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The map label for this gene is proC [H]

Identifier: 77465365

GI number: 77465365

Start: 428054

End: 428821

Strand: Direct

Name: proC [H]

Synonym: RSP_3364

Alternate gene names: 77465365

Gene position: 428054-428821 (Clockwise)

Preceding gene: 77465364

Following gene: 77465366

Centisome position: 45.39

GC content: 74.22

Gene sequence:

>768_bases
ATGGGCTCGGCGATGCTCGAGGGCTGGCTCGGACGGGGCCTTGCGCTCTCCGCCGTCTGGGTGACGGACCCCAGGCCGTC
GGACTGGCTGAAATCGCTCGCGGCGCGCGGGCTGCATCTGAACGAGGCGCTGCCCGACGAGCCCGCGGTGGTGCTGGTCG
CGGTCAAGCCGCAGATGATGTCCGAGGCCCTGCCGGGGCTCGCGGCGCTCGGCGAAGGGCGGGTGCTTTTCCTGACGGTC
GCGGCGGGCACGCCCATCTCCTATTACGAACGCACGCTGGGCGCGGCCACGCCGGTGATCCGCGCCATGCCGAACACACC
CGCGGCGGTCGGCCGCGGCATCACGGCGCTGGTGGGCAATGCTGCCGCCTCGGAGGCGCAGATGGCGCTGGCCGAGGATC
TCCTCTCGGCGGTGGGCCAGGTGGTCCGGCTCGAGGGCGAGCATCAGATGGATGCGGTGACCGCGGTCTCGGGCTCGGGG
CCGGCCTATGTCTTCCACCTGATCGAGGCGCTCGCCGCAGCGGGCGAGGCCGAGGGGCTGCCGGCCGATCTCGCCATGAC
CCTCGCCCGCGCCACCGTCACCGGCGCGGGCGAGCTTGCCCATCGCGCGCCGGAAAGCGCGAGCCAGCTGCGCGTGAACG
TGACCTCGCCGGGGGGCACGACGGCGGCGGCGCTCGGCGTGCTGATGGATCCCGAGAGCGGCCTGCCGCCGCTCCTCCGC
CGCGCGGTGAAGGCTGCGGCCGACCGCGGACGGGAGCTCGGCCGATGA

Upstream 100 bases:

>100_bases
GGCCTACGGCCGCGCCTAGTCTTTCCCCGCACAAACGGGGGAAACAATGGATCTTGCGGATCTTGGCCGCCGGGGGCTGG
TGCTGCTCGGCTGCGGGAAG

Downstream 100 bases:

>100_bases
TCGCCTACGAGGATTTCGCCAAGGTCGACATCCGCGTGGGCCGCATCACCCGCGCCGAACCCTTCCCCGAGGCACGCAAG
CCCGCCCTGAAGCTCTGGGT

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 255; Mature: 254

Protein sequence:

>255_residues
MGSAMLEGWLGRGLALSAVWVTDPRPSDWLKSLAARGLHLNEALPDEPAVVLVAVKPQMMSEALPGLAALGEGRVLFLTV
AAGTPISYYERTLGAATPVIRAMPNTPAAVGRGITALVGNAAASEAQMALAEDLLSAVGQVVRLEGEHQMDAVTAVSGSG
PAYVFHLIEALAAAGEAEGLPADLAMTLARATVTGAGELAHRAPESASQLRVNVTSPGGTTAAALGVLMDPESGLPPLLR
RAVKAAADRGRELGR

Sequences:

>Translated_255_residues
MGSAMLEGWLGRGLALSAVWVTDPRPSDWLKSLAARGLHLNEALPDEPAVVLVAVKPQMMSEALPGLAALGEGRVLFLTV
AAGTPISYYERTLGAATPVIRAMPNTPAAVGRGITALVGNAAASEAQMALAEDLLSAVGQVVRLEGEHQMDAVTAVSGSG
PAYVFHLIEALAAAGEAEGLPADLAMTLARATVTGAGELAHRAPESASQLRVNVTSPGGTTAAALGVLMDPESGLPPLLR
RAVKAAADRGRELGR
>Mature_254_residues
GSAMLEGWLGRGLALSAVWVTDPRPSDWLKSLAARGLHLNEALPDEPAVVLVAVKPQMMSEALPGLAALGEGRVLFLTVA
AGTPISYYERTLGAATPVIRAMPNTPAAVGRGITALVGNAAASEAQMALAEDLLSAVGQVVRLEGEHQMDAVTAVSGSGP
AYVFHLIEALAAAGEAEGLPADLAMTLARATVTGAGELAHRAPESASQLRVNVTSPGGTTAAALGVLMDPESGLPPLLRR
AVKAAADRGRELGR

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797095, Length=216, Percent_Identity=39.8148148148148, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI24797097, Length=216, Percent_Identity=39.8148148148148, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI21361454, Length=266, Percent_Identity=36.0902255639098, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI198041662, Length=263, Percent_Identity=29.6577946768061, Blast_Score=96, Evalue=2e-20,
Organism=Escherichia coli, GI1786585, Length=259, Percent_Identity=30.8880308880309, Blast_Score=103, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17569021, Length=259, Percent_Identity=33.2046332046332, Blast_Score=114, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17540664, Length=276, Percent_Identity=25.7246376811594, Blast_Score=67, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6320861, Length=213, Percent_Identity=34.7417840375587, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI21358587, Length=258, Percent_Identity=38.7596899224806, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24647700, Length=171, Percent_Identity=42.6900584795322, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24648116, Length=254, Percent_Identity=32.6771653543307, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 25976; Mature: 25845

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSAMLEGWLGRGLALSAVWVTDPRPSDWLKSLAARGLHLNEALPDEPAVVLVAVKPQMM
CCCHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEECHHHH
SEALPGLAALGEGRVLFLTVAAGTPISYYERTLGAATPVIRAMPNTPAAVGRGITALVGN
HHHCCCHHHCCCCCEEEEEEECCCCHHHHHHHHHHHCHHHHCCCCCCHHHHCCHHHHHCC
AAASEAQMALAEDLLSAVGQVVRLEGEHQMDAVTAVSGSGPAYVFHLIEALAAAGEAEGL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHEEECCCCHHHHHHHHHHHHHCCCCCCC
PADLAMTLARATVTGAGELAHRAPESASQLRVNVTSPGGTTAAALGVLMDPESGLPPLLR
CHHHHHHHHHHHHCCCHHHHHCCCCCCCEEEEEEECCCCHHHHHHHEEECCCCCCCHHHH
RAVKAAADRGRELGR
HHHHHHHHHHHHCCC
>Mature Secondary Structure 
GSAMLEGWLGRGLALSAVWVTDPRPSDWLKSLAARGLHLNEALPDEPAVVLVAVKPQMM
CCHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEECHHHH
SEALPGLAALGEGRVLFLTVAAGTPISYYERTLGAATPVIRAMPNTPAAVGRGITALVGN
HHHCCCHHHCCCCCEEEEEEECCCCHHHHHHHHHHHCHHHHCCCCCCHHHHCCHHHHHCC
AAASEAQMALAEDLLSAVGQVVRLEGEHQMDAVTAVSGSGPAYVFHLIEALAAAGEAEGL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHEEECCCCHHHHHHHHHHHHHCCCCCCC
PADLAMTLARATVTGAGELAHRAPESASQLRVNVTSPGGTTAAALGVLMDPESGLPPLLR
CHHHHHHHHHHHHCCCHHHHHCCCCCCCEEEEEEECCCCHHHHHHHEEECCCCCCCHHHH
RAVKAAADRGRELGR
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]