGTRSYSNISIGLLGHIT
CCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEHHHHHH
AGVLGMSYADASQTVIFPALGLKSTWIDVPTDAMGRYAFGYDRKTDAPTRVTPGVLDDEA
HHHHHCCCCCCCCEEEEECCCCCCEEEECCHHHHCCEEECCCCCCCCCCCCCCCCCCCCC
YGVKSSARDMLTLLDLELGTGTASPEVQTAVATTQEGRFQTRLYTQAMIWEAYPWPVDPE
CCCHHHHHHHHHHHEEECCCCCCCCCHHHHEEECCCCCHHHHHHHHHHHEECCCCCCCHH
RLVEGNGYDFILQPQPVDEVDTTPDRRVILNKTGSTNGFGGYIAIVPSEDLGVVVLANRN
HHHCCCCCEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEEEECCCCCEEEEECCC
YPNEARVRATYDLITHILAE
CCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKHLSPLSILLMVGALTPALAQDTTPSFESAAAAAFESVIEEHDIPGLVVGVTHGGRHSF
CCCCCHHHHHHHHHHHCHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHH
YQTGLASREDQQPVTPDTLFELGSISKIFNVTLAALAEERGALSLDAPVADYLPSLRGSP
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHCCCC
AGELTLIDLATHHTGGLPLQVPDEVADVDRLVDWLRSWRPPEPGTRSYSNISIGLLGHIT
CCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEHHHHHH
AGVLGMSYADASQTVIFPALGLKSTWIDVPTDAMGRYAFGYDRKTDAPTRVTPGVLDDEA
HHHHHCCCCCCCCEEEEECCCCCCEEEECCHHHHCCEEECCCCCCCCCCCCCCCCCCCCC
YGVKSSARDMLTLLDLELGTGTASPEVQTAVATTQEGRFQTRLYTQAMIWEAYPWPVDPE
CCCHHHHHHHHHHHEEECCCCCCCCCHHHHEEECCCCCHHHHHHHHHHHEECCCCCCCHH
RLVEGNGYDFILQPQPVDEVDTTPDRRVILNKTGSTNGFGGYIAIVPSEDLGVVVLANRN
HHHCCCCCEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEEEECCCCCEEEEECCC
YPNEARVRATYDLITHILAE
CCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA