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The map label for this gene is coaE

Identifier: 77461044

GI number: 77461044

Start: 5443505

End: 5444128

Strand: Direct

Name: coaE

Synonym: Pfl01_4823

Alternate gene names: 77461044

Gene position: 5443505-5444128 (Clockwise)

Preceding gene: 77461043

Following gene: 77461045

Centisome position: 84.55

GC content: 61.38

Gene sequence:

>624_bases
ATGAATACCCCTGTGGAAAAACCCTGGATTCTCGGCCTGACCGGCGGCATCGGCAGCGGCAAAAGCGCCGCCGCCCAGCA
CTTCATCGATCTTGGTATCCACGTGGTGGACGCTGATCACGCGGCGCGCTGGGTGGTCGAACCGGGCCGTCCGGCGCTGG
CGAAGATCGCCGAACACTTCGGCCCCGACGTGTTGCAGGCCGACGGCACGCTGGATCGTGCAGCCCTGCGCAAACTGATC
TTCGAGGTGCCGGAGCAACGGCGCTGGCTCGAAGCCTTATTGCATCCGTTGATCGCCGAAGAAATCGCCCATCACCTGGC
GCTGGCAAAATCGCCTTATGCGATTCTGGTTTCGCCGCTGCTGATCGAATCCGGGCAATACGCGATGACCCAGCGAATTC
TGGTAATCGACGCACCGCAACAACTGCAGATCGAACGCACCTTGCAGCGTGACCAGACCAGCGAACAGCAGGTCCAGGCG
ATCCTCAAAGCCCAGTCCAGCCGCGAAGACCGCATCAGCCGTGCCGACGATGTGGTGGTCAACGACCGCGACCTCGCTTG
GCTGCACAGCGAGGTCGAGCGCCTGCATCACTTTTACCTGACTTTATCCGGAGGCCAATCATGA

Upstream 100 bases:

>100_bases
CGCCGATTCCCTTCGGCCCGTATCTGGCAATTGCCGGCTGGATTGCCTTGCTCTGGGGTGGTCAAATAACCGGCTTCTAT
TGGCAGTTTGTCGGTTTGAA

Downstream 100 bases:

>100_bases
GCCAGACCCCAACCGTCAACTGCCCGACTTGCGGCGCGCCCGTGGAATTCACCCCGGAGAACAAATACCGTCCGTTCTGC
TCGGACCGCTGCAAACTCAT

Product: dephospho-CoA kinase

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MNTPVEKPWILGLTGGIGSGKSAAAQHFIDLGIHVVDADHAARWVVEPGRPALAKIAEHFGPDVLQADGTLDRAALRKLI
FEVPEQRRWLEALLHPLIAEEIAHHLALAKSPYAILVSPLLIESGQYAMTQRILVIDAPQQLQIERTLQRDQTSEQQVQA
ILKAQSSREDRISRADDVVVNDRDLAWLHSEVERLHHFYLTLSGGQS

Sequences:

>Translated_207_residues
MNTPVEKPWILGLTGGIGSGKSAAAQHFIDLGIHVVDADHAARWVVEPGRPALAKIAEHFGPDVLQADGTLDRAALRKLI
FEVPEQRRWLEALLHPLIAEEIAHHLALAKSPYAILVSPLLIESGQYAMTQRILVIDAPQQLQIERTLQRDQTSEQQVQA
ILKAQSSREDRISRADDVVVNDRDLAWLHSEVERLHHFYLTLSGGQS
>Mature_207_residues
MNTPVEKPWILGLTGGIGSGKSAAAQHFIDLGIHVVDADHAARWVVEPGRPALAKIAEHFGPDVLQADGTLDRAALRKLI
FEVPEQRRWLEALLHPLIAEEIAHHLALAKSPYAILVSPLLIESGQYAMTQRILVIDAPQQLQIERTLQRDQTSEQQVQA
ILKAQSSREDRISRADDVVVNDRDLAWLHSEVERLHHFYLTLSