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The map label for this gene is glyA [H]

Identifier: 77461098

GI number: 77461098

Start: 5500130

End: 5501383

Strand: Direct

Name: glyA [H]

Synonym: Pfl01_4877

Alternate gene names: 77461098

Gene position: 5500130-5501383 (Clockwise)

Preceding gene: 77461097

Following gene: 77461099

Centisome position: 85.43

GC content: 61.16

Gene sequence:

>1254_bases
ATGTTCAGCCGTGATTTGACTATTGCCAAGTACGACGCCGATCTTTTTGCCGCCATGGAGCAAGAAGCCCAGCGCCAGGA
AGAACACATCGAGCTGATCGCTTCGGAGAACTACACCAGCCCAGCGGTGATGGAAGCTCAAGGCTCGGTACTGACCAACA
AGTACGCCGAAGGCTACCCGGGCAAGCGCTACTACGGTGGTTGCGAGTACGTCGACGTTGTCGAGCAACTGGCCATCGAC
CGCGCCAAGGAACTGTTCGGCGCCGACTACGCCAACGTTCAGCCGCACGCTGGCTCCCAAGCCAACGCCGCTGTCTACCT
GGCCCTGCTGTCGGCCGGTGACACCATCCTGGGCATGAGCCTGGCTCACGGCGGTCACCTGACCCACGGCGCCAGCGTTT
CCTCCTCCGGCAAGCTGTACAACGCCATCCAGTACGGCATCGATGCCAACGGCCTGATCGACTACGACGAAGTCGAGCGC
CTGGCGGTCGAGCACAAGCCGAAAATGATCGTGGCCGGTTTCTCTGCCTACTCGCAGATCCTCGACTTCCCGCGCTTCCG
TGCCATCGCCGACAAGGTTGGCGCCTACCTGTTCGTCGACATGGCTCACGTGGCCGGTCTGGTCGCCGCTGGCGTCTACC
CGAACCCGGTTCCGTTCGCTGACGTCGTGACCACCACCACCCACAAGACCCTGCGCGGTCCACGTGGTGGCCTGATCCTG
GCCAAGGCCAACGCCGACATCGAGAAGAAGCTGAACTCCGCCGTATTCCCGGGCGCCCAAGGTGGCCCGCTGGAGCACGT
GATCGCCGCCAAAGCGATCTGCTTCAAGGAAGCACTGCAGCCTGAGTTCAAGGCTTACCAGCAACAAGTGGTGAAAAACG
CCCAGGCCATGGCCGGCGTGTTCATCGAGCGCGGTTTCGACGTGGTTTCCGGCGGTACTGAAAACCACCTGTTCCTGCTG
TCGCTGATCAAGCAGGAAATCTCCGGTAAAGACGCCGACGCCGCTCTGGGCAAAGCGTTCATCACTGTGAACAAGAACTC
CGTGCCAAACGACCCACGCTCCCCGTTCGTCACCTCCGGCCTGCGCTTCGGTACTCCGGCAGTGACCACTCGCGGCTTCA
AAGAGGCGGAGTGCAAAGAGCTGGCGGGCTGGATCTGCGACATCCTGGCTGACCTGAACAACGAAGCGGTGATCGACGCC
GTTCGTGAGAAAGTCAAAGCCATCTGCAAGAAACTGCCGGTATACGGCGCTTGA

Upstream 100 bases:

>100_bases
GAACGCCACTTGTCTGCGACATGATGTCGTTTCATATGCCATCCAAAACCTGTTGGGGTAGAATGCCCCCCTTTTCTGCC
CCCGATCCTTGAGGACCGCC

Downstream 100 bases:

>100_bases
TTGCGACGTTAAACCCGTAACATGAAAAACCGGCCAGTGATGGCCGGTTTTTTTTCGCCCGCAAAAAAGTTTCGATCGCT
AAATGGCTCAAGGTCGGGGC

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT 1; Serine methylase 1 [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MFSRDLTIAKYDADLFAAMEQEAQRQEEHIELIASENYTSPAVMEAQGSVLTNKYAEGYPGKRYYGGCEYVDVVEQLAID
RAKELFGADYANVQPHAGSQANAAVYLALLSAGDTILGMSLAHGGHLTHGASVSSSGKLYNAIQYGIDANGLIDYDEVER
LAVEHKPKMIVAGFSAYSQILDFPRFRAIADKVGAYLFVDMAHVAGLVAAGVYPNPVPFADVVTTTTHKTLRGPRGGLIL
AKANADIEKKLNSAVFPGAQGGPLEHVIAAKAICFKEALQPEFKAYQQQVVKNAQAMAGVFIERGFDVVSGGTENHLFLL
SLIKQEISGKDADAALGKAFITVNKNSVPNDPRSPFVTSGLRFGTPAVTTRGFKEAECKELAGWICDILADLNNEAVIDA
VREKVKAICKKLPVYGA

Sequences:

>Translated_417_residues
MFSRDLTIAKYDADLFAAMEQEAQRQEEHIELIASENYTSPAVMEAQGSVLTNKYAEGYPGKRYYGGCEYVDVVEQLAID
RAKELFGADYANVQPHAGSQANAAVYLALLSAGDTILGMSLAHGGHLTHGASVSSSGKLYNAIQYGIDANGLIDYDEVER
LAVEHKPKMIVAGFSAYSQILDFPRFRAIADKVGAYLFVDMAHVAGLVAAGVYPNPVPFADVVTTTTHKTLRGPRGGLIL
AKANADIEKKLNSAVFPGAQGGPLEHVIAAKAICFKEALQPEFKAYQQQVVKNAQAMAGVFIERGFDVVSGGTENHLFLL
SLIKQEISGKDADAALGKAFITVNKNSVPNDPRSPFVTSGLRFGTPAVTTRGFKEAECKELAGWICDILADLNNEAVIDA
VREKVKAICKKLPVYGA
>Mature_417_residues
MFSRDLTIAKYDADLFAAMEQEAQRQEEHIELIASENYTSPAVMEAQGSVLTNKYAEGYPGKRYYGGCEYVDVVEQLAID
RAKELFGADYANVQPHAGSQANAAVYLALLSAGDTILGMSLAHGGHLTHGASVSSSGKLYNAIQYGIDANGLIDYDEVER
LAVEHKPKMIVAGFSAYSQILDFPRFRAIADKVGAYLFVDMAHVAGLVAAGVYPNPVPFADVVTTTTHKTLRGPRGGLIL
AKANADIEKKLNSAVFPGAQGGPLEHVIAAKAICFKEALQPEFKAYQQQVVKNAQAMAGVFIERGFDVVSGGTENHLFLL
SLIKQEISGKDADAALGKAFITVNKNSVPNDPRSPFVTSGLRFGTPAVTTRGFKEAECKELAGWICDILADLNNEAVIDA
VREKVKAICKKLPVYGA

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI261862352, Length=402, Percent_Identity=45.5223880597015, Blast_Score=349, Evalue=3e-96,
Organism=Homo sapiens, GI261862350, Length=402, Percent_Identity=45.5223880597015, Blast_Score=349, Evalue=3e-96,
Organism=Homo sapiens, GI261862348, Length=402, Percent_Identity=45.5223880597015, Blast_Score=349, Evalue=3e-96,
Organism=Homo sapiens, GI19923315, Length=402, Percent_Identity=45.5223880597015, Blast_Score=348, Evalue=4e-96,
Organism=Homo sapiens, GI261862346, Length=401, Percent_Identity=44.3890274314214, Blast_Score=333, Evalue=1e-91,
Organism=Homo sapiens, GI22547186, Length=451, Percent_Identity=41.6851441241685, Blast_Score=317, Evalue=1e-86,
Organism=Homo sapiens, GI22547189, Length=438, Percent_Identity=39.4977168949772, Blast_Score=282, Evalue=5e-76,
Organism=Escherichia coli, GI1788902, Length=416, Percent_Identity=73.7980769230769, Blast_Score=629, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25144732, Length=400, Percent_Identity=47.25, Blast_Score=360, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI25144729, Length=400, Percent_Identity=47.25, Blast_Score=360, Evalue=1e-99,
Organism=Saccharomyces cerevisiae, GI6319739, Length=401, Percent_Identity=45.6359102244389, Blast_Score=358, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6323087, Length=397, Percent_Identity=43.8287153652393, Blast_Score=335, Evalue=1e-92,
Organism=Drosophila melanogaster, GI24640005, Length=454, Percent_Identity=44.0528634361233, Blast_Score=374, Evalue=1e-104,
Organism=Drosophila melanogaster, GI221329721, Length=454, Percent_Identity=44.0528634361233, Blast_Score=372, Evalue=1e-103,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 44795; Mature: 44795

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSRDLTIAKYDADLFAAMEQEAQRQEEHIELIASENYTSPAVMEAQGSVLTNKYAEGYP
CCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHCCCC
GKRYYGGCEYVDVVEQLAIDRAKELFGADYANVQPHAGSQANAAVYLALLSAGDTILGMS
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEHHCCCCEEEEH
LAHGGHLTHGASVSSSGKLYNAIQYGIDANGLIDYDEVERLAVEHKPKMIVAGFSAYSQI
HCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEECHHHHHHH
LDFPRFRAIADKVGAYLFVDMAHVAGLVAAGVYPNPVPFADVVTTTTHKTLRGPRGGLIL
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEE
AKANADIEKKLNSAVFPGAQGGPLEHVIAAKAICFKEALQPEFKAYQQQVVKNAQAMAGV
EECCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
FIERGFDVVSGGTENHLFLLSLIKQEISGKDADAALGKAFITVNKNSVPNDPRSPFVTSG
HHHCCCCEECCCCCCHHHHHHHHHHHHCCCCCHHHHCEEEEEEECCCCCCCCCCCHHHCC
LRFGTPAVTTRGFKEAECKELAGWICDILADLNNEAVIDAVREKVKAICKKLPVYGA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MFSRDLTIAKYDADLFAAMEQEAQRQEEHIELIASENYTSPAVMEAQGSVLTNKYAEGYP
CCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHCCCC
GKRYYGGCEYVDVVEQLAIDRAKELFGADYANVQPHAGSQANAAVYLALLSAGDTILGMS
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEHHCCCCEEEEH
LAHGGHLTHGASVSSSGKLYNAIQYGIDANGLIDYDEVERLAVEHKPKMIVAGFSAYSQI
HCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEECHHHHHHH
LDFPRFRAIADKVGAYLFVDMAHVAGLVAAGVYPNPVPFADVVTTTTHKTLRGPRGGLIL
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEE
AKANADIEKKLNSAVFPGAQGGPLEHVIAAKAICFKEALQPEFKAYQQQVVKNAQAMAGV
EECCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
FIERGFDVVSGGTENHLFLLSLIKQEISGKDADAALGKAFITVNKNSVPNDPRSPFVTSG
HHHCCCCEECCCCCCHHHHHHHHHHHHCCCCCHHHHCEEEEEEECCCCCCCCCCCHHHCC
LRFGTPAVTTRGFKEAECKELAGWICDILADLNNEAVIDAVREKVKAICKKLPVYGA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA