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The map label for this gene is fkl [H]

Identifier: 77461702

GI number: 77461702

Start: 6149348

End: 6150013

Strand: Direct

Name: fkl [H]

Synonym: Pfl01_5481

Alternate gene names: 77461702

Gene position: 6149348-6150013 (Clockwise)

Preceding gene: 77461700

Following gene: 77461710

Centisome position: 95.51

GC content: 59.16

Gene sequence:

>666_bases
ATGTCGCGCTACCTTTTTTTATCCCTCTGCATGATTTTCTCCATGGCTCAGGCCGACGAAAAAACCACCGCGAACGATGC
CCATGATCTGGCTTACAGCCTCGGTGCCAGCCTCGGTGAACGACTGCGTCAGGAAGTGCCGCAGCTACAGATCCAGGCAC
TGATCGAAGGTCTGCAACAGGCTTATCAAGGTAAGCCGCTGGCATTGAGCGAAGCACGTATCGAGCAGATCCTCGCCGAT
CACGAATCGCAGACAGCCGAGCAGGCAGCCATGCCTTCGACTGAAGCCGCGATGGAAAACGAGCGACGGTTTCTCACCGC
CGAAAAAGCCAAGCCGGGTGTAAAGGAGCTGGCCGACGGCATCCTGTTGACCGAGCTGACACCGGGAAATGGCACGAAGG
CCGGCCCGGATGGAAAAGTGCAGGTGCTGTACATCGGTCGACTGCCTGACGGCACCGTGTTCGATCAGAACAGTCAGCCG
CAGTGGTTCAATCTCGACAGCGTGATCGCCGGATGGCGCACCGCGCTGCAGAACATGCCGGTCGGCGCGAAGTGGCGACT
GGTGATTCCATCGGATCAGGCTTATGGCGCCGACGGTGCCGGTGACTTGATCGCGCCGTTCACACCGTTGGTGTTCGAAG
TGGAATTGCGCGGCGCGACCAGTTGA

Upstream 100 bases:

>100_bases
TGCAGGCTTGCGAAAAACTTCTGCACCTTGGCAAAAGCAGTTCACCGTTGCAGACGTTCGCGCTGGCATAATCCTCCGCA
ATTCAGGACGGAGAGTGCCC

Downstream 100 bases:

>100_bases
TCGCCCAATAAAAAACGGTGCGCCTGGGGCGCACCGTTTTTGTGTCTTGCGAGGTTCGATTCAGGCCTGAACCGAATCCT
CTTCCTTGTGTGCGGTATGC

Product: FKBP-type peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 221; Mature: 220

Protein sequence:

>221_residues
MSRYLFLSLCMIFSMAQADEKTTANDAHDLAYSLGASLGERLRQEVPQLQIQALIEGLQQAYQGKPLALSEARIEQILAD
HESQTAEQAAMPSTEAAMENERRFLTAEKAKPGVKELADGILLTELTPGNGTKAGPDGKVQVLYIGRLPDGTVFDQNSQP
QWFNLDSVIAGWRTALQNMPVGAKWRLVIPSDQAYGADGAGDLIAPFTPLVFEVELRGATS

Sequences:

>Translated_221_residues
MSRYLFLSLCMIFSMAQADEKTTANDAHDLAYSLGASLGERLRQEVPQLQIQALIEGLQQAYQGKPLALSEARIEQILAD
HESQTAEQAAMPSTEAAMENERRFLTAEKAKPGVKELADGILLTELTPGNGTKAGPDGKVQVLYIGRLPDGTVFDQNSQP
QWFNLDSVIAGWRTALQNMPVGAKWRLVIPSDQAYGADGAGDLIAPFTPLVFEVELRGATS
>Mature_220_residues
SRYLFLSLCMIFSMAQADEKTTANDAHDLAYSLGASLGERLRQEVPQLQIQALIEGLQQAYQGKPLALSEARIEQILADH
ESQTAEQAAMPSTEAAMENERRFLTAEKAKPGVKELADGILLTELTPGNGTKAGPDGKVQVLYIGRLPDGTVFDQNSQPQ
WFNLDSVIAGWRTALQNMPVGAKWRLVIPSDQAYGADGAGDLIAPFTPLVFEVELRGATS

Specific function: PPIases accelerate the folding of proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cytoplasm And Periplasmic Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Escherichia coli, GI87082390, Length=191, Percent_Identity=35.6020942408377, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1789745, Length=208, Percent_Identity=35.5769230769231, Blast_Score=81, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6323566, Length=113, Percent_Identity=37.1681415929204, Blast_Score=66, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6323482, Length=112, Percent_Identity=36.6071428571429, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 23990; Mature: 23859

Theoretical pI: Translated: 4.43; Mature: 4.43

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRYLFLSLCMIFSMAQADEKTTANDAHDLAYSLGASLGERLRQEVPQLQIQALIEGLQQ
CCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYQGKPLALSEARIEQILADHESQTAEQAAMPSTEAAMENERRFLTAEKAKPGVKELADG
HHCCCCCEEHHHHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHEEEHHCCCCCHHHHHCC
ILLTELTPGNGTKAGPDGKVQVLYIGRLPDGTVFDQNSQPQWFNLDSVIAGWRTALQNMP
EEEEEECCCCCCCCCCCCCEEEEEEEECCCCCEECCCCCCCEECHHHHHHHHHHHHHCCC
VGAKWRLVIPSDQAYGADGAGDLIAPFTPLVFEVELRGATS
CCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEECCCCC
>Mature Secondary Structure 
SRYLFLSLCMIFSMAQADEKTTANDAHDLAYSLGASLGERLRQEVPQLQIQALIEGLQQ
CHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYQGKPLALSEARIEQILADHESQTAEQAAMPSTEAAMENERRFLTAEKAKPGVKELADG
HHCCCCCEEHHHHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHEEEHHCCCCCHHHHHCC
ILLTELTPGNGTKAGPDGKVQVLYIGRLPDGTVFDQNSQPQWFNLDSVIAGWRTALQNMP
EEEEEECCCCCCCCCCCCCEEEEEEEECCCCCEECCCCCCCEECHHHHHHHHHHHHHCCC
VGAKWRLVIPSDQAYGADGAGDLIAPFTPLVFEVELRGATS
CCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2514124; 2110144; 10984043 [H]