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The map label for this gene is gcvT [H]

Identifier: 77465565

GI number: 77465565

Start: 661269

End: 663764

Strand: Reverse

Name: gcvT [H]

Synonym: RSP_3566

Alternate gene names: 77465565

Gene position: 663764-661269 (Counterclockwise)

Preceding gene: 77465566

Following gene: 77465552

Centisome position: 70.39

GC content: 66.71

Gene sequence:

>2496_bases
ATGAAGACCCATGTGAAAGCCCTTGTCGTCGGCGGCGGTGCTGTCGGGAACGGCATCGCCTACCATCTCGCCAAGGCCGG
CTGGGACACGATGCTGGTCGAGCGCGACGAGCTCACCGCGGGCTCCACCTGGCACGCCGCGGGGCTTCTGCCGCTCTTCA
ACATGAGCTACGCCACCACCCACATCCACAAGTATTCGGTCGATTTCTACAAGGGGCTCGAGGCCGAGACCGGGCTCAAC
CCCGGCTTCTATGTCGTGGGCAACCTGCGCATGGCCCAGACCGACGCGCGGATGGACGAATACATGCTCTATTCCTCCGT
AGCCGAGACGGCGGGGGTCTATCATGAGTTCCTGAGCCCGAAGGAGATCGCGGAGCGCTGGCCCCTCGTGCGCACCGAGG
ATCTCAAGGGCGCGCTCTTCCACCCGCAGGATGGCTACATCAACCCCGCCGACGTGACGCAGGCCATGGCCAAGGGCGCG
CGGCAGCTCGGCTGCACCATCGAGCGCCGGATCCAGGTCAACGGCTACCGCTGGACGGGCCGCGAATGGATCGTCTCCTG
CGTGCGGATGGCCGAGCAGGGCGGCAACCTCGTCCCGACTGAGGAAAGCTTCGAGATCCATGCCGAACATGTGGTGACCG
CCACCGGCAACCATGCGCAGCGCACCGCCCGGCTTCTGGGCATCAAGATCCCGGCCATTCCGGTCGAGCACCAATATATC
GTGACCGAGCCCGACCCGGCGCTGGTCGAATGGCGCAAGACCAACCCGCAGCACCCCGTCCTGCGCGACGCCGACGCCAA
ATGGTATGTCCGCGAAGAGCGCGGCGGCTGGATCCTCGGCCCCTACGAGCGCAACGCTCCGGCCCGCTTCCTCTATGACG
TGCCCTCGAGCTTCCGCGCCGACCTCTTCCCGCTCGATCTCGAGCGGATCGAGGAGGAATACATGTCGATGATCCACCGG
ATCCCCTCGTCCGAGACCGTGGGCCTGAAGGACGATTACAACGGCCCGATCTGCTACACGCCCGACGGCAACCCGCTGGT
GGGTCCCGCCCCGGGCCTGCGCAACATGTGGCTGGCGGAAGGGTTCAGCTTCGGCATCACTGCGGCGGGCGGCACTGGCC
ACTATCTCGCGCAGATGATGACCGAGGGCGAGGCCGAGATCGACATGGCCTCGCTCGATCCCCGGCGCTACGGCAGCTGG
ATGACGACCGAATACGCGGCGCGGAAGAACGAGGAATGCTACGAGCATGTCTTCATCCTCCACCACCCTGACGAGGAGCG
CGAAGCCTGTCGTCCGCTGCGCACCGCCCCGGTCTACGACCGGCAGAAAGCGCTCGGCGCGCAGTTCGGGCAGGTCAACG
GCTGGGAGCGGCCGAACTACTACGGGCCTGCGGATGCGCCGGCCGGTTTCGACCACGCATCCCGCAGCTTCCGCCGCGGT
GCCTGGCATCCGTTCGCCCGCGCCGAGGCCGAGGCGCTGCGCGAGACCGCGGGCCTGATCGACGCCACCGCCTTCACCAA
GCATCTGGTGCGCGGCCCCGGCGCCACGGCCTTCCTCGACTGGTTCACCTGCAACAAGCTGCCGGCTGTGGGCCGGATCA
ACCTGACCTACGCGCTGACGCCCGCCGGCACCACGCGCACCGAATATACCATCGTGCGGTTGGCCGAGAACGAATATTAC
CTCGTGTCCGCCGGTGCCTGGACGGCCTACGACGCCGACTGGCTGAGGAAATGCGCCGAAGACAGGATCGGCGATTTCGG
CTGGATCGACATCCATGACGTGACGACCCAGTGGGGGGTCTTTGCGCTGGCCGGACCCAATGCGCGCGCGATCCTGAACG
AGGTGGTGAAGGATGCCGACCCCGCCACCCGGCTCTCGAACAAGCGTTTCCCCTGGCTCAGCTACCGCGACATCGAGCTT
GGCATGTGCCCGGTGCGGGCGGTGCGGGTGGCCTATACGGGCGAACTCGGGTGGGAGCTGCACCATCCGATCGAGATGTC
GACCTATCTCTGGGACCTGCTGCTGAAGGCGGGCGAAAAGCACGGGCTGAAGCTCGTGGGGGCGCGGGCGCAGAACTGGC
TGCGGCAGGAAAAGAGCTACCGCGCCTTCGGCAACGAGCTCGGCCGCGATGCGACGCCGATGGAAGCGGGGCTCGACCGG
TTCATCGACCTCGGCAAGGACTTTCAGGGCAAGGAAGCGATGCTCGCGACCGGCATCCGCTCGAAATGCGTGACGCTCCT
GATCGACGGGCCGGCGGATGCCGATCCGTGGGGCAAGGAGGCGCTGCTTCTGAACGGCGAGAAGGTGGGCCGGCTCACCT
CGGGCGGCTGGTCGGTGGCCTTCGGCAAGCAGATCGGCATGGGCTATGTCCGCCCCGATCTGGCCGAGGTGGGCACGAAG
CTGCAGCTGCGCATGTTCCGCGAGACCTGCGAGGCCGTGGTGGCCGAGGATTCGCCCTACGATCCGAAGAACGTTCGGAT
CCGTCAGGACGGCTGA

Upstream 100 bases:

>100_bases
CGCCCATGTCGTTTTCGGACGCCAAATGTCGGGCTCACCTCTCCGCAGCGGCGGCGATCAGTCATTGATGCGGCAAACCC
TGCGGTGACGGAGTGCGCGG

Downstream 100 bases:

>100_bases
TCCCGGGGACGGGGGGCACGTTCGGATCCGTCAGGACTGTGCTGATCCCGGGGACGGGGGGCTGTCTGCCCCCCGCCGCC
GGCCGGGGCCGGCGGCCCCC

Product: dimethylglycine dehydrogenase

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 831; Mature: 831

Protein sequence:

>831_residues
MKTHVKALVVGGGAVGNGIAYHLAKAGWDTMLVERDELTAGSTWHAAGLLPLFNMSYATTHIHKYSVDFYKGLEAETGLN
PGFYVVGNLRMAQTDARMDEYMLYSSVAETAGVYHEFLSPKEIAERWPLVRTEDLKGALFHPQDGYINPADVTQAMAKGA
RQLGCTIERRIQVNGYRWTGREWIVSCVRMAEQGGNLVPTEESFEIHAEHVVTATGNHAQRTARLLGIKIPAIPVEHQYI
VTEPDPALVEWRKTNPQHPVLRDADAKWYVREERGGWILGPYERNAPARFLYDVPSSFRADLFPLDLERIEEEYMSMIHR
IPSSETVGLKDDYNGPICYTPDGNPLVGPAPGLRNMWLAEGFSFGITAAGGTGHYLAQMMTEGEAEIDMASLDPRRYGSW
MTTEYAARKNEECYEHVFILHHPDEEREACRPLRTAPVYDRQKALGAQFGQVNGWERPNYYGPADAPAGFDHASRSFRRG
AWHPFARAEAEALRETAGLIDATAFTKHLVRGPGATAFLDWFTCNKLPAVGRINLTYALTPAGTTRTEYTIVRLAENEYY
LVSAGAWTAYDADWLRKCAEDRIGDFGWIDIHDVTTQWGVFALAGPNARAILNEVVKDADPATRLSNKRFPWLSYRDIEL
GMCPVRAVRVAYTGELGWELHHPIEMSTYLWDLLLKAGEKHGLKLVGARAQNWLRQEKSYRAFGNELGRDATPMEAGLDR
FIDLGKDFQGKEAMLATGIRSKCVTLLIDGPADADPWGKEALLLNGEKVGRLTSGGWSVAFGKQIGMGYVRPDLAEVGTK
LQLRMFRETCEAVVAEDSPYDPKNVRIRQDG

Sequences:

>Translated_831_residues
MKTHVKALVVGGGAVGNGIAYHLAKAGWDTMLVERDELTAGSTWHAAGLLPLFNMSYATTHIHKYSVDFYKGLEAETGLN
PGFYVVGNLRMAQTDARMDEYMLYSSVAETAGVYHEFLSPKEIAERWPLVRTEDLKGALFHPQDGYINPADVTQAMAKGA
RQLGCTIERRIQVNGYRWTGREWIVSCVRMAEQGGNLVPTEESFEIHAEHVVTATGNHAQRTARLLGIKIPAIPVEHQYI
VTEPDPALVEWRKTNPQHPVLRDADAKWYVREERGGWILGPYERNAPARFLYDVPSSFRADLFPLDLERIEEEYMSMIHR
IPSSETVGLKDDYNGPICYTPDGNPLVGPAPGLRNMWLAEGFSFGITAAGGTGHYLAQMMTEGEAEIDMASLDPRRYGSW
MTTEYAARKNEECYEHVFILHHPDEEREACRPLRTAPVYDRQKALGAQFGQVNGWERPNYYGPADAPAGFDHASRSFRRG
AWHPFARAEAEALRETAGLIDATAFTKHLVRGPGATAFLDWFTCNKLPAVGRINLTYALTPAGTTRTEYTIVRLAENEYY
LVSAGAWTAYDADWLRKCAEDRIGDFGWIDIHDVTTQWGVFALAGPNARAILNEVVKDADPATRLSNKRFPWLSYRDIEL
GMCPVRAVRVAYTGELGWELHHPIEMSTYLWDLLLKAGEKHGLKLVGARAQNWLRQEKSYRAFGNELGRDATPMEAGLDR
FIDLGKDFQGKEAMLATGIRSKCVTLLIDGPADADPWGKEALLLNGEKVGRLTSGGWSVAFGKQIGMGYVRPDLAEVGTK
LQLRMFRETCEAVVAEDSPYDPKNVRIRQDG
>Mature_831_residues
MKTHVKALVVGGGAVGNGIAYHLAKAGWDTMLVERDELTAGSTWHAAGLLPLFNMSYATTHIHKYSVDFYKGLEAETGLN
PGFYVVGNLRMAQTDARMDEYMLYSSVAETAGVYHEFLSPKEIAERWPLVRTEDLKGALFHPQDGYINPADVTQAMAKGA
RQLGCTIERRIQVNGYRWTGREWIVSCVRMAEQGGNLVPTEESFEIHAEHVVTATGNHAQRTARLLGIKIPAIPVEHQYI
VTEPDPALVEWRKTNPQHPVLRDADAKWYVREERGGWILGPYERNAPARFLYDVPSSFRADLFPLDLERIEEEYMSMIHR
IPSSETVGLKDDYNGPICYTPDGNPLVGPAPGLRNMWLAEGFSFGITAAGGTGHYLAQMMTEGEAEIDMASLDPRRYGSW
MTTEYAARKNEECYEHVFILHHPDEEREACRPLRTAPVYDRQKALGAQFGQVNGWERPNYYGPADAPAGFDHASRSFRRG
AWHPFARAEAEALRETAGLIDATAFTKHLVRGPGATAFLDWFTCNKLPAVGRINLTYALTPAGTTRTEYTIVRLAENEYY
LVSAGAWTAYDADWLRKCAEDRIGDFGWIDIHDVTTQWGVFALAGPNARAILNEVVKDADPATRLSNKRFPWLSYRDIEL
GMCPVRAVRVAYTGELGWELHHPIEMSTYLWDLLLKAGEKHGLKLVGARAQNWLRQEKSYRAFGNELGRDATPMEAGLDR
FIDLGKDFQGKEAMLATGIRSKCVTLLIDGPADADPWGKEALLLNGEKVGRLTSGGWSVAFGKQIGMGYVRPDLAEVGTK
LQLRMFRETCEAVVAEDSPYDPKNVRIRQDG

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0665

COG function: function code E; Glycine/D-amino acid oxidases (deaminating)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI24797151, Length=848, Percent_Identity=34.6698113207547, Blast_Score=493, Evalue=1e-139,
Organism=Homo sapiens, GI197927446, Length=883, Percent_Identity=31.2570781426954, Blast_Score=344, Evalue=3e-94,
Organism=Homo sapiens, GI21361378, Length=883, Percent_Identity=31.2570781426954, Blast_Score=344, Evalue=3e-94,
Organism=Homo sapiens, GI194306651, Length=809, Percent_Identity=27.9357231149567, Blast_Score=307, Evalue=2e-83,
Organism=Homo sapiens, GI44662838, Length=420, Percent_Identity=25.2380952380952, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI257796256, Length=299, Percent_Identity=29.0969899665552, Blast_Score=85, Evalue=3e-16,
Organism=Homo sapiens, GI257796258, Length=406, Percent_Identity=24.6305418719212, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI257796254, Length=237, Percent_Identity=30.379746835443, Blast_Score=82, Evalue=3e-15,
Organism=Escherichia coli, GI1789272, Length=307, Percent_Identity=25.7328990228013, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71994045, Length=821, Percent_Identity=28.8672350791717, Blast_Score=283, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI71994052, Length=828, Percent_Identity=28.5024154589372, Blast_Score=279, Evalue=6e-75,
Organism=Caenorhabditis elegans, GI32563613, Length=812, Percent_Identity=26.7241379310345, Blast_Score=250, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6320222, Length=336, Percent_Identity=26.7857142857143, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28571104, Length=814, Percent_Identity=29.7297297297297, Blast_Score=335, Evalue=7e-92,
Organism=Drosophila melanogaster, GI20130091, Length=878, Percent_Identity=29.8405466970387, Blast_Score=324, Evalue=2e-88,
Organism=Drosophila melanogaster, GI20129441, Length=333, Percent_Identity=24.9249249249249, Blast_Score=88, Evalue=3e-17,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 92857; Mature: 92857

