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The map label for this gene is trpC [H]

Identifier: 77461334

GI number: 77461334

Start: 5745484

End: 5746320

Strand: Reverse

Name: trpC [H]

Synonym: Pfl01_5113

Alternate gene names: 77461334

Gene position: 5746320-5745484 (Counterclockwise)

Preceding gene: 77461335

Following gene: 77461333

Centisome position: 89.25

GC content: 61.29

Gene sequence:

>837_bases
ATGAGTGTACCGACGGTTCTGGAAAACATTCTGGCCCGCAAGTTTCAGGAAGTCGCCGAGCGTAGCGCCCGTGTGAGCCT
GAGCGAGCTGGAAAGTCTGGCCAAGGCGGCCGATGCACCCCGTGGTTTTGCCCAGGCATTGCTGGCGCAGGCCAAGAAAA
AACAACCGGCAGTGATCGCCGAAATCAAGAAGGCGTCGCCGAGCAAGGGCGTGATCCGCGAGAACTTCGTTCCTGCCGAT
ATCGCCAAAAGCTACGAGAAGGGCGGGGCGACCTGCCTGTCGGTGCTGACCGACATCGACTACTTCCAGGGCGCCGATGC
CTACCTGCAACAGGCCCGCGTTGCCTGCTCGCTGCCGGTGATCCGCAAAGACTTCATGATCGATCCGTACCAGATCGTCG
AGGCCCGTGCCTTGGGCGCCGATTGCGTGCTGCTGATCGTCTCCGCACTGGATGACGTAAAAATGGCCGAGCTGGCGTCG
GTGGCCAAAGACGTCGGCCTCGATGTGCTGGTGGAAGTGCACGACGGCGATGAGTTGGAGCGCGCGTTGAAAACCCTCGA
CACGCCGCTGGTCGGGGTCAACAACCGCAACCTGCACACCTTTGACGTCAGCCTGGAAACTACCCTCGACCTGCTGCCGC
GCATTCCGCGCGATCGTCTGGTCATCACCGAGAGCGGGATCCTCAACCGTGCCGATGTCGAGCTGATGGAAATCAGCGAC
GTTTACGCGTTCCTGGTCGGCGAAGCGTTCATGCGCGCCGAAAACCCGGGCATCGAACTACAACGTCTGTTCTTCCCTGA
GCGCGGCGTACCGGTGAGCGGTTCGACCCTCGACTGA

Upstream 100 bases:

>100_bases
GCGTGGCACTGGCCCACGACGCTCTGCACACCGGTCTTGCTCGGGAAAAACTCGAGGAGTTGGGTGCCTTTACCGCGGTA
TTCAAAGTGGAGAATGAGGG

Downstream 100 bases:

>100_bases
TCGAGTCTTCGCAGGCGCCCGTCCCCTGTGGGAGCGGGCTTGCCCGCGAAGGCGGCATAAGATTCACCTCAGACTCAACG
TCCTATGGAAACCTTATGAT

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 278; Mature: 277

Protein sequence:

>278_residues
MSVPTVLENILARKFQEVAERSARVSLSELESLAKAADAPRGFAQALLAQAKKKQPAVIAEIKKASPSKGVIRENFVPAD
IAKSYEKGGATCLSVLTDIDYFQGADAYLQQARVACSLPVIRKDFMIDPYQIVEARALGADCVLLIVSALDDVKMAELAS
VAKDVGLDVLVEVHDGDELERALKTLDTPLVGVNNRNLHTFDVSLETTLDLLPRIPRDRLVITESGILNRADVELMEISD
VYAFLVGEAFMRAENPGIELQRLFFPERGVPVSGSTLD

Sequences:

>Translated_278_residues
MSVPTVLENILARKFQEVAERSARVSLSELESLAKAADAPRGFAQALLAQAKKKQPAVIAEIKKASPSKGVIRENFVPAD
IAKSYEKGGATCLSVLTDIDYFQGADAYLQQARVACSLPVIRKDFMIDPYQIVEARALGADCVLLIVSALDDVKMAELAS
VAKDVGLDVLVEVHDGDELERALKTLDTPLVGVNNRNLHTFDVSLETTLDLLPRIPRDRLVITESGILNRADVELMEISD
VYAFLVGEAFMRAENPGIELQRLFFPERGVPVSGSTLD
>Mature_277_residues
SVPTVLENILARKFQEVAERSARVSLSELESLAKAADAPRGFAQALLAQAKKKQPAVIAEIKKASPSKGVIRENFVPADI
AKSYEKGGATCLSVLTDIDYFQGADAYLQQARVACSLPVIRKDFMIDPYQIVEARALGADCVLLIVSALDDVKMAELASV
AKDVGLDVLVEVHDGDELERALKTLDTPLVGVNNRNLHTFDVSLETTLDLLPRIPRDRLVITESGILNRADVELMEISDV
YAFLVGEAFMRAENPGIELQRLFFPERGVPVSGSTLD

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=267, Percent_Identity=39.7003745318352, Blast_Score=153, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6322638, Length=261, Percent_Identity=40.6130268199234, Blast_Score=162, Evalue=6e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 30294; Mature: 30163

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVPTVLENILARKFQEVAERSARVSLSELESLAKAADAPRGFAQALLAQAKKKQPAVIA
CCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHH
EIKKASPSKGVIRENFVPADIAKSYEKGGATCLSVLTDIDYFQGADAYLQQARVACSLPV
HHHHCCCCCCCHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCH
IRKDFMIDPYQIVEARALGADCVLLIVSALDDVKMAELASVAKDVGLDVLVEVHDGDELE
HHHHHCCCHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEEECCCHHHH
RALKTLDTPLVGVNNRNLHTFDVSLETTLDLLPRIPRDRLVITESGILNRADVELMEISD
HHHHHHCCCEEECCCCCEEEEEEEHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHHHHHH
VYAFLVGEAFMRAENPGIELQRLFFPERGVPVSGSTLD
HHHHHHHHHHHHCCCCCCEEHEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SVPTVLENILARKFQEVAERSARVSLSELESLAKAADAPRGFAQALLAQAKKKQPAVIA
CCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHH
EIKKASPSKGVIRENFVPADIAKSYEKGGATCLSVLTDIDYFQGADAYLQQARVACSLPV
HHHHCCCCCCCHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCH
IRKDFMIDPYQIVEARALGADCVLLIVSALDDVKMAELASVAKDVGLDVLVEVHDGDELE
HHHHHCCCHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEEECCCHHHH
RALKTLDTPLVGVNNRNLHTFDVSLETTLDLLPRIPRDRLVITESGILNRADVELMEISD
HHHHHHCCCEEECCCCCEEEEEEEHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHHHHHH
VYAFLVGEAFMRAENPGIELQRLFFPERGVPVSGSTLD
HHHHHHHHHHHHCCCCCCEEHEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA