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The map label for this gene is frdB [H]

Identifier: 77465164

GI number: 77465164

Start: 199085

End: 199813

Strand: Reverse

Name: frdB [H]

Synonym: RSP_3150

Alternate gene names: 77465164

Gene position: 199813-199085 (Counterclockwise)

Preceding gene: 77465165

Following gene: 77465163

Centisome position: 21.19

GC content: 69.0

Gene sequence:

>729_bases
ATGCTTGACGGCCCTCAGACCCTGTCCGTCTCGATCTGGCGCGGGACCGGCACGACCGGGGCGTTCCAAGGCTTCGAGGT
GCCGCGGCAGGGCAGCCAGACCGTGCTCGACGTGGTGTCCTGGATCCAGCAGAACCTCGATCCGACGCTGACCTACCGCT
ATGCCTGCCGGGTCGGCATGTGCGGCTCCTGCGCCATGATGGTGAACGGGGTGCCGCGCTGGACCTGCCGGACCCATGTG
AACAAGGTCGATCAGGGCGGTGCGCTCACCATCGGGCCGCTGCGCAACCTGCCGGTCATCAAGGATCTCGCGGCCGACAT
GGACCCGTTCTTCGAGAAATGGGTCAAGGCCGAAGGGCTCTTCCACCCCGCCCGCACGCGCCACGAGGAAGTGGCGCGGG
TCGATCCCGCTTCCGAGGCGCGGCGCACCGCCGACCGGGCCATCGAATGCATCAACTGCTCGGTCTGCTATGCCGCCTGC
GACACCGTGGCGGGCAACCCGGATTATCTCGGGCCCGCCGCCCTCAACCGCGCCTGGAGCGTGGTGAACGACGAGCGCGA
CGCGGGCCGGGCCGAGGTGCTGGCGGCCGTCTCGGTCTCGGGCGGCTGCCACAACTGCCACAGCCAGGGAAGCTGCACGC
GCCACTGCCCGAACGAGCTTTCGCCGCTCGATTCCATCGCGGGCCTCAAGCGCGAGACGGCCCGCAGTTTCTGGCGCAAA
GGACGCTGA

Upstream 100 bases:

>100_bases
TCTTCTGTAAGTCTGACTTTCTATAACCGTCAGAATTTCTCGTTTTTTCTTCAGTTTGTCTTTCAATAAGCTGGGGAAGA
CGAAAGCGCGGAGGAAAGCG

Downstream 100 bases:

>100_bases
CCCATGCTCGATCTGCGACTCTACATGCTGCAACGGCTCTCGGCGCTGGTGATGGCGCCCCTCGTGCTGGGCCATCTGGC
GCTGATGATCTACGCGGTGC

Product: succinate dehydrogenase subunit B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MLDGPQTLSVSIWRGTGTTGAFQGFEVPRQGSQTVLDVVSWIQQNLDPTLTYRYACRVGMCGSCAMMVNGVPRWTCRTHV
NKVDQGGALTIGPLRNLPVIKDLAADMDPFFEKWVKAEGLFHPARTRHEEVARVDPASEARRTADRAIECINCSVCYAAC
DTVAGNPDYLGPAALNRAWSVVNDERDAGRAEVLAAVSVSGGCHNCHSQGSCTRHCPNELSPLDSIAGLKRETARSFWRK
GR

Sequences:

>Translated_242_residues
MLDGPQTLSVSIWRGTGTTGAFQGFEVPRQGSQTVLDVVSWIQQNLDPTLTYRYACRVGMCGSCAMMVNGVPRWTCRTHV
NKVDQGGALTIGPLRNLPVIKDLAADMDPFFEKWVKAEGLFHPARTRHEEVARVDPASEARRTADRAIECINCSVCYAAC
DTVAGNPDYLGPAALNRAWSVVNDERDAGRAEVLAAVSVSGGCHNCHSQGSCTRHCPNELSPLDSIAGLKRETARSFWRK
GR
>Mature_242_residues
MLDGPQTLSVSIWRGTGTTGAFQGFEVPRQGSQTVLDVVSWIQQNLDPTLTYRYACRVGMCGSCAMMVNGVPRWTCRTHV
NKVDQGGALTIGPLRNLPVIKDLAADMDPFFEKWVKAEGLFHPARTRHEEVARVDPASEARRTADRAIECINCSVCYAAC
DTVAGNPDYLGPAALNRAWSVVNDERDAGRAEVLAAVSVSGGCHNCHSQGSCTRHCPNELSPLDSIAGLKRETARSFWRK
GR

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=241, Percent_Identity=33.6099585062241, Blast_Score=122, Evalue=3e-28,
Organism=Escherichia coli, GI1790596, Length=214, Percent_Identity=34.5794392523364, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1786943, Length=203, Percent_Identity=32.0197044334975, Blast_Score=105, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17533915, Length=240, Percent_Identity=32.9166666666667, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6322987, Length=203, Percent_Identity=33.4975369458128, Blast_Score=111, Evalue=8e-26,
Organism=Drosophila melanogaster, GI17137106, Length=235, Percent_Identity=32.3404255319149, Blast_Score=128, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24643156, Length=229, Percent_Identity=32.3144104803493, Blast_Score=120, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 26379; Mature: 26379

Theoretical pI: Translated: 7.83; Mature: 7.83

Prosite motif: PS00197 2FE2S_FER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
5.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDGPQTLSVSIWRGTGTTGAFQGFEVPRQGSQTVLDVVSWIQQNLDPTLTYRYACRVGM
CCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEHHHHCCCC
CGSCAMMVNGVPRWTCRTHVNKVDQGGALTIGPLRNLPVIKDLAADMDPFFEKWVKAEGL
CCCHHHHHCCCCCHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHCCCHHHHHHHHHCCC
FHPARTRHEEVARVDPASEARRTADRAIECINCSVCYAACDTVAGNPDYLGPAALNRAWS
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
VVNDERDAGRAEVLAAVSVSGGCHNCHSQGSCTRHCPNELSPLDSIAGLKRETARSFWRK
HHCCCCCCCHHHHHEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
GR
CC
>Mature Secondary Structure
MLDGPQTLSVSIWRGTGTTGAFQGFEVPRQGSQTVLDVVSWIQQNLDPTLTYRYACRVGM
CCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEHHHHCCCC
CGSCAMMVNGVPRWTCRTHVNKVDQGGALTIGPLRNLPVIKDLAADMDPFFEKWVKAEGL
CCCHHHHHCCCCCHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHCCCHHHHHHHHHCCC
FHPARTRHEEVARVDPASEARRTADRAIECINCSVCYAACDTVAGNPDYLGPAALNRAWS
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
VVNDERDAGRAEVLAAVSVSGGCHNCHSQGSCTRHCPNELSPLDSIAGLKRETARSFWRK
HHCCCCCCCHHHHHEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
GR
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]