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The map label for this gene is ghrA [H]

Identifier: 77465444

GI number: 77465444

Start: 512299

End: 513240

Strand: Direct

Name: ghrA [H]

Synonym: RSP_3442

Alternate gene names: 77465444

Gene position: 512299-513240 (Clockwise)

Preceding gene: 77465443

Following gene: 77465456

Centisome position: 54.33

GC content: 71.66

Gene sequence:

>942_bases
ATGTCGCGGATCGCGCTTGTCACCCGTCTGTCGCCCGAGGCCGAGGCCCATTGGGCGGGCCATCTCGCCCGCGCCCTGCC
CGGCGAGCGGATCGACGGCTTCCGCGAGCTGAGCCCCGCCGAGCGGGCCGAGGTGGACATCGCCATCGTGGCCAATCCCG
ACCCGGCCGATCTGGCCGAGCTTCCGAACCTCGTCTGGATCCACAGCCTCTGGGCCGGGGTCGAGCGGCTGGTGGCCGAA
CTGGGCCATCTCGCGCGCCCCATCGTGCGGCTCGTCGACCCCGAGCTCGCCCGCACCATGGCCGAGGCGGCTTTGGCCTG
GACCTATTATCTCTTCCGCGACATGCCGGCCTATGCCGCCCAGCAGCGCGCCCGCGTCTGGAAGGGGCTGCCCTACAAAC
GCCCCGAGCGCACGACAGTGGGCGTGCTGGGCTTGGGCGAACTCGGGGCGGCGGCGGCCCTCCGGCTCCGCGACGCGGGC
TTCGACGTCCATGGCTGGAGCCGGTCGCCCAAGGAGATCGCGGGTGTGACCTGCCATGCCGGCGAAGAAACGCTCGAGCG
GATGCTGGGGCAGGTCGAGATCCTCGTCTGCCTCCTGCCGCTCACGGGCGAAACGCGGGGGCTTCTCGATGCGCGCCGGC
TGGCGTGCCTGCCCGAGGGAGCGCAGATCGTCAACTTCGCCCGCGGCCCGATCCTCGACAGCGCGGCGCTGATCGAAGCA
CTCGACAGCGGCCGGATCGGCCATGCGGTGCTCGACGTGTTCGAGGTCGAGCCCCTGCCCGAGGCCTCGCCCTTCTGGGG
CCATCCGAAGGTGACCGTGCTGCCGCATATCTCAGCCGCCACCGACCCCGAGACCGCCTCGGCCATCGTGGGCGCGCATG
TGGCCGACTACCGCGCGACCGGCCGTATCCCGCCCTCGGTCGATCTCACCCGCGGCTACTGA

Upstream 100 bases:

>100_bases
CAGTGATCTTCGGCGGGGCCGCGAGGGCCCGCCTTCCGTCTCCCCACTCCCCGGGCAAGGGCTCGTCCCTGCCCGGGGCC
TTTTGTGAAAGGCTCTCCCC

Downstream 100 bases:

>100_bases
AAGGCGGCCCGCGCCCCGCCCCGGCGAGCCCGGGGCGCAGGCTCCGGTTCAGCAGCAGGCGGGTGTTTCGAGAGCTTTCC
GGCAAAGGCGCCCCCCGGGA

Product: 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: 2-ketoacid reductase [H]

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MSRIALVTRLSPEAEAHWAGHLARALPGERIDGFRELSPAERAEVDIAIVANPDPADLAELPNLVWIHSLWAGVERLVAE
LGHLARPIVRLVDPELARTMAEAALAWTYYLFRDMPAYAAQQRARVWKGLPYKRPERTTVGVLGLGELGAAAALRLRDAG
FDVHGWSRSPKEIAGVTCHAGEETLERMLGQVEILVCLLPLTGETRGLLDARRLACLPEGAQIVNFARGPILDSAALIEA
LDSGRIGHAVLDVFEVEPLPEASPFWGHPKVTVLPHISAATDPETASAIVGAHVADYRATGRIPPSVDLTRGY

Sequences:

>Translated_313_residues
MSRIALVTRLSPEAEAHWAGHLARALPGERIDGFRELSPAERAEVDIAIVANPDPADLAELPNLVWIHSLWAGVERLVAE
LGHLARPIVRLVDPELARTMAEAALAWTYYLFRDMPAYAAQQRARVWKGLPYKRPERTTVGVLGLGELGAAAALRLRDAG
FDVHGWSRSPKEIAGVTCHAGEETLERMLGQVEILVCLLPLTGETRGLLDARRLACLPEGAQIVNFARGPILDSAALIEA
LDSGRIGHAVLDVFEVEPLPEASPFWGHPKVTVLPHISAATDPETASAIVGAHVADYRATGRIPPSVDLTRGY
>Mature_312_residues
SRIALVTRLSPEAEAHWAGHLARALPGERIDGFRELSPAERAEVDIAIVANPDPADLAELPNLVWIHSLWAGVERLVAEL
GHLARPIVRLVDPELARTMAEAALAWTYYLFRDMPAYAAQQRARVWKGLPYKRPERTTVGVLGLGELGAAAALRLRDAGF
DVHGWSRSPKEIAGVTCHAGEETLERMLGQVEILVCLLPLTGETRGLLDARRLACLPEGAQIVNFARGPILDSAALIEAL
DSGRIGHAVLDVFEVEPLPEASPFWGHPKVTVLPHISAATDPETASAIVGAHVADYRATGRIPPSVDLTRGY

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=185, Percent_Identity=31.8918918918919, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI6912396, Length=227, Percent_Identity=28.6343612334802, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI145580578, Length=207, Percent_Identity=30.9178743961353, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI4557499, Length=207, Percent_Identity=30.9178743961353, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI4557497, Length=209, Percent_Identity=33.0143540669856, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI61743967, Length=209, Percent_Identity=33.0143540669856, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI145580575, Length=174, Percent_Identity=32.183908045977, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI87081824, Length=302, Percent_Identity=35.0993377483444, Blast_Score=174, Evalue=5e-45,
Organism=Escherichia coli, GI87082289, Length=288, Percent_Identity=30.2083333333333, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1789279, Length=222, Percent_Identity=24.3243243243243, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=187, Percent_Identity=31.5508021390374, Blast_Score=88, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6324055, Length=146, Percent_Identity=35.6164383561644, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321253, Length=145, Percent_Identity=33.1034482758621, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320925, Length=253, Percent_Identity=24.1106719367589, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322116, Length=249, Percent_Identity=23.2931726907631, Blast_Score=66, Evalue=7e-12,
Organism=Drosophila melanogaster, GI28574286, Length=149, Percent_Identity=36.9127516778523, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI19921140, Length=146, Percent_Identity=33.5616438356164, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI45551003, Length=162, Percent_Identity=35.1851851851852, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45552429, Length=162, Percent_Identity=35.1851851851852, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24585514, Length=162, Percent_Identity=35.1851851851852, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28574282, Length=162, Percent_Identity=35.1851851851852, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28574284, Length=162, Percent_Identity=35.1851851851852, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24585516, Length=150, Percent_Identity=32.6666666666667, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI28571528, Length=149, Percent_Identity=35.5704697986577, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 33879; Mature: 33748

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRIALVTRLSPEAEAHWAGHLARALPGERIDGFRELSPAERAEVDIAIVANPDPADLAE
CCCEEEEEECCCCHHHHHHHHHHHHCCCHHCCCHHHCCCHHHCCEEEEEEECCCCHHHHH
LPNLVWIHSLWAGVERLVAELGHLARPIVRLVDPELARTMAEAALAWTYYLFRDMPAYAA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCHHHHH
QQRARVWKGLPYKRPERTTVGVLGLGELGAAAALRLRDAGFDVHGWSRSPKEIAGVTCHA
HHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCHHHHHCEEECC
GEETLERMLGQVEILVCLLPLTGETRGLLDARRLACLPEGAQIVNFARGPILDSAALIEA
CHHHHHHHHHHHEEEHEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHH
LDSGRIGHAVLDVFEVEPLPEASPFWGHPKVTVLPHISAATDPETASAIVGAHVADYRAT
HHCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHC
GRIPPSVDLTRGY
CCCCCCCCCCCCC
>Mature Secondary Structure 
SRIALVTRLSPEAEAHWAGHLARALPGERIDGFRELSPAERAEVDIAIVANPDPADLAE
CCEEEEEECCCCHHHHHHHHHHHHCCCHHCCCHHHCCCHHHCCEEEEEEECCCCHHHHH
LPNLVWIHSLWAGVERLVAELGHLARPIVRLVDPELARTMAEAALAWTYYLFRDMPAYAA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCHHHHH
QQRARVWKGLPYKRPERTTVGVLGLGELGAAAALRLRDAGFDVHGWSRSPKEIAGVTCHA
HHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCHHHHHCEEECC
GEETLERMLGQVEILVCLLPLTGETRGLLDARRLACLPEGAQIVNFARGPILDSAALIEA
CHHHHHHHHHHHEEEHEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHH
LDSGRIGHAVLDVFEVEPLPEASPFWGHPKVTVLPHISAATDPETASAIVGAHVADYRAT
HHCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHC
GRIPPSVDLTRGY
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA