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The map label for this gene is gyaR [H]

Identifier: 77465367

GI number: 77465367

Start: 429147

End: 430094

Strand: Direct

Name: gyaR [H]

Synonym: RSP_3366

Alternate gene names: 77465367

Gene position: 429147-430094 (Clockwise)

Preceding gene: 77465366

Following gene: 77465368

Centisome position: 45.51

GC content: 72.47

Gene sequence:

>948_bases
TTGAGACTGCTCATCACCCGCCCCCTGCCCGACCGGATTCTCGAGGCCGCCCGCGCCCGGTTCGAGGTCACGGTTCGCAA
CAGCACCAAGCCGCTCTCGCCCGAGGAGCTGCGCCGCGCGCTGGCCGAGCACGATGCCGTGCTGCCGACGCTGGGCGATC
TCTTCCGCGCCGAGGTCTTCGCCGACGTGCCGCAGCCGCGCGCCCGGATCCTCGCCAACTTCGGCGTGGGGACGAACCAT
ATCGACGTGGCCGCCGCGACCGCCGCCGGGATCGCCGTCACCAACACGCCGGGCGCCGTCACCGACGCCACCGCCGACAT
CGCGCTCACGCTAATGCTGATGACGGCGCGCCGGGCCGGCGAAGGCGAGCGGCTGGTGCGCCGCGGCGCGTGGGAGGGCT
GGCATCCGACGCAGATGCTCGGTCTCCACATGACGGGAAAACGGCTCGGCATCCTCGGCATGGGCCGGATCGGCAAGGCC
ATCGCGCGCCGCGCCCACCACGGCTTCGGGATGGAGATCACCTTCTTCAACCGCTCGCCCGTCGCCGATCCGGGCGTCCC
CGCCCGACAGGTGGGATTGGCCGAGGCGCTGGACGCCGATATCGTCGTGGTGGCCGTGCCCGCGACGCCCGCGACCCACC
ATCTCGTCGATGCGGCGGCGCTCAGCCAGATGCGGCCCGGCGCGATCCTCGTCAACATCGCCCGCGGCGACATCGTCGAC
GAAACGGCGCTGATCGCGGCACTCGCCGAAGGCCGGCTCGCCGGCGCGGGGCTCGACGTCTACGAGTTCGAGCCCGAGGT
GCCCGCCGCGCTCCGCGCGATGGAGAATGTGACCCTCCTGCCTCATCTGGGGACCGCGGCCCTCGAGGTGCGCGAGGGCA
TGGGGCTCATGGCGGTCGAGAACCTCCTGGCCTTCGCCGACGGCCGGCCGCTGCCGAACGCGGTCTGA

Upstream 100 bases:

>100_bases
CGGTCCTGTCGGAGGTGCTGGTGCTGGGCGTGCCGGATGCCGAGGGCGAGGTGGTGCTGATCGGACCCGGCCAGGACGTG
CCACTCGGAGGGAAGCTCTT

Downstream 100 bases:

>100_bases
CGATGCGCCGGTGCCGCCGCTCAGGTCCTGTCGGCCGCACCGGGCGCCCCAGCCGCCGCCGGGGGTTCGATGCCCCCGGC
GGCGGCTCCCTCCGTCCGGG

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MRLLITRPLPDRILEAARARFEVTVRNSTKPLSPEELRRALAEHDAVLPTLGDLFRAEVFADVPQPRARILANFGVGTNH
IDVAAATAAGIAVTNTPGAVTDATADIALTLMLMTARRAGEGERLVRRGAWEGWHPTQMLGLHMTGKRLGILGMGRIGKA
IARRAHHGFGMEITFFNRSPVADPGVPARQVGLAEALDADIVVVAVPATPATHHLVDAAALSQMRPGAILVNIARGDIVD
ETALIAALAEGRLAGAGLDVYEFEPEVPAALRAMENVTLLPHLGTAALEVREGMGLMAVENLLAFADGRPLPNAV

Sequences:

>Translated_315_residues
MRLLITRPLPDRILEAARARFEVTVRNSTKPLSPEELRRALAEHDAVLPTLGDLFRAEVFADVPQPRARILANFGVGTNH
IDVAAATAAGIAVTNTPGAVTDATADIALTLMLMTARRAGEGERLVRRGAWEGWHPTQMLGLHMTGKRLGILGMGRIGKA
IARRAHHGFGMEITFFNRSPVADPGVPARQVGLAEALDADIVVVAVPATPATHHLVDAAALSQMRPGAILVNIARGDIVD
ETALIAALAEGRLAGAGLDVYEFEPEVPAALRAMENVTLLPHLGTAALEVREGMGLMAVENLLAFADGRPLPNAV
>Mature_315_residues
MRLLITRPLPDRILEAARARFEVTVRNSTKPLSPEELRRALAEHDAVLPTLGDLFRAEVFADVPQPRARILANFGVGTNH
IDVAAATAAGIAVTNTPGAVTDATADIALTLMLMTARRAGEGERLVRRGAWEGWHPTQMLGLHMTGKRLGILGMGRIGKA
IARRAHHGFGMEITFFNRSPVADPGVPARQVGLAEALDADIVVVAVPATPATHHLVDAAALSQMRPGAILVNIARGDIVD
ETALIAALAEGRLAGAGLDVYEFEPEVPAALRAMENVTLLPHLGTAALEVREGMGLMAVENLLAFADGRPLPNAV

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=321, Percent_Identity=35.5140186915888, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI23308577, Length=295, Percent_Identity=33.2203389830508, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI4557497, Length=241, Percent_Identity=36.5145228215768, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI61743967, Length=241, Percent_Identity=36.5145228215768, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI145580578, Length=241, Percent_Identity=34.8547717842324, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI4557499, Length=241, Percent_Identity=34.8547717842324, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI145580575, Length=241, Percent_Identity=34.8547717842324, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI87082289, Length=317, Percent_Identity=36.9085173501577, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1789279, Length=327, Percent_Identity=30.5810397553517, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1787645, Length=258, Percent_Identity=29.4573643410853, Blast_Score=104, Evalue=8e-24,
Organism=Escherichia coli, GI1788660, Length=200, Percent_Identity=30.5, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI87081824, Length=154, Percent_Identity=31.1688311688312, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=303, Percent_Identity=30.3630363036304, Blast_Score=123, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6324055, Length=236, Percent_Identity=38.5593220338983, Blast_Score=153, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6320925, Length=238, Percent_Identity=30.672268907563, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6322116, Length=238, Percent_Identity=30.2521008403361, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6321253, Length=173, Percent_Identity=36.9942196531792, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6325144, Length=165, Percent_Identity=30.3030303030303, Blast_Score=94, Evalue=3e-20,
Organism=Drosophila melanogaster, GI28571528, Length=308, Percent_Identity=39.2857142857143, Blast_Score=185, Evalue=3e-47,
Organism=Drosophila melanogaster, GI45552429, Length=318, Percent_Identity=31.1320754716981, Blast_Score=144, Evalue=8e-35,
Organism=Drosophila melanogaster, GI24585514, Length=318, Percent_Identity=31.1320754716981, Blast_Score=144, Evalue=9e-35,
Organism=Drosophila melanogaster, GI28574282, Length=318, Percent_Identity=31.1320754716981, Blast_Score=144, Evalue=9e-35,
Organism=Drosophila melanogaster, GI28574284, Length=318, Percent_Identity=31.1320754716981, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI45551003, Length=318, Percent_Identity=31.1320754716981, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24585516, Length=316, Percent_Identity=30.0632911392405, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI28574286, Length=311, Percent_Identity=31.1897106109325, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24646446, Length=246, Percent_Identity=36.1788617886179, Blast_Score=124, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24646448, Length=246, Percent_Identity=36.1788617886179, Blast_Score=124, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24646452, Length=246, Percent_Identity=36.1788617886179, Blast_Score=124, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24646450, Length=246, Percent_Identity=36.1788617886179, Blast_Score=124, Evalue=6e-29,
Organism=Drosophila melanogaster, GI62472511, Length=246, Percent_Identity=36.1788617886179, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI19921140, Length=285, Percent_Identity=30.8771929824561, Blast_Score=117, Evalue=7e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 33372; Mature: 33372

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLITRPLPDRILEAARARFEVTVRNSTKPLSPEELRRALAEHDAVLPTLGDLFRAEVF
CEEEEECCCHHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHH
ADVPQPRARILANFGVGTNHIDVAAATAAGIAVTNTPGAVTDATADIALTLMLMTARRAG
HCCCCHHHHHHHHCCCCCCCEEEEEHHHCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCC
EGERLVRRGAWEGWHPTQMLGLHMTGKRLGILGMGRIGKAIARRAHHGFGMEITFFNRSP
CHHHHHHHCCCCCCCCHHEEEEEECCCEECEEECCHHHHHHHHHHHCCCCEEEEEECCCC
VADPGVPARQVGLAEALDADIVVVAVPATPATHHLVDAAALSQMRPGAILVNIARGDIVD
CCCCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCH
ETALIAALAEGRLAGAGLDVYEFEPEVPAALRAMENVTLLPHLGTAALEVREGMGLMAVE
HHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHCCEEECCCCHHHHHHHHCCCHHHHH
NLLAFADGRPLPNAV
HHHHHHCCCCCCCCC
>Mature Secondary Structure
MRLLITRPLPDRILEAARARFEVTVRNSTKPLSPEELRRALAEHDAVLPTLGDLFRAEVF
CEEEEECCCHHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHH
ADVPQPRARILANFGVGTNHIDVAAATAAGIAVTNTPGAVTDATADIALTLMLMTARRAG
HCCCCHHHHHHHHCCCCCCCEEEEEHHHCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCC
EGERLVRRGAWEGWHPTQMLGLHMTGKRLGILGMGRIGKAIARRAHHGFGMEITFFNRSP
CHHHHHHHCCCCCCCCHHEEEEEECCCEECEEECCHHHHHHHHHHHCCCCEEEEEECCCC
VADPGVPARQVGLAEALDADIVVVAVPATPATHHLVDAAALSQMRPGAILVNIARGDIVD
CCCCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCH
ETALIAALAEGRLAGAGLDVYEFEPEVPAALRAMENVTLLPHLGTAALEVREGMGLMAVE
HHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHCCEEECCCCHHHHHHHHCCCHHHHH
NLLAFADGRPLPNAV
HHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA