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The map label for this gene is pyrC [H]

Identifier: 77461536

GI number: 77461536

Start: 5979513

End: 5980784

Strand: Direct

Name: pyrC [H]

Synonym: Pfl01_5315

Alternate gene names: 77461536

Gene position: 5979513-5980784 (Clockwise)

Preceding gene: 77461535

Following gene: 77461538

Centisome position: 92.87

GC content: 67.06

Gene sequence:

>1272_bases
GTGAAGCTCAGCATTCTCGGCGCCCGCGTCATCGATCCAAGCAGCGGCCTGGATCAAATCACCGATATTCACGTTGAAGC
CTGCAAGATCGTCGCCCTCGGCGCGGCACCGGCCGGCTTCACCGCCGTCGAAACCATCGACGCTCAAGGCCTGGTGGCCG
CTCCGGGGCTGGTCGACCTCAATGTCGCCCTGCGCGAGCCGGGCTACAGCCGCAAAGGCACCATCGCCAGCGAAACCCGC
GCTGCGGCGGCCGGCGGCGTGACAAGCCTGTGCTGCCCGCCGAAAACCAGACCGGTGCTCGACACCTCCGCCGTGGCCGA
GCTGATCCTCGACCGCGCCCGCGAGGCCGGCAACACCAAGGTGTTCCCGATCGGGGCGCTGAGCAAAGGTCTGGATGGCG
AGCAGCTTGCAGAACTCGTTGCCCTGCGCGACGCCGGTTGCGTGGCGTTCGGCAACGGCCTGGAAAGCTTCCGCAACACC
CGCACCCTGTGCCGGGCGCTGGATTACGCGGCGACCTTCGACCTGACGGTGATTTTCAACTCGCAGGATCACGACCTGGC
CGACGGCGGCCTGGCCCACGAAGGCGCCACCGCCAGTTTCCTCGGCCTGCCGGGCATCCCGGAAACCGCTGAAACCGTGG
CCCTGGCCCGGGATCTGCTGCTGGTCGAACAGACCGGCGTGCGCGCGCACTTCAGCCAGCTGACCAGCGCTCGCGGCGTG
GCTCTGATTGCCCAGGCCCAGGCTCGTGGCTTGAAAGTCACGGCGGATGTCGCCCTGTATCAGCTGATCCTCACGGACGA
AGCGCTGATCGACTTCAGCAGCCTGTATCACGTGCAACCGCCGCTGCGCACCCGTGCGGATCGCGACGGTCTGCGTGAAG
CGGTGAAGTCCGGCGTGGTCTCGGCCATCTCCAGCCATCACCAGCCCCATGAACGCGATGCCAAACTGGCACCGTTCGGC
GCGACCGAGCCGGGCATCAGCAGCGTCGAACTGCTGCTGCCGCTGGCAATGACGCTGGTGGAGGATGGTCTGCTGGACCT
GCCGACCCTGCTCTCACGCCTGAGCGCCGGCCCGGCCGAGGCCTTGCGCCTGCCGGCGGGCAAACTGGCGGTGGGTGGCG
CGGCGGATATCGTGCTGTTCGATCCGAAGGCTTCGACCGTTGCCGGCGAAACCTGGCTGTCGAAAGGCGAGAACTGCCCG
TTTCTCGGCCATAGCCTGCCGGGTGTTGTGCGTTACACGCTGGTGGATGGCCGGATCAGCCATCAGGCGTAA

Upstream 100 bases:

>100_bases
TCAATCAAGTCACCTACGGCATCGCAATCCGTATGGCCGTGCTGTCGATGGCCATGAGCGGACAGACTGCCCAGCGCCAA
TTCGAGCAGGAGAACGCCCA

Downstream 100 bases:

>100_bases
AAAAAATGGCGAGGGAGCCAGCTCCCTCGCCATCACTTACTGAAATGCGCCCCGCCCTTCGGCATTACGCACCGACACCT
GATCGTTCAGCGTCCAGAAG

Product: dihydroorotase

Products: N-carbamoyl-L-aspartate

Alternate protein names: Aspartate carbamoyltransferase 44 kDa Non-catalytic chain [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MKLSILGARVIDPSSGLDQITDIHVEACKIVALGAAPAGFTAVETIDAQGLVAAPGLVDLNVALREPGYSRKGTIASETR
AAAAGGVTSLCCPPKTRPVLDTSAVAELILDRAREAGNTKVFPIGALSKGLDGEQLAELVALRDAGCVAFGNGLESFRNT
RTLCRALDYAATFDLTVIFNSQDHDLADGGLAHEGATASFLGLPGIPETAETVALARDLLLVEQTGVRAHFSQLTSARGV
ALIAQAQARGLKVTADVALYQLILTDEALIDFSSLYHVQPPLRTRADRDGLREAVKSGVVSAISSHHQPHERDAKLAPFG
ATEPGISSVELLLPLAMTLVEDGLLDLPTLLSRLSAGPAEALRLPAGKLAVGGAADIVLFDPKASTVAGETWLSKGENCP
FLGHSLPGVVRYTLVDGRISHQA

Sequences:

>Translated_423_residues
MKLSILGARVIDPSSGLDQITDIHVEACKIVALGAAPAGFTAVETIDAQGLVAAPGLVDLNVALREPGYSRKGTIASETR
AAAAGGVTSLCCPPKTRPVLDTSAVAELILDRAREAGNTKVFPIGALSKGLDGEQLAELVALRDAGCVAFGNGLESFRNT
RTLCRALDYAATFDLTVIFNSQDHDLADGGLAHEGATASFLGLPGIPETAETVALARDLLLVEQTGVRAHFSQLTSARGV
ALIAQAQARGLKVTADVALYQLILTDEALIDFSSLYHVQPPLRTRADRDGLREAVKSGVVSAISSHHQPHERDAKLAPFG
ATEPGISSVELLLPLAMTLVEDGLLDLPTLLSRLSAGPAEALRLPAGKLAVGGAADIVLFDPKASTVAGETWLSKGENCP
FLGHSLPGVVRYTLVDGRISHQA
>Mature_423_residues
MKLSILGARVIDPSSGLDQITDIHVEACKIVALGAAPAGFTAVETIDAQGLVAAPGLVDLNVALREPGYSRKGTIASETR
AAAAGGVTSLCCPPKTRPVLDTSAVAELILDRAREAGNTKVFPIGALSKGLDGEQLAELVALRDAGCVAFGNGLESFRNT
RTLCRALDYAATFDLTVIFNSQDHDLADGGLAHEGATASFLGLPGIPETAETVALARDLLLVEQTGVRAHFSQLTSARGV
ALIAQAQARGLKVTADVALYQLILTDEALIDFSSLYHVQPPLRTRADRDGLREAVKSGVVSAISSHHQPHERDAKLAPFG
ATEPGISSVELLLPLAMTLVEDGLLDLPTLLSRLSAGPAEALRLPAGKLAVGGAADIVLFDPKASTVAGETWLSKGENCP
FLGHSLPGVVRYTLVDGRISHQA

Specific function: Non-functional DHOase [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. PyrC' subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=408, Percent_Identity=30.6372549019608, Blast_Score=120, Evalue=4e-27,
Organism=Escherichia coli, GI1786722, Length=421, Percent_Identity=24.7030878859857, Blast_Score=101, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI193204318, Length=424, Percent_Identity=27.3584905660377, Blast_Score=113, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6322218, Length=388, Percent_Identity=26.5463917525773, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24642586, Length=410, Percent_Identity=25.8536585365854, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: 3.5.2.3

Molecular weight: Translated: 44045; Mature: 44045

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLSILGARVIDPSSGLDQITDIHVEACKIVALGAAPAGFTAVETIDAQGLVAAPGLVDL
CEEEEEEEEEECCCCCHHHHHHHHHEEEEEEEECCCCCCCEEEEEECCCCEEECCCEEEE
NVALREPGYSRKGTIASETRAAAAGGVTSLCCPPKTRPVLDTSAVAELILDRAREAGNTK
EEEECCCCCCCCCCCHHHHHHHHCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCE
VFPIGALSKGLDGEQLAELVALRDAGCVAFGNGLESFRNTRTLCRALDYAATFDLTVIFN
EEECCHHHCCCCHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHEEEEEEEEC
SQDHDLADGGLAHEGATASFLGLPGIPETAETVALARDLLLVEQTGVRAHFSQLTSARGV
CCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCE
ALIAQAQARGLKVTADVALYQLILTDEALIDFSSLYHVQPPLRTRADRDGLREAVKSGVV
EEEEEHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHH
SAISSHHQPHERDAKLAPFGATEPGISSVELLLPLAMTLVEDGLLDLPTLLSRLSAGPAE
HHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHH
ALRLPAGKLAVGGAADIVLFDPKASTVAGETWLSKGENCPFLGHSLPGVVRYTLVDGRIS
HHCCCCCCEEECCCEEEEEECCCCCCCCCHHHHHCCCCCCCCCCCCCCEEEEEEECCCCC
HQA
CCC
>Mature Secondary Structure
MKLSILGARVIDPSSGLDQITDIHVEACKIVALGAAPAGFTAVETIDAQGLVAAPGLVDL
CEEEEEEEEEECCCCCHHHHHHHHHEEEEEEEECCCCCCCEEEEEECCCCEEECCCEEEE
NVALREPGYSRKGTIASETRAAAAGGVTSLCCPPKTRPVLDTSAVAELILDRAREAGNTK
EEEECCCCCCCCCCCHHHHHHHHCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCE
VFPIGALSKGLDGEQLAELVALRDAGCVAFGNGLESFRNTRTLCRALDYAATFDLTVIFN
EEECCHHHCCCCHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHEEEEEEEEC
SQDHDLADGGLAHEGATASFLGLPGIPETAETVALARDLLLVEQTGVRAHFSQLTSARGV
CCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCE
ALIAQAQARGLKVTADVALYQLILTDEALIDFSSLYHVQPPLRTRADRDGLREAVKSGVV
EEEEEHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHH
SAISSHHQPHERDAKLAPFGATEPGISSVELLLPLAMTLVEDGLLDLPTLLSRLSAGPAE
HHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHH
ALRLPAGKLAVGGAADIVLFDPKASTVAGETWLSKGENCPFLGHSLPGVVRYTLVDGRIS
HHCCCCCCEEECCCEEEEEECCCCCCCCCHHHHHCCCCCCCCCCCCCCEEEEEEECCCCC
HQA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-dihydroorotate; H2O

Specific reaction: (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]