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The map label for this gene is oxyR [H]

Identifier: 77461779

GI number: 77461779

Start: 6225182

End: 6226111

Strand: Direct

Name: oxyR [H]

Synonym: Pfl01_5558

Alternate gene names: 77461779

Gene position: 6225182-6226111 (Clockwise)

Preceding gene: 77461778

Following gene: 77461780

Centisome position: 96.69

GC content: 63.23

Gene sequence:

>930_bases
ATGACTCTCACAGAATTACGCTACATCGTTACCCTCGCCCAAGAGCAGCATTTCGGCCACGCGGCCGAGCGTTGCCACGT
CAGCCAGCCGACCCTGTCGGTGGGCGTGAAAAAGCTTGAAGACGAACTCGGTGTGCTGATTTTCGAGCGCAGCAAAAGCG
CCGTGCGCCTGACCCCGGTCGGCGAAGGCATCGTCGCCCAGGCGCAGAAAGTGCTGGAGCAGGCCCAAGGCATCCGCGAG
CTGGCCCAGGCCGGCAAGAACCAGCTGACCGCCCCACTGAAAGTCGGCGCAATCTACACCGTCGGCCCGTACCTGTTCCC
GCACCTGATTCCGCAACTGCACCGGGTCGCCCCGCAGATGCCGTTGTACATCGAAGAAAACTTCACCCATGTGCTGCGCG
ACAAATTGCGCAACGGCGAACTGGACGCGATCATCATCGCCCTGCCGTTCAACGAAGCCGACGTGCTGACCCTGCAGCTC
TACGACGAGCCGTTCTACGTCCTGATGCCGGCCCAGCACCCGTGGACGCAAAAAGAATCCATCGATGCCGCCCTGCTCAA
CGACAAGAGCCTGCTGCTGCTCGGCGAAGGCCACTGCTTCCGCGATCAAGTATTGGAAGCCTGCCCGACCCTGACCAAGG
GCAACGACGGCGCCAAGCACACCACGGTCGAATCCAGCTCGCTGGAAACCATTCGCCACATGGTTGCGTCCGGCCTGGGC
ATCTCGATCCTGCCGCTGTCGGCGGTAGACAGCCATCACTACGCTCCGGGCGTGATCGAAGTGCGTCCACTGTCGGCACC
AGTGCCGTTCCGCACCGTGGCCATCGCCTGGCGCGCCAGCTTCCCACGGCCGAAAGCCATCGAGATCCTCGCCGATTCCA
TACGCCTGTGCTCGGTCGCCAAGCCTGCCGCGCCGGTCACGGCCGGTTAA

Upstream 100 bases:

>100_bases
AACCGGCATTGCCCGGTGTCGCATTCATCACTCAGTCTGATAACGTGCGTCTATCGATTGCAGCCGGTATGCTTGGCCCG
CATCTTCATGGACGCTTGCT

Downstream 100 bases:

>100_bases
GCCAGCGTCATGACGGAGCTGTCGCAGGTGTCGGTCACCGCACTCAAGGGTGTCGGTGAAGCCATGGCCGAGAAACTGGC
CAAGGTCGGTCTGGAAAACC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Morphology and auto-aggregation control protein [H]

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MTLTELRYIVTLAQEQHFGHAAERCHVSQPTLSVGVKKLEDELGVLIFERSKSAVRLTPVGEGIVAQAQKVLEQAQGIRE
LAQAGKNQLTAPLKVGAIYTVGPYLFPHLIPQLHRVAPQMPLYIEENFTHVLRDKLRNGELDAIIIALPFNEADVLTLQL
YDEPFYVLMPAQHPWTQKESIDAALLNDKSLLLLGEGHCFRDQVLEACPTLTKGNDGAKHTTVESSSLETIRHMVASGLG
ISILPLSAVDSHHYAPGVIEVRPLSAPVPFRTVAIAWRASFPRPKAIEILADSIRLCSVAKPAAPVTAG

Sequences:

>Translated_309_residues
MTLTELRYIVTLAQEQHFGHAAERCHVSQPTLSVGVKKLEDELGVLIFERSKSAVRLTPVGEGIVAQAQKVLEQAQGIRE
LAQAGKNQLTAPLKVGAIYTVGPYLFPHLIPQLHRVAPQMPLYIEENFTHVLRDKLRNGELDAIIIALPFNEADVLTLQL
YDEPFYVLMPAQHPWTQKESIDAALLNDKSLLLLGEGHCFRDQVLEACPTLTKGNDGAKHTTVESSSLETIRHMVASGLG
ISILPLSAVDSHHYAPGVIEVRPLSAPVPFRTVAIAWRASFPRPKAIEILADSIRLCSVAKPAAPVTAG
>Mature_308_residues
TLTELRYIVTLAQEQHFGHAAERCHVSQPTLSVGVKKLEDELGVLIFERSKSAVRLTPVGEGIVAQAQKVLEQAQGIREL
AQAGKNQLTAPLKVGAIYTVGPYLFPHLIPQLHRVAPQMPLYIEENFTHVLRDKLRNGELDAIIIALPFNEADVLTLQLY
DEPFYVLMPAQHPWTQKESIDAALLNDKSLLLLGEGHCFRDQVLEACPTLTKGNDGAKHTTVESSSLETIRHMVASGLGI
SILPLSAVDSHHYAPGVIEVRPLSAPVPFRTVAIAWRASFPRPKAIEILADSIRLCSVAKPAAPVTAG

Specific function: Hydrogen peroxide sensor. Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS (a regulatory RNA), dps, fur and grxA. OxyR expression is negatively autoregulated by binding to a 43 bp region upstre

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790399, Length=295, Percent_Identity=40.6779661016949, Blast_Score=225, Evalue=3e-60,
Organism=Escherichia coli, GI1788887, Length=301, Percent_Identity=28.5714285714286, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1788748, Length=296, Percent_Identity=27.027027027027, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI2367136, Length=270, Percent_Identity=27.037037037037, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI157672245, Length=302, Percent_Identity=24.1721854304636, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1787530, Length=254, Percent_Identity=26.7716535433071, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788297, Length=257, Percent_Identity=28.7937743190661, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787806, Length=283, Percent_Identity=22.9681978798587, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI145693105, Length=283, Percent_Identity=25.4416961130742, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787879, Length=254, Percent_Identity=26.7716535433071, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787601, Length=184, Percent_Identity=26.6304347826087, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI87082132, Length=261, Percent_Identity=24.1379310344828, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1788296, Length=247, Percent_Identity=24.6963562753036, Blast_Score=68, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33784; Mature: 33652

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLTELRYIVTLAQEQHFGHAAERCHVSQPTLSVGVKKLEDELGVLIFERSKSAVRLTPV
CCHHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHCEEEEECCCCEEEEEEC
GEGIVAQAQKVLEQAQGIRELAQAGKNQLTAPLKVGAIYTVGPYLFPHLIPQLHRVAPQM
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECEEEEHHHHHHHHHHHHHHHHCCCC
PLYIEENFTHVLRDKLRNGELDAIIIALPFNEADVLTLQLYDEPFYVLMPAQHPWTQKES
CEEEECCHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEEECCCEEEEECCCCCCCCCCC
IDAALLNDKSLLLLGEGHCFRDQVLEACPTLTKGNDGAKHTTVESSSLETIRHMVASGLG
CCEEEECCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCEEEECCHHHHHHHHHHHCCCC
ISILPLSAVDSHHYAPGVIEVRPLSAPVPFRTVAIAWRASFPRPKAIEILADSIRLCSVA
EEEEEEECCCCCCCCCCEEEEEECCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCC
KPAAPVTAG
CCCCCCCCC
>Mature Secondary Structure 
TLTELRYIVTLAQEQHFGHAAERCHVSQPTLSVGVKKLEDELGVLIFERSKSAVRLTPV
CHHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHCEEEEECCCCEEEEEEC
GEGIVAQAQKVLEQAQGIRELAQAGKNQLTAPLKVGAIYTVGPYLFPHLIPQLHRVAPQM
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECEEEEHHHHHHHHHHHHHHHHCCCC
PLYIEENFTHVLRDKLRNGELDAIIIALPFNEADVLTLQLYDEPFYVLMPAQHPWTQKES
CEEEECCHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEEECCCEEEEECCCCCCCCCCC
IDAALLNDKSLLLLGEGHCFRDQVLEACPTLTKGNDGAKHTTVESSSLETIRHMVASGLG
CCEEEECCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCEEEECCHHHHHHHHHHHCCCC
ISILPLSAVDSHHYAPGVIEVRPLSAPVPFRTVAIAWRASFPRPKAIEILADSIRLCSVA
EEEEEEECCCCCCCCCCEEEEEECCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCC
KPAAPVTAG
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]