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The map label for this gene is ribA [H]

Identifier: 77461232

GI number: 77461232

Start: 5648080

End: 5648742

Strand: Reverse

Name: ribA [H]

Synonym: Pfl01_5011

Alternate gene names: 77461232

Gene position: 5648742-5648080 (Counterclockwise)

Preceding gene: 77461233

Following gene: 77461231

Centisome position: 87.74

GC content: 61.09

Gene sequence:

>663_bases
ATGCCGCCCAGCGAATCTCGGACTTTTCAGATCAGGAGTACACCGGTGCCTGTCGTTTTTGTCGCCGCTTCCAAGCTGCC
AACGCCTTTTGCGCAATTCACCATGCACGGTTTTCTCGATGAAGCCACCGGCCGCGAGCACGTTGTGCTGAGCCTGGGTG
AGATTGCCGACGGAGCCCCGGTACTCGGCCGTCTGCACTCCGAATGCCTGACCGGCGATGCCTTGTTCAGCCAGCGTTGC
GACTGCGGTTCGCAACTCGAAGGCGCCCTCAAGGCGATCGCTCGCGAAGGCCGTGGCGTGTTGCTTTACCTGCGTCAGGA
AGGGCGCGGCATCGGTCTTTTGAACAAGATTCGTGCCTATGAATTGCAGGACGGCGGCGCCGACACCGTTGAAGCCAACG
AGCGTCTGGGCTTTGCTGCCGACCAGCGTGATTACGCCATGTGCCTGCCGATGCTCGAGCATCTGGGCGTCAAATCCCTG
CGTCTGATGACCAACAACCCGCGCAAGGTCAAAGCCTTGACCGACATGGGCATCGTCGTCGCCGAGCGCGTGCCGCTGCA
CACCGGCCACAATCCGCACAACAAACTCTATCTGGCGACCAAGGCCAGCAAGCTCGACCACATGATGGGCAACGAGCATC
AGGGCGAGGTAGACCGGGCGTGA

Upstream 100 bases:

>100_bases
TCCCTTCGAATGAACGCGATAAGGCCGAGCCTGTTATCAAACTTTTTGATAGTTATCCCCGATAATTCAGCCTAAGCGCC
TGCGGGTACCTGCTGTTACA

Downstream 100 bases:

>100_bases
CCCGCGGGCAAGTGCGGCGCCGTCTGTCGATCGCCTGGTGGAAATACCTGGCGCTGGCGCTGTTGCCGCTGTTCGTGATC
AACGGAGTGTTCGGCCAGGG

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: GTP cyclohydrolase II [H]

Number of amino acids: Translated: 220; Mature: 219

Protein sequence:

>220_residues
MPPSESRTFQIRSTPVPVVFVAASKLPTPFAQFTMHGFLDEATGREHVVLSLGEIADGAPVLGRLHSECLTGDALFSQRC
DCGSQLEGALKAIAREGRGVLLYLRQEGRGIGLLNKIRAYELQDGGADTVEANERLGFAADQRDYAMCLPMLEHLGVKSL
RLMTNNPRKVKALTDMGIVVAERVPLHTGHNPHNKLYLATKASKLDHMMGNEHQGEVDRA

Sequences:

>Translated_220_residues
MPPSESRTFQIRSTPVPVVFVAASKLPTPFAQFTMHGFLDEATGREHVVLSLGEIADGAPVLGRLHSECLTGDALFSQRC
DCGSQLEGALKAIAREGRGVLLYLRQEGRGIGLLNKIRAYELQDGGADTVEANERLGFAADQRDYAMCLPMLEHLGVKSL
RLMTNNPRKVKALTDMGIVVAERVPLHTGHNPHNKLYLATKASKLDHMMGNEHQGEVDRA
>Mature_219_residues
PPSESRTFQIRSTPVPVVFVAASKLPTPFAQFTMHGFLDEATGREHVVLSLGEIADGAPVLGRLHSECLTGDALFSQRCD
CGSQLEGALKAIAREGRGVLLYLRQEGRGIGLLNKIRAYELQDGGADTVEANERLGFAADQRDYAMCLPMLEHLGVKSLR
LMTNNPRKVKALTDMGIVVAERVPLHTGHNPHNKLYLATKASKLDHMMGNEHQGEVDRA

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=189, Percent_Identity=63.4920634920635, Blast_Score=248, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6319438, Length=170, Percent_Identity=41.1764705882353, Blast_Score=120, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000926 [H]

Pfam domain/function: PF00925 GTP_cyclohydro2 [H]

EC number: =3.5.4.25 [H]

Molecular weight: Translated: 24040; Mature: 23909

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPSESRTFQIRSTPVPVVFVAASKLPTPFAQFTMHGFLDEATGREHVVLSLGEIADGAP
CCCCCCCEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCH
VLGRLHSECLTGDALFSQRCDCGSQLEGALKAIAREGRGVLLYLRQEGRGIGLLNKIRAY
HHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHEEE
ELQDGGADTVEANERLGFAADQRDYAMCLPMLEHLGVKSLRLMTNNPRKVKALTDMGIVV
EECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCEEEEHHHCCEEE
AERVPLHTGHNPHNKLYLATKASKLDHMMGNEHQGEVDRA
ECCCCCCCCCCCCCEEEEEECHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
PPSESRTFQIRSTPVPVVFVAASKLPTPFAQFTMHGFLDEATGREHVVLSLGEIADGAP
CCCCCCEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCH
VLGRLHSECLTGDALFSQRCDCGSQLEGALKAIAREGRGVLLYLRQEGRGIGLLNKIRAY
HHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHEEE
ELQDGGADTVEANERLGFAADQRDYAMCLPMLEHLGVKSLRLMTNNPRKVKALTDMGIVV
EECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCEEEEHHHCCEEE
AERVPLHTGHNPHNKLYLATKASKLDHMMGNEHQGEVDRA
ECCCCCCCCCCCCCEEEEEECHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA