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The map label for this gene is argD2 [H]

Identifier: 77461385

GI number: 77461385

Start: 5805005

End: 5806288

Strand: Reverse

Name: argD2 [H]

Synonym: Pfl01_5164

Alternate gene names: 77461385

Gene position: 5806288-5805005 (Counterclockwise)

Preceding gene: 77461387

Following gene: 77461384

Centisome position: 90.18

GC content: 62.23

Gene sequence:

>1284_bases
ATGAATCTGTTCAGTTTGCGGCGCCAGACGCCGAGCCTCGATGACCTGGCTTTTGAAACCCAAGAATCGGATGCCGCTGA
TGGCCTGAATGCCGAACGTCTGATGCCCAGCGTCGAGCGTCCGCAGCAGGTATTCGTTCGCGGTCAAGGCTCCTGGCTAT
GGGACAGCAATGACCGCGCCTACCTGGACTTTTCCCAGGCCGGAGGCGCCAATAGCCTCGGCCACAGCCCTTCGGCGCTG
GTCAAAGCCATTGCCAACCAGGCCCAGGCCCTGATCAATCCCGGTTTCAATCTGCACAACCGCGGCATGCTCAGCCTTGC
CGAACGTCTTTGTGCGAGCACTGGCAGTGATCAGGCATACCTGCTCAACAGTGGCAGCGAAGCCTGTGAGGCGGCGATCA
AACTGGCGCGCAAATGGGGCCAGCTGCATCGCGGCGGCGCCTCGCGGATCATTGTCGCCAGACAAGGCTGTCACGGACGT
AGTCTGGCGACGATTTCGGCGTCGGACAGTTGCAACCTGCACAACCGTTTCGCACCGTTGCTGCCCGGTTTCGATCCGGT
ACCGTTCAATGACCTGCCGGCGCTGCATGCAGCAGTGGATGCGCAGACCGTAGCAATCATGCTCGAACCGATCCAGAGCG
ATGCCGGAGTAATCCCTGCGACCGAGCATTACCTCAAGGGTGTTGAACGCCTCTGCCGTGAGCTGGGGATTCTGCTGATT
CTCGACGAGGTTCAGACCGGCATCGGCCGTTGTGGCACCTTACTCGCCGAACAGTCCTACGGCGTGCGCGCCGATATCGT
CGTGCTCGGCAAAGGCCTCGGCGGCGGTGTTCCACTGGCGGCGCTGCTGGCGCGAGGCAAGGCCTGCTGTTTCGATTCTG
GCGAGCTGGGCGGTACTCATCATGGCAACGCGCTAATGACCGCCGCAGGGCTGGTGGTGCTCGACAGCGTGCAGGACCGT
GCATTCCTCGAACAGATCCGCGACAACTGCCAGCATCTGCGCGAAGGGCTCGCCCGTCTGGCCTATCGTTATGAGCATGG
CGAGTTACGCGGGCAGGGGCTGTTCTGGGGACTGAGCCTGTCGGAAGACTCCGCCGAGGCCGTTGTCAAAGCCGCGCTTC
ACGAAGGTTTGCTGCTCAACGCCCCACAAGCCGACTGCCTGCGCTTCACACCGGCGCTCAACGTCAGCAAGGCCAACATC
GACGAAATGCTCCTGCGCCTGGCCCGCGCCTTCTCCCGGGTACGCACCGCGCAACTGCAATGCCGCAAAGGGATTGCCGT
CTGA

Upstream 100 bases:

>100_bases
CATTCACAAGGCTTACAGGGCCGGAAAGCGCAATGACCAGCGTTTGTTTTGAAAGTGTTTGCATAGGCAGTTCAAAAAAC
CTCGATCGAGGTTTTTTTCA

Downstream 100 bases:

>100_bases
GCTGAAATTTCCCACCCGAATTCAAGAACCGTCTCGCGGTATAACGCACGCCCCACTCCTGATTCTTTTGGCGTGGGGCG
TTTTTTTGTGGCCGGATAAT

Product: aminotransferase

Products: NA

Alternate protein names: ACOAT 2 [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MNLFSLRRQTPSLDDLAFETQESDAADGLNAERLMPSVERPQQVFVRGQGSWLWDSNDRAYLDFSQAGGANSLGHSPSAL
VKAIANQAQALINPGFNLHNRGMLSLAERLCASTGSDQAYLLNSGSEACEAAIKLARKWGQLHRGGASRIIVARQGCHGR
SLATISASDSCNLHNRFAPLLPGFDPVPFNDLPALHAAVDAQTVAIMLEPIQSDAGVIPATEHYLKGVERLCRELGILLI
LDEVQTGIGRCGTLLAEQSYGVRADIVVLGKGLGGGVPLAALLARGKACCFDSGELGGTHHGNALMTAAGLVVLDSVQDR
AFLEQIRDNCQHLREGLARLAYRYEHGELRGQGLFWGLSLSEDSAEAVVKAALHEGLLLNAPQADCLRFTPALNVSKANI
DEMLLRLARAFSRVRTAQLQCRKGIAV

Sequences:

>Translated_427_residues
MNLFSLRRQTPSLDDLAFETQESDAADGLNAERLMPSVERPQQVFVRGQGSWLWDSNDRAYLDFSQAGGANSLGHSPSAL
VKAIANQAQALINPGFNLHNRGMLSLAERLCASTGSDQAYLLNSGSEACEAAIKLARKWGQLHRGGASRIIVARQGCHGR
SLATISASDSCNLHNRFAPLLPGFDPVPFNDLPALHAAVDAQTVAIMLEPIQSDAGVIPATEHYLKGVERLCRELGILLI
LDEVQTGIGRCGTLLAEQSYGVRADIVVLGKGLGGGVPLAALLARGKACCFDSGELGGTHHGNALMTAAGLVVLDSVQDR
AFLEQIRDNCQHLREGLARLAYRYEHGELRGQGLFWGLSLSEDSAEAVVKAALHEGLLLNAPQADCLRFTPALNVSKANI
DEMLLRLARAFSRVRTAQLQCRKGIAV
>Mature_427_residues
MNLFSLRRQTPSLDDLAFETQESDAADGLNAERLMPSVERPQQVFVRGQGSWLWDSNDRAYLDFSQAGGANSLGHSPSAL
VKAIANQAQALINPGFNLHNRGMLSLAERLCASTGSDQAYLLNSGSEACEAAIKLARKWGQLHRGGASRIIVARQGCHGR
SLATISASDSCNLHNRFAPLLPGFDPVPFNDLPALHAAVDAQTVAIMLEPIQSDAGVIPATEHYLKGVERLCRELGILLI
LDEVQTGIGRCGTLLAEQSYGVRADIVVLGKGLGGGVPLAALLARGKACCFDSGELGGTHHGNALMTAAGLVVLDSVQDR
AFLEQIRDNCQHLREGLARLAYRYEHGELRGQGLFWGLSLSEDSAEAVVKAALHEGLLLNAPQADCLRFTPALNVSKANI
DEMLLRLARAFSRVRTAQLQCRKGIAV

Specific function: Involved In Both The Arginine And Lysine Biosynthetic Pathways. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=367, Percent_Identity=34.0599455040872, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI284507298, Length=292, Percent_Identity=36.3013698630137, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI37574042, Length=437, Percent_Identity=27.0022883295195, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI24119277, Length=416, Percent_Identity=28.6057692307692, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI226442705, Length=437, Percent_Identity=27.0022883295195, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI13994255, Length=437, Percent_Identity=25.4004576659039, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI226442709, Length=387, Percent_Identity=27.1317829457364, Blast_Score=92, Evalue=7e-19,
Organism=Escherichia coli, GI1789759, Length=389, Percent_Identity=34.9614395886889, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1788044, Length=385, Percent_Identity=36.3636363636364, Blast_Score=226, Evalue=3e-60,
Organism=Escherichia coli, GI145693181, Length=389, Percent_Identity=32.9048843187661, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1789016, Length=403, Percent_Identity=29.7766749379653, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1787560, Length=404, Percent_Identity=28.2178217821782, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1786349, Length=307, Percent_Identity=30.2931596091205, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1786991, Length=358, Percent_Identity=29.0502793296089, Blast_Score=99, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI25144271, Length=377, Percent_Identity=34.2175066312997, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI25144274, Length=280, Percent_Identity=35, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI32564660, Length=435, Percent_Identity=25.2873563218391, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71992977, Length=418, Percent_Identity=28.4688995215311, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI71981843, Length=149, Percent_Identity=34.2281879194631, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324432, Length=398, Percent_Identity=28.643216080402, Blast_Score=174, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6323470, Length=393, Percent_Identity=30.2798982188295, Blast_Score=162, Evalue=1e-40,
Organism=Drosophila melanogaster, GI21357415, Length=401, Percent_Identity=31.6708229426434, Blast_Score=191, Evalue=6e-49,
Organism=Drosophila melanogaster, GI161085790, Length=425, Percent_Identity=26.3529411764706, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI28574759, Length=427, Percent_Identity=26.2295081967213, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21356575, Length=423, Percent_Identity=26.4775413711584, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.11 [H]

Molecular weight: Translated: 45787; Mature: 45787

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLFSLRRQTPSLDDLAFETQESDAADGLNAERLMPSVERPQQVFVRGQGSWLWDSNDRA
CCCHHHHCCCCCHHHHEECCCCCCCCCCCCHHHHCCCCCCCCEEEEECCCCEEECCCCCE
YLDFSQAGGANSLGHSPSALVKAIANQAQALINPGFNLHNRGMLSLAERLCASTGSDQAY
EEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCEE
LLNSGSEACEAAIKLARKWGQLHRGGASRIIVARQGCHGRSLATISASDSCNLHNRFAPL
EECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEECCCCCCCCCCHHHC
LPGFDPVPFNDLPALHAAVDAQTVAIMLEPIQSDAGVIPATEHYLKGVERLCRELGILLI
CCCCCCCCCCCCCHHHHHHHHHEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCEEEE
LDEVQTGIGRCGTLLAEQSYGVRADIVVLGKGLGGGVPLAALLARGKACCFDSGELGGTH
EHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHCCCEEECCCCCCCCCC
HGNALMTAAGLVVLDSVQDRAFLEQIRDNCQHLREGLARLAYRYEHGELRGQGLFWGLSL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEC
SEDSAEAVVKAALHEGLLLNAPQADCLRFTPALNVSKANIDEMLLRLARAFSRVRTAQLQ
CCHHHHHHHHHHHHCCEEECCCCHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
CRKGIAV
HHCCCCC
>Mature Secondary Structure
MNLFSLRRQTPSLDDLAFETQESDAADGLNAERLMPSVERPQQVFVRGQGSWLWDSNDRA
CCCHHHHCCCCCHHHHEECCCCCCCCCCCCHHHHCCCCCCCCEEEEECCCCEEECCCCCE
YLDFSQAGGANSLGHSPSALVKAIANQAQALINPGFNLHNRGMLSLAERLCASTGSDQAY
EEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCEE
LLNSGSEACEAAIKLARKWGQLHRGGASRIIVARQGCHGRSLATISASDSCNLHNRFAPL
EECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEECCCCCCCCCCHHHC
LPGFDPVPFNDLPALHAAVDAQTVAIMLEPIQSDAGVIPATEHYLKGVERLCRELGILLI
CCCCCCCCCCCCCHHHHHHHHHEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCEEEE
LDEVQTGIGRCGTLLAEQSYGVRADIVVLGKGLGGGVPLAALLARGKACCFDSGELGGTH
EHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHCCCEEECCCCCCCCCC
HGNALMTAAGLVVLDSVQDRAFLEQIRDNCQHLREGLARLAYRYEHGELRGQGLFWGLSL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEC
SEDSAEAVVKAALHEGLLLNAPQADCLRFTPALNVSKANIDEMLLRLARAFSRVRTAQLQ
CCHHHHHHHHHHHHCCEEECCCCHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
CRKGIAV
HHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12910271 [H]