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The map label for this gene is folE2

Identifier: 77461878

GI number: 77461878

Start: 6339125

End: 6340021

Strand: Direct

Name: folE2

Synonym: Pfl01_5658

Alternate gene names: 77461878

Gene position: 6339125-6340021 (Clockwise)

Preceding gene: 77461876

Following gene: 77461879

Centisome position: 98.46

GC content: 57.97

Gene sequence:

>897_bases
ATGAACGCGCTGACTTTGCCGGATGTCGCGGCTCAAGCCGCCCGCCAGGCCCTGCCTCTCGAATGGGTGGGGATGTGCGG
CATCGCATTACCTGTGTTTATCGAAGGCCAACGCTTGGCTGCCAAAGCGGATGCAGGCGTCAGCCTGGATGATGGAGACG
CACGCGGCATTCACATGTCGCGGCTCTATCTGGGGCTGGAAGCGATGGAGCAGCAGAACCTTTCTCCTGCCCTTTTACGA
CAAGTTTTGCAGCGCTTTCTCGACAGCCACGAAGATCTGTCCGAAGCCGCCTATCTTAATATCCATATTGATTTGCTCCT
CAGAAGGCCCGCGTTGGTCAGCCCTTTGGCGGGATGGAAAAACTATCCCGTCACTGTTTCAGCCCAGCTAAAAAACAAAG
TGTTCCACGTGGAACTGAAAATCGACGTCGCGTATTCCTCAACTTGCCCGTGCTCTGCGGCATTGGCGAGGCAGTTGATC
CAGCAACAATTCGTCGACGACTTCGCCAACAAACCACTGCAACACGCCGATGTGTTGGCGTGGCTCGGTTCGACCCAAGG
CATCGTGGCCACACCTCACAGCCAGCGCAGTACTGCCCAGCTACATTTGCACCTGGATGAATTCGTCGACGAACTACCGC
TGACGTCCATCATCAACGACGCCGAAGCAGCCCTCGGCACCGCCGTGCAAACCGCTGTGAAACGCGCCGACGAACAAGCC
TTCGCCCTCGCCAACGGCCAGAACCTTATGTTCTGCGAAGACGCTGCACGACGCCTGAACCTGGCACTGCGTGGCTCACC
CGGTATCAGCCAATTCCACGTACGAGTCATCCACGCCGAAAGCCTTCATGCTCACGACGCCGTCGCCGAGAGTCATTGGC
GCCGGGAGCAGCCATGA

Upstream 100 bases:

>100_bases
AGTGACGTCTGTGCATATGAAAGCCTGTTCATGAAAAAGGCATCGTGGTTTGAATTGTTATAATGTAACATCAAATTCAA
TTACCATGATGGAACTGCTC

Downstream 100 bases:

>100_bases
TTCGCTGCCACAACCTGAGCTGGGGAATACCCGGCCAACCGCTCACTGCACCGCTCAGCCTAAGGCTGGAAAGCGGCAGC
ATGACGGCAATCATCGGCAT

Product: putative GTP cyclohydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MNALTLPDVAAQAARQALPLEWVGMCGIALPVFIEGQRLAAKADAGVSLDDGDARGIHMSRLYLGLEAMEQQNLSPALLR
QVLQRFLDSHEDLSEAAYLNIHIDLLLRRPALVSPLAGWKNYPVTVSAQLKNKVFHVELKIDVAYSSTCPCSAALARQLI
QQQFVDDFANKPLQHADVLAWLGSTQGIVATPHSQRSTAQLHLHLDEFVDELPLTSIINDAEAALGTAVQTAVKRADEQA
FALANGQNLMFCEDAARRLNLALRGSPGISQFHVRVIHAESLHAHDAVAESHWRREQP

Sequences:

>Translated_298_residues
MNALTLPDVAAQAARQALPLEWVGMCGIALPVFIEGQRLAAKADAGVSLDDGDARGIHMSRLYLGLEAMEQQNLSPALLR
QVLQRFLDSHEDLSEAAYLNIHIDLLLRRPALVSPLAGWKNYPVTVSAQLKNKVFHVELKIDVAYSSTCPCSAALARQLI
QQQFVDDFANKPLQHADVLAWLGSTQGIVATPHSQRSTAQLHLHLDEFVDELPLTSIINDAEAALGTAVQTAVKRADEQA
FALANGQNLMFCEDAARRLNLALRGSPGISQFHVRVIHAESLHAHDAVAESHWRREQP
>Mature_298_residues
MNALTLPDVAAQAARQALPLEWVGMCGIALPVFIEGQRLAAKADAGVSLDDGDARGIHMSRLYLGLEAMEQQNLSPALLR
QVLQRFLDSHEDLSEAAYLNIHIDLLLRRPALVSPLAGWKNYPVTVSAQLKNKVFHVELKIDVAYSSTCPCSAALARQLI
QQQFVDDFANKPLQHADVLAWLGSTQGIVATPHSQRSTAQLHLHLDEFVDELPLTSIINDAEAALGTAVQTAVKRADEQA
FALANGQNLMFCEDAARRLNLALRGSPGISQFHVRVIHAESLHAHDAVAESHWRREQP

Specific function: Converts GTP to 7,8-dihydroneopterin triphosphate

COG id: COG1469

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase IV family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCH4_PSEPF (Q3K4B0)

Other databases:

- EMBL:   CP000094
- RefSeq:   YP_351385.1
- ProteinModelPortal:   Q3K4B0
- SMR:   Q3K4B0
- STRING:   Q3K4B0
- GeneID:   3717452
- GenomeReviews:   CP000094_GR
- KEGG:   pfo:Pfl01_5658
- eggNOG:   COG1469
- HOGENOM:   HBG466315
- OMA:   FCEDAAR
- ProtClustDB:   PRK13674
- BioCyc:   PFLU205922:PFL_5658-MONOMER
- HAMAP:   MF_01527_B
- InterPro:   IPR022838
- InterPro:   IPR003801
- InterPro:   IPR002042
- Gene3D:   G3DSA:3.10.270.10

Pfam domain/function: PF02649 DUF198

EC number: =3.5.4.16

Molecular weight: Translated: 32631; Mature: 32631

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNALTLPDVAAQAARQALPLEWVGMCGIALPVFIEGQRLAAKADAGVSLDDGDARGIHMS
CCCCCCCHHHHHHHHHCCCHHHHHHHHHHHEEEECCCCCEECCCCCCEECCCCCCCEEHH
RLYLGLEAMEQQNLSPALLRQVLQRFLDSHEDLSEAAYLNIHIDLLLRRPALVSPLAGWK
HHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHEEEEEEEEEEECCCCHHHHHCCCC
NYPVTVSAQLKNKVFHVELKIDVAYSSTCPCSAALARQLIQQQFVDDFANKPLQHADVLA
CCCEEEEEECCCCEEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
WLGSTQGIVATPHSQRSTAQLHLHLDEFVDELPLTSIINDAEAALGTAVQTAVKRADEQA
HHCCCCCEEECCCCCCCCEEEEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHH
FALANGQNLMFCEDAARRLNLALRGSPGISQFHVRVIHAESLHAHDAVAESHWRREQP
EEEECCCEEEEEHHHHHHEEEEEECCCCCCEEEEEEEEECCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNALTLPDVAAQAARQALPLEWVGMCGIALPVFIEGQRLAAKADAGVSLDDGDARGIHMS
CCCCCCCHHHHHHHHHCCCHHHHHHHHHHHEEEECCCCCEECCCCCCEECCCCCCCEEHH
RLYLGLEAMEQQNLSPALLRQVLQRFLDSHEDLSEAAYLNIHIDLLLRRPALVSPLAGWK
HHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHEEEEEEEEEEECCCCHHHHHCCCC
NYPVTVSAQLKNKVFHVELKIDVAYSSTCPCSAALARQLIQQQFVDDFANKPLQHADVLA
CCCEEEEEECCCCEEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
WLGSTQGIVATPHSQRSTAQLHLHLDEFVDELPLTSIINDAEAALGTAVQTAVKRADEQA
HHCCCCCEEECCCCCCCCEEEEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHH
FALANGQNLMFCEDAARRLNLALRGSPGISQFHVRVIHAESLHAHDAVAESHWRREQP
EEEECCCEEEEEHHHHHHEEEEEECCCCCCEEEEEEEEECCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA