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The map label for this gene is algC [H]

Identifier: 77461763

GI number: 77461763

Start: 6211099

End: 6212496

Strand: Direct

Name: algC [H]

Synonym: Pfl01_5542

Alternate gene names: 77461763

Gene position: 6211099-6212496 (Clockwise)

Preceding gene: 77461762

Following gene: 77461764

Centisome position: 96.47

GC content: 62.09

Gene sequence:

>1398_bases
ATGAGCACCCCCGCCCAAGTCGCCCCGAAGCTTCCTGACAGCATCTTCCGCGCCTACGACATTCGCGGCACCGTGCCGGA
ATTCCTCAATGCCGAAACCGCCTACTGGATCGGCCGCGCCATCGGCTCCCAAAGCCTGGCCCAAGGCGAACCGAACGTGT
CCGTCGGTCGTGACGGCCGCCTGTCCGGTCCGGAACTGGTTGCCGCACTGATCCGCGGCATCGCCGAGAGCGGCTGCCAC
GTCAGCGACGTCGGCCTGGTGCCGACCCCGGCGCTGTACTACGCCGCCAACGTGCTGGCCGGCAAATCCGGCGTAATGCT
CACTGGCAGCCATAACCCGTCGAACTACAACGGCTTCAAGATCGTGATCGCCGGCGATACCCTCGCCAACGAACAGATCC
AGGCCCTGCACGAGCGCCTCAAGACCGGCAACCTGAGCAGCGGCACCGGCAGCGTGACCCAGGTCGAAATCCTCGACCGC
TACAACACCGAAATCGTCCAGGACATCAAACTGGCCCGGCGCCTGAAAGTCGTGGTCGACTGCGGCAACGGCGCGGCCGG
CGTGATCGCCCCGCAACTGATCGAAGCGCTGAACTGCGAAGTCATCCCGCTGTTCTGCGATGTCGACGGCAACTTCCCGA
ACCATCACCCGGACCCGGGCAAGCCTGAGAACCTCGTCGACCTGATCGCCAAGGTCAAGGAAACCAACGCCGACATCGGC
CTGGCCTTCGACGGCGACGGCGACCGCGTCGGCGTGGTGACCAACACCGGCACCATCGTGTTTCCGGACCGCCTGCTGAT
GCTGTTCGCCCGTGACGTGGTGGCGCGCAACCCGGACGCGGAGATCATCTTCGACGTCAAATGCACCCGTCGCCTGATCC
CGCTGATCAAGGAATATGGCGGTCGGCCGCTAATGTGGAAGACCGGTCACTCGTTGATCAAAAAGAAAATGAAACAATCC
GGCGCGCTGTTGGCCGGCGAAATGAGCGGGCACATTTTCTTCAAGGAACGCTGGTTCGGTTTCGACGACGGCATTTACAG
CGCCGCGCGGCTGCTGGAAATCCTCAGCAAGGAAAAATCTTCGGCCGAGGAGCTGTTCGCGACCTTCCCGAACGATATTT
CCACGCCGGAAATCAATATCCATGTGACCGAAGAGAGCAAATTCAGCATCATTGATGCACTGCACGATGCGCAGTGGGGC
CCAGGCGCCGACCTGACCACCATTGACGGCGTGCGGGTCGACTACGCCAAAGGCTGGGGCCTGGTGCGCGCATCCAACAC
CACACCGGTGCTGGTGCTGCGTTTCGAGGCCGATGACGAGGCTGAACTGCAGCGCATCAAGGCTGTGTTCCATGCCCAAC
TGAAACGCGTTGCACCTGATCTCCAACTACCGTTCTGA

Upstream 100 bases:

>100_bases
GAACTCTCTGTGAAAACCGCCGTCATACCCTTCAGTTTGAGCTTGCCGTCGAATAATCGTCGGTGTGTCCAGCCACTTTC
GAGATGGAGCATTTTTGCAG

Downstream 100 bases:

>100_bases
TTGCTGATTCACCCGGAGCCCTGAATGACCCTCGAACGCGATGCCGCCGCCAACACTGCCAAGGTCCTGTCCGAAGCGCT
GCCTTATATCCGCCGATACG

Product: phosphomannomutase

Products: NA

Alternate protein names: PMM / PGM [H]

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MSTPAQVAPKLPDSIFRAYDIRGTVPEFLNAETAYWIGRAIGSQSLAQGEPNVSVGRDGRLSGPELVAALIRGIAESGCH
VSDVGLVPTPALYYAANVLAGKSGVMLTGSHNPSNYNGFKIVIAGDTLANEQIQALHERLKTGNLSSGTGSVTQVEILDR
YNTEIVQDIKLARRLKVVVDCGNGAAGVIAPQLIEALNCEVIPLFCDVDGNFPNHHPDPGKPENLVDLIAKVKETNADIG
LAFDGDGDRVGVVTNTGTIVFPDRLLMLFARDVVARNPDAEIIFDVKCTRRLIPLIKEYGGRPLMWKTGHSLIKKKMKQS
GALLAGEMSGHIFFKERWFGFDDGIYSAARLLEILSKEKSSAEELFATFPNDISTPEINIHVTEESKFSIIDALHDAQWG
PGADLTTIDGVRVDYAKGWGLVRASNTTPVLVLRFEADDEAELQRIKAVFHAQLKRVAPDLQLPF

Sequences:

>Translated_465_residues
MSTPAQVAPKLPDSIFRAYDIRGTVPEFLNAETAYWIGRAIGSQSLAQGEPNVSVGRDGRLSGPELVAALIRGIAESGCH
VSDVGLVPTPALYYAANVLAGKSGVMLTGSHNPSNYNGFKIVIAGDTLANEQIQALHERLKTGNLSSGTGSVTQVEILDR
YNTEIVQDIKLARRLKVVVDCGNGAAGVIAPQLIEALNCEVIPLFCDVDGNFPNHHPDPGKPENLVDLIAKVKETNADIG
LAFDGDGDRVGVVTNTGTIVFPDRLLMLFARDVVARNPDAEIIFDVKCTRRLIPLIKEYGGRPLMWKTGHSLIKKKMKQS
GALLAGEMSGHIFFKERWFGFDDGIYSAARLLEILSKEKSSAEELFATFPNDISTPEINIHVTEESKFSIIDALHDAQWG
PGADLTTIDGVRVDYAKGWGLVRASNTTPVLVLRFEADDEAELQRIKAVFHAQLKRVAPDLQLPF
>Mature_464_residues
STPAQVAPKLPDSIFRAYDIRGTVPEFLNAETAYWIGRAIGSQSLAQGEPNVSVGRDGRLSGPELVAALIRGIAESGCHV
SDVGLVPTPALYYAANVLAGKSGVMLTGSHNPSNYNGFKIVIAGDTLANEQIQALHERLKTGNLSSGTGSVTQVEILDRY
NTEIVQDIKLARRLKVVVDCGNGAAGVIAPQLIEALNCEVIPLFCDVDGNFPNHHPDPGKPENLVDLIAKVKETNADIGL
AFDGDGDRVGVVTNTGTIVFPDRLLMLFARDVVARNPDAEIIFDVKCTRRLIPLIKEYGGRPLMWKTGHSLIKKKMKQSG
ALLAGEMSGHIFFKERWFGFDDGIYSAARLLEILSKEKSSAEELFATFPNDISTPEINIHVTEESKFSIIDALHDAQWGP
GADLTTIDGVRVDYAKGWGLVRASNTTPVLVLRFEADDEAELQRIKAVFHAQLKRVAPDLQLPF

Specific function: The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to it

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1788361, Length=453, Percent_Identity=31.7880794701987, Blast_Score=188, Evalue=6e-49,
Organism=Escherichia coli, GI1789566, Length=438, Percent_Identity=28.5388127853881, Blast_Score=114, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2; =5.4.2.8 [H]

Molecular weight: Translated: 50478; Mature: 50347

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPAQVAPKLPDSIFRAYDIRGTVPEFLNAETAYWIGRAIGSQSLAQGEPNVSVGRDGR
CCCCHHCCCCCCHHHHHHHCCCCCCHHHHCCCHHHHHHHHHCCCHHHCCCCCCCCCCCCC
LSGPELVAALIRGIAESGCHVSDVGLVPTPALYYAANVLAGKSGVMLTGSHNPSNYNGFK
CCCHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCEE
IVIAGDTLANEQIQALHERLKTGNLSSGTGSVTQVEILDRYNTEIVQDIKLARRLKVVVD
EEEECCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEHHHCCHHHHHHHHHHHHEEEEEE
CGNGAAGVIAPQLIEALNCEVIPLFCDVDGNFPNHHPDPGKPENLVDLIAKVKETNADIG
CCCCCCCHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEE
LAFDGDGDRVGVVTNTGTIVFPDRLLMLFARDVVARNPDAEIIFDVKCTRRLIPLIKEYG
EEECCCCCEEEEEECCCEEEEHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHC
GRPLMWKTGHSLIKKKMKQSGALLAGEMSGHIFFKERWFGFDDGIYSAARLLEILSKEKS
CCCEEECCCHHHHHHHHHHCCCEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCC
SAEELFATFPNDISTPEINIHVTEESKFSIIDALHDAQWGPGADLTTIDGVRVDYAKGWG
CHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHCCCCCCCCCCEEECCEEEEECCCCE
LVRASNTTPVLVLRFEADDEAELQRIKAVFHAQLKRVAPDLQLPF
EEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
STPAQVAPKLPDSIFRAYDIRGTVPEFLNAETAYWIGRAIGSQSLAQGEPNVSVGRDGR
CCCHHCCCCCCHHHHHHHCCCCCCHHHHCCCHHHHHHHHHCCCHHHCCCCCCCCCCCCC
LSGPELVAALIRGIAESGCHVSDVGLVPTPALYYAANVLAGKSGVMLTGSHNPSNYNGFK
CCCHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCEE
IVIAGDTLANEQIQALHERLKTGNLSSGTGSVTQVEILDRYNTEIVQDIKLARRLKVVVD
EEEECCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEHHHCCHHHHHHHHHHHHEEEEEE
CGNGAAGVIAPQLIEALNCEVIPLFCDVDGNFPNHHPDPGKPENLVDLIAKVKETNADIG
CCCCCCCHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEE
LAFDGDGDRVGVVTNTGTIVFPDRLLMLFARDVVARNPDAEIIFDVKCTRRLIPLIKEYG
EEECCCCCEEEEEECCCEEEEHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHC
GRPLMWKTGHSLIKKKMKQSGALLAGEMSGHIFFKERWFGFDDGIYSAARLLEILSKEKS
CCCEEECCCHHHHHHHHHHCCCEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCC
SAEELFATFPNDISTPEINIHVTEESKFSIIDALHDAQWGPGADLTTIDGVRVDYAKGWG
CHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHCCCCCCCCCCEEECCEEEEECCCCE
LVRASNTTPVLVLRFEADDEAELQRIKAVFHAQLKRVAPDLQLPF
EEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]