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The map label for this gene is abc1 [C]

Identifier: 77465311

GI number: 77465311

Start: 365803

End: 367158

Strand: Direct

Name: abc1 [C]

Synonym: RSP_3305

Alternate gene names: 77465311

Gene position: 365803-367158 (Clockwise)

Preceding gene: 77465309

Following gene: 77465312

Centisome position: 38.79

GC content: 68.44

Gene sequence:

>1356_bases
ATGTCCTCCTCCCGTCCCGACCCCCGCGCCCTGCCGGTCCCGAGTGGCCGAATTTCCCGTCTTGCGCGATTTGGCAGCCT
CGCCTCGGGCGTAGCCGGCAACGTGGCGTTGCAGGGCGCGCGCCAGCTCGCCCAGGGCAGGCGGCCCACGATGAGCGAGC
TGATCCTGACTCCGGCCAATGTCGCGCGGCTGGCGGAAGAGCTCGCCCGGATGCGCGGCGCGGCCATGAAGATGGGTCAG
CTCCTGTCGATGGATGCCGGCGAGATGCTGCCGCCCGAGCTTGCCGCAATTCTGGCGCGGCTCCGGGCGGATGCGCATTA
CATGCCGCCCCAGCAACTGCGCAGCGTCCTGACCGCAGCCTGGGGACCCGACTGGCAGCGCCGCTTCCGCAGCTTCAACG
TCCGCCCGATTGCCGCCGCCTCCATCGGGCAGGTCCATCGCGCGATGACGAAGGACGGCGAGGACCTCGCCATCAAGGTG
CAATATCCCGGCGTGCGGCGCTCGATCGACAGCGACGTGGACAATGTGGCCGCCCTGCTGCGCCTGTCGGGTCTGGTGCC
GAAGGGGCTCGACGTGGCGGCGATGCTGGCCGAGGCCAAGCGGCAACTCCACGAGGAGGCCGATTACGGGCGGGAGGGGC
GCTGTCTCGCGCGGTTCGGCGCCCTGCTGGCGGAATCGCCTGACTTCTGCGTGCCCCGGCTGCACGAGGCGCTGACCACG
CCCGATGTGCTGGCGATGAGCCATGTGGCGGGGCAACCGGTCGAGGATCTGGCGGAGGCGCCGCAGGACCTGCGCGACCG
CGTGATGACGCTTCTGATCGGCCTCATGTTCCGCGAGCTGTTCGACTTCGGCCTGATGCAGACCGACCCGAACTTCGCCA
ACTACCGCCACGATGCCGCGACCGGGCAGGTGGTTCTGCTCGACTTCGGCGCCACCCGCGATATCGACCCCGGCATGGCA
GACGGTTACCGGCGGCTCCTGCGCGCGGGCCTCGCGGGCGACCTGCCGGCATCGGAGGCGGAGATGCGGGCGCTCGGCTT
CCTGTCGGATGCGGTGCCGCCGGACCTCCGCGCCCTGATGATGCGGATGTTCGAGATCTCGATGGAACCTCTGCGGGCGC
CGATCTTCGACTTCGGCGCGAACGACATGGCGCTGCGGTTGCGCGACCTCGGGATGGAGATCGGAGAGCGGCGCGAGATC
CATCATCTGCCGCCGGTCGAGACCTTCTATATCCAGCGCAAGTTCGGCGGCATGTATCTGCTGGCCAGCCGCCTTCGCGC
CCGGGTCGCCATCCGCGATCTGATTTATCCTCATATAAACGATGGGTTGAACGAAGTAACTTCAGGCAGCGCGTGA

Upstream 100 bases:

>100_bases
CGTCAAAAGTGTGGGATATGGTCATTTTGACACAGTCCCTGCTTGCGTTGCCCCTTGCCCAGCCTAGTTTTTCGCCAGTT
TCGAAACGAGTGTTCCGATC

Downstream 100 bases:

>100_bases
CGTCATGAGCAGCGCCCGCGTGACCTTGTCACACGACGGGCGCGGCGATGGGGCCTATGGTCGGCGCGCCGCGGCCCTCT
GCCGCGGACCGTTCAGCAAG

Product: putative ubiquinol-cytochrome-c reductase assembly protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MSSSRPDPRALPVPSGRISRLARFGSLASGVAGNVALQGARQLAQGRRPTMSELILTPANVARLAEELARMRGAAMKMGQ
LLSMDAGEMLPPELAAILARLRADAHYMPPQQLRSVLTAAWGPDWQRRFRSFNVRPIAAASIGQVHRAMTKDGEDLAIKV
QYPGVRRSIDSDVDNVAALLRLSGLVPKGLDVAAMLAEAKRQLHEEADYGREGRCLARFGALLAESPDFCVPRLHEALTT
PDVLAMSHVAGQPVEDLAEAPQDLRDRVMTLLIGLMFRELFDFGLMQTDPNFANYRHDAATGQVVLLDFGATRDIDPGMA
DGYRRLLRAGLAGDLPASEAEMRALGFLSDAVPPDLRALMMRMFEISMEPLRAPIFDFGANDMALRLRDLGMEIGERREI
HHLPPVETFYIQRKFGGMYLLASRLRARVAIRDLIYPHINDGLNEVTSGSA

Sequences:

>Translated_451_residues
MSSSRPDPRALPVPSGRISRLARFGSLASGVAGNVALQGARQLAQGRRPTMSELILTPANVARLAEELARMRGAAMKMGQ
LLSMDAGEMLPPELAAILARLRADAHYMPPQQLRSVLTAAWGPDWQRRFRSFNVRPIAAASIGQVHRAMTKDGEDLAIKV
QYPGVRRSIDSDVDNVAALLRLSGLVPKGLDVAAMLAEAKRQLHEEADYGREGRCLARFGALLAESPDFCVPRLHEALTT
PDVLAMSHVAGQPVEDLAEAPQDLRDRVMTLLIGLMFRELFDFGLMQTDPNFANYRHDAATGQVVLLDFGATRDIDPGMA
DGYRRLLRAGLAGDLPASEAEMRALGFLSDAVPPDLRALMMRMFEISMEPLRAPIFDFGANDMALRLRDLGMEIGERREI
HHLPPVETFYIQRKFGGMYLLASRLRARVAIRDLIYPHINDGLNEVTSGSA
>Mature_450_residues
SSSRPDPRALPVPSGRISRLARFGSLASGVAGNVALQGARQLAQGRRPTMSELILTPANVARLAEELARMRGAAMKMGQL
LSMDAGEMLPPELAAILARLRADAHYMPPQQLRSVLTAAWGPDWQRRFRSFNVRPIAAASIGQVHRAMTKDGEDLAIKVQ
YPGVRRSIDSDVDNVAALLRLSGLVPKGLDVAAMLAEAKRQLHEEADYGREGRCLARFGALLAESPDFCVPRLHEALTTP
DVLAMSHVAGQPVEDLAEAPQDLRDRVMTLLIGLMFRELFDFGLMQTDPNFANYRHDAATGQVVLLDFGATRDIDPGMAD
GYRRLLRAGLAGDLPASEAEMRALGFLSDAVPPDLRALMMRMFEISMEPLRAPIFDFGANDMALRLRDLGMEIGERREIH
HLPPVETFYIQRKFGGMYLLASRLRARVAIRDLIYPHINDGLNEVTSGSA

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI27363457, Length=436, Percent_Identity=38.302752293578, Blast_Score=272, Evalue=5e-73,
Organism=Homo sapiens, GI34147522, Length=439, Percent_Identity=36.2186788154898, Blast_Score=268, Evalue=7e-72,
Organism=Homo sapiens, GI217416386, Length=367, Percent_Identity=38.1471389645777, Blast_Score=236, Evalue=5e-62,
Organism=Homo sapiens, GI40254938, Length=292, Percent_Identity=30.4794520547945, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI41393593, Length=307, Percent_Identity=29.9674267100977, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI217035081, Length=225, Percent_Identity=30.6666666666667, Blast_Score=87, Evalue=4e-17,
Organism=Escherichia coli, GI2367309, Length=333, Percent_Identity=24.3243243243243, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI32565180, Length=435, Percent_Identity=36.7816091954023, Blast_Score=280, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17559152, Length=325, Percent_Identity=26.7692307692308, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6321319, Length=431, Percent_Identity=37.122969837587, Blast_Score=300, Evalue=5e-82,
Organism=Drosophila melanogaster, GI18859849, Length=421, Percent_Identity=37.0546318289786, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI22024280, Length=362, Percent_Identity=25.1381215469613, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24662575, Length=270, Percent_Identity=24.4444444444444, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 49551; Mature: 49420

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSRPDPRALPVPSGRISRLARFGSLASGVAGNVALQGARQLAQGRRPTMSELILTPAN
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHCCCHH
VARLAEELARMRGAAMKMGQLLSMDAGEMLPPELAAILARLRADAHYMPPQQLRSVLTAA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
WGPDWQRRFRSFNVRPIAAASIGQVHRAMTKDGEDLAIKVQYPGVRRSIDSDVDNVAALL
CCCHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHCCHHHHHHHH
RLSGLVPKGLDVAAMLAEAKRQLHEEADYGREGRCLARFGALLAESPDFCVPRLHEALTT
HHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCC
PDVLAMSHVAGQPVEDLAEAPQDLRDRVMTLLIGLMFRELFDFGLMQTDPNFANYRHDAA
CHHHHHHHHCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCC
TGQVVLLDFGATRDIDPGMADGYRRLLRAGLAGDLPASEAEMRALGFLSDAVPPDLRALM
CCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHH
MRMFEISMEPLRAPIFDFGANDMALRLRDLGMEIGERREIHHLPPVETFYIQRKFGGMYL
HHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHEEHHHHHCCHHH
LASRLRARVAIRDLIYPHINDGLNEVTSGSA
HHHHHHHHHHHHHHHHHHHHCCHHHHCCCCC
>Mature Secondary Structure 
SSSRPDPRALPVPSGRISRLARFGSLASGVAGNVALQGARQLAQGRRPTMSELILTPAN
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHCCCHH
VARLAEELARMRGAAMKMGQLLSMDAGEMLPPELAAILARLRADAHYMPPQQLRSVLTAA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
WGPDWQRRFRSFNVRPIAAASIGQVHRAMTKDGEDLAIKVQYPGVRRSIDSDVDNVAALL
CCCHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHCCHHHHHHHH
RLSGLVPKGLDVAAMLAEAKRQLHEEADYGREGRCLARFGALLAESPDFCVPRLHEALTT
HHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCC
PDVLAMSHVAGQPVEDLAEAPQDLRDRVMTLLIGLMFRELFDFGLMQTDPNFANYRHDAA
CHHHHHHHHCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCC
TGQVVLLDFGATRDIDPGMADGYRRLLRAGLAGDLPASEAEMRALGFLSDAVPPDLRALM
CCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHH
MRMFEISMEPLRAPIFDFGANDMALRLRDLGMEIGERREIHHLPPVETFYIQRKFGGMYL
HHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHEEHHHHHCCHHH
LASRLRARVAIRDLIYPHINDGLNEVTSGSA
HHHHHHHHHHHHHHHHHHHHCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]