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The map label for this gene is fklB [H]

Identifier: 77461085

GI number: 77461085

Start: 5482135

End: 5482752

Strand: Reverse

Name: fklB [H]

Synonym: Pfl01_4864

Alternate gene names: 77461085

Gene position: 5482752-5482135 (Counterclockwise)

Preceding gene: 77461086

Following gene: 77461081

Centisome position: 85.16

GC content: 61.65

Gene sequence:

>618_bases
ATGTCCGAAGTAAATCTGTCCACCGACGAAACCCGCGTCAGCTACGGTATCGGCCGTCAGCTGGGTGACCAGCTGCGCGA
CAACCCGCCACCGGGTGTCAGCCTGGACGCCATCCTGGCCGGTCTGACCGACGCATTCGCCGGCAAGGAAAGCCGTGTCA
GCCAGGAAGCCATGTCCGCCAGCTTCAAGGTGATCCGCGAGATCATGCAAGCTGAAGCCGCTGCCAAGGCTGAAGCCGCC
GCAGGCGAAGGTCTGGCATTCCTGGCTGAAAACGCCAAGAAAGAAGGCATCACGACTCTGGCATCCGGCCTGCAGTTCGA
AGTGCTGACTCAGGGTGAAGGCGCCAAGCCATCCCGTGAAGACACCGTGCGTACTCACTACCACGGCACACTGATCGACG
GCACTGTGTTCGACAGCTCCTACGAGCGCGGCCAGCCGGCTGAATTCCCGGTCGGTGGCGTTATCGCGGGCTGGACCGAA
GCCCTGCAACTGATGAATGCCGGCAGCAAATGGCGTCTGTACGTGCCGAGCGAACTGGCTTACGGCGCTCAAGGCGTTGG
CAGCATCCCGCCGCACAGCGTTCTGGTATTTGACGTCGAGCTGCTCGAGGTTCTGTAA

Upstream 100 bases:

>100_bases
CATCTGTGCTAGTCTGCTCGCCCTTTTGGTTCCGGGCGCGCCGGGACGCGCTGTGTACGCACGGCGTGTTCCGAGGCCGT
CCGCACAGCGGAGCAGTGTC

Downstream 100 bases:

>100_bases
TCCCGTTACCCTGCACAAGCGTGGCTTGTGCAGGGTTTCTCCGCGTTTTTCATACTTCGATCTTGTTGTGCAGTTCACTG
GTCGGGCGCAAGGCCCGGGC

Product: FKBP-type peptidylprolyl isomerase

Products: NA

Alternate protein names: FKBP22; PPIase; Rotamase [H]

Number of amino acids: Translated: 205; Mature: 204

Protein sequence:

>205_residues
MSEVNLSTDETRVSYGIGRQLGDQLRDNPPPGVSLDAILAGLTDAFAGKESRVSQEAMSASFKVIREIMQAEAAAKAEAA
AGEGLAFLAENAKKEGITTLASGLQFEVLTQGEGAKPSREDTVRTHYHGTLIDGTVFDSSYERGQPAEFPVGGVIAGWTE
ALQLMNAGSKWRLYVPSELAYGAQGVGSIPPHSVLVFDVELLEVL

Sequences:

>Translated_205_residues
MSEVNLSTDETRVSYGIGRQLGDQLRDNPPPGVSLDAILAGLTDAFAGKESRVSQEAMSASFKVIREIMQAEAAAKAEAA
AGEGLAFLAENAKKEGITTLASGLQFEVLTQGEGAKPSREDTVRTHYHGTLIDGTVFDSSYERGQPAEFPVGGVIAGWTE
ALQLMNAGSKWRLYVPSELAYGAQGVGSIPPHSVLVFDVELLEVL
>Mature_204_residues
SEVNLSTDETRVSYGIGRQLGDQLRDNPPPGVSLDAILAGLTDAFAGKESRVSQEAMSASFKVIREIMQAEAAAKAEAAA
GEGLAFLAENAKKEGITTLASGLQFEVLTQGEGAKPSREDTVRTHYHGTLIDGTVFDSSYERGQPAEFPVGGVIAGWTEA
LQLMNAGSKWRLYVPSELAYGAQGVGSIPPHSVLVFDVELLEVL

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cytoplasm. Periplasm. Note=According to PubMed:7610040 it is periplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=106, Percent_Identity=45.2830188679245, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI4503725, Length=106, Percent_Identity=45.2830188679245, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI4758380, Length=106, Percent_Identity=39.622641509434, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI33469985, Length=85, Percent_Identity=45.8823529411765, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI4503727, Length=109, Percent_Identity=41.2844036697248, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI206725530, Length=92, Percent_Identity=45.6521739130435, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI17149844, Length=92, Percent_Identity=45.6521739130435, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI17149842, Length=92, Percent_Identity=45.6521739130435, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI8923659, Length=89, Percent_Identity=40.4494382022472, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI192448443, Length=87, Percent_Identity=44.8275862068966, Blast_Score=71, Evalue=7e-13,
Organism=Escherichia coli, GI87082390, Length=206, Percent_Identity=53.3980582524272, Blast_Score=211, Evalue=3e-56,
Organism=Escherichia coli, GI1789745, Length=213, Percent_Identity=39.906103286385, Blast_Score=146, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71993519, Length=106, Percent_Identity=40.5660377358491, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17540882, Length=106, Percent_Identity=41.5094339622642, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17561782, Length=100, Percent_Identity=39, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320727, Length=88, Percent_Identity=54.5454545454545, Blast_Score=89, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6324194, Length=105, Percent_Identity=45.7142857142857, Blast_Score=84, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323566, Length=117, Percent_Identity=34.1880341880342, Blast_Score=63, Evalue=4e-11,
Organism=Drosophila melanogaster, GI281363946, Length=110, Percent_Identity=43.6363636363636, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI17352457, Length=110, Percent_Identity=43.6363636363636, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24655568, Length=106, Percent_Identity=43.3962264150943, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21356629, Length=88, Percent_Identity=46.5909090909091, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24583150, Length=104, Percent_Identity=39.4230769230769, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 21741; Mature: 21609

Theoretical pI: Translated: 4.37; Mature: 4.37

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEVNLSTDETRVSYGIGRQLGDQLRDNPPPGVSLDAILAGLTDAFAGKESRVSQEAMSA
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHH
SFKVIREIMQAEAAAKAEAAAGEGLAFLAENAKKEGITTLASGLQFEVLTQGEGAKPSRE
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCC
DTVRTHYHGTLIDGTVFDSSYERGQPAEFPVGGVIAGWTEALQLMNAGSKWRLYVPSELA
CCEEHEECCEEEECEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECHHHH
YGAQGVGSIPPHSVLVFDVELLEVL
CCCCCCCCCCCCEEEEEEHHHHHHC
>Mature Secondary Structure 
SEVNLSTDETRVSYGIGRQLGDQLRDNPPPGVSLDAILAGLTDAFAGKESRVSQEAMSA
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHH
SFKVIREIMQAEAAAKAEAAAGEGLAFLAENAKKEGITTLASGLQFEVLTQGEGAKPSRE
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCC
DTVRTHYHGTLIDGTVFDSSYERGQPAEFPVGGVIAGWTEALQLMNAGSKWRLYVPSELA
CCEEHEECCEEEECEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECHHHH
YGAQGVGSIPPHSVLVFDVELLEVL
CCCCCCCCCCCCEEEEEEHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 8703024; 9298646 [H]