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The map label for this gene is ttuC [H]

Identifier: 77465390

GI number: 77465390

Start: 452647

End: 453729

Strand: Direct

Name: ttuC [H]

Synonym: RSP_3388

Alternate gene names: 77465390

Gene position: 452647-453729 (Clockwise)

Preceding gene: 77465389

Following gene: 77465391

Centisome position: 48.0

GC content: 70.82

Gene sequence:

>1083_bases
ATGGACATACGCACCCACAGGATCGCCGCCATTCCCGGCGACGGGATCGGGATCGAGGTGGTCGCGGCGGGGCTCGAGGT
GCTCGAGGCGCTGGCCGACCGCGACGGCGGCTTCCGCTTCGACGTGGAGAGCTTCGACTGGGGAACCGACCGCTACCGGC
GCACCGGCGCCTTCATGCCCGAGGACGGGGCCGACCGGCTGCGCGGCTTCGACGCGATCCTGTTCGGCGCGGTGGGCGCG
CCCGACGTGGCCGACCATCTGACGCTCTGGGGGCTGCGCCTCGCCATCTGCCAGCCGCTCGACCAATATGCCAATGTGCG
GCCGACCCGGATGCTGCCCGGCATCCGCAGCCCGCTCCGCCATGTCGGGGAGAGCGAGCTCGACTGGGTGATCGTGCGCG
AGAATTCCGAGGGCGAATATGCCGGGCAAGGCGGGCGCTCGCACCCCGGCCTGCCGCTGGAGGTGGCCACGGATGTGTCG
ATCTTCACCCGCGCCGGGGTCGAGCGAATCATGCGCTTCGCCTTCCGCCTTGCGCAGTCGCGGCCGCGCAAGCTCCTGAC
CGTGGTGACCAAATCCAACGCGCAGCGGCACGGCATGGTGCTCTGGGACCAGATCGCGGGCGAGGTCGCGCGCGAGTTCC
CGGACGTGCGCTGGGACAAGATGCTGGTCGATGCCATGACGGTGCGCATGGTGCAGAAGCCCGCATCGCTCGACACGATC
GTCGCCACGAACCTTCATGCGGACATCCTGTCGGATCTCGCCGCGGCACTGGCGGGCTCCATCGGCGTGGCGCCCACCGC
CAACCTCAACCCCGAGCGCGACACGCCCTCGATGTTCGAGCCGATCCACGGCTCGGCCTTCGACATCACCGGGCGGGGCA
TCGCGAACCCGGTGGCCACCTTCTGGACCGCCGCCATGATGCTCGAGCATCTGGGGGAGGCCGAGGCCGCGGGGCGGCTG
ATGACCGCCGTGGGCCGGGTGACGGCGGACGAGGATCTCCATACGCCCGACCTCGGCGGTCGGGCCACCACGCGGCAGGT
GACGGATGCCCTGATCGCGGCCCTGCGCGGCCGCAACGCCTGA

Upstream 100 bases:

>100_bases
TCTCGGGCGTGGCCATCGTGCTCGGCTTCTGGTGGCTCATGGCCCACGTCCTGCTGCTGCGGATGCCTTCCGGCATCCTG
TTCTGAACCGGAGACTTGAT

Downstream 100 bases:

>100_bases
GGAGCACGACATGGCAGACAATCACCTGAAGATCGCGGTCATCGCCGGCGACGGCATCGGCAAGGAAGTGGTGCCGGAAG
GGCTGCGGGTGCTCGAAGCG

Product: putative isocitrate/isopropylmalate dehydrogenase / tartrate dehydrogenase ttuC

Products: NA

Alternate protein names: TDH; D-malate dehydrogenase [decarboxylating] [H]

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MDIRTHRIAAIPGDGIGIEVVAAGLEVLEALADRDGGFRFDVESFDWGTDRYRRTGAFMPEDGADRLRGFDAILFGAVGA
PDVADHLTLWGLRLAICQPLDQYANVRPTRMLPGIRSPLRHVGESELDWVIVRENSEGEYAGQGGRSHPGLPLEVATDVS
IFTRAGVERIMRFAFRLAQSRPRKLLTVVTKSNAQRHGMVLWDQIAGEVAREFPDVRWDKMLVDAMTVRMVQKPASLDTI
VATNLHADILSDLAAALAGSIGVAPTANLNPERDTPSMFEPIHGSAFDITGRGIANPVATFWTAAMMLEHLGEAEAAGRL
MTAVGRVTADEDLHTPDLGGRATTRQVTDALIAALRGRNA

Sequences:

>Translated_360_residues
MDIRTHRIAAIPGDGIGIEVVAAGLEVLEALADRDGGFRFDVESFDWGTDRYRRTGAFMPEDGADRLRGFDAILFGAVGA
PDVADHLTLWGLRLAICQPLDQYANVRPTRMLPGIRSPLRHVGESELDWVIVRENSEGEYAGQGGRSHPGLPLEVATDVS
IFTRAGVERIMRFAFRLAQSRPRKLLTVVTKSNAQRHGMVLWDQIAGEVAREFPDVRWDKMLVDAMTVRMVQKPASLDTI
VATNLHADILSDLAAALAGSIGVAPTANLNPERDTPSMFEPIHGSAFDITGRGIANPVATFWTAAMMLEHLGEAEAAGRL
MTAVGRVTADEDLHTPDLGGRATTRQVTDALIAALRGRNA
>Mature_360_residues
MDIRTHRIAAIPGDGIGIEVVAAGLEVLEALADRDGGFRFDVESFDWGTDRYRRTGAFMPEDGADRLRGFDAILFGAVGA
PDVADHLTLWGLRLAICQPLDQYANVRPTRMLPGIRSPLRHVGESELDWVIVRENSEGEYAGQGGRSHPGLPLEVATDVS
IFTRAGVERIMRFAFRLAQSRPRKLLTVVTKSNAQRHGMVLWDQIAGEVAREFPDVRWDKMLVDAMTVRMVQKPASLDTI
VATNLHADILSDLAAALAGSIGVAPTANLNPERDTPSMFEPIHGSAFDITGRGIANPVATFWTAAMMLEHLGEAEAAGRL
MTAVGRVTADEDLHTPDLGGRATTRQVTDALIAALRGRNA

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=345, Percent_Identity=31.8840579710145, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI4758582, Length=258, Percent_Identity=35.6589147286822, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI28178816, Length=353, Percent_Identity=32.0113314447592, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI28178821, Length=358, Percent_Identity=30.4469273743017, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI28178838, Length=239, Percent_Identity=34.7280334728033, Blast_Score=131, Evalue=9e-31,
Organism=Homo sapiens, GI28178819, Length=207, Percent_Identity=32.8502415458937, Blast_Score=109, Evalue=4e-24,
Organism=Escherichia coli, GI1788101, Length=360, Percent_Identity=48.8888888888889, Blast_Score=341, Evalue=5e-95,
Organism=Escherichia coli, GI87081683, Length=344, Percent_Identity=34.3023255813954, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1787381, Length=355, Percent_Identity=28.169014084507, Blast_Score=114, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71986051, Length=356, Percent_Identity=33.9887640449438, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17550882, Length=353, Percent_Identity=33.4277620396601, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI25144293, Length=354, Percent_Identity=28.5310734463277, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17505779, Length=258, Percent_Identity=31.7829457364341, Blast_Score=144, Evalue=9e-35,
Organism=Saccharomyces cerevisiae, GI6322097, Length=365, Percent_Identity=36.4383561643836, Blast_Score=195, Evalue=9e-51,
Organism=Saccharomyces cerevisiae, GI6324709, Length=354, Percent_Identity=32.2033898305085, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6324291, Length=356, Percent_Identity=32.0224719101124, Blast_Score=157, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6319830, Length=363, Percent_Identity=31.6804407713499, Blast_Score=149, Evalue=7e-37,
Organism=Drosophila melanogaster, GI24643268, Length=351, Percent_Identity=31.6239316239316, Blast_Score=175, Evalue=5e-44,
Organism=Drosophila melanogaster, GI24643270, Length=351, Percent_Identity=31.6239316239316, Blast_Score=175, Evalue=5e-44,
Organism=Drosophila melanogaster, GI24661184, Length=359, Percent_Identity=30.6406685236769, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI281362242, Length=343, Percent_Identity=31.7784256559767, Blast_Score=154, Evalue=8e-38,
Organism=Drosophila melanogaster, GI24648872, Length=343, Percent_Identity=31.7784256559767, Blast_Score=154, Evalue=8e-38,
Organism=Drosophila melanogaster, GI161078635, Length=359, Percent_Identity=28.4122562674095, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI161078637, Length=359, Percent_Identity=28.4122562674095, Blast_Score=143, Evalue=1e-34,
Organism=Drosophila melanogaster, GI161078633, Length=359, Percent_Identity=28.4122562674095, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24650122, Length=359, Percent_Identity=28.4122562674095, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI161078639, Length=273, Percent_Identity=30.7692307692308, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI20130355, Length=358, Percent_Identity=26.2569832402235, Blast_Score=113, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR011829 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.93; =4.1.1.73; =1.1.1.83 [H]

Molecular weight: Translated: 39063; Mature: 39063

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIRTHRIAAIPGDGIGIEVVAAGLEVLEALADRDGGFRFDVESFDWGTDRYRRTGAFMP
CCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHCCCCCC
EDGADRLRGFDAILFGAVGAPDVADHLTLWGLRLAICQPLDQYANVRPTRMLPGIRSPLR
CCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHH
HVGESELDWVIVRENSEGEYAGQGGRSHPGLPLEVATDVSIFTRAGVERIMRFAFRLAQS
HCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEHCCCHHHHHHHHHHHHHHHHHHHHHC
RPRKLLTVVTKSNAQRHGMVLWDQIAGEVAREFPDVRWDKMLVDAMTVRMVQKPASLDTI
CCHHEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHH
VATNLHADILSDLAAALAGSIGVAPTANLNPERDTPSMFEPIHGSAFDITGRGIANPVAT
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCCEEEECCCCCCHHHHH
FWTAAMMLEHLGEAEAAGRLMTAVGRVTADEDLHTPDLGGRATTRQVTDALIAALRGRNA
HHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDIRTHRIAAIPGDGIGIEVVAAGLEVLEALADRDGGFRFDVESFDWGTDRYRRTGAFMP
CCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHCCCCCC
EDGADRLRGFDAILFGAVGAPDVADHLTLWGLRLAICQPLDQYANVRPTRMLPGIRSPLR
CCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHH
HVGESELDWVIVRENSEGEYAGQGGRSHPGLPLEVATDVSIFTRAGVERIMRFAFRLAQS
HCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEHCCCHHHHHHHHHHHHHHHHHHHHHC
RPRKLLTVVTKSNAQRHGMVLWDQIAGEVAREFPDVRWDKMLVDAMTVRMVQKPASLDTI
CCHHEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHH
VATNLHADILSDLAAALAGSIGVAPTANLNPERDTPSMFEPIHGSAFDITGRGIANPVAT
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCCEEEECCCCCCHHHHH
FWTAAMMLEHLGEAEAAGRLMTAVGRVTADEDLHTPDLGGRATTRQVTDALIAALRGRNA
HHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7592429 [H]