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The map label for this gene is clpB [H]

Identifier: 77461055

GI number: 77461055

Start: 5451827

End: 5454391

Strand: Reverse

Name: clpB [H]

Synonym: Pfl01_4834

Alternate gene names: 77461055

Gene position: 5454391-5451827 (Counterclockwise)

Preceding gene: 77461056

Following gene: 77461054

Centisome position: 84.72

GC content: 59.96

Gene sequence:

>2565_bases
ATGCGTATAGACCGTTTAACCAGCAAATTGCAGTTGGCGTTGTCCGATGCCCAATCCCTGGCTGTTGGCCACGATCATCC
TGCCATCGAGCCGGCGCATTTGATGCAGGCCATGCTTGAACAGCAGGGTGGTTCGATCAAACCCCTGTTGATGCAGGTGG
GCTTCGACGTCAACAGCTTGCGTAAAGAGCTGACCAAAGAGCTCGATCAATTACCGAAAATCCAGAATCCGACCGGCGAC
GTCAACATGTCGCAGGATCTGGCGCGTCTGCTCAACCAGGCCGATCGTCTGGCCCAGCAGAAGGGCGATCAGTTCATTTC
CAGCGAGCTGGTGCTGCTCGCCGCGATGGACGAGAACAGCAAGCTCGGGAAGTTGCTGCTCGGCCAGGGCGTGAGCAAAA
AGGCTCTGGAAAATGCAATCAACAACCTGCGCGGTGGCGAGGCGGTCAACGACGCCAACCACGAAGAGTCGCGTCAGGCA
CTGGATAAGTACACCGTCGACCTGACCAAACGCGCCGAAGAAGGCAAGCTTGACCCGGTGATCGGCCGTGACGACGAGAT
CCGTCGCACCATTCAGGTGCTGCAACGCCGTACCAAGAACAACCCGGTGCTGATCGGCGAGCCTGGCGTGGGTAAAACCG
CGATTGCCGAAGGTCTGGCCCAGCGCATCATCAATGGTGAAGTGCCGGACGGCCTGCGCGGCAAGCGTCTGCTGTCCCTC
GATATGGGGGCGCTGATTGCCGGTGCCAAGTATCGCGGCGAGTTTGAAGAGCGCCTGAAAGCGCTGCTCAACGAGCTGTC
GAAGCAGGAAGGGCAGATCATTCTGTTCATCGACGAACTGCACACCATGGTCGGCGCCGGCAAGGGCGAAGGCTCGATGG
ACGCCGGCAACATGCTTAAACCGGCCCTGGCCCGTGGTGAGCTGCATTGCGTCGGCGCGACCACGCTCAACGAGTACCGC
CAATATATAGAGAAGGACGCGGCCCTCGAGCGACGCTTCCAGAAAGTGCTGGTGGACGAGCCGAGCGAAGAGGACACCAT
CGCGATCCTGCGTGGCCTCAAGGAGCGTTACGAGGTTCACCACAAGGTGGCGATCACCGACGGCGCGATCATCGCGGCGG
CCAAGCTCAGCCATCGCTACATCACTGACCGGCAGCTGCCGGACAAGGCGATCGACCTGATCGACGAGGCGGCCAGCCGC
ATCCGCATGGAGATCGACTCCAAGCCGGAAGTGCTGGATCGTCTTGAGCGGCGCCTGATTCAACTGAAGGTGGAATCTCA
GGCACTGAAGAAAGAAAGTGACGACGCGGCGAAGAAACGTCTGGAGAAACTCCAGGAAGAAATCGATCGCCACGAGCGTG
AGTACTCCGATCTGGAAGAAATCTGGAACTCGGAAAAAGCCGAGGTGCAGGGCTCTGCGCAGATTCAGCAGAAGATCGAA
CAGTCCCGTCAGGAGCTGGAAGCCGCGCGCCGTAAAGGCGACCTGAACCGCATGGCCGAGTTGCAGTATGGGGTGATCCC
GGATCTGGAACGCAGCCTGCAAATGGTCGACCAGCACGGCAAGAGCGAAAACCAGTTGCTGCGCAGCAAGGTGACCGAAG
AGGAAATCGCCGAAGTCGTTTCGAAGTGGACCGGTATTCCGGTGTCGAAAATGCTCGAAGGCGAACGCGACAAGCTGATG
AAGATGGAAAGCCTGTTGCATCAACGCGTGATCGGCCAGGACGAAGCGGTGGTGGCAGTAGCCAACGCGGTGCGGCGTTC
CCGTGCCGGGTTGTCCGACCCGAACCGCCCGAGCGGCTCGTTCATGTTCCTCGGCCCGACCGGTGTCGGTAAAACCGAGC
TGTGCAAGGCGCTGGCCGAATTCCTCTTCGATACGGAAGAGGCGATGGTGCGAATCGACATGTCCGAGTTCATGGAGAAA
CATTCCGTGGCACGGTTGATCGGGGCACCACCGGGCTACGTCGGCTACGAAGAGGGTGGTTACCTGACCGAAGCGGTACG
GCGCAAGCCTTACTCGGTGATCCTGCTGGACGAAGTCGAGAAGGCGCATCCGGACGTGTTCAACATCCTGCTGCAAGTGC
TGGAGGACGGACGTCTGACCGACAGCCATGGCCGCACGGTGGACTTCCGCAATACCGTGATCGTCATGACCTCCAATCTC
GGTTCGATGCAGATCCAGGAACTGGTCGGTGATCGTGAAGCACAACGGGCAGCGGTGATGGATGCGATTTCCACCCACTT
CCGTCCGGAGTTCATCAACCGCGTTGACGAAGTGGTGATCTTCGAGCCATTGGCGCGGGATCAGATCGCGGGCATCACCG
AGATCCAGCTGGGCCGTCTGCGCAACCGTCTGGCCGAGCGCGAGCTGAAGCTGGAACTGAGCCCTGAGGCGATGGACAAG
CTGATTGCCGTCGGTTACGACCCGGTCTATGGCGCACGGCCGCTGAAGCGGGCGATCCAGCGCTGGATCGAGAACCCGTT
GGCGCAGTTGATCCTGTCGGGACGCTTCATGCCGGGCGAGACCGCAACCGGTGTGGTGGAGAACGACGAGATCACGTTCA
ACTGA

Upstream 100 bases:

>100_bases
TTGAATCTTCCAGAATCGACCGCATCTATAGCGGTATCTGGCAGGTTTCTTTATTCAGGATGGTTTTTTAGGTCCGGCCT
GCTCAAAAGGAAGGTGACCC

Downstream 100 bases:

>100_bases
CACCTGCCGGTGGTGAAGTAAGGAAGGCCTCGCACTGCGAGGCCTTTTTTTTCGCCAGGCTGTTGAACTCAAAGGAAAAG
GCTTGTAAAGTGCGCCCCGC

Product: chaperone clpB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 854; Mature: 854

Protein sequence:

>854_residues
MRIDRLTSKLQLALSDAQSLAVGHDHPAIEPAHLMQAMLEQQGGSIKPLLMQVGFDVNSLRKELTKELDQLPKIQNPTGD
VNMSQDLARLLNQADRLAQQKGDQFISSELVLLAAMDENSKLGKLLLGQGVSKKALENAINNLRGGEAVNDANHEESRQA
LDKYTVDLTKRAEEGKLDPVIGRDDEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIAEGLAQRIINGEVPDGLRGKRLLSL
DMGALIAGAKYRGEFEERLKALLNELSKQEGQIILFIDELHTMVGAGKGEGSMDAGNMLKPALARGELHCVGATTLNEYR
QYIEKDAALERRFQKVLVDEPSEEDTIAILRGLKERYEVHHKVAITDGAIIAAAKLSHRYITDRQLPDKAIDLIDEAASR
IRMEIDSKPEVLDRLERRLIQLKVESQALKKESDDAAKKRLEKLQEEIDRHEREYSDLEEIWNSEKAEVQGSAQIQQKIE
QSRQELEAARRKGDLNRMAELQYGVIPDLERSLQMVDQHGKSENQLLRSKVTEEEIAEVVSKWTGIPVSKMLEGERDKLM
KMESLLHQRVIGQDEAVVAVANAVRRSRAGLSDPNRPSGSFMFLGPTGVGKTELCKALAEFLFDTEEAMVRIDMSEFMEK
HSVARLIGAPPGYVGYEEGGYLTEAVRRKPYSVILLDEVEKAHPDVFNILLQVLEDGRLTDSHGRTVDFRNTVIVMTSNL
GSMQIQELVGDREAQRAAVMDAISTHFRPEFINRVDEVVIFEPLARDQIAGITEIQLGRLRNRLAERELKLELSPEAMDK
LIAVGYDPVYGARPLKRAIQRWIENPLAQLILSGRFMPGETATGVVENDEITFN

Sequences:

>Translated_854_residues
MRIDRLTSKLQLALSDAQSLAVGHDHPAIEPAHLMQAMLEQQGGSIKPLLMQVGFDVNSLRKELTKELDQLPKIQNPTGD
VNMSQDLARLLNQADRLAQQKGDQFISSELVLLAAMDENSKLGKLLLGQGVSKKALENAINNLRGGEAVNDANHEESRQA
LDKYTVDLTKRAEEGKLDPVIGRDDEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIAEGLAQRIINGEVPDGLRGKRLLSL
DMGALIAGAKYRGEFEERLKALLNELSKQEGQIILFIDELHTMVGAGKGEGSMDAGNMLKPALARGELHCVGATTLNEYR
QYIEKDAALERRFQKVLVDEPSEEDTIAILRGLKERYEVHHKVAITDGAIIAAAKLSHRYITDRQLPDKAIDLIDEAASR
IRMEIDSKPEVLDRLERRLIQLKVESQALKKESDDAAKKRLEKLQEEIDRHEREYSDLEEIWNSEKAEVQGSAQIQQKIE
QSRQELEAARRKGDLNRMAELQYGVIPDLERSLQMVDQHGKSENQLLRSKVTEEEIAEVVSKWTGIPVSKMLEGERDKLM
KMESLLHQRVIGQDEAVVAVANAVRRSRAGLSDPNRPSGSFMFLGPTGVGKTELCKALAEFLFDTEEAMVRIDMSEFMEK
HSVARLIGAPPGYVGYEEGGYLTEAVRRKPYSVILLDEVEKAHPDVFNILLQVLEDGRLTDSHGRTVDFRNTVIVMTSNL
GSMQIQELVGDREAQRAAVMDAISTHFRPEFINRVDEVVIFEPLARDQIAGITEIQLGRLRNRLAERELKLELSPEAMDK
LIAVGYDPVYGARPLKRAIQRWIENPLAQLILSGRFMPGETATGVVENDEITFN
>Mature_854_residues
MRIDRLTSKLQLALSDAQSLAVGHDHPAIEPAHLMQAMLEQQGGSIKPLLMQVGFDVNSLRKELTKELDQLPKIQNPTGD
VNMSQDLARLLNQADRLAQQKGDQFISSELVLLAAMDENSKLGKLLLGQGVSKKALENAINNLRGGEAVNDANHEESRQA
LDKYTVDLTKRAEEGKLDPVIGRDDEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIAEGLAQRIINGEVPDGLRGKRLLSL
DMGALIAGAKYRGEFEERLKALLNELSKQEGQIILFIDELHTMVGAGKGEGSMDAGNMLKPALARGELHCVGATTLNEYR
QYIEKDAALERRFQKVLVDEPSEEDTIAILRGLKERYEVHHKVAITDGAIIAAAKLSHRYITDRQLPDKAIDLIDEAASR
IRMEIDSKPEVLDRLERRLIQLKVESQALKKESDDAAKKRLEKLQEEIDRHEREYSDLEEIWNSEKAEVQGSAQIQQKIE
QSRQELEAARRKGDLNRMAELQYGVIPDLERSLQMVDQHGKSENQLLRSKVTEEEIAEVVSKWTGIPVSKMLEGERDKLM
KMESLLHQRVIGQDEAVVAVANAVRRSRAGLSDPNRPSGSFMFLGPTGVGKTELCKALAEFLFDTEEAMVRIDMSEFMEK
HSVARLIGAPPGYVGYEEGGYLTEAVRRKPYSVILLDEVEKAHPDVFNILLQVLEDGRLTDSHGRTVDFRNTVIVMTSNL
GSMQIQELVGDREAQRAAVMDAISTHFRPEFINRVDEVVIFEPLARDQIAGITEIQLGRLRNRLAERELKLELSPEAMDK
LIAVGYDPVYGARPLKRAIQRWIENPLAQLILSGRFMPGETATGVVENDEITFN

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=301, Percent_Identity=36.5448504983389, Blast_Score=202, Evalue=1e-51,
Organism=Escherichia coli, GI1788943, Length=854, Percent_Identity=69.3208430913349, Blast_Score=1209, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=418, Percent_Identity=41.1483253588517, Blast_Score=286, Evalue=3e-78,
Organism=Saccharomyces cerevisiae, GI6320464, Length=708, Percent_Identity=53.1073446327684, Blast_Score=767, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323002, Length=861, Percent_Identity=42.8571428571429, Blast_Score=678, Evalue=0.0,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR017730
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150
- InterPro:   IPR002078 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 95554; Mature: 95554

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIDRLTSKLQLALSDAQSLAVGHDHPAIEPAHLMQAMLEQQGGSIKPLLMQVGFDVNSL
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHCCCHHHH
RKELTKELDQLPKIQNPTGDVNMSQDLARLLNQADRLAQQKGDQFISSELVLLAAMDENS
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCC
KLGKLLLGQGVSKKALENAINNLRGGEAVNDANHEESRQALDKYTVDLTKRAEEGKLDPV
HHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
IGRDDEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIAEGLAQRIINGEVPDGLRGKRLLSL
CCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEE
DMGALIAGAKYRGEFEERLKALLNELSKQEGQIILFIDELHTMVGAGKGEGSMDAGNMLK
CHHHHHHCCHHCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCCCCCCCCHHH
PALARGELHCVGATTLNEYRQYIEKDAALERRFQKVLVDEPSEEDTIAILRGLKERYEVH
HHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
HKVAITDGAIIAAAKLSHRYITDRQLPDKAIDLIDEAASRIRMEIDSKPEVLDRLERRLI
HHEEEECCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
QLKVESQALKKESDDAAKKRLEKLQEEIDRHEREYSDLEEIWNSEKAEVQGSAQIQQKIE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHH
QSRQELEAARRKGDLNRMAELQYGVIPDLERSLQMVDQHGKSENQLLRSKVTEEEIAEVV
HHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHH
SKWTGIPVSKMLEGERDKLMKMESLLHQRVIGQDEAVVAVANAVRRSRAGLSDPNRPSGS
HHHCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
FMFLGPTGVGKTELCKALAEFLFDTEEAMVRIDMSEFMEKHSVARLIGAPPGYVGYEEGG
EEEECCCCCCHHHHHHHHHHHHHCCHHHHEEECHHHHHHHHHHHHHHCCCCCCCCCCCCC
YLTEAVRRKPYSVILLDEVEKAHPDVFNILLQVLEDGRLTDSHGRTVDFRNTVIVMTSNL
HHHHHHHCCCCEEEEECCHHHHCCHHHHHHHHHHHCCCCCCCCCCEEEECCEEEEEECCC
GSMQIQELVGDREAQRAAVMDAISTHFRPEFINRVDEVVIFEPLARDQIAGITEIQLGRL
CHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHEEEECCHHHHHHCCCHHHHHHHH
RNRLAERELKLELSPEAMDKLIAVGYDPVYGARPLKRAIQRWIENPLAQLILSGRFMPGE
HHHHHHHHHHEEECHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TATGVVENDEITFN
CCCCEEECCCEECC
>Mature Secondary Structure
MRIDRLTSKLQLALSDAQSLAVGHDHPAIEPAHLMQAMLEQQGGSIKPLLMQVGFDVNSL
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHCCCHHHH
RKELTKELDQLPKIQNPTGDVNMSQDLARLLNQADRLAQQKGDQFISSELVLLAAMDENS
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCC
KLGKLLLGQGVSKKALENAINNLRGGEAVNDANHEESRQALDKYTVDLTKRAEEGKLDPV
HHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
IGRDDEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIAEGLAQRIINGEVPDGLRGKRLLSL
CCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEE
DMGALIAGAKYRGEFEERLKALLNELSKQEGQIILFIDELHTMVGAGKGEGSMDAGNMLK
CHHHHHHCCHHCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCCCCCCCCHHH
PALARGELHCVGATTLNEYRQYIEKDAALERRFQKVLVDEPSEEDTIAILRGLKERYEVH
HHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
HKVAITDGAIIAAAKLSHRYITDRQLPDKAIDLIDEAASRIRMEIDSKPEVLDRLERRLI
HHEEEECCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
QLKVESQALKKESDDAAKKRLEKLQEEIDRHEREYSDLEEIWNSEKAEVQGSAQIQQKIE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHH
QSRQELEAARRKGDLNRMAELQYGVIPDLERSLQMVDQHGKSENQLLRSKVTEEEIAEVV
HHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHH
SKWTGIPVSKMLEGERDKLMKMESLLHQRVIGQDEAVVAVANAVRRSRAGLSDPNRPSGS
HHHCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
FMFLGPTGVGKTELCKALAEFLFDTEEAMVRIDMSEFMEKHSVARLIGAPPGYVGYEEGG
EEEECCCCCCHHHHHHHHHHHHHCCHHHHEEECHHHHHHHHHHHHHHCCCCCCCCCCCCC
YLTEAVRRKPYSVILLDEVEKAHPDVFNILLQVLEDGRLTDSHGRTVDFRNTVIVMTSNL
HHHHHHHCCCCEEEEECCHHHHCCHHHHHHHHHHHCCCCCCCCCCEEEECCEEEEEECCC
GSMQIQELVGDREAQRAAVMDAISTHFRPEFINRVDEVVIFEPLARDQIAGITEIQLGRL
CHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHEEEECCHHHHHHCCCHHHHHHHH
RNRLAERELKLELSPEAMDKLIAVGYDPVYGARPLKRAIQRWIENPLAQLILSGRFMPGE
HHHHHHHHHHEEECHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TATGVVENDEITFN
CCCCEEECCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12534463 [H]