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTHVKALVVGGGAVGNGIAYHLAKAGWDTMLVERDELTAGSTWHAAGLLPLFNMSYATT
CCCCEEEEEEECCCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCHHHCCHHHHCCCHHEE
HIHKYSVDFYKGLEAETGLNPGFYVVGNLRMAQTDARMDEYMLYSSVAETAGVYHEFLSP
EEEEEECHHHHCCCCCCCCCCCEEEEECEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCH
KEIAERWPLVRTEDLKGALFHPQDGYINPADVTQAMAKGARQLGCTIERRIQVNGYRWTG
HHHHHHCCCEEECCCCCCEECCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEEECCEEECC
REWIVSCVRMAEQGGNLVPTEESFEIHAEHVVTATGNHAQRTARLLGIKIPAIPVEHQYI
HHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEECCCHHHHHHHHHEEECCCCCCCCEEE
VTEPDPALVEWRKTNPQHPVLRDADAKWYVREERGGWILGPYERNAPARFLYDVPSSFRA
EECCCCCEEEEECCCCCCCCEECCCCEEEEEECCCCEEECCCCCCCCCEEEEECCCCCCC
DLFPLDLERIEEEYMSMIHRIPSSETVGLKDDYNGPICYTPDGNPLVGPAPGLRNMWLAE
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCHHHHHC
GFSFGITAAGGTGHYLAQMMTEGEAEIDMASLDPRRYGSWMTTEYAARKNEECYEHVFIL
CCCCEEEECCCCHHHHHHHHHCCCCCEEEECCCHHHCCCCCHHHHHHCCCCCHHHEEEEE
HHPDEEREACRPLRTAPVYDRQKALGAQFGQVNGWERPNYYGPADAPAGFDHASRSFRRG
ECCCCHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCC
AWHPFARAEAEALRETAGLIDATAFTKHLVRGPGATAFLDWFTCNKLPAVGRINLTYALT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHCCCCCCCCEEEEEEEEC
PAGTTRTEYTIVRLAENEYYLVSAGAWTAYDADWLRKCAEDRIGDFGWIDIHDVTTQWGV
CCCCCCCEEEEEEEECCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCE
FALAGPNARAILNEVVKDADPATRLSNKRFPWLSYRDIELGMCPVRAVRVAYTGELGWEL
EEEECCCHHHHHHHHHHCCCCHHHHCCCCCCCCEECCCCCCCCCEEEEEEEEECCCCCEE
HHPIEMSTYLWDLLLKAGEKHGLKLVGARAQNWLRQEKSYRAFGNELGRDATPMEAGLDR
CCCCHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
FIDLGKDFQGKEAMLATGIRSKCVTLLIDGPADADPWGKEALLLNGEKVGRLTSGGWSVA
HHHCCCCCCCCHHHHHHCCCCCEEEEEECCCCCCCCCCCCEEEECCCHHCEEECCCEEEE
FGKQIGMGYVRPDLAEVGTKLQLRMFRETCEAVVAEDSPYDPKNVRIRQDG
ECHHCCCCCCCCCHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCC
>Mature Secondary Structure
MKTHVKALVVGGGAVGNGIAYHLAKAGWDTMLVERDELTAGSTWHAAGLLPLFNMSYATT
CCCCEEEEEEECCCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCHHHCCHHHHCCCHHEE
HIHKYSVDFYKGLEAETGLNPGFYVVGNLRMAQTDARMDEYMLYSSVAETAGVYHEFLSP
EEEEEECHHHHCCCCCCCCCCCEEEEECEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCH
KEIAERWPLVRTEDLKGALFHPQDGYINPADVTQAMAKGARQLGCTIERRIQVNGYRWTG
HHHHHHCCCEEECCCCCCEECCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEEECCEEECC
REWIVSCVRMAEQGGNLVPTEESFEIHAEHVVTATGNHAQRTARLLGIKIPAIPVEHQYI
HHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEECCCHHHHHHHHHEEECCCCCCCCEEE
VTEPDPALVEWRKTNPQHPVLRDADAKWYVREERGGWILGPYERNAPARFLYDVPSSFRA
EECCCCCEEEEECCCCCCCCEECCCCEEEEEECCCCEEECCCCCCCCCEEEEECCCCCCC
DLFPLDLERIEEEYMSMIHRIPSSETVGLKDDYNGPICYTPDGNPLVGPAPGLRNMWLAE
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCHHHHHC
GFSFGITAAGGTGHYLAQMMTEGEAEIDMASLDPRRYGSWMTTEYAARKNEECYEHVFIL
CCCCEEEECCCCHHHHHHHHHCCCCCEEEECCCHHHCCCCCHHHHHHCCCCCHHHEEEEE
HHPDEEREACRPLRTAPVYDRQKALGAQFGQVNGWERPNYYGPADAPAGFDHASRSFRRG
ECCCCHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCC
AWHPFARAEAEALRETAGLIDATAFTKHLVRGPGATAFLDWFTCNKLPAVGRINLTYALT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHCCCCCCCCEEEEEEEEC
PAGTTRTEYTIVRLAENEYYLVSAGAWTAYDADWLRKCAEDRIGDFGWIDIHDVTTQWGV
CCCCCCCEEEEEEEECCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCE
FALAGPNARAILNEVVKDADPATRLSNKRFPWLSYRDIELGMCPVRAVRVAYTGELGWEL
EEEECCCHHHHHHHHHHCCCCHHHHCCCCCCCCEECCCCCCCCCEEEEEEEEECCCCCEE
HHPIEMSTYLWDLLLKAGEKHGLKLVGARAQNWLRQEKSYRAFGNELGRDATPMEAGLDR
CCCCHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
FIDLGKDFQGKEAMLATGIRSKCVTLLIDGPADADPWGKEALLLNGEKVGRLTSGGWSVA
HHHCCCCCCCCHHHHHHCCCCCEEEEEECCCCCCCCCCCCEEEECCCHHCEEECCCEEEE
FGKQIGMGYVRPDLAEVGTKLQLRMFRETCEAVVAEDSPYDPKNVRIRQDG
ECHHCCCCCCCCCHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA