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The map label for this gene is pepP [H]

Identifier: 77461655

GI number: 77461655

Start: 6101730

End: 6103064

Strand: Reverse

Name: pepP [H]

Synonym: Pfl01_5434

Alternate gene names: 77461655

Gene position: 6103064-6101730 (Counterclockwise)

Preceding gene: 77461656

Following gene: 77461654

Centisome position: 94.79

GC content: 62.62

Gene sequence:

>1335_bases
ATGATCCATATCCCGAAAGCGGAATACGCCCGGCGCCGCAAGGCGCTGATGGCGCAGATGGAACCCAACAGCATCGCGAT
CCTGCCTGCCGCCGCGGTCGCCATTCGCAACCGCGACGTCGAGCATGTCTATCGCCAGGACAGCGACTTCCAGTACCTCA
GCGGTTTCCCCGAGCCACAGGCGGTCATCGTCCTGATGCCCGGTCGCGAACACGGCGAGTACGTGCTGTTCTGCCGTGAA
CGCAACGCCGAACGCGAACTCTGGGACGGCCTGCGCGCCGGCCAGGAAGGTGCGATCCGCGATTTCGGCGCCGATGACGC
TTTCCCCATCACCGACATCGACGACATTCTGCCGGGCCTGATCGAAGGCCGCGACCGGGTGTATTCGGCCATGGGCAGCA
ACCCGGAATTCGACCGCCACCTGATGGACTGGATCAACGTTATCCGCTCCAAGGCGCACCTCGGCGCCCAGCCGCCGAAC
GAATTCGTTGCCCTGGATCACCTGCTGCACGACATGCGCCTGTATAAATCGGCGGCAGAAGTGAAGGTGATGCGCGAAGC
GGCGCGGATTTCCGCCCAGGCTCACATCCGGGCGATGCAGGCCAGCCGTGCCGGGCTGTATGAGTACAGCCTCGAAGCCG
AACTCGATTACGAGTTCCGCAAGGGCGGGGCGAAGATGCCGGCATACGGCTCGATCGTCGCTGCCGGGCGCAACAGCTGC
ATCCTGCATTACCAGCAAAATGACGCACTGCTCAAGGACGGCGATCTGGTGCTGATCGACGCCGGTTGCGAAATCGACTG
CTACGCCAGCGACATCACCCGCACCTGGCCGGTCAACGGCAAGTTCTCCGCCGAGCAGAAAGCGATCTACGAATTGGTGT
TGGCCTCGCAGGAAGCGGCATTCGCCGAAATTGCTCCGAACAAGCACTGGAACCAGGCGCACGAAGCCACGGTTCGGGTC
ATCACCACCGGGCTGGTGAAGCTGGGGTTGTTGCAGGGCGAAGTCGACGAATTGATCGCTACCGAGGCCTACAAGGCGTT
TTATATGCACCGCGCCGGTCACTGGCTGGGCATGGATGTGCATGACGTCGGCGAATACAAGGTCGGCGGCGAATGGCGGG
TGCTGGAAGTCGGCATGGCGCTGACCGTGGAGCCGGGCATCTACATCGCCCCGGACAATCAGAACGTAGCGAAGAAATGG
CGCGGCATTGGCGTGCGCATCGAGGATGACGTGGTAGTGACCAAGAGCGGTTGTGAAATCCTGACCGGCGGCGTGCCGAA
AACCGTCGCCGAGATCGAAGCCCTGATGGCGCAAGCACGGACCTGCGCGGCATGA

Upstream 100 bases:

>100_bases
CGCGCCGCTGCTGTTGTTCTCCGAAACCAAAAAGGCCGACGTGCCGCCAGCGGCCAAGCCGTCGCTGCACTGATCGCGTG
CCAGGGAAAGCCATCTGCCC

Downstream 100 bases:

>100_bases
GTCGGGTCAATCTGGCAATCATCGGTGGCGGTCTGGTCGGCGCCAGTCTGGCGTTGGCCTTGCAGGCCGGGGCCAAGGCC
CGTGGCTGGAAGATCGTGCT

Product: aminopeptidase P

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MIHIPKAEYARRRKALMAQMEPNSIAILPAAAVAIRNRDVEHVYRQDSDFQYLSGFPEPQAVIVLMPGREHGEYVLFCRE
RNAERELWDGLRAGQEGAIRDFGADDAFPITDIDDILPGLIEGRDRVYSAMGSNPEFDRHLMDWINVIRSKAHLGAQPPN
EFVALDHLLHDMRLYKSAAEVKVMREAARISAQAHIRAMQASRAGLYEYSLEAELDYEFRKGGAKMPAYGSIVAAGRNSC
ILHYQQNDALLKDGDLVLIDAGCEIDCYASDITRTWPVNGKFSAEQKAIYELVLASQEAAFAEIAPNKHWNQAHEATVRV
ITTGLVKLGLLQGEVDELIATEAYKAFYMHRAGHWLGMDVHDVGEYKVGGEWRVLEVGMALTVEPGIYIAPDNQNVAKKW
RGIGVRIEDDVVVTKSGCEILTGGVPKTVAEIEALMAQARTCAA

Sequences:

>Translated_444_residues
MIHIPKAEYARRRKALMAQMEPNSIAILPAAAVAIRNRDVEHVYRQDSDFQYLSGFPEPQAVIVLMPGREHGEYVLFCRE
RNAERELWDGLRAGQEGAIRDFGADDAFPITDIDDILPGLIEGRDRVYSAMGSNPEFDRHLMDWINVIRSKAHLGAQPPN
EFVALDHLLHDMRLYKSAAEVKVMREAARISAQAHIRAMQASRAGLYEYSLEAELDYEFRKGGAKMPAYGSIVAAGRNSC
ILHYQQNDALLKDGDLVLIDAGCEIDCYASDITRTWPVNGKFSAEQKAIYELVLASQEAAFAEIAPNKHWNQAHEATVRV
ITTGLVKLGLLQGEVDELIATEAYKAFYMHRAGHWLGMDVHDVGEYKVGGEWRVLEVGMALTVEPGIYIAPDNQNVAKKW
RGIGVRIEDDVVVTKSGCEILTGGVPKTVAEIEALMAQARTCAA
>Mature_444_residues
MIHIPKAEYARRRKALMAQMEPNSIAILPAAAVAIRNRDVEHVYRQDSDFQYLSGFPEPQAVIVLMPGREHGEYVLFCRE
RNAERELWDGLRAGQEGAIRDFGADDAFPITDIDDILPGLIEGRDRVYSAMGSNPEFDRHLMDWINVIRSKAHLGAQPPN
EFVALDHLLHDMRLYKSAAEVKVMREAARISAQAHIRAMQASRAGLYEYSLEAELDYEFRKGGAKMPAYGSIVAAGRNSC
ILHYQQNDALLKDGDLVLIDAGCEIDCYASDITRTWPVNGKFSAEQKAIYELVLASQEAAFAEIAPNKHWNQAHEATVRV
ITTGLVKLGLLQGEVDELIATEAYKAFYMHRAGHWLGMDVHDVGEYKVGGEWRVLEVGMALTVEPGIYIAPDNQNVAKKW
RGIGVRIEDDVVVTKSGCEILTGGVPKTVAEIEALMAQARTCAA

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=456, Percent_Identity=35.7456140350877, Blast_Score=287, Evalue=1e-77,
Organism=Homo sapiens, GI149589008, Length=481, Percent_Identity=33.8877338877339, Blast_Score=226, Evalue=4e-59,
Organism=Homo sapiens, GI260593665, Length=315, Percent_Identity=39.6825396825397, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI260593663, Length=476, Percent_Identity=30.8823529411765, Blast_Score=183, Evalue=3e-46,
Organism=Escherichia coli, GI1789275, Length=441, Percent_Identity=46.9387755102041, Blast_Score=400, Evalue=1e-113,
Organism=Escherichia coli, GI1788728, Length=264, Percent_Identity=33.7121212121212, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1790282, Length=286, Percent_Identity=28.6713286713287, Blast_Score=94, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17508215, Length=469, Percent_Identity=32.409381663113, Blast_Score=194, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI71989583, Length=369, Percent_Identity=28.4552845528455, Blast_Score=147, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6320922, Length=449, Percent_Identity=30.2895322939866, Blast_Score=207, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6321118, Length=470, Percent_Identity=30.6382978723404, Blast_Score=183, Evalue=6e-47,
Organism=Drosophila melanogaster, GI19920384, Length=422, Percent_Identity=33.8862559241706, Blast_Score=231, Evalue=1e-60,
Organism=Drosophila melanogaster, GI21357079, Length=480, Percent_Identity=32.0833333333333, Blast_Score=201, Evalue=1e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 49335; Mature: 49335

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHIPKAEYARRRKALMAQMEPNSIAILPAAAVAIRNRDVEHVYRQDSDFQYLSGFPEPQ
CCCCCCHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHCCCHHHHHCCCCCCHHHCCCCCCC
AVIVLMPGREHGEYVLFCRERNAERELWDGLRAGQEGAIRDFGADDAFPITDIDDILPGL
EEEEEECCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHH
IEGRDRVYSAMGSNPEFDRHLMDWINVIRSKAHLGAQPPNEFVALDHLLHDMRLYKSAAE
HCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
VKVMREAARISAQAHIRAMQASRAGLYEYSLEAELDYEFRKGGAKMPAYGSIVAAGRNSC
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECEEECCHHHCCCCCCCCCCCEEECCCCCE
ILHYQQNDALLKDGDLVLIDAGCEIDCYASDITRTWPVNGKFSAEQKAIYELVLASQEAA
EEEEECCCCEEECCCEEEEECCCCEEEEECCCCEECCCCCCCCHHHHHHHHHHHHCCCHH
FAEIAPNKHWNQAHEATVRVITTGLVKLGLLQGEVDELIATEAYKAFYMHRAGHWLGMDV
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCEECCCH
HDVGEYKVGGEWRVLEVGMALTVEPGIYIAPDNQNVAKKWRGIGVRIEDDVVVTKSGCEI
HHCCCEEECCCEEEEEECEEEEECCCEEECCCCCHHHHHHCCCCEEEECCEEEEECCCEE
LTGGVPKTVAEIEALMAQARTCAA
EECCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIHIPKAEYARRRKALMAQMEPNSIAILPAAAVAIRNRDVEHVYRQDSDFQYLSGFPEPQ
CCCCCCHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHCCCHHHHHCCCCCCHHHCCCCCCC
AVIVLMPGREHGEYVLFCRERNAERELWDGLRAGQEGAIRDFGADDAFPITDIDDILPGL
EEEEEECCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHH
IEGRDRVYSAMGSNPEFDRHLMDWINVIRSKAHLGAQPPNEFVALDHLLHDMRLYKSAAE
HCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
VKVMREAARISAQAHIRAMQASRAGLYEYSLEAELDYEFRKGGAKMPAYGSIVAAGRNSC
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECEEECCHHHCCCCCCCCCCCEEECCCCCE
ILHYQQNDALLKDGDLVLIDAGCEIDCYASDITRTWPVNGKFSAEQKAIYELVLASQEAA
EEEEECCCCEEECCCEEEEECCCCEEEEECCCCEECCCCCCCCHHHHHHHHHHHHCCCHH
FAEIAPNKHWNQAHEATVRVITTGLVKLGLLQGEVDELIATEAYKAFYMHRAGHWLGMDV
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCEECCCH
HDVGEYKVGGEWRVLEVGMALTVEPGIYIAPDNQNVAKKWRGIGVRIEDDVVVTKSGCEI
HHCCCEEECCCEEEEEECEEEEECCCEEECCCCCHHHHHHCCCCEEEECCEEEEECCCEE
LTGGVPKTVAEIEALMAQARTCAA
EECCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]