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The map label for this gene is ribD [H]

Identifier: 77461240

GI number: 77461240

Start: 5653960

End: 5655090

Strand: Reverse

Name: ribD [H]

Synonym: Pfl01_5019

Alternate gene names: 77461240

Gene position: 5655090-5653960 (Counterclockwise)

Preceding gene: 77461241

Following gene: 77461239

Centisome position: 87.83

GC content: 66.93

Gene sequence:

>1131_bases
ATGACCGCCGCCGAGCAGGCCATCCTCGACGCTCACTTCATGGCCCGGGCCCTGGAGCTGGCGCGCAAGGGGCATTACAC
GACTCACCCCAATCCACGGGTCGGCTGCGTGATTGTGCGCGACGGGCAGATTGTCGGCGAAGGCTGGCATGAGCGCGCCG
GCGAACCCCACGCCGAAGTCCACGCCCTGCGCGCCGCCGGTGAACGGGCCCGTGGCGCCACGGCTTACGTCACCCTCGAA
CCTTGCAGCCACCACGGCCGTACGCCGCCGTGCGCCGATGCGCTGGTGAATGCCGGTATTGGCCGGGTGGTTGCGGCGAT
GCGTGATCCGAATCCTCAAGTCGCCGGACGCGGCCTGCAGCGCTTGACCGATGCCGGCATCGCCACCGAAAGCGGCGTGC
TGGAAGCTGAGGCGCGCAAGCTCAATCAAGGTTTTCTGAAGCGCATGGAACACGGCTTGCCGTTCGTGCGGGTCAAGTTG
GCCATGAGCCTCGATGGCCGTACAGCGATGGAAAGCGGTGAGAGCCAATGGATCACCGGCCCTGCCGCGCGTTCGGCGGT
GCAGCGTCTGCGCGCCCAGGCCAGCGTGGTGCTGACCGGCGCCGACACGGTGCTGGCCGATGGCGCACGCCTGACCGTTC
GCGGCGAGGAGCTGGGGCTGGATGCCGCACAAACCGCGCTGGCCCTGAGCCGTCCGCCGCTGCGGGTACTGATCGACGGA
CGTCTGCGGGTGCCGCTGGATGCGCCGTTCTTCAAGGCCGGCCCGGCGCTGGTCGCCACCTGCGTGGCCATCGAAGAACA
GTACGCCCACGGCCCGGAATGCCTGATCGTGCCGGGCGATGACGGTCAGGTCGATCTGCACCAATTGCTGATCGAACTGG
CCAACCGTGGCGTCAACGAAGTGCTGGTCGAGGCTGGCCCACGACTGGCCGGCGCCTTTGCCCAGTTCGGTCTGGTCGAC
GAGTTCGTGATCTTCATTGCCGGCAAGTTCCTCGGCTCCACGGCGCGTCCGCTTCTGGACTGGCCGCTGGCCTGTATGAA
GGATGCGCCCGAGCTGAAAATCACTGAAATTCGCGCGGTTGGCGATGACTGGCGAGTCACTGCCATCCCTGTCCCATCGG
CGAGCGTATAA

Upstream 100 bases:

>100_bases
AAGTCGCCTACATCCGTTTCGCTTCCGTGTACCGCCGCTTCCAGGACCTCAACGAATTCCGCGAAGAGATCGACCGCCTC
GCCCGTGAACCGGTGAAAGA

Downstream 100 bases:

>100_bases
TTCCCGGCCATCGCGTTAGCGCTGGCTTCGTTCTCAAGGAGAACCCCATGTTTACCGGCATCATCGAATCCATCGGCAGT
ATCCGCGCACTGACCCCAAA

Product: 5-amino-6-(5-phosphoribosylamino)uracil reductase / diaminohydroxyphosphoribosylaminopyrimidine deaminase

Products: NA

Alternate protein names: Diaminohydroxyphosphoribosylaminopyrimidine deaminase; DRAP deaminase; Riboflavin-specific deaminase; 5-amino-6-(5-phosphoribosylamino)uracil reductase; HTP reductase [H]

Number of amino acids: Translated: 376; Mature: 375

Protein sequence:

>376_residues
MTAAEQAILDAHFMARALELARKGHYTTHPNPRVGCVIVRDGQIVGEGWHERAGEPHAEVHALRAAGERARGATAYVTLE
PCSHHGRTPPCADALVNAGIGRVVAAMRDPNPQVAGRGLQRLTDAGIATESGVLEAEARKLNQGFLKRMEHGLPFVRVKL
AMSLDGRTAMESGESQWITGPAARSAVQRLRAQASVVLTGADTVLADGARLTVRGEELGLDAAQTALALSRPPLRVLIDG
RLRVPLDAPFFKAGPALVATCVAIEEQYAHGPECLIVPGDDGQVDLHQLLIELANRGVNEVLVEAGPRLAGAFAQFGLVD
EFVIFIAGKFLGSTARPLLDWPLACMKDAPELKITEIRAVGDDWRVTAIPVPSASV

Sequences:

>Translated_376_residues
MTAAEQAILDAHFMARALELARKGHYTTHPNPRVGCVIVRDGQIVGEGWHERAGEPHAEVHALRAAGERARGATAYVTLE
PCSHHGRTPPCADALVNAGIGRVVAAMRDPNPQVAGRGLQRLTDAGIATESGVLEAEARKLNQGFLKRMEHGLPFVRVKL
AMSLDGRTAMESGESQWITGPAARSAVQRLRAQASVVLTGADTVLADGARLTVRGEELGLDAAQTALALSRPPLRVLIDG
RLRVPLDAPFFKAGPALVATCVAIEEQYAHGPECLIVPGDDGQVDLHQLLIELANRGVNEVLVEAGPRLAGAFAQFGLVD
EFVIFIAGKFLGSTARPLLDWPLACMKDAPELKITEIRAVGDDWRVTAIPVPSASV
>Mature_375_residues
TAAEQAILDAHFMARALELARKGHYTTHPNPRVGCVIVRDGQIVGEGWHERAGEPHAEVHALRAAGERARGATAYVTLEP
CSHHGRTPPCADALVNAGIGRVVAAMRDPNPQVAGRGLQRLTDAGIATESGVLEAEARKLNQGFLKRMEHGLPFVRVKLA
MSLDGRTAMESGESQWITGPAARSAVQRLRAQASVVLTGADTVLADGARLTVRGEELGLDAAQTALALSRPPLRVLIDGR
LRVPLDAPFFKAGPALVATCVAIEEQYAHGPECLIVPGDDGQVDLHQLLIELANRGVNEVLVEAGPRLAGAFAQFGLVDE
FVIFIAGKFLGSTARPLLDWPLACMKDAPELKITEIRAVGDDWRVTAIPVPSASV

Specific function: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate [H]

COG id: COG1985

COG function: function code H; Pyrimidine reductase, riboflavin biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HTP reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786616, Length=359, Percent_Identity=56.2674094707521, Blast_Score=389, Evalue=1e-109,
Organism=Escherichia coli, GI145693172, Length=149, Percent_Identity=34.2281879194631, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193
- InterPro:   IPR004794
- InterPro:   IPR011549
- InterPro:   IPR002734 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1; PF01872 RibD_C [H]

EC number: =3.5.4.26; =1.1.1.193 [H]

Molecular weight: Translated: 40014; Mature: 39883

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAAEQAILDAHFMARALELARKGHYTTHPNPRVGCVIVRDGQIVGEGWHERAGEPHAEV
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCEEECCCHHHCCCCCHHHH
HALRAAGERARGATAYVTLEPCSHHGRTPPCADALVNAGIGRVVAAMRDPNPQVAGRGLQ
HHHHHHCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHCCHHHHHHHHCCCCHHHHHHHHH
RLTDAGIATESGVLEAEARKLNQGFLKRMEHGLPFVRVKLAMSLDGRTAMESGESQWITG
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHCCCCCEEEC
PAARSAVQRLRAQASVVLTGADTVLADGARLTVRGEELGLDAAQTALALSRPPLRVLIDG
HHHHHHHHHHHHCCEEEEECCCCEEECCCEEEEECHHHCCHHHHHHHHHCCCCEEEEECC
RLRVPLDAPFFKAGPALVATCVAIEEQYAHGPECLIVPGDDGQVDLHQLLIELANRGVNE
EEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCHHH
VLVEAGPRLAGAFAQFGLVDEFVIFIAGKFLGSTARPLLDWPLACMKDAPELKITEIRAV
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHCCCCCEEEEEEEEC
GDDWRVTAIPVPSASV
CCCCEEEEECCCCCCC
>Mature Secondary Structure 
TAAEQAILDAHFMARALELARKGHYTTHPNPRVGCVIVRDGQIVGEGWHERAGEPHAEV
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCEEECCCHHHCCCCCHHHH
HALRAAGERARGATAYVTLEPCSHHGRTPPCADALVNAGIGRVVAAMRDPNPQVAGRGLQ
HHHHHHCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHCCHHHHHHHHCCCCHHHHHHHHH
RLTDAGIATESGVLEAEARKLNQGFLKRMEHGLPFVRVKLAMSLDGRTAMESGESQWITG
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHCCCCCEEEC
PAARSAVQRLRAQASVVLTGADTVLADGARLTVRGEELGLDAAQTALALSRPPLRVLIDG
HHHHHHHHHHHHCCEEEEECCCCEEECCCEEEEECHHHCCHHHHHHHHHCCCCEEEEECC
RLRVPLDAPFFKAGPALVATCVAIEEQYAHGPECLIVPGDDGQVDLHQLLIELANRGVNE
EEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCHHH
VLVEAGPRLAGAFAQFGLVDEFVIFIAGKFLGSTARPLLDWPLACMKDAPELKITEIRAV
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHCCCCCEEEEEEEEC
GDDWRVTAIPVPSASV
CCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1406588; 9278503; 9068650 [H]