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The map label for this gene is ribB [H]

Identifier: 77461238

GI number: 77461238

Start: 5652142

End: 5653233

Strand: Reverse

Name: ribB [H]

Synonym: Pfl01_5017

Alternate gene names: 77461238

Gene position: 5653233-5652142 (Counterclockwise)

Preceding gene: 77461239

Following gene: 77461237

Centisome position: 87.8

GC content: 62.27

Gene sequence:

>1092_bases
GTGGCGCTCAATAGCATCGAAGAACTGGTTGAAGACATCCGCCAAGGCAAGATGGTCATTCTCATGGATGACGAAGACCG
CGAGAACGAAGGCGACCTGATCATGGCCGCCGAATGCTGCAAGGCCGAGCACATCAACTTCATGGCCAAGTACGCCCGTG
GCCTGATCTGCATGCCGATGAGCCGCGAGCGTTGCGAAACCCTGAAGTTGCCGCTAATGGCGCCACGCAACGGTTCCGGT
TTCGGCACCAAGTTCACCGTCTCGATCGAAGCCGCCGAAGGCGTGACCACCGGCATCTCCGCCGCTGACCGCGCACGCAC
CGTGCAAGCGGCCGCTGCGAAAGACGCCAAGGCGGAAGACATCGTCAGCCCGGGCCACATTTTCCCGCTGATGGCCCAGG
CTGGTGGCACCCTGGCCCGCGCCGGTCACACCGAAGCCGCCTGCGACCTGGCGCGCATGGCCGGTTTCGAGCCAAGCGGC
GTGATCTGCGAAGTGATGAACGACGACGGCACCATGTCCCGTCGCGCCGAACTGGAAGCTTTCGCCGCCGAACACGACAT
CAAGATTGGCACCATCGCCGACCTGATTCACTACCGGATGATCCACGAACGTACCGTTCAGCGGATTGCCGAGCAGCCGC
TGGACAGCGAACTGGGCCAATTCAACCTGGTGACCTATCGTGATTCCGTGGAAGGCGATGTGCACATGGCACTGACCCTC
GGCACCGTTTGCGCCGAAGAACCGACCCTGGTTCGCGTGCACAACATGGATCCGCTGCGCGACCTGCTGATGGTCAAGCA
GCCGGGCCGCTGGAGCCTGCGCGCCGCCATGGCTGCGGTCGCCGAGGCCGGCAGCGGTGTGGTGTTGCTGCTCGGTCACC
CGCTGGATGGCGACGTGTTGCTGGCGCACATCCGCGAAACCGGCGATCAGGCGGCGGTGAAAAAACCGACCACCTACAGC
ATCGTCGGTGCCGGTTCGCAGATCCTGCGTGACCTCGGCGTGCGCAAAATGCGTTTGATGAGCGCGCCGATGAAGTTCAA
TGCGATATCCGGTTTCGATCTGGAAGTTGTAGAATACGTGCCCTCCGAATAA

Upstream 100 bases:

>100_bases
CTTTTGGGCGACAAGGCTGCCGAGCCATCGTCCGGTGGCATCACTGAAAGCTTTCTGGCCGCCAACGGCTACCTCAAATC
CTGACTGAAGGGGGTGCCTT

Downstream 100 bases:

>100_bases
TGACCGGTTGTTTCCGGCTCCGAATTCGCGGCAAATAAATCACTGAGGGACGCGAAACAGACGCGTCCCGGCTCTTTAAG
AGATCTGACGAATGACCCTG

Product: bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein

Products: NA

Alternate protein names: DHBP synthase [H]

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MALNSIEELVEDIRQGKMVILMDDEDRENEGDLIMAAECCKAEHINFMAKYARGLICMPMSRERCETLKLPLMAPRNGSG
FGTKFTVSIEAAEGVTTGISAADRARTVQAAAAKDAKAEDIVSPGHIFPLMAQAGGTLARAGHTEAACDLARMAGFEPSG
VICEVMNDDGTMSRRAELEAFAAEHDIKIGTIADLIHYRMIHERTVQRIAEQPLDSELGQFNLVTYRDSVEGDVHMALTL
GTVCAEEPTLVRVHNMDPLRDLLMVKQPGRWSLRAAMAAVAEAGSGVVLLLGHPLDGDVLLAHIRETGDQAAVKKPTTYS
IVGAGSQILRDLGVRKMRLMSAPMKFNAISGFDLEVVEYVPSE

Sequences:

>Translated_363_residues
MALNSIEELVEDIRQGKMVILMDDEDRENEGDLIMAAECCKAEHINFMAKYARGLICMPMSRERCETLKLPLMAPRNGSG
FGTKFTVSIEAAEGVTTGISAADRARTVQAAAAKDAKAEDIVSPGHIFPLMAQAGGTLARAGHTEAACDLARMAGFEPSG
VICEVMNDDGTMSRRAELEAFAAEHDIKIGTIADLIHYRMIHERTVQRIAEQPLDSELGQFNLVTYRDSVEGDVHMALTL
GTVCAEEPTLVRVHNMDPLRDLLMVKQPGRWSLRAAMAAVAEAGSGVVLLLGHPLDGDVLLAHIRETGDQAAVKKPTTYS
IVGAGSQILRDLGVRKMRLMSAPMKFNAISGFDLEVVEYVPSE
>Mature_362_residues
ALNSIEELVEDIRQGKMVILMDDEDRENEGDLIMAAECCKAEHINFMAKYARGLICMPMSRERCETLKLPLMAPRNGSGF
GTKFTVSIEAAEGVTTGISAADRARTVQAAAAKDAKAEDIVSPGHIFPLMAQAGGTLARAGHTEAACDLARMAGFEPSGV
ICEVMNDDGTMSRRAELEAFAAEHDIKIGTIADLIHYRMIHERTVQRIAEQPLDSELGQFNLVTYRDSVEGDVHMALTLG
TVCAEEPTLVRVHNMDPLRDLLMVKQPGRWSLRAAMAAVAEAGSGVVLLLGHPLDGDVLLAHIRETGDQAAVKKPTTYSI
VGAGSQILRDLGVRKMRLMSAPMKFNAISGFDLEVVEYVPSE

Specific function: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=199, Percent_Identity=51.7587939698493, Blast_Score=218, Evalue=5e-58,
Organism=Saccharomyces cerevisiae, GI6320695, Length=206, Percent_Identity=41.747572815534, Blast_Score=164, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12 [H]

Molecular weight: Translated: 39336; Mature: 39205

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALNSIEELVEDIRQGKMVILMDDEDRENEGDLIMAAECCKAEHINFMAKYARGLICMPM
CCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEHHHHCHHHHHHHHHHHCCEEEECC
SRERCETLKLPLMAPRNGSGFGTKFTVSIEAAEGVTTGISAADRARTVQAAAAKDAKAED
CHHHHHHCCCCEECCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCHHH
IVSPGHIFPLMAQAGGTLARAGHTEAACDLARMAGFEPSGVICEVMNDDGTMSRRAELEA
CCCCCCHHHHHHHCCCCEEECCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHH
FAAEHDIKIGTIADLIHYRMIHERTVQRIAEQPLDSELGQFNLVTYRDSVEGDVHMALTL
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCEEEEEECCCCCCCEEEEEEE
GTVCAEEPTLVRVHNMDPLRDLLMVKQPGRWSLRAAMAAVAEAGSGVVLLLGHPLDGDVL
HHHHCCCCCEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHH
LAHIRETGDQAAVKKPTTYSIVGAGSQILRDLGVRKMRLMSAPMKFNAISGFDLEVVEYV
HHHHHHCCCHHHCCCCCEEEEECCCHHHHHHHCHHHHHHHCCCCCCCCCCCCCCHHEECC
PSE
CCC
>Mature Secondary Structure 
ALNSIEELVEDIRQGKMVILMDDEDRENEGDLIMAAECCKAEHINFMAKYARGLICMPM
CCCHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEHHHHCHHHHHHHHHHHCCEEEECC
SRERCETLKLPLMAPRNGSGFGTKFTVSIEAAEGVTTGISAADRARTVQAAAAKDAKAED
CHHHHHHCCCCEECCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCHHH
IVSPGHIFPLMAQAGGTLARAGHTEAACDLARMAGFEPSGVICEVMNDDGTMSRRAELEA
CCCCCCHHHHHHHCCCCEEECCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHH
FAAEHDIKIGTIADLIHYRMIHERTVQRIAEQPLDSELGQFNLVTYRDSVEGDVHMALTL
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCEEEEEECCCCCCCEEEEEEE
GTVCAEEPTLVRVHNMDPLRDLLMVKQPGRWSLRAAMAAVAEAGSGVVLLLGHPLDGDVL
HHHHCCCCCEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHH
LAHIRETGDQAAVKKPTTYSIVGAGSQILRDLGVRKMRLMSAPMKFNAISGFDLEVVEYV
HHHHHHCCCHHHCCCCCEEEEECCCHHHHHHHCHHHHHHHCCCCCCCCCCCCCCHHEECC
PSE
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]