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The map label for this gene is lpd3 [H]

Identifier: 77461891

GI number: 77461891

Start: 6354015

End: 6355415

Strand: Direct

Name: lpd3 [H]

Synonym: Pfl01_5671

Alternate gene names: 77461891

Gene position: 6354015-6355415 (Clockwise)

Preceding gene: 77461885

Following gene: 77461893

Centisome position: 98.69

GC content: 63.1

Gene sequence:

>1401_bases
ATGAGCAACTATGACGTGGTGATTCTGGGCGGTGGCCCCGGCGGTTATAACGCAGCGATCCGCGCCGGCCAGTTGGGCCT
CAAGGCCGCGTGCGTCGAGGGCCGCGCCACGCTGGGTGGCACCTGCCTGAACGTCGGCTGCATGCCGTCCAAGGCGCTTT
TGCATGCGTCAGAGCTCTACGAAGCGGCGCTGGGCGCGGAGTTCGCCAACCTCGGCATCGAAGTCAAACCCACGCTCAAC
CTTGCGCAAATGATGAAGCAGAAAGACGAAAGCGTGAGCGGCCTGACCAAAGGCATTGAATTCCTGTTCCGCAAAAACAA
GGTCGACTGGATCAAGGGCTGGGGCCACATCGACGGCCCCGGAAAAGTCAGCGTGACCGGTGATCAGGGCAGCCGCATCG
AACTGACGGCCAAGGACATCGTCATCGCCACCGGCTCCGAACCCACTCCCCTGCCCGGCGTGGAGATCGACAACAAGCGC
ATCCTCGACTCGACCGGTGCGCTGTCCTTGAGCGAAGTGCCCAAGCATCTGGTGGTGATTGGTGCGGGCGTGATCGGTCT
CGAACTCGGCTCGGTCTGGCGCCGGCTCGGCGCGCAGGTAACGGTGGTGGAATACTTAGACCGCATCTGCCCCGGCGTCG
ACGGCGAAGCCGGCAAGACTCTGCAACGCTCGCTGAGCAAACAGGGCATCAGCTTCAAGCTGAGCTCGAAAGTGACCAGC
GCCACTTCATCGGCCAACGGCGTACAACTCAGCGTGGAGCCCGCCGCTGGCGGCAGCGCGGAAATCCTTGAAGCCGATTA
CGTGCTGGTGGCCATCGGTCGTCGTCCGTACACCCAGGGCCTGGGCCTGGAAAACGTCGGCCTGAGCACCGACAAACGCG
GCATGCTCGCCAATAAACAGCATCGCACTGAAGCGCCTGGCGTGTGGGTGATCGGTGACGTGACCTCCGGGCCGATGCTC
GCGCACAAGGCCGAAGACGAAGCCATGGCCTGCATCGAACAGATCGTCGGCAAGGCCGGCGAGGTCAATTACGACCTGAT
TCCCAACGTGATCTACACCCGCCCCGAGCTGGCCAGCGTCGGCAAGACCGAAGAGCAGCTGAAGGCGGAAGGCCGGGCGT
ACAAGGTCGGCAAATTCCCGTTCACCGCCAACAGCCGGGCGAAGATCAATCACGAGACCGAAGGCTTCGCCAAAGTCATC
GCCGATGAGCGCACCGACGAAGTCCTCGGCGTGCACCTGGTCGGCCCGAGCGTCAGCGAAATGATCGGCGAGTTCTGCGT
GGCCATGGAGTTCAGCGCCTCGGCCGAGGACATCGCGCTGACCTGTCACCCGCATCCAACCCGCTCCGAAGCGTTGCGTC
AGGCAGCGATGAATGTCGAGGGGATGGCGACGCAGATGTAA

Upstream 100 bases:

>100_bases
GAAGCCTTGACCGAAATGTCGGGAAACGCTCATATTACGTTCGTAATTTTTAGCACGAACTACTTTTACTGATCCGCATC
CTTCAGCCAGGAGCAAGAGC

Downstream 100 bases:

>100_bases
GCACTGTGCGAATACTTCCCGCGCAATGCGGGAAGTATCAGGACGGCAGATGCCCCAGCGGCAACGCGCCGGGTGTCTTC
ACCGTGTGGATCGCAAAATT

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase 3; LPD-3 [H]

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MSNYDVVILGGGPGGYNAAIRAGQLGLKAACVEGRATLGGTCLNVGCMPSKALLHASELYEAALGAEFANLGIEVKPTLN
LAQMMKQKDESVSGLTKGIEFLFRKNKVDWIKGWGHIDGPGKVSVTGDQGSRIELTAKDIVIATGSEPTPLPGVEIDNKR
ILDSTGALSLSEVPKHLVVIGAGVIGLELGSVWRRLGAQVTVVEYLDRICPGVDGEAGKTLQRSLSKQGISFKLSSKVTS
ATSSANGVQLSVEPAAGGSAEILEADYVLVAIGRRPYTQGLGLENVGLSTDKRGMLANKQHRTEAPGVWVIGDVTSGPML
AHKAEDEAMACIEQIVGKAGEVNYDLIPNVIYTRPELASVGKTEEQLKAEGRAYKVGKFPFTANSRAKINHETEGFAKVI
ADERTDEVLGVHLVGPSVSEMIGEFCVAMEFSASAEDIALTCHPHPTRSEALRQAAMNVEGMATQM

Sequences:

>Translated_466_residues
MSNYDVVILGGGPGGYNAAIRAGQLGLKAACVEGRATLGGTCLNVGCMPSKALLHASELYEAALGAEFANLGIEVKPTLN
LAQMMKQKDESVSGLTKGIEFLFRKNKVDWIKGWGHIDGPGKVSVTGDQGSRIELTAKDIVIATGSEPTPLPGVEIDNKR
ILDSTGALSLSEVPKHLVVIGAGVIGLELGSVWRRLGAQVTVVEYLDRICPGVDGEAGKTLQRSLSKQGISFKLSSKVTS
ATSSANGVQLSVEPAAGGSAEILEADYVLVAIGRRPYTQGLGLENVGLSTDKRGMLANKQHRTEAPGVWVIGDVTSGPML
AHKAEDEAMACIEQIVGKAGEVNYDLIPNVIYTRPELASVGKTEEQLKAEGRAYKVGKFPFTANSRAKINHETEGFAKVI
ADERTDEVLGVHLVGPSVSEMIGEFCVAMEFSASAEDIALTCHPHPTRSEALRQAAMNVEGMATQM
>Mature_465_residues
SNYDVVILGGGPGGYNAAIRAGQLGLKAACVEGRATLGGTCLNVGCMPSKALLHASELYEAALGAEFANLGIEVKPTLNL
AQMMKQKDESVSGLTKGIEFLFRKNKVDWIKGWGHIDGPGKVSVTGDQGSRIELTAKDIVIATGSEPTPLPGVEIDNKRI
LDSTGALSLSEVPKHLVVIGAGVIGLELGSVWRRLGAQVTVVEYLDRICPGVDGEAGKTLQRSLSKQGISFKLSSKVTSA
TSSANGVQLSVEPAAGGSAEILEADYVLVAIGRRPYTQGLGLENVGLSTDKRGMLANKQHRTEAPGVWVIGDVTSGPMLA
HKAEDEAMACIEQIVGKAGEVNYDLIPNVIYTRPELASVGKTEEQLKAEGRAYKVGKFPFTANSRAKINHETEGFAKVIA
DERTDEVLGVHLVGPSVSEMIGEFCVAMEFSASAEDIALTCHPHPTRSEALRQAAMNVEGMATQM

Specific function: LPD-3 may substitute for lipoamide dehydrogenase of the 2-oxoglutarate dehydrogenase and pyruvate multienzyme complexes when the latter is inactive or missing [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=457, Percent_Identity=54.0481400437637, Blast_Score=497, Evalue=1e-140,
Organism=Homo sapiens, GI50301238, Length=473, Percent_Identity=28.1183932346723, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI33519430, Length=435, Percent_Identity=26.2068965517241, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI33519428, Length=435, Percent_Identity=26.2068965517241, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI33519426, Length=435, Percent_Identity=26.2068965517241, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI148277065, Length=435, Percent_Identity=26.2068965517241, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI148277071, Length=435, Percent_Identity=26.2068965517241, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI291045266, Length=431, Percent_Identity=26.9141531322506, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI22035672, Length=473, Percent_Identity=28.3298097251586, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI291045268, Length=426, Percent_Identity=26.2910798122066, Blast_Score=115, Evalue=7e-26,
Organism=Escherichia coli, GI1786307, Length=463, Percent_Identity=39.0928725701944, Blast_Score=313, Evalue=1e-86,
Organism=Escherichia coli, GI87082354, Length=462, Percent_Identity=31.8181818181818, Blast_Score=220, Evalue=1e-58,
Organism=Escherichia coli, GI87081717, Length=459, Percent_Identity=28.9760348583878, Blast_Score=184, Evalue=9e-48,
Organism=Escherichia coli, GI1789915, Length=442, Percent_Identity=28.2805429864253, Blast_Score=161, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI32565766, Length=455, Percent_Identity=55.6043956043956, Blast_Score=514, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI17557007, Length=490, Percent_Identity=27.3469387755102, Blast_Score=142, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI71983419, Length=448, Percent_Identity=28.7946428571429, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI71983429, Length=448, Percent_Identity=28.7946428571429, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI71982272, Length=482, Percent_Identity=26.1410788381743, Blast_Score=123, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6321091, Length=466, Percent_Identity=53.2188841201717, Blast_Score=468, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6325240, Length=473, Percent_Identity=35.9408033826639, Blast_Score=265, Evalue=2e-71,
Organism=Saccharomyces cerevisiae, GI6325166, Length=465, Percent_Identity=29.8924731182796, Blast_Score=177, Evalue=2e-45,
Organism=Drosophila melanogaster, GI21358499, Length=454, Percent_Identity=55.2863436123348, Blast_Score=503, Evalue=1e-142,
Organism=Drosophila melanogaster, GI24640549, Length=478, Percent_Identity=27.4058577405858, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24640553, Length=476, Percent_Identity=27.1008403361345, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24640551, Length=478, Percent_Identity=27.4058577405858, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI17737741, Length=487, Percent_Identity=24.6406570841889, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 49194; Mature: 49063

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNYDVVILGGGPGGYNAAIRAGQLGLKAACVEGRATLGGTCLNVGCMPSKALLHASELY
CCCCEEEEECCCCCCCCHHEECCCCCCEEEEECCCCCCCCEEEEECCCCHHHHHHHHHHH
EAALGAEFANLGIEVKPTLNLAQMMKQKDESVSGLTKGIEFLFRKNKVDWIKGWGHIDGP
HHHHCCHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCC
GKVSVTGDQGSRIELTAKDIVIATGSEPTPLPGVEIDNKRILDSTGALSLSEVPKHLVVI
CEEEEECCCCCEEEEEEEEEEEECCCCCCCCCCCEECCCEEECCCCCEEHHHCCCEEEEE
GAGVIGLELGSVWRRLGAQVTVVEYLDRICPGVDGEAGKTLQRSLSKQGISFKLSSKVTS
ECCHHHHHHHHHHHHHCCEEEHHHHHHHHCCCCCCCCCHHHHHHHHHCCCEEEECCCHHH
ATSSANGVQLSVEPAAGGSAEILEADYVLVAIGRRPYTQGLGLENVGLSTDKRGMLANKQ
CCCCCCCEEEEEECCCCCCCEEEECCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
HRTEAPGVWVIGDVTSGPMLAHKAEDEAMACIEQIVGKAGEVNYDLIPNVIYTRPELASV
CCCCCCCEEEEECCCCCCEEEECCCHHHHHHHHHHHCCCCCCCCEECCCEEECCCHHHHC
GKTEEQLKAEGRAYKVGKFPFTANSRAKINHETEGFAKVIADERTDEVLGVHLVGPSVSE
CCCHHHHHHCCCEEEEECCCCCCCCCCEECCCHHHHHHHHHCCCCCCEEEEEEECCCHHH
MIGEFCVAMEFSASAEDIALTCHPHPTRSEALRQAAMNVEGMATQM
HHHHHHHEEECCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SNYDVVILGGGPGGYNAAIRAGQLGLKAACVEGRATLGGTCLNVGCMPSKALLHASELY
CCCEEEEECCCCCCCCHHEECCCCCCEEEEECCCCCCCCEEEEECCCCHHHHHHHHHHH
EAALGAEFANLGIEVKPTLNLAQMMKQKDESVSGLTKGIEFLFRKNKVDWIKGWGHIDGP
HHHHCCHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCC
GKVSVTGDQGSRIELTAKDIVIATGSEPTPLPGVEIDNKRILDSTGALSLSEVPKHLVVI
CEEEEECCCCCEEEEEEEEEEEECCCCCCCCCCCEECCCEEECCCCCEEHHHCCCEEEEE
GAGVIGLELGSVWRRLGAQVTVVEYLDRICPGVDGEAGKTLQRSLSKQGISFKLSSKVTS
ECCHHHHHHHHHHHHHCCEEEHHHHHHHHCCCCCCCCCHHHHHHHHHCCCEEEECCCHHH
ATSSANGVQLSVEPAAGGSAEILEADYVLVAIGRRPYTQGLGLENVGLSTDKRGMLANKQ
CCCCCCCEEEEEECCCCCCCEEEECCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
HRTEAPGVWVIGDVTSGPMLAHKAEDEAMACIEQIVGKAGEVNYDLIPNVIYTRPELASV
CCCCCCCEEEEECCCCCCEEEECCCHHHHHHHHHHHCCCCCCCCEECCCEEECCCHHHHC
GKTEEQLKAEGRAYKVGKFPFTANSRAKINHETEGFAKVIADERTDEVLGVHLVGPSVSE
CCCHHHHHHCCCEEEEECCCCCCCCCCEECCCHHHHHHHHHCCCCCCEEEEEEECCCHHH
MIGEFCVAMEFSASAEDIALTCHPHPTRSEALRQAAMNVEGMATQM
HHHHHHHEEECCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1722146; 2914869 [H]