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The map label for this gene is dorC [H]

Identifier: 77465060

GI number: 77465060

Start: 81663

End: 82841

Strand: Direct

Name: dorC [H]

Synonym: RSP_3046

Alternate gene names: 77465060

Gene position: 81663-82841 (Clockwise)

Preceding gene: 77465058

Following gene: 77465061

Centisome position: 8.66

GC content: 64.46

Gene sequence:

>1179_bases
GTGATCAGCAGGATTTGGAAGGCTTTCTGGCGACCGAGCACGAAATGGGGGCTCGGCGTCCTGCTCGTGACCGGCGGCAT
CGCCGGTGCGGTCGGATGGAACGGGTTCCACTATGTGGTGGAAAAGACCACCACGACGGAATTCTGCATCAGCTGCCACT
CGATGCGGGACAACAACTACGAGGAATACAAGACCACCATCCACTACCAGAACACCTCGGGCGTGCGGGCGGAATGCGCC
GACTGTCACGTCCCGAAATCCGGCTGGAAGCTCTACCGCGCGAAGCTCCTCGCCGCGAAGGACCTCTGGGGCGAAATTCA
GGGCACCATCGACACGCGTGAGAAGTTCGAGGCGCACCGGCTCGAGATGGCCGAGACCGTCTGGGCCGACATGAAGGCCA
ACGACTCGGCCACCTGCCGGACCTGCCACTCGTTCAACGCGATGGACTTCGCCCACCAGAAGCCCGAGGCCTCGAAGCAG
ATGCAGCAGGCGATGAACGAGGGCGGAACCTGCATCGACTGCCACAAGGGCATCGCCCACAAGCTGCCCGACATGGCCAG
CGGCTACCGCGCGCTGTTCTCGAAGCTCGAGAAGGCCTCGCAGTCGCTCAAGCCCAGCAAGGGCGAGACGCTCTATCCGC
TCCAGACCATCGAGGCCTATCTCGAGCGGCCCTCGGGCGACAAGGCGAAGGCCGACGGCCGGCTTCTGGCCGCGACGCCG
ATGCAGGTGGTCGACGTGAAGGGTGAGTGGGTGCAGGTCGCGGTGAAGGGCTGGCAGCAGGAAGGCGCCGAGCGGGTCAT
CTACGAGAAGCAGGGCAAGCGGATCTTCAACGCCGCACTGGCGCCGACGGCCACGGGCTCGATCGTGGCGGGCGCGTCCA
TGGTCGATCCGGACACCGAACAGACCTGGACGGATGTCTCGCTGACGGCCTGGGTGCGCAACCGCGACCTGACCGACGAC
CAGGAAGCGCTCTGGCAGTATGGCAAGCAGATGTTCAACGGTGCCTGCGGCATGTGTCACGTCCTGCCCCACACCGAGCA
TTTCCTCGCCAACCAGTGGATCGGCACGCTCAACGCCATGAAGAGCCGGGCGCCGCTCGATGACGAACAGTTCCGCCTCG
TGCAGCGCTACGTCCAGATGCATGCGAAGGACGTGGAACCGGAAGGAGCTGCGGAATGA

Upstream 100 bases:

>100_bases
ACAGAGGCAGCAAGCCGGTGGACCTTCGGGGAAGGACCGGCGCGCCCGCCGCATTCCTGCGGCATGGGGGCGTTCTCGCG
GCCGGGCTTCGGAGGCAAAA

Downstream 100 bases:

>100_bases
CCCTCGCGCATTCCCTCCCCAGCGCCCACATGCCCGTCCCGGCGCCTGCCGCCGGGGCCGGCGAGATCGCCCCGCTCTGT
GCCTGGCTGGCCGAAGTGTT

Product: DMSO/TMAO pentaheme cytochrome c subunit

Products: H2O; trimethylamine; NAD [C]

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MISRIWKAFWRPSTKWGLGVLLVTGGIAGAVGWNGFHYVVEKTTTTEFCISCHSMRDNNYEEYKTTIHYQNTSGVRAECA
DCHVPKSGWKLYRAKLLAAKDLWGEIQGTIDTREKFEAHRLEMAETVWADMKANDSATCRTCHSFNAMDFAHQKPEASKQ
MQQAMNEGGTCIDCHKGIAHKLPDMASGYRALFSKLEKASQSLKPSKGETLYPLQTIEAYLERPSGDKAKADGRLLAATP
MQVVDVKGEWVQVAVKGWQQEGAERVIYEKQGKRIFNAALAPTATGSIVAGASMVDPDTEQTWTDVSLTAWVRNRDLTDD
QEALWQYGKQMFNGACGMCHVLPHTEHFLANQWIGTLNAMKSRAPLDDEQFRLVQRYVQMHAKDVEPEGAAE

Sequences:

>Translated_392_residues
MISRIWKAFWRPSTKWGLGVLLVTGGIAGAVGWNGFHYVVEKTTTTEFCISCHSMRDNNYEEYKTTIHYQNTSGVRAECA
DCHVPKSGWKLYRAKLLAAKDLWGEIQGTIDTREKFEAHRLEMAETVWADMKANDSATCRTCHSFNAMDFAHQKPEASKQ
MQQAMNEGGTCIDCHKGIAHKLPDMASGYRALFSKLEKASQSLKPSKGETLYPLQTIEAYLERPSGDKAKADGRLLAATP
MQVVDVKGEWVQVAVKGWQQEGAERVIYEKQGKRIFNAALAPTATGSIVAGASMVDPDTEQTWTDVSLTAWVRNRDLTDD
QEALWQYGKQMFNGACGMCHVLPHTEHFLANQWIGTLNAMKSRAPLDDEQFRLVQRYVQMHAKDVEPEGAAE
>Mature_392_residues
MISRIWKAFWRPSTKWGLGVLLVTGGIAGAVGWNGFHYVVEKTTTTEFCISCHSMRDNNYEEYKTTIHYQNTSGVRAECA
DCHVPKSGWKLYRAKLLAAKDLWGEIQGTIDTREKFEAHRLEMAETVWADMKANDSATCRTCHSFNAMDFAHQKPEASKQ
MQQAMNEGGTCIDCHKGIAHKLPDMASGYRALFSKLEKASQSLKPSKGETLYPLQTIEAYLERPSGDKAKADGRLLAATP
MQVVDVKGEWVQVAVKGWQQEGAERVIYEKQGKRIFNAALAPTATGSIVAGASMVDPDTEQTWTDVSLTAWVRNRDLTDD
QEALWQYGKQMFNGACGMCHVLPHTEHFLANQWIGTLNAMKSRAPLDDEQFRLVQRYVQMHAKDVEPEGAAE

Specific function: Part of the anaerobic respiratory chain of trimethylamine-N-oxide reductase TorA. Acts by transferring electrons from the membranous menaquinones to TorA. This transfer probably involves an electron transfer pathway from menaquinones to the N-terminal dom

COG id: COG3005

COG function: function code C; Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TorC/TorY family [H]

Homologues:

Organism=Escherichia coli, GI1787230, Length=385, Percent_Identity=42.0779220779221, Blast_Score=323, Evalue=8e-90,
Organism=Escherichia coli, GI1788181, Length=351, Percent_Identity=37.6068376068376, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI1788530, Length=185, Percent_Identity=54.0540540540541, Blast_Score=209, Evalue=2e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009154
- InterPro:   IPR011031
- InterPro:   IPR005126 [H]

Pfam domain/function: PF03264 Cytochrom_NNT [H]

EC number: NA

Molecular weight: Translated: 43903; Mature: 43903

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS51008 MULTIHEME_CYTC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISRIWKAFWRPSTKWGLGVLLVTGGIAGAVGWNGFHYVVEKTTTTEFCISCHSMRDNNY
CHHHHHHHHCCCCCCCCCEEEEEECCCHHCCCCCCEEEEEECCCHHHHHHHHHHHCCCCH
EEYKTTIHYQNTSGVRAECADCHVPKSGWKLYRAKLLAAKDLWGEIQGTIDTREKFEAHR
HHHEEEEEEECCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LEMAETVWADMKANDSATCRTCHSFNAMDFAHQKPEASKQMQQAMNEGGTCIDCHKGIAH
HHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHCCCHHHHHHHHHHHCCCCEEEHHHHHHH
KLPDMASGYRALFSKLEKASQSLKPSKGETLYPLQTIEAYLERPSGDKAKADGRLLAATP
HCCHHHHHHHHHHHHHHHHHHHCCCCCCCEECHHHHHHHHHHCCCCCCCCCCCEEEEECC
MQVVDVKGEWVQVAVKGWQQEGAERVIYEKQGKRIFNAALAPTATGSIVAGASMVDPDTE
EEEEECCCCEEHHHHHHHHHCCHHHHHHHHCCCCHHHHHHCCCCCCCCEECCCCCCCCCC
QTWTDVSLTAWVRNRDLTDDQEALWQYGKQMFNGACGMCHVLPHTEHFLANQWIGTLNAM
CCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHH
KSRAPLDDEQFRLVQRYVQMHAKDVEPEGAAE
HHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MISRIWKAFWRPSTKWGLGVLLVTGGIAGAVGWNGFHYVVEKTTTTEFCISCHSMRDNNY
CHHHHHHHHCCCCCCCCCEEEEEECCCHHCCCCCCEEEEEECCCHHHHHHHHHHHCCCCH
EEYKTTIHYQNTSGVRAECADCHVPKSGWKLYRAKLLAAKDLWGEIQGTIDTREKFEAHR
HHHEEEEEEECCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LEMAETVWADMKANDSATCRTCHSFNAMDFAHQKPEASKQMQQAMNEGGTCIDCHKGIAH
HHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHCCCHHHHHHHHHHHCCCCEEEHHHHHHH
KLPDMASGYRALFSKLEKASQSLKPSKGETLYPLQTIEAYLERPSGDKAKADGRLLAATP
HCCHHHHHHHHHHHHHHHHHHHCCCCCCCEECHHHHHHHHHHCCCCCCCCCCCEEEEECC
MQVVDVKGEWVQVAVKGWQQEGAERVIYEKQGKRIFNAALAPTATGSIVAGASMVDPDTE
EEEEECCCCEEHHHHHHHHHCCHHHHHHHHCCCCHHHHHHCCCCCCCCEECCCCCCCCCC
QTWTDVSLTAWVRNRDLTDDQEALWQYGKQMFNGACGMCHVLPHTEHFLANQWIGTLNAM
CCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHH
KSRAPLDDEQFRLVQRYVQMHAKDVEPEGAAE
HHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: trimethylamine-N-oxide; NADH [C]

Specific reaction: trimethylamine-N-oxide + NADH = H2O + trimethylamine + NAD [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]