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The map label for this gene is fabB [H]

Identifier: 77465190

GI number: 77465190

Start: 229489

End: 230718

Strand: Reverse

Name: fabB [H]

Synonym: RSP_3177

Alternate gene names: 77465190

Gene position: 230718-229489 (Counterclockwise)

Preceding gene: 77465191

Following gene: 77465189

Centisome position: 24.47

GC content: 67.07

Gene sequence:

>1230_bases
ATGCGCCGCGTCGTCATCACCGGGATCGGCATCGTCTCGCCGATCGGGAACAATGCCGCCGAAGTGGAAGCGAGCCTGCG
CGCCGGCCGCTCGGGCATCTCCTTCTCGGAGGACTATGCCCACCACGGCTTCCGCAGCCAGATCCACGGGATGCCCGATC
TCGTGCTCGAGGACCATGTCGACAAGCGCGACCTGCGCTTCATGGGCGCCGGAGCCGCCTACAACTTCATCGCGATGGAG
CAGGCGATCAAGGATTCGGGCCTCGAGGCCACCGAGGTCTCGAACCCGCGCACCGGTCTCGTGATGGGCTCGGGCGGGCC
GTCGACCTCGAACTTCTTCCAGGCCCACAAGATCGTCATCGAGAAGGGCTCGCCCAAGCGGATGGGTCCCTTCATGGTGA
CGCGCTGCATGAGCTCGACCAACTCGGCCTGCCTTGCCACGCCCTTCAAGATCAAGGGCGTGAACTATTCGATCACCTCG
GCCTGCTCCACCTCGGCCCATTGCATCGGCAACGGCACCGAGCTGATCCAGATGGGCAAGCAGGACATCGTCTTCGCCGG
CGGCGGGGAAGAGCTCGACTGGACGCTCTCCTGCCTCTTCGACGCGATGGGGGCCATGTCGTCGAAATACAACGATGCGC
CCGAGACCGCCTCGCGGCCGTTCGACGCCACGCGCGACGGGTTCGTGATCGCGGGCGGCGGCGGCGTGGTCGTGCTGGAA
GAGCTCGAGCATGCGCTGGCGCGCGGCGCGAAGATCTATGCCGAAGTGACCGGCTACGGGGCCACCTCGGACGGGGCCGA
CATGGTGGCGCCGTCGGGCGAAGGCGGCGAGCGGTCGATGCGGCTGGCGCTCGGCACGCTGCCCGAGGGGCGCCGGGTCG
ATTACATCAACGCACACGGCACCTCGACGCCCGCGGGCGACGTGACCGAGGTGCGCGCGATCCGGCGGATCTTCGGCGAG
GGCAAGGTTCCGCCGATCTCCTCCACCAAGTCGCTCACCGGCCATTCGCTGGGGGCCACCGGCGTGCACGAGGCGATCTA
TTCGATCCTGATGATGCAGGGCGACTTCATCGCGGCCTCGGCCAACGTGACCCAGCTCGACCCCGAGATCCAGCCGGACG
AGATCGCCACCACCCTGCGCGAGGGGGTCGAGATCGACTCGGTCCTGTCCAACAGCTTCGGCTTCGGCGGCACCAACGCC
AGTCTGCTCCTGAGCAAGTTCAACAACTGA

Upstream 100 bases:

>100_bases
GCGGACGGCCGCGTCTTCGCCGATGGCGAAGAGATCTACAGCGTCAAGGACATGAAAGTCGGTCTGGCCGCTGCGGCCTG
ATCGAGGGGGAGGAACACCG

Downstream 100 bases:

>100_bases
GGGTGCGGCGATGGCCGATCTGATGAAGGGTAAACGCGGTCTGGTGATGGGGGTCGCGAACGACCGCTCGATCGCCTGGG
GCATTGCACGCGCCCTGGCC

Product: 3-oxoacyl-[acyl-carrier-protein] synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MRRVVITGIGIVSPIGNNAAEVEASLRAGRSGISFSEDYAHHGFRSQIHGMPDLVLEDHVDKRDLRFMGAGAAYNFIAME
QAIKDSGLEATEVSNPRTGLVMGSGGPSTSNFFQAHKIVIEKGSPKRMGPFMVTRCMSSTNSACLATPFKIKGVNYSITS
ACSTSAHCIGNGTELIQMGKQDIVFAGGGEELDWTLSCLFDAMGAMSSKYNDAPETASRPFDATRDGFVIAGGGGVVVLE
ELEHALARGAKIYAEVTGYGATSDGADMVAPSGEGGERSMRLALGTLPEGRRVDYINAHGTSTPAGDVTEVRAIRRIFGE
GKVPPISSTKSLTGHSLGATGVHEAIYSILMMQGDFIAASANVTQLDPEIQPDEIATTLREGVEIDSVLSNSFGFGGTNA
SLLLSKFNN

Sequences:

>Translated_409_residues
MRRVVITGIGIVSPIGNNAAEVEASLRAGRSGISFSEDYAHHGFRSQIHGMPDLVLEDHVDKRDLRFMGAGAAYNFIAME
QAIKDSGLEATEVSNPRTGLVMGSGGPSTSNFFQAHKIVIEKGSPKRMGPFMVTRCMSSTNSACLATPFKIKGVNYSITS
ACSTSAHCIGNGTELIQMGKQDIVFAGGGEELDWTLSCLFDAMGAMSSKYNDAPETASRPFDATRDGFVIAGGGGVVVLE
ELEHALARGAKIYAEVTGYGATSDGADMVAPSGEGGERSMRLALGTLPEGRRVDYINAHGTSTPAGDVTEVRAIRRIFGE
GKVPPISSTKSLTGHSLGATGVHEAIYSILMMQGDFIAASANVTQLDPEIQPDEIATTLREGVEIDSVLSNSFGFGGTNA
SLLLSKFNN
>Mature_409_residues
MRRVVITGIGIVSPIGNNAAEVEASLRAGRSGISFSEDYAHHGFRSQIHGMPDLVLEDHVDKRDLRFMGAGAAYNFIAME
QAIKDSGLEATEVSNPRTGLVMGSGGPSTSNFFQAHKIVIEKGSPKRMGPFMVTRCMSSTNSACLATPFKIKGVNYSITS
ACSTSAHCIGNGTELIQMGKQDIVFAGGGEELDWTLSCLFDAMGAMSSKYNDAPETASRPFDATRDGFVIAGGGGVVVLE
ELEHALARGAKIYAEVTGYGATSDGADMVAPSGEGGERSMRLALGTLPEGRRVDYINAHGTSTPAGDVTEVRAIRRIFGE
GKVPPISSTKSLTGHSLGATGVHEAIYSILMMQGDFIAASANVTQLDPEIQPDEIATTLREGVEIDSVLSNSFGFGGTNA
SLLLSKFNN

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=423, Percent_Identity=36.4066193853428, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI41872631, Length=341, Percent_Identity=27.5659824046921, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI223972627, Length=141, Percent_Identity=39.7163120567376, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1788663, Length=412, Percent_Identity=59.4660194174757, Blast_Score=469, Evalue=1e-133,
Organism=Escherichia coli, GI1787337, Length=412, Percent_Identity=38.8349514563107, Blast_Score=258, Evalue=4e-70,
Organism=Caenorhabditis elegans, GI71983541, Length=419, Percent_Identity=35.3221957040573, Blast_Score=204, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI71983535, Length=263, Percent_Identity=41.06463878327, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17550940, Length=276, Percent_Identity=27.536231884058, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI212642053, Length=364, Percent_Identity=24.7252747252747, Blast_Score=89, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6320904, Length=444, Percent_Identity=30.8558558558559, Blast_Score=185, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24644341, Length=421, Percent_Identity=37.29216152019, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI19920632, Length=384, Percent_Identity=26.3020833333333, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI221330659, Length=384, Percent_Identity=26.3020833333333, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24581345, Length=431, Percent_Identity=23.6658932714617, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 43042; Mature: 43042

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00606 B_KETOACYL_SYNTHASE ; PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVITGIGIVSPIGNNAAEVEASLRAGRSGISFSEDYAHHGFRSQIHGMPDLVLEDHV
CCEEEEECCEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHCCHHHHHCCCCCHHHHCCC
DKRDLRFMGAGAAYNFIAMEQAIKDSGLEATEVSNPRTGLVMGSGGPSTSNFFQAHKIVI
CCCCEEEEECCCHHHHHHHHHHHHHCCCCHHCCCCCCCEEEEECCCCCCHHHHEEEEEEE
EKGSPKRMGPFMVTRCMSSTNSACLATPFKIKGVNYSITSACSTSAHCIGNGTELIQMGK
ECCCCCCCCHHHHHHHHHCCCCEEEECCEEEECCCEEECCCCCCCCEEECCCHHHHHCCC
QDIVFAGGGEELDWTLSCLFDAMGAMSSKYNDAPETASRPFDATRDGFVIAGGGGVVVLE
CEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEHH
ELEHALARGAKIYAEVTGYGATSDGADMVAPSGEGGERSMRLALGTLPEGRRVDYINAHG
HHHHHHHCCCEEEEEEECCCCCCCCCCEECCCCCCCCCEEEEEEECCCCCCEEEEEECCC
TSTPAGDVTEVRAIRRIFGEGKVPPISSTKSLTGHSLGATGVHEAIYSILMMQGDFIAAS
CCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEC
ANVTQLDPEIQPDEIATTLREGVEIDSVLSNSFGFGGTNASLLLSKFNN
CCCEECCCCCCHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHEEEEECCC
>Mature Secondary Structure
MRRVVITGIGIVSPIGNNAAEVEASLRAGRSGISFSEDYAHHGFRSQIHGMPDLVLEDHV
CCEEEEECCEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHCCHHHHHCCCCCHHHHCCC
DKRDLRFMGAGAAYNFIAMEQAIKDSGLEATEVSNPRTGLVMGSGGPSTSNFFQAHKIVI
CCCCEEEEECCCHHHHHHHHHHHHHCCCCHHCCCCCCCEEEEECCCCCCHHHHEEEEEEE
EKGSPKRMGPFMVTRCMSSTNSACLATPFKIKGVNYSITSACSTSAHCIGNGTELIQMGK
ECCCCCCCCHHHHHHHHHCCCCEEEECCEEEECCCEEECCCCCCCCEEECCCHHHHHCCC
QDIVFAGGGEELDWTLSCLFDAMGAMSSKYNDAPETASRPFDATRDGFVIAGGGGVVVLE
CEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEHH
ELEHALARGAKIYAEVTGYGATSDGADMVAPSGEGGERSMRLALGTLPEGRRVDYINAHG
HHHHHHHCCCEEEEEEECCCCCCCCCCEECCCCCCCCCEEEEEEECCCCCCEEEEEECCC
TSTPAGDVTEVRAIRRIFGEGKVPPISSTKSLTGHSLGATGVHEAIYSILMMQGDFIAAS
CCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEC
ANVTQLDPEIQPDEIATTLREGVEIDSVLSNSFGFGGTNASLLLSKFNN
CCCEECCCCCCHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]