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The map label for this gene is strD [H]

Identifier: 77461351

GI number: 77461351

Start: 5764273

End: 5764944

Strand: Reverse

Name: strD [H]

Synonym: Pfl01_5130

Alternate gene names: 77461351

Gene position: 5764944-5764273 (Counterclockwise)

Preceding gene: 77461352

Following gene: 77461350

Centisome position: 89.54

GC content: 62.5

Gene sequence:

>672_bases
ATGAAGGCAATGATTCTGGCGGCCGGCAAAGGCGAGCGCATGCGCCCGCTGACCCTGACCACCCCCAAACCGCTGGTGCG
AGCCGGCGGCGTGCCGCTGATTGAATATCACCTGCGTGCCCTGGCCGCGGCCGGTTTCAACGAGATCGTGATCAACCATG
CCTGGCTCGGACAGCAGATCGAAGATCATCTGGGCGATGGTTCGCAATTCGGCGTGTCGATCCAGTACTCGCCTGAAGGG
GAACCTTTGGAAACCGGCGGCGGAATTTTCCGCGCCTTGCCGCTGTTGGGCGAAGACGCGTTTCTGGTGGTCAACGGTGA
CATCTGGACCGATTACGACTTCAGCGTGCTGCATCAGCCGATCAACGGCCTGGCGCATCTGGTGCTGGCGGACAATCCGG
CGCATCACCCGACAGGGGATTTCACCCTGACCGACGGCCAGGTGCGTGATGGCCAGGCCGATTTGGCAACCCTGACCTAC
AGCGGCATAGCCGTACTGCATCCGCAGTTGTTCGACGGCTGCCGCGACGGTGCCTTCAAACTGGCGCCGCTGTTGCGTAA
AGCCATGGCGGACGGGCAGGTGACCGGCGAGCGGTTGAAGGGGCACTGGGTCGATGTCGGTACGCACGAGCGTCTGGCCG
AAGCTGAAGCCTTGATAGAAGCGAGTCGCTGA

Upstream 100 bases:

>100_bases
TGCCGCGGTTCTTCTCTTATATAGAAGCGGTCATCGCGCGCCGTCCCGAGTTGGCGGATCTGCAGGCACTGCTCGCCAGC
CTGCGTGGTGGAGCGACGGC

Downstream 100 bases:

>100_bases
TATGTTGTGGCCAGGGACTCTGATTGGAGCCGGAGCGGGTTTTGCTATCGCCAGCATTCCGGGGGCCATGCTTGGGGCTT
TGTTGGGACAGGCGCTGGAT

Product: nucleotidyl transferase

Products: NA

Alternate protein names: Sugar-nucleotidylation enzyme; dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MKAMILAAGKGERMRPLTLTTPKPLVRAGGVPLIEYHLRALAAAGFNEIVINHAWLGQQIEDHLGDGSQFGVSIQYSPEG
EPLETGGGIFRALPLLGEDAFLVVNGDIWTDYDFSVLHQPINGLAHLVLADNPAHHPTGDFTLTDGQVRDGQADLATLTY
SGIAVLHPQLFDGCRDGAFKLAPLLRKAMADGQVTGERLKGHWVDVGTHERLAEAEALIEASR

Sequences:

>Translated_223_residues
MKAMILAAGKGERMRPLTLTTPKPLVRAGGVPLIEYHLRALAAAGFNEIVINHAWLGQQIEDHLGDGSQFGVSIQYSPEG
EPLETGGGIFRALPLLGEDAFLVVNGDIWTDYDFSVLHQPINGLAHLVLADNPAHHPTGDFTLTDGQVRDGQADLATLTY
SGIAVLHPQLFDGCRDGAFKLAPLLRKAMADGQVTGERLKGHWVDVGTHERLAEAEALIEASR
>Mature_223_residues
MKAMILAAGKGERMRPLTLTTPKPLVRAGGVPLIEYHLRALAAAGFNEIVINHAWLGQQIEDHLGDGSQFGVSIQYSPEG
EPLETGGGIFRALPLLGEDAFLVVNGDIWTDYDFSVLHQPINGLAHLVLADNPAHHPTGDFTLTDGQVRDGQADLATLTY
SGIAVLHPQLFDGCRDGAFKLAPLLRKAMADGQVTGERLKGHWVDVGTHERLAEAEALIEASR

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=220, Percent_Identity=30.4545454545455, Blast_Score=97, Evalue=9e-21,
Organism=Homo sapiens, GI11761619, Length=220, Percent_Identity=30.4545454545455, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI31881779, Length=233, Percent_Identity=27.4678111587983, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI45447090, Length=233, Percent_Identity=27.4678111587983, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI133931050, Length=219, Percent_Identity=28.7671232876712, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17509979, Length=161, Percent_Identity=34.1614906832298, Blast_Score=71, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320148, Length=224, Percent_Identity=31.6964285714286, Blast_Score=93, Evalue=4e-20,
Organism=Drosophila melanogaster, GI21355443, Length=218, Percent_Identity=27.0642201834862, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24644084, Length=218, Percent_Identity=27.0642201834862, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24653912, Length=127, Percent_Identity=39.3700787401575, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005908
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 23999; Mature: 23999

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAMILAAGKGERMRPLTLTTPKPLVRAGGVPLIEYHLRALAAAGFNEIVINHAWLGQQI
CCEEEEECCCCCCCCCEEECCCCHHHHHCCCCHHHHHHHHHHHCCCHHEEEEHHHHHHHH
EDHLGDGSQFGVSIQYSPEGEPLETGGGIFRALPLLGEDAFLVVNGDIWTDYDFSVLHQP
HHHCCCCCCEEEEEEECCCCCCCCCCCCCEEHHHHCCCCEEEEEECCEECCCCHHHHHHH
INGLAHLVLADNPAHHPTGDFTLTDGQVRDGQADLATLTYSGIAVLHPQLFDGCRDGAFK
HHHHEEEEEECCCCCCCCCCEEEECCCCCCCCCCEEEEEECCEEEECHHHHHHHCCCCHH
LAPLLRKAMADGQVTGERLKGHWVDVGTHERLAEAEALIEASR
HHHHHHHHHCCCCCCCHHHCCEEEECCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKAMILAAGKGERMRPLTLTTPKPLVRAGGVPLIEYHLRALAAAGFNEIVINHAWLGQQI
CCEEEEECCCCCCCCCEEECCCCHHHHHCCCCHHHHHHHHHHHCCCHHEEEEHHHHHHHH
EDHLGDGSQFGVSIQYSPEGEPLETGGGIFRALPLLGEDAFLVVNGDIWTDYDFSVLHQP
HHHCCCCCCEEEEEEECCCCCCCCCCCCCEEHHHHCCCCEEEEEECCEECCCCHHHHHHH
INGLAHLVLADNPAHHPTGDFTLTDGQVRDGQADLATLTYSGIAVLHPQLFDGCRDGAFK
HHHHEEEEEECCCCCCCCCCEEEECCCCCCCCCCEEEEEECCEEEECHHHHHHHCCCCHH
LAPLLRKAMADGQVTGERLKGHWVDVGTHERLAEAEALIEASR
HHHHHHHHHCCCCCCCHHHCCEEEECCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3118332 [H]