Click here to switch to the map view.

The map label for this gene is hbd [H]

Identifier: 77461453

GI number: 77461453

Start: 5887352

End: 5888317

Strand: Direct

Name: hbd [H]

Synonym: Pfl01_5232

Alternate gene names: 77461453

Gene position: 5887352-5888317 (Clockwise)

Preceding gene: 77461452

Following gene: 77461454

Centisome position: 91.44

GC content: 63.46

Gene sequence:

>966_bases
ATGAGCTTTATCACCGAAATCAAAACCTTCGCAGCACTCGGCAGCGGCGTCATCGGCAGCGGCTGGGTCGCCCGCGCCCT
CGCCCACGGCCTCGACGTGGTGGCCTGGGACCCGGCGCCGGGCGCTGAAGCGGCGCTGCGCAAACGCGTGGCCAATGCCT
GGGGCGCGCTGGAGAAAAACGGTCTGGCGCCGGGCGCTTCGCAGGATCGCCTGCGCTTTGTCGCAACCATTGAAGAGTGC
GTGCGCGATGCGGATTTCATTCAGGAAAGTGCCCCGGAACGCCTCGAACTGAAACTGGACCTGCACAGCAAGATCAGCGC
GGCGGCCAAGCCGAATGCCCTGATCGGGTCCAGCACCTCGGGTCTGTTGCCAAGCGAGTTCTACGAGAGTTCGACTCACC
CGGAACGTTGCGTGGTCGGTCACCCGTTCAACCCGGTTTACCTGCTGCCATTGGTGGAAGTGGTCGGCGGCAAGAACACC
GCGCCCGAAGCCGTGCAGGCCGCGATGAAAGTCTACGAATCCCTCGGCATGCGCCCGCTGCATGTGCGCAAGGAAGTGCC
GGGCTTCATCGCCGACCGCCTGCTCGAAGCGCTGTGGCGCGAGGCGCTGCACCTGGTCAACGACGGGGTGGCGACCACCG
GTGAAATCGATGATGCGATCCGCTTTGGCGCGGGGCTGCGCTGGTCGTTCATGGGTACGTTCCTGACTTACACCCTGGCC
GGTGGCGATGCCGGTATGCGCCACTTCATGTCGCAGTTCGGCCCGGCGTTGCAGTTGCCGTGGACATACCTGCCGGCACC
GGAACTGACCGACAAGTTGATCGACGATGTGGTGGACGGCACCAGCGATCAACTGGGCCGGCACAGTATTTCGGCGCTGG
AACGCTATCGTGATGATTGCCTGCTGGCGGTGCTTGAGGCGGTGAAGACCACCAAAGAAAAGCACGGGATGAGTTTCAGC
GAGTAA

Upstream 100 bases:

>100_bases
AAGAAAATGGGCCTGACCCAGCGCGGCTGAAATCACCCTTTCCCCCGGTGGGCGGGCGATTGACGCCCACCGTTTTTTTG
CCTCACTCCAGGAAGTGACC

Downstream 100 bases:

>100_bases
TCGCATATTGAGCGTCCCACGCAAAGCGTGGGAACGCTCGTGTCTGGAGATAAACATGCCCACCCTCACCACCTACCAAA
CCCGCATCATCCCCGACTGG

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MSFITEIKTFAALGSGVIGSGWVARALAHGLDVVAWDPAPGAEAALRKRVANAWGALEKNGLAPGASQDRLRFVATIEEC
VRDADFIQESAPERLELKLDLHSKISAAAKPNALIGSSTSGLLPSEFYESSTHPERCVVGHPFNPVYLLPLVEVVGGKNT
APEAVQAAMKVYESLGMRPLHVRKEVPGFIADRLLEALWREALHLVNDGVATTGEIDDAIRFGAGLRWSFMGTFLTYTLA
GGDAGMRHFMSQFGPALQLPWTYLPAPELTDKLIDDVVDGTSDQLGRHSISALERYRDDCLLAVLEAVKTTKEKHGMSFS
E

Sequences:

