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The map label for this gene is mutM [H]

Identifier: 77461572

GI number: 77461572

Start: 6009905

End: 6010717

Strand: Reverse

Name: mutM [H]

Synonym: Pfl01_5351

Alternate gene names: 77461572

Gene position: 6010717-6009905 (Counterclockwise)

Preceding gene: 77461573

Following gene: 77461571

Centisome position: 93.36

GC content: 64.94

Gene sequence:

>813_bases
ATGCCTGAACTGCCGGAAGTCGAAACCACCCGTCGCGGTATTGCTCCGCACCTGGAGGGCCAGCGCGTCAGCCGGGTGAT
CGTGCGTGACCGGCGGCTGCGCTGGCCGATTCCCGAAGACCTCGATGTGCGCCTGTCCGGGCAACGCATCGTGCTGGTTG
AGCGGCGCGCCAAGTATCTGCTGATCAACGCCGAAGTCGGCACGCTGATCAGCCACTTGGGCATGTCGGGCAACCTTCGG
CTGGTTGAGGTCGGGATGCCGGCGGCCAAGCATGAGCATGTCGATATCGAACTGGAGTCGGGCCTGGCCCTGCGCTACAC
CGATCCACGGCGCTTCGGGGCGATGCTCTGGAGCAACGACCCGCTCAATCACGAGTTGCTGATCCGCCTGGGTCCGGAGC
CGTTGACCGATCTGTTCGATGGCGAGCGGTTGTATCAGCTGTCACGCGGGCGCTCGATGGCGGTCAAGCCGTTCATCATG
GACAACGCGGTGGTGGTGGGGGTCGGCAATATCTACGCGACCGAGGCGCTGTTCGCCGCCGGTATCGATCCGCGGCGAGA
GGCCAAGGGCATTTCCCGGGCGCGCTATCTGAAGCTGGCGATCGAGATCAAACGCATCCTCGCTGCGGCCATTGAGCGCG
GCGGCACCACGTTGCGCGACTTCATTGGTGGCGACGGGCAGCCGGGGTATTTCCAGCAGGAGCTGTTTGTCTACGGTCGC
GGTGGCGAGCACTGCAAGGTCTGCGGTACGGGCCTGCGGGAAATGAAGCTCGGCCAGCGCGCCAGCGTCTGGTGTCCGCG
CTGCCAAAGCTGA

Upstream 100 bases:

>100_bases
GAATACATCGGCCTCTCGGATTACGACTTCGAAACGTTGAAGCAGACGATTCGCGAACTTGGCGCGCACTGATTCAAGAA
GCTGATGATTCGAGGAACTG

Downstream 100 bases:

>100_bases
GCAAGGCATCCGAAAAAGTCCTACGGTCTATAGTGAGTTGTCTCACTGTTCAGCCCGAAGGATCGTGCCATGAAGTCCTT
GCAAACCCTCATCGTTGCAC

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 270; Mature: 269

Protein sequence:

>270_residues
MPELPEVETTRRGIAPHLEGQRVSRVIVRDRRLRWPIPEDLDVRLSGQRIVLVERRAKYLLINAEVGTLISHLGMSGNLR
LVEVGMPAAKHEHVDIELESGLALRYTDPRRFGAMLWSNDPLNHELLIRLGPEPLTDLFDGERLYQLSRGRSMAVKPFIM
DNAVVVGVGNIYATEALFAAGIDPRREAKGISRARYLKLAIEIKRILAAAIERGGTTLRDFIGGDGQPGYFQQELFVYGR
GGEHCKVCGTGLREMKLGQRASVWCPRCQS

Sequences:

>Translated_270_residues
MPELPEVETTRRGIAPHLEGQRVSRVIVRDRRLRWPIPEDLDVRLSGQRIVLVERRAKYLLINAEVGTLISHLGMSGNLR
LVEVGMPAAKHEHVDIELESGLALRYTDPRRFGAMLWSNDPLNHELLIRLGPEPLTDLFDGERLYQLSRGRSMAVKPFIM
DNAVVVGVGNIYATEALFAAGIDPRREAKGISRARYLKLAIEIKRILAAAIERGGTTLRDFIGGDGQPGYFQQELFVYGR
GGEHCKVCGTGLREMKLGQRASVWCPRCQS
>Mature_269_residues
PELPEVETTRRGIAPHLEGQRVSRVIVRDRRLRWPIPEDLDVRLSGQRIVLVERRAKYLLINAEVGTLISHLGMSGNLRL
VEVGMPAAKHEHVDIELESGLALRYTDPRRFGAMLWSNDPLNHELLIRLGPEPLTDLFDGERLYQLSRGRSMAVKPFIMD
NAVVVGVGNIYATEALFAAGIDPRREAKGISRARYLKLAIEIKRILAAAIERGGTTLRDFIGGDGQPGYFQQELFVYGRG
GEHCKVCGTGLREMKLGQRASVWCPRCQS

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=269, Percent_Identity=55.3903345724907, Blast_Score=302, Evalue=1e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 30248; Mature: 30116

Theoretical pI: Translated: 9.42; Mature: 9.42

Prosite motif: PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETTRRGIAPHLEGQRVSRVIVRDRRLRWPIPEDLDVRLSGQRIVLVERRAKYL
CCCCCCCHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEECCCEEEEEECCCEEE
LINAEVGTLISHLGMSGNLRLVEVGMPAAKHEHVDIELESGLALRYTDPRRFGAMLWSND
EEECHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEEEECCCEEEEECCHHHHHHEEECCC
PLNHELLIRLGPEPLTDLFDGERLYQLSRGRSMAVKPFIMDNAVVVGVGNIYATEALFAA
CCCCEEEEEECCCHHHHHHCCHHHHHHHCCCCEEECEEEECCEEEEEECCHHHHHHHHHC
GIDPRREAKGISRARYLKLAIEIKRILAAAIERGGTTLRDFIGGDGQPGYFQQELFVYGR
CCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCEEEEEEEEEC
GGEHCKVCGTGLREMKLGQRASVWCPRCQS
CCCEEEEECCCHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
PELPEVETTRRGIAPHLEGQRVSRVIVRDRRLRWPIPEDLDVRLSGQRIVLVERRAKYL
CCCCCCHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEECCCEEEEEECCCEEE
LINAEVGTLISHLGMSGNLRLVEVGMPAAKHEHVDIELESGLALRYTDPRRFGAMLWSND
EEECHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEEEECCCEEEEECCHHHHHHEEECCC
PLNHELLIRLGPEPLTDLFDGERLYQLSRGRSMAVKPFIMDNAVVVGVGNIYATEALFAA
CCCCEEEEEECCCHHHHHHCCHHHHHHHCCCCEEECEEEECCEEEEEECCHHHHHHHHHC
GIDPRREAKGISRARYLKLAIEIKRILAAAIERGGTTLRDFIGGDGQPGYFQQELFVYGR
CCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCEEEEEEEEEC
GGEHCKVCGTGLREMKLGQRASVWCPRCQS
CCCEEEEECCCHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA