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The map label for this gene is degP [H]

Identifier: 77465252

GI number: 77465252

Start: 299440

End: 300891

Strand: Direct

Name: degP [H]

Synonym: RSP_3242

Alternate gene names: 77465252

Gene position: 299440-300891 (Clockwise)

Preceding gene: 77465249

Following gene: 77465253

Centisome position: 31.75

GC content: 69.9

Gene sequence:

>1452_bases
ATGCCGATGCCCACCCCGCGTTCCTCGCTGAAGGCCGTCCTGATCGCCAGCACCCTCATCACCGCCGGTGTCGCCGGCAC
GGCCCTGCCGCCGACCGCGGCCCGGGCCGAGGTGCCGATGCAGGGCTATGCCGATCTCGTCGCCCGCGTCTCGCCCGCCG
TCGTCTTCATCGAGGTGACGGCCAAGTCGAAGGAGTCCACGCCGATGGCGGGCTCTCCCTTCGAGGAATTCCTCCGCCGC
TTCGGCGAGATCGACCCGCAGTTCCGCATGCCGCAGGCCCCCGAGGGCGGGCAGGTCATGCACGGGCTCGGGTCGGGCTT
CCTGATCTCGCAGGACGGCATCATCGTCACCAACAACCATGTGGTCGAAAATGCGACCGACATGAAGGTCAAGCTCGAGG
ACGGCCGCGAGTTCAAGGCCGAAGTCGTGGGCACCGATCCGATGACCGACATCGCGGTGATCCGGCTGAAGGATGCCAAG
GACCTGCCCTTCGTCGAGCTTGGCGACAGCGAGAAGCTGCGCGTGGGGGATGCGGTGGTGGCCGTCGGCAACCCGTTCGG
GCTGGGCGGCACCGTGACCTCGGGCATCGTCTCGGCCATGGGGCGCAACATCAACTCGGGCCCCTACGACGACTACATCC
AGACCGACGCGGCCATCAACCGCGGCAACTCGGGCGGCCCGCTGTTCGACACCGAGGGCAAGGTCGTCGGCATGAACACC
GCGATCTTCTCGCCCTCCGGCGGCTCGGTGGGCATCGGCTTCTCGATCCCCGCGAACACGGTCAAGGATGTCGTGGCGCA
GCTTCAGGACAAGGGTTCGGTCTCGCGCGGCTGGCTCGGGGTCACGGTTCAGGGCATGACTCCCGAGATCGCTCAGGCCA
TGGGGCTTGAGGGGCGCGACGGGGCCCTTGTGGCCGAGGTGCAGCAGGGTAGCCCCGCCGACGAGGGCGGTCTCGAGAGC
GGCGACGTCATCACGGCGGTGAACGGTCAGGAGCTGACGGAGCGGGCGAGCCTGCCGCGGCTGATCGCGGCCATCCCGAA
CGGCGAGAAAGCCCAACTCACGGTCCAGCGCGATGGACGCCAGCAGGAGATGACCGTGACGATCGGAGAACTGACCCCCG
ACCGGGCGCAGGTCGCCTCGGCCGAGTCGCCCGAAGGGCTCGGCGGGCCGCTCGGCATCGAGGTCCAGCCGCTCGAGCCC
GCGCTGGCACGCCAGCTCGGCCTGCCGGACGGCGCCTCGGGCGTCGTGGTGACGGCGGTCGATCCCTCGGGGCCGAACGC
CGACCGGCTCGCGCCGGGCGACGTGATCCAGGAAGCGGCCGGCCACCCGATCGAGACGCCGCGCGATCTGGCCTCGGCGA
TGCGCGAGGCGCGCGGCAAGGGCGTGATGCTGATGAAGGTGCTGCGGCAGGGCAACCCGGTCTATGTGGGCGCCGAAGTG
GCCTCGTCCTGA

Upstream 100 bases:

>100_bases
CGCAAGTGCCGCGCCCATGTTGTCCCCCAAGGCCCGCGTCCCTGCGGTCCGCGGTTCCGGCCGCCGGGCCGGGCGCGCCC
CGGTAACCAAGGAGAGTTCC

Downstream 100 bases:

>100_bases
CAAGCGCCGCCGTCCCGGGCGCGTCCCGCGCGGCCCGGGGCGCTCTGCCGGATCGACCGGCCCGTGAAGCGGATACGGGC
CCCACATCGGGGCCCGTATC

Product: putative trypsin-like serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 483; Mature: 482

Protein sequence:

>483_residues
MPMPTPRSSLKAVLIASTLITAGVAGTALPPTAARAEVPMQGYADLVARVSPAVVFIEVTAKSKESTPMAGSPFEEFLRR
FGEIDPQFRMPQAPEGGQVMHGLGSGFLISQDGIIVTNNHVVENATDMKVKLEDGREFKAEVVGTDPMTDIAVIRLKDAK
DLPFVELGDSEKLRVGDAVVAVGNPFGLGGTVTSGIVSAMGRNINSGPYDDYIQTDAAINRGNSGGPLFDTEGKVVGMNT
AIFSPSGGSVGIGFSIPANTVKDVVAQLQDKGSVSRGWLGVTVQGMTPEIAQAMGLEGRDGALVAEVQQGSPADEGGLES
GDVITAVNGQELTERASLPRLIAAIPNGEKAQLTVQRDGRQQEMTVTIGELTPDRAQVASAESPEGLGGPLGIEVQPLEP
ALARQLGLPDGASGVVVTAVDPSGPNADRLAPGDVIQEAAGHPIETPRDLASAMREARGKGVMLMKVLRQGNPVYVGAEV
ASS

Sequences:

>Translated_483_residues
MPMPTPRSSLKAVLIASTLITAGVAGTALPPTAARAEVPMQGYADLVARVSPAVVFIEVTAKSKESTPMAGSPFEEFLRR
FGEIDPQFRMPQAPEGGQVMHGLGSGFLISQDGIIVTNNHVVENATDMKVKLEDGREFKAEVVGTDPMTDIAVIRLKDAK
DLPFVELGDSEKLRVGDAVVAVGNPFGLGGTVTSGIVSAMGRNINSGPYDDYIQTDAAINRGNSGGPLFDTEGKVVGMNT
AIFSPSGGSVGIGFSIPANTVKDVVAQLQDKGSVSRGWLGVTVQGMTPEIAQAMGLEGRDGALVAEVQQGSPADEGGLES
GDVITAVNGQELTERASLPRLIAAIPNGEKAQLTVQRDGRQQEMTVTIGELTPDRAQVASAESPEGLGGPLGIEVQPLEP
ALARQLGLPDGASGVVVTAVDPSGPNADRLAPGDVIQEAAGHPIETPRDLASAMREARGKGVMLMKVLRQGNPVYVGAEV
ASS
>Mature_482_residues
PMPTPRSSLKAVLIASTLITAGVAGTALPPTAARAEVPMQGYADLVARVSPAVVFIEVTAKSKESTPMAGSPFEEFLRRF
GEIDPQFRMPQAPEGGQVMHGLGSGFLISQDGIIVTNNHVVENATDMKVKLEDGREFKAEVVGTDPMTDIAVIRLKDAKD
LPFVELGDSEKLRVGDAVVAVGNPFGLGGTVTSGIVSAMGRNINSGPYDDYIQTDAAINRGNSGGPLFDTEGKVVGMNTA
IFSPSGGSVGIGFSIPANTVKDVVAQLQDKGSVSRGWLGVTVQGMTPEIAQAMGLEGRDGALVAEVQQGSPADEGGLESG
DVITAVNGQELTERASLPRLIAAIPNGEKAQLTVQRDGRQQEMTVTIGELTPDRAQVASAESPEGLGGPLGIEVQPLEPA
LARQLGLPDGASGVVVTAVDPSGPNADRLAPGDVIQEAAGHPIETPRDLASAMREARGKGVMLMKVLRQGNPVYVGAEVA
SS

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=307, Percent_Identity=36.4820846905537, Blast_Score=178, Evalue=9e-45,
Organism=Homo sapiens, GI22129776, Length=313, Percent_Identity=36.1022364217252, Blast_Score=173, Evalue=4e-43,
Organism=Homo sapiens, GI24308541, Length=259, Percent_Identity=36.2934362934363, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI7019477, Length=351, Percent_Identity=34.4729344729345, Blast_Score=155, Evalue=8e-38,
Organism=Escherichia coli, GI1786356, Length=472, Percent_Identity=37.0762711864407, Blast_Score=277, Evalue=1e-75,
Organism=Escherichia coli, GI1789629, Length=353, Percent_Identity=42.2096317280453, Blast_Score=262, Evalue=4e-71,
Organism=Escherichia coli, GI1789630, Length=272, Percent_Identity=37.1323529411765, Blast_Score=173, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24646839, Length=352, Percent_Identity=32.3863636363636, Blast_Score=159, Evalue=3e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 49954; Mature: 49823

Theoretical pI: Translated: 4.41; Mature: 4.41

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMPTPRSSLKAVLIASTLITAGVAGTALPPTAARAEVPMQGYADLVARVSPAVVFIEVT
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEEE
AKSKESTPMAGSPFEEFLRRFGEIDPQFRMPQAPEGGQVMHGLGSGFLISQDGIIVTNNH
ECCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCEEEECCCEEEECCE
VVENATDMKVKLEDGREFKAEVVGTDPMTDIAVIRLKDAKDLPFVELGDSEKLRVGDAVV
EECCCCCEEEEECCCCEEEEEEECCCCCCCEEEEEEECCCCCCEEEECCCCCEEECCEEE
AVGNPFGLGGTVTSGIVSAMGRNINSGPYDDYIQTDAAINRGNSGGPLFDTEGKVVGMNT
EECCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHCCHHHCCCCCCCCEECCCCCEEEEEE
AIFSPSGGSVGIGFSIPANTVKDVVAQLQDKGSVSRGWLGVTVQGMTPEIAQAMGLEGRD
EEECCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHCCCCCC
GALVAEVQQGSPADEGGLESGDVITAVNGQELTERASLPRLIAAIPNGEKAQLTVQRDGR
CCEEEEECCCCCCCCCCCCCCCEEEEECCHHHHHHHCCCEEEEECCCCCCEEEEEECCCC
QQEMTVTIGELTPDRAQVASAESPEGLGGPLGIEVQPLEPALARQLGLPDGASGVVVTAV
CEEEEEEEECCCCCHHHHCCCCCCCCCCCCCCEEEECCCHHHHHHCCCCCCCCCEEEEEE
DPSGPNADRLAPGDVIQEAAGHPIETPRDLASAMREARGKGVMLMKVLRQGNPVYVGAEV
CCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEHHHHHHCCCCEEEEEEE
ASS
CCC
>Mature Secondary Structure 
PMPTPRSSLKAVLIASTLITAGVAGTALPPTAARAEVPMQGYADLVARVSPAVVFIEVT
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEEE
AKSKESTPMAGSPFEEFLRRFGEIDPQFRMPQAPEGGQVMHGLGSGFLISQDGIIVTNNH
ECCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCEEEECCCEEEECCE
VVENATDMKVKLEDGREFKAEVVGTDPMTDIAVIRLKDAKDLPFVELGDSEKLRVGDAVV
EECCCCCEEEEECCCCEEEEEEECCCCCCCEEEEEEECCCCCCEEEECCCCCEEECCEEE
AVGNPFGLGGTVTSGIVSAMGRNINSGPYDDYIQTDAAINRGNSGGPLFDTEGKVVGMNT
EECCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHCCHHHCCCCCCCCEECCCCCEEEEEE
AIFSPSGGSVGIGFSIPANTVKDVVAQLQDKGSVSRGWLGVTVQGMTPEIAQAMGLEGRD
EEECCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHCCCCCC
GALVAEVQQGSPADEGGLESGDVITAVNGQELTERASLPRLIAAIPNGEKAQLTVQRDGR
CCEEEEECCCCCCCCCCCCCCCEEEEECCHHHHHHHCCCEEEEECCCCCCEEEEEECCCC
QQEMTVTIGELTPDRAQVASAESPEGLGGPLGIEVQPLEPALARQLGLPDGASGVVVTAV
CEEEEEEEECCCCCHHHHCCCCCCCCCCCCCCEEEECCCHHHHHHCCCCCCCCCEEEEEE
DPSGPNADRLAPGDVIQEAAGHPIETPRDLASAMREARGKGVMLMKVLRQGNPVYVGAEV
CCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEHHHHHHCCCCEEEEEEE
ASS
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7861951 [H]