>Translated_321_residues
MSFITEIKTFAALGSGVIGSGWVARALAHGLDVVAWDPAPGAEAALRKRVANAWGALEKNGLAPGASQDRLRFVATIEEC
VRDADFIQESAPERLELKLDLHSKISAAAKPNALIGSSTSGLLPSEFYESSTHPERCVVGHPFNPVYLLPLVEVVGGKNT
APEAVQAAMKVYESLGMRPLHVRKEVPGFIADRLLEALWREALHLVNDGVATTGEIDDAIRFGAGLRWSFMGTFLTYTLA
GGDAGMRHFMSQFGPALQLPWTYLPAPELTDKLIDDVVDGTSDQLGRHSISALERYRDDCLLAVLEAVKTTKEKHGMSFS
E
>Mature_320_residues
SFITEIKTFAALGSGVIGSGWVARALAHGLDVVAWDPAPGAEAALRKRVANAWGALEKNGLAPGASQDRLRFVATIEECV
RDADFIQESAPERLELKLDLHSKISAAAKPNALIGSSTSGLLPSEFYESSTHPERCVVGHPFNPVYLLPLVEVVGGKNTA
PEAVQAAMKVYESLGMRPLHVRKEVPGFIADRLLEALWREALHLVNDGVATTGEIDDAIRFGAGLRWSFMGTFLTYTLAG
GDAGMRHFMSQFGPALQLPWTYLPAPELTDKLIDDVVDGTSDQLGRHSISALERYRDDCLLAVLEAVKTTKEKHGMSFSE

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI115430219, Length=300, Percent_Identity=30, Blast_Score=144, Evalue=8e-35,
Organism=Homo sapiens, GI296179429, Length=228, Percent_Identity=28.9473684210526, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI296179427, Length=245, Percent_Identity=26.9387755102041, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI68989263, Length=286, Percent_Identity=24.8251748251748, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI261878539, Length=286, Percent_Identity=24.8251748251748, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1787661, Length=262, Percent_Identity=29.0076335877863, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI1788682, Length=140, Percent_Identity=29.2857142857143, Blast_Score=64, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI115533614, Length=250, Percent_Identity=28.8, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI193203623, Length=249, Percent_Identity=28.9156626506024, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17549919, Length=303, Percent_Identity=27.0627062706271, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17553560, Length=305, Percent_Identity=28.5245901639344, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17563036, Length=234, Percent_Identity=27.7777777777778, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17508953, Length=207, Percent_Identity=25.6038647342995, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI25144276, Length=207, Percent_Identity=25.6038647342995, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17508951, Length=207, Percent_Identity=25.6038647342995, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71985923, Length=221, Percent_Identity=25.3393665158371, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17558304, Length=221, Percent_Identity=24.8868778280543, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45549573, Length=295, Percent_Identity=29.8305084745763, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI20129993, Length=252, Percent_Identity=30.1587301587302, Blast_Score=127, Evalue=7e-30,
Organism=Drosophila melanogaster, GI19921000, Length=215, Percent_Identity=26.5116279069767, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24583077, Length=215, Percent_Identity=26.5116279069767, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24583079, Length=215, Percent_Identity=26.5116279069767, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 34754; Mature: 34623

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFITEIKTFAALGSGVIGSGWVARALAHGLDVVAWDPAPGAEAALRKRVANAWGALEKN
CCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHC
GLAPGASQDRLRFVATIEECVRDADFIQESAPERLELKLDLHSKISAAAKPNALIGSSTS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHCCCCCEECCCCC
GLLPSEFYESSTHPERCVVGHPFNPVYLLPLVEVVGGKNTAPEAVQAAMKVYESLGMRPL
CCCCHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCC
HVRKEVPGFIADRLLEALWREALHLVNDGVATTGEIDDAIRFGAGLRWSFMGTFLTYTLA
HHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHC
GGDAGMRHFMSQFGPALQLPWTYLPAPELTDKLIDDVVDGTSDQLGRHSISALERYRDDC
CCHHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LLAVLEAVKTTKEKHGMSFSE
HHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SFITEIKTFAALGSGVIGSGWVARALAHGLDVVAWDPAPGAEAALRKRVANAWGALEKN
CHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHC
GLAPGASQDRLRFVATIEECVRDADFIQESAPERLELKLDLHSKISAAAKPNALIGSSTS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHCCCCCEECCCCC
GLLPSEFYESSTHPERCVVGHPFNPVYLLPLVEVVGGKNTAPEAVQAAMKVYESLGMRPL
CCCCHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCC
HVRKEVPGFIADRLLEALWREALHLVNDGVATTGEIDDAIRFGAGLRWSFMGTFLTYTLA
HHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHC
GGDAGMRHFMSQFGPALQLPWTYLPAPELTDKLIDDVVDGTSDQLGRHSISALERYRDDC
CCHHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LLAVLEAVKTTKEKHGMSFSE
HHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA