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The map label for this gene is surA

Identifier: 77461354

GI number: 77461354

Start: 5768921

End: 5770201

Strand: Direct

Name: surA

Synonym: Pfl01_5133

Alternate gene names: 77461354

Gene position: 5768921-5770201 (Clockwise)

Preceding gene: 77461353

Following gene: 77461355

Centisome position: 89.6

GC content: 61.05

Gene sequence:

>1281_bases
ATGCTGGGCGCGCTGTTCCTGGGTACCGCGGCCAACGCCGCGGTGCAGTCCATCGATAGAGTGGTGGCCATCGTCGACAA
CGATGTGGTCATGCAGAGCCAGCTGGATCAACGCGTCCACGAAGTTCAGCAAACCATCGCCAAGCGTGGCGGCGGTCTGC
CGCCTCCGGGCGTGCTGGATCAACAGGTGCTCGAGCGCCTGATCGTCGAAAACCTGCAACTGCAGATCGGCGAACGCTCC
GGTATCCGCATCACCGATGAAGAACTGAACCAGGCTGTCGGCACCATTGCCCAGCGCAACAACATGACCCCGGAACAGTT
CCGTATCGCCCTGTCCCGTGATGGCCTGTCCTATGAGGACGCTCGCGAGCAGATCCGCCGCGAAATGGTCATCAGCCGTG
TGCGCCAGCGCCGCGTGGCCGAGCGCATTCAGGTCTCGGAACAGGAAGTGAAGAACTTCCTCGCCTCCGATCTGGGCAAG
ATGCAACTGTCCGAAGAACTGCACCTGGCCAACATCCTGATTCCGACCCCGGAAAGCGCCAACTCCGAAGCGATTCAGAG
TGCTGCCCGCAAGGCGATGGAGGTTTACCAGCAGCTCAAGCAAGGTGCTGACTTCGGCCAGATGGCCGTGGCCAACTCCG
CCAGTGACAACGCGCTGGAAGGCGGCGATATGGGCTGGCGTAAAGCCGCTCAACTGCCACCGCCGTTCGACCGTGAACTG
AGCAGCATGGCGACTGGCGACATCACTCAACCGGCACGCACTCCGGGTGGTTTCATCATCCTGAAGCTGCTGGAAAAACG
TGGTGGCGAGAGCCAGATGCGCGACGAAGTGCATGTGCGCCACATTCTGGTCAAGCCAAGTCCGGTTCGCGACGAAGCCA
AGACCAAGGAACTGGCCCAATCGCTCTACAACCGCATCGAAGCCGGTGAAGATTTCGCCGAACTGGCCAAGAAGTATTCG
GAAGATCCGGGCTCTGCCCTCAACGGCGGCGACCTGAACTGGATCGACCCGAACGCACTGGTACCGGAATTCCGCGCCGT
GATGGCCAAGTCCCCGCAGGGTCAGCTGTCCAAGCCGTTCCAGACCCAGTACGGCTGGCACGTTCTGGAAGTCCTTGGCC
GTCGCGCCACTGACAGCACCGAACAGGCCCGTGAGCAGCAAGCGATGACCGTACTGCGTAACCGCAAATACGACGAAGAG
CTGCAGACCTGGCTGCGTCAGATCCGTGACGAAGCGTACGTTGAGATCAAACTCCCTGGTGCAGACCAGGCAGCGCAGTG
A

Upstream 100 bases:

>100_bases
GGCGGCCTCACCGGCGCCAAGGTAGAGAGCTTCCTCGACAAAGGCATCCAAGGTTATCGTCAACGTGAAGACCAAGCTTT
CTGATTGTCTGCGCCCGCTG

Downstream 100 bases:

>100_bases
AACCCAAGCGTTTCGCGCTGACACCCGGCGAACCGGCCGGCATCGGTCCCGACCTGTGCCTGCTGCTCGCCTCGCAAGCC
CAGCCACACCCCCTGATTGC

Product: PpiC-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: Peptidyl-prolyl cis-trans isomerase surA; PPIase surA; Rotamase surA

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MLGALFLGTAANAAVQSIDRVVAIVDNDVVMQSQLDQRVHEVQQTIAKRGGGLPPPGVLDQQVLERLIVENLQLQIGERS
GIRITDEELNQAVGTIAQRNNMTPEQFRIALSRDGLSYEDAREQIRREMVISRVRQRRVAERIQVSEQEVKNFLASDLGK
MQLSEELHLANILIPTPESANSEAIQSAARKAMEVYQQLKQGADFGQMAVANSASDNALEGGDMGWRKAAQLPPPFDREL
SSMATGDITQPARTPGGFIILKLLEKRGGESQMRDEVHVRHILVKPSPVRDEAKTKELAQSLYNRIEAGEDFAELAKKYS
EDPGSALNGGDLNWIDPNALVPEFRAVMAKSPQGQLSKPFQTQYGWHVLEVLGRRATDSTEQAREQQAMTVLRNRKYDEE
LQTWLRQIRDEAYVEIKLPGADQAAQ

Sequences:

>Translated_426_residues
MLGALFLGTAANAAVQSIDRVVAIVDNDVVMQSQLDQRVHEVQQTIAKRGGGLPPPGVLDQQVLERLIVENLQLQIGERS
GIRITDEELNQAVGTIAQRNNMTPEQFRIALSRDGLSYEDAREQIRREMVISRVRQRRVAERIQVSEQEVKNFLASDLGK
MQLSEELHLANILIPTPESANSEAIQSAARKAMEVYQQLKQGADFGQMAVANSASDNALEGGDMGWRKAAQLPPPFDREL
SSMATGDITQPARTPGGFIILKLLEKRGGESQMRDEVHVRHILVKPSPVRDEAKTKELAQSLYNRIEAGEDFAELAKKYS
EDPGSALNGGDLNWIDPNALVPEFRAVMAKSPQGQLSKPFQTQYGWHVLEVLGRRATDSTEQAREQQAMTVLRNRKYDEE
LQTWLRQIRDEAYVEIKLPGADQAAQ
>Mature_426_residues
MLGALFLGTAANAAVQSIDRVVAIVDNDVVMQSQLDQRVHEVQQTIAKRGGGLPPPGVLDQQVLERLIVENLQLQIGERS
GIRITDEELNQAVGTIAQRNNMTPEQFRIALSRDGLSYEDAREQIRREMVISRVRQRRVAERIQVSEQEVKNFLASDLGK
MQLSEELHLANILIPTPESANSEAIQSAARKAMEVYQQLKQGADFGQMAVANSASDNALEGGDMGWRKAAQLPPPFDREL
SSMATGDITQPARTPGGFIILKLLEKRGGESQMRDEVHVRHILVKPSPVRDEAKTKELAQSLYNRIEAGEDFAELAKKYS
EDPGSALNGGDLNWIDPNALVPEFRAVMAKSPQGQLSKPFQTQYGWHVLEVLGRRATDSTEQAREQQAMTVLRNRKYDEE
LQTWLRQIRDEAYVEIKLPGADQAAQ

Specific function: Chaperone involved in the correct folding and assembly of outer membrane proteins. It recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Periplasm. Note=Is capable of associating with the outer membrane (By similarity)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PpiC domains

Homologues:

Organism=Escherichia coli, GI1786238, Length=419, Percent_Identity=40.8114558472554, Blast_Score=311, Evalue=7e-86,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): SURA_PSEPF (Q3K5T4)

Other databases:

- EMBL:   CP000094
- RefSeq:   YP_350861.1
- HSSP:   P24327
- ProteinModelPortal:   Q3K5T4
- SMR:   Q3K5T4
- STRING:   Q3K5T4
- GeneID:   3717051
- GenomeReviews:   CP000094_GR
- KEGG:   pfo:Pfl01_5133
- eggNOG:   COG0760
- HOGENOM:   HBG391483
- OMA:   RHILIKT
- ProtClustDB:   CLSK865971
- BioCyc:   PFLU205922:PFL_5133-MONOMER
- HAMAP:   MF_01183
- InterPro:   IPR000297
- InterPro:   IPR023034
- InterPro:   IPR015391
- InterPro:   IPR008880

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N; SSF109998 Trigger_fac_C_bac

EC number: =5.2.1.8

Molecular weight: Translated: 47451; Mature: 47451

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS01096 PPIC_PPIASE_1; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGALFLGTAANAAVQSIDRVVAIVDNDVVMQSQLDQRVHEVQQTIAKRGGGLPPPGVLD
CCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
QQVLERLIVENLQLQIGERSGIRITDEELNQAVGTIAQRNNMTPEQFRIALSRDGLSYED
HHHHHHHHHHHHHHHCCCCCCCEECHHHHHHHHHHHHHHCCCCHHHHEEHHHCCCCCHHH
AREQIRREMVISRVRQRRVAERIQVSEQEVKNFLASDLGKMQLSEELHLANILIPTPESA
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCC
NSEAIQSAARKAMEVYQQLKQGADFGQMAVANSASDNALEGGDMGWRKAAQLPPPFDREL
CHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCCHHHHH
SSMATGDITQPARTPGGFIILKLLEKRGGESQMRDEVHVRHILVKPSPVRDEAKTKELAQ
HHHHCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHEEECCCCCCHHHHHHHHHH
SLYNRIEAGEDFAELAKKYSEDPGSALNGGDLNWIDPNALVPEFRAVMAKSPQGQLSKPF
HHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCH
QTQYGWHVLEVLGRRATDSTEQAREQQAMTVLRNRKYDEELQTWLRQIRDEAYVEIKLPG
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEECCC
ADQAAQ
CCCCCC
>Mature Secondary Structure
MLGALFLGTAANAAVQSIDRVVAIVDNDVVMQSQLDQRVHEVQQTIAKRGGGLPPPGVLD
CCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
QQVLERLIVENLQLQIGERSGIRITDEELNQAVGTIAQRNNMTPEQFRIALSRDGLSYED
HHHHHHHHHHHHHHHCCCCCCCEECHHHHHHHHHHHHHHCCCCHHHHEEHHHCCCCCHHH
AREQIRREMVISRVRQRRVAERIQVSEQEVKNFLASDLGKMQLSEELHLANILIPTPESA
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCC
NSEAIQSAARKAMEVYQQLKQGADFGQMAVANSASDNALEGGDMGWRKAAQLPPPFDREL
CHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCCHHHHH
SSMATGDITQPARTPGGFIILKLLEKRGGESQMRDEVHVRHILVKPSPVRDEAKTKELAQ
HHHHCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHEEECCCCCCHHHHHHHHHH
SLYNRIEAGEDFAELAKKYSEDPGSALNGGDLNWIDPNALVPEFRAVMAKSPQGQLSKPF
HHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCH
QTQYGWHVLEVLGRRATDSTEQAREQQAMTVLRNRKYDEELQTWLRQIRDEAYVEIKLPG
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEECCC
ADQAAQ
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA