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The map label for this gene is iclR [H]

Identifier: 77461964

GI number: 77461964

Start: 3427058

End: 3428608

Strand: Reverse

Name: iclR [H]

Synonym: Pfl01_2985

Alternate gene names: 77461964

Gene position: 3428608-3427058 (Counterclockwise)

Preceding gene: 77459236

Following gene: 77459205

Centisome position: 53.25

GC content: 48.36

Gene sequence:

>1551_bases
ATGCCTCAAACAAACCGCTCTATCACTACGTCTTCGCTGGTAGCCCCAGCATCCAGCCATACTCGGTTGATCCAGGTTGT
AGACGCTCTTGTGAAACGAACCAATGGAGAGCCTTGGGGCGTTCGAGAGCTTGCGGCAGAGCTTTCCGAGAGCCGGAGTA
CCGTTAATCGGATTCTGGTCTCTCTGGTCGACATAGGGTTTGCTAGCGAGGCGGGCGATGGCAAGTACAGTGTTGGGCCT
AGGATTGATGTTTTAACAAAAGCGCTCAGTGATTCCAGTGTACTTCTCGGACTACGTGGAAAATCGCTTTGTCAACTCGC
TGAAGTCTCTAAGTGTACGGCTCTTGTTTCTATCTACTGCCCTCGCAGCAAAGGTTATTTCATTGCAGCTTGTAGCGAGG
CCGAATCGCCACTCACGTTCAGGCCTCAGTTAGGCGTGGTCTATCCATTGAGCTTCGGAGACATTGGTAGACAGTTGGCT
AACTATCTCGACGCAAATGCTTTATGTCCCCCCCCGCAAGATGAGAAGGGTAATCTGGATTATATTTTTCGCAATGATAA
TGCACTTGGGCTGCTATCGGAGTCTGAGTTCCCCAGCGCGCTATCAATCGCTGTAGAAAGGATAGCGAGCGGGCTAATCA
TATCAGTCTCTGTCCACTCCGCTGGTAATGCAGAGCCAAGAATACGACGGCCGTTGGATGCTGATGTGCTGCGAGTTATC
GAAGAGATAACCGGTGATATCGAGTCGAAGACATTTCAGAAGCTTCAGGCTTATCCCGCTATTTCCACAAAAGATAATAA
ATCGACGGTTGATCGACTTGAAAGACTTCTCTTGCTTGTCTGTATGTTCCCTGATGGATTAATTAATTCTGTTGAATTGT
ACGATCAGCTTCTTTGCAATGCGTCTACTGCTAAACGACTGATACAATCAGGCGTTGAAGCCGAGCTGGTCAGTTTAGTT
GGCGGCACCTTGTATCCAGGCCCAAGGCTCTACCAATGGACGGCTATGATGAACTCCGCTCATCGAAATCTTGCTGATAT
TACTAGAAAGATCCTGTTTTCATTAGTTCAAGAGACCGGCGAGACGATAGCGCTTCTTTCATTCGATGAAGTGACTGAAA
AGGCCGAGTTTCTTGACGTCATACAGGGATGGAGACCTATTCAATATAAGCTCCATGTGAATGTGGAAGTCCCGCTCTAT
GCCGGTGCTGCCGGCAAGGCTGTACTGGCTTACTGTGCCCCCCACTTGGTTGACTCTCTTAAGCTTGTAAAGATCACCGA
CGCGACGATTACTTCCCGCAATGTGCTTAAGGAAGAATTGGTAACCATAAAAGAGCGAGGCTGGGCTACCGGGGAAGGTG
AACGTGTACTAGGCGCTTTTGGTTTGGCTGTACCTTTTTTTGTCGATGGTAAAATTCGAGGGTCAATCTCAGCGACCATT
CCTCAATACCGTAAAGATGAGCGCGATCTAACGATGCTAACTGGTCTGATGCGTGAAGCAACTGCAAAGATTGAGCGCTT
ATTGTCACTAGGCGTAAAATGGGACAAATGA

Upstream 100 bases:

>100_bases
CTTCTAGAACGCCGGGATAGTTGTCAACAGCCAAGTGTGAATTGCAGTAGGGCGGCTTTAGACCCCAGAATGGGGGCCCC
AACCTTCAATCTGACTTGCG

Downstream 100 bases:

>100_bases
CCTATCGATAAGCTGCTGAGGCCTAAAAAGCCTTAACAATGTTCTACGTCAGAAGTCTACGGTCACCGCGGTGTATAGCG
CCCTTCACCCGGGGAGTGCA

Product: regulatory proteins, IclR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 516; Mature: 515

Protein sequence:

>516_residues
MPQTNRSITTSSLVAPASSHTRLIQVVDALVKRTNGEPWGVRELAAELSESRSTVNRILVSLVDIGFASEAGDGKYSVGP
RIDVLTKALSDSSVLLGLRGKSLCQLAEVSKCTALVSIYCPRSKGYFIAACSEAESPLTFRPQLGVVYPLSFGDIGRQLA
NYLDANALCPPPQDEKGNLDYIFRNDNALGLLSESEFPSALSIAVERIASGLIISVSVHSAGNAEPRIRRPLDADVLRVI
EEITGDIESKTFQKLQAYPAISTKDNKSTVDRLERLLLLVCMFPDGLINSVELYDQLLCNASTAKRLIQSGVEAELVSLV
GGTLYPGPRLYQWTAMMNSAHRNLADITRKILFSLVQETGETIALLSFDEVTEKAEFLDVIQGWRPIQYKLHVNVEVPLY
AGAAGKAVLAYCAPHLVDSLKLVKITDATITSRNVLKEELVTIKERGWATGEGERVLGAFGLAVPFFVDGKIRGSISATI
PQYRKDERDLTMLTGLMREATAKIERLLSLGVKWDK

Sequences:

>Translated_516_residues
MPQTNRSITTSSLVAPASSHTRLIQVVDALVKRTNGEPWGVRELAAELSESRSTVNRILVSLVDIGFASEAGDGKYSVGP
RIDVLTKALSDSSVLLGLRGKSLCQLAEVSKCTALVSIYCPRSKGYFIAACSEAESPLTFRPQLGVVYPLSFGDIGRQLA
NYLDANALCPPPQDEKGNLDYIFRNDNALGLLSESEFPSALSIAVERIASGLIISVSVHSAGNAEPRIRRPLDADVLRVI
EEITGDIESKTFQKLQAYPAISTKDNKSTVDRLERLLLLVCMFPDGLINSVELYDQLLCNASTAKRLIQSGVEAELVSLV
GGTLYPGPRLYQWTAMMNSAHRNLADITRKILFSLVQETGETIALLSFDEVTEKAEFLDVIQGWRPIQYKLHVNVEVPLY
AGAAGKAVLAYCAPHLVDSLKLVKITDATITSRNVLKEELVTIKERGWATGEGERVLGAFGLAVPFFVDGKIRGSISATI
PQYRKDERDLTMLTGLMREATAKIERLLSLGVKWDK
>Mature_515_residues
PQTNRSITTSSLVAPASSHTRLIQVVDALVKRTNGEPWGVRELAAELSESRSTVNRILVSLVDIGFASEAGDGKYSVGPR
IDVLTKALSDSSVLLGLRGKSLCQLAEVSKCTALVSIYCPRSKGYFIAACSEAESPLTFRPQLGVVYPLSFGDIGRQLAN
YLDANALCPPPQDEKGNLDYIFRNDNALGLLSESEFPSALSIAVERIASGLIISVSVHSAGNAEPRIRRPLDADVLRVIE
EITGDIESKTFQKLQAYPAISTKDNKSTVDRLERLLLLVCMFPDGLINSVELYDQLLCNASTAKRLIQSGVEAELVSLVG
GTLYPGPRLYQWTAMMNSAHRNLADITRKILFSLVQETGETIALLSFDEVTEKAEFLDVIQGWRPIQYKLHVNVEVPLYA
GAAGKAVLAYCAPHLVDSLKLVKITDATITSRNVLKEELVTIKERGWATGEGERVLGAFGLAVPFFVDGKIRGSISATIP
QYRKDERDLTMLTGLMREATAKIERLLSLGVKWDK

Specific function: Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyr

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI87082359, Length=218, Percent_Identity=29.3577981651376, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 56342; Mature: 56211

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQTNRSITTSSLVAPASSHTRLIQVVDALVKRTNGEPWGVRELAAELSESRSTVNRILV
CCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
SLVDIGFASEAGDGKYSVGPRIDVLTKALSDSSVLLGLRGKSLCQLAEVSKCTALVSIYC
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHEEEEEEE
PRSKGYFIAACSEAESPLTFRPQLGVVYPLSFGDIGRQLANYLDANALCPPPQDEKGNLD
CCCCCEEEEEECCCCCCCEECCCCCEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCEE
YIFRNDNALGLLSESEFPSALSIAVERIASGLIISVSVHSAGNAEPRIRRPLDADVLRVI
EEEECCCEEEECCCCCCCHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCHHHHHHH
EEITGDIESKTFQKLQAYPAISTKDNKSTVDRLERLLLLVCMFPDGLINSVELYDQLLCN
HHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
ASTAKRLIQSGVEAELVSLVGGTLYPGPRLYQWTAMMNSAHRNLADITRKILFSLVQETG
HHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
ETIALLSFDEVTEKAEFLDVIQGWRPIQYKLHVNVEVPLYAGAAGKAVLAYCAPHLVDSL
CEEEEEEHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEEEEECCCHHHHHHHHHHHHHCCE
KLVKITDATITSRNVLKEELVTIKERGWATGEGERVLGAFGLAVPFFVDGKIRGSISATI
EEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCEEECCEECCCEECCC
PQYRKDERDLTMLTGLMREATAKIERLLSLGVKWDK
CHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PQTNRSITTSSLVAPASSHTRLIQVVDALVKRTNGEPWGVRELAAELSESRSTVNRILV
CCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
SLVDIGFASEAGDGKYSVGPRIDVLTKALSDSSVLLGLRGKSLCQLAEVSKCTALVSIYC
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHEEEEEEE
PRSKGYFIAACSEAESPLTFRPQLGVVYPLSFGDIGRQLANYLDANALCPPPQDEKGNLD
CCCCCEEEEEECCCCCCCEECCCCCEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCEE
YIFRNDNALGLLSESEFPSALSIAVERIASGLIISVSVHSAGNAEPRIRRPLDADVLRVI
EEEECCCEEEECCCCCCCHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCHHHHHHH
EEITGDIESKTFQKLQAYPAISTKDNKSTVDRLERLLLLVCMFPDGLINSVELYDQLLCN
HHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
ASTAKRLIQSGVEAELVSLVGGTLYPGPRLYQWTAMMNSAHRNLADITRKILFSLVQETG
HHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
ETIALLSFDEVTEKAEFLDVIQGWRPIQYKLHVNVEVPLYAGAAGKAVLAYCAPHLVDSL
CEEEEEEHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEEEEECCCHHHHHHHHHHHHHCCE
KLVKITDATITSRNVLKEELVTIKERGWATGEGERVLGAFGLAVPFFVDGKIRGSISATI
EEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCEEECCEECCCEECCC
PQYRKDERDLTMLTGLMREATAKIERLLSLGVKWDK
CHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2185227; 1995431; 8265357; 9278503; 1995429 [H]