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The map label for this gene is mltA [H]

Identifier: 77461494

GI number: 77461494

Start: 5933802

End: 5935010

Strand: Direct

Name: mltA [H]

Synonym: Pfl01_5273

Alternate gene names: 77461494

Gene position: 5933802-5935010 (Clockwise)

Preceding gene: 77461492

Following gene: 77461497

Centisome position: 92.16

GC content: 64.6

Gene sequence:

>1209_bases
ATGGAGCACTTCAGCAACCGGCACAGGAAATTCTCCATGAACAGCCGCTTCAAGGCCTGGCGTCATCCGCTCCTCGTCAC
CCTCCCGTTGCTGGCGATCCTCGCCGGATGCACCGGTGGCGACAGCGCCAAGCCGAAAACCCACGCCCTGGCCACGTATT
CCAGTGCCACCTGGGAAGCACTGCCAACAGTGTCCGATAGCGATCTGGTGGCCGGTTTCGGTTCCTGGCGCAGCGCCTGC
ACCCGGCTCAAGGCTGACCCGGTCTGGGGCGCGACCTGTGCGGCAGCCGCCAACGTGCCGCAAAAAGCCGGCGACATCCG
CGCGTTCCTCAAGCAGAACCTCGACGTCTTCGGCCTGCGCGCCGAGAACGACAACCCCAACGGTCTGATCACCGGCTATT
ACGAACCGGTCTATCCCGGCAGCCTGACGCAAACCGCCAGCGCCAACGTGCCGGTGTACGGCGTGCCCGAGGACATGATC
ATTGTCTCGCTGGACAGCATTTATCCGGAACTGAAAGGCAAGCGCCTGCGCGGCCGCCTCGAAGGTCGCGTGCTCAAGCC
TTACGACGACGCGGCGACCATCGAGAGCCAGGGCGTCAAGGCGCCGGTCGTGGCGTGGCTGACCGATCCGATGAACCTGC
AATTCCTGCAGATTCAGGGTTCGGGGCGGATTCAGACCGATGACGGCCGACAACTGCGCATCGCCTACGCCGACCAGAAT
GGTCATCCGTACCGACCGATCGGCCGTTGGCTGGTGGAACAGGGCGAGCTGAAAAAAGAAGAAGTCACCATGGGTGCGAT
CAGCAACTGGGCCAAGGCCAACCCTTCGCGCATTCCGGAACTGCTGGCGAGCAATCCGAGCTACGTGTTCTTCACCCGCA
ATCCGGACAGCAACGAAGGGCCACGCGGCTCGCTGAACGTGCCGCTGACCGCCGGTTACAGCGCGGCTGTGGACCGCAAG
GTGATTCCGCTAGGCAGCCTGTTGTGGCTGTCGACCACTCGCCCGGACGGCACGCCGCTGGTACGCCCGGTGGCTGCGCA
GGACACCGGCGGCGCGATTGCCGGTGAGGTTCGCGCGGATCTGTTCTGGGGCACCGGCGATGCCGCCGGGCAACTGGCTG
GCGACATGAAACAGCAGGGGCAGATCTGGATGCTCTGGCCAAAAGGCGCGGCGTTGCCGCAAGTCCCGCAGGTGGCCGAC
AAGCCGTAA

Upstream 100 bases:

>100_bases
AGAGTCATGGTGGCTTCAGGTCACGGAAATCGGCGGCCAGTATCCTCGCGTCACCGCCAAACACCAATAGCCCTATTAAC
AATAAGGGTTGCTTGAGCGC

Downstream 100 bases:

>100_bases
GCGCAACGCAAAAGATCGCAGGCCTCGTCAGCCTGCGATCTTTTCAGGTTCAGATCGAAACGAAGAAGAAGCTGGCAATC
AGCACTATCCCGACAAACCA

Product: MltA

Products: Muramic Acid Residue [C]

Alternate protein names: Mlt38; Murein hydrolase A [H]

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MEHFSNRHRKFSMNSRFKAWRHPLLVTLPLLAILAGCTGGDSAKPKTHALATYSSATWEALPTVSDSDLVAGFGSWRSAC
TRLKADPVWGATCAAAANVPQKAGDIRAFLKQNLDVFGLRAENDNPNGLITGYYEPVYPGSLTQTASANVPVYGVPEDMI
IVSLDSIYPELKGKRLRGRLEGRVLKPYDDAATIESQGVKAPVVAWLTDPMNLQFLQIQGSGRIQTDDGRQLRIAYADQN
GHPYRPIGRWLVEQGELKKEEVTMGAISNWAKANPSRIPELLASNPSYVFFTRNPDSNEGPRGSLNVPLTAGYSAAVDRK
VIPLGSLLWLSTTRPDGTPLVRPVAAQDTGGAIAGEVRADLFWGTGDAAGQLAGDMKQQGQIWMLWPKGAALPQVPQVAD
KP

Sequences:

>Translated_402_residues
MEHFSNRHRKFSMNSRFKAWRHPLLVTLPLLAILAGCTGGDSAKPKTHALATYSSATWEALPTVSDSDLVAGFGSWRSAC
TRLKADPVWGATCAAAANVPQKAGDIRAFLKQNLDVFGLRAENDNPNGLITGYYEPVYPGSLTQTASANVPVYGVPEDMI
IVSLDSIYPELKGKRLRGRLEGRVLKPYDDAATIESQGVKAPVVAWLTDPMNLQFLQIQGSGRIQTDDGRQLRIAYADQN
GHPYRPIGRWLVEQGELKKEEVTMGAISNWAKANPSRIPELLASNPSYVFFTRNPDSNEGPRGSLNVPLTAGYSAAVDRK
VIPLGSLLWLSTTRPDGTPLVRPVAAQDTGGAIAGEVRADLFWGTGDAAGQLAGDMKQQGQIWMLWPKGAALPQVPQVAD
KP
>Mature_402_residues
MEHFSNRHRKFSMNSRFKAWRHPLLVTLPLLAILAGCTGGDSAKPKTHALATYSSATWEALPTVSDSDLVAGFGSWRSAC
TRLKADPVWGATCAAAANVPQKAGDIRAFLKQNLDVFGLRAENDNPNGLITGYYEPVYPGSLTQTASANVPVYGVPEDMI
IVSLDSIYPELKGKRLRGRLEGRVLKPYDDAATIESQGVKAPVVAWLTDPMNLQFLQIQGSGRIQTDDGRQLRIAYADQN
GHPYRPIGRWLVEQGELKKEEVTMGAISNWAKANPSRIPELLASNPSYVFFTRNPDSNEGPRGSLNVPLTAGYSAAVDRK
VIPLGSLLWLSTTRPDGTPLVRPVAAQDTGGAIAGEVRADLFWGTGDAAGQLAGDMKQQGQIWMLWPKGAALPQVPQVAD
KP

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=377, Percent_Identity=28.6472148541114, Blast_Score=129, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 43541; Mature: 43541

Theoretical pI: Translated: 8.98; Mature: 8.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHFSNRHRKFSMNSRFKAWRHPLLVTLPLLAILAGCTGGDSAKPKTHALATYSSATWEA
CCCCCCCCEEECCCCHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCHHC
LPTVSDSDLVAGFGSWRSACTRLKADPVWGATCAAAANVPQKAGDIRAFLKQNLDVFGLR
CCCCCCCCCEECCHHHHHHHHHCCCCCCCCCHHHHHCCCCHHHHHHHHHHHCCCCEEEEE
AENDNPNGLITGYYEPVYPGSLTQTASANVPVYGVPEDMIIVSLDSIYPELKGKRLRGRL
ECCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEECCCCEEEEEEHHHCHHHCCCHHHHHC
EGRVLKPYDDAATIESQGVKAPVVAWLTDPMNLQFLQIQGSGRIQTDDGRQLRIAYADQN
CCCEECCCCCCCCHHCCCCCCCEEEEECCCCCEEEEEEECCCEEECCCCCEEEEEEECCC
GHPYRPIGRWLVEQGELKKEEVTMGAISNWAKANPSRIPELLASNPSYVFFTRNPDSNEG
CCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEECCCCCCCC
PRGSLNVPLTAGYSAAVDRKVIPLGSLLWLSTTRPDGTPLVRPVAAQDTGGAIAGEVRAD
CCCCEECEEECCCHHHCCCEEECCCCEEEEEECCCCCCCCEEEEECCCCCCCEEECEEEE
LFWGTGDAAGQLAGDMKQQGQIWMLWPKGAALPQVPQVADKP
EEECCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEHFSNRHRKFSMNSRFKAWRHPLLVTLPLLAILAGCTGGDSAKPKTHALATYSSATWEA
CCCCCCCCEEECCCCHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCHHC
LPTVSDSDLVAGFGSWRSACTRLKADPVWGATCAAAANVPQKAGDIRAFLKQNLDVFGLR
CCCCCCCCCEECCHHHHHHHHHCCCCCCCCCHHHHHCCCCHHHHHHHHHHHCCCCEEEEE
AENDNPNGLITGYYEPVYPGSLTQTASANVPVYGVPEDMIIVSLDSIYPELKGKRLRGRL
ECCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEECCCCEEEEEEHHHCHHHCCCHHHHHC
EGRVLKPYDDAATIESQGVKAPVVAWLTDPMNLQFLQIQGSGRIQTDDGRQLRIAYADQN
CCCEECCCCCCCCHHCCCCCCCEEEEECCCCCEEEEEEECCCEEECCCCCEEEEEEECCC
GHPYRPIGRWLVEQGELKKEEVTMGAISNWAKANPSRIPELLASNPSYVFFTRNPDSNEG
CCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEECCCCCCCC
PRGSLNVPLTAGYSAAVDRKVIPLGSLLWLSTTRPDGTPLVRPVAAQDTGGAIAGEVRAD
CCCCEECEEECCCHHHCCCEEECCCCEEEEEECCCCCCCCEEEEECCCCCCCEEECEEEE
LFWGTGDAAGQLAGDMKQQGQIWMLWPKGAALPQVPQVADKP
EEECCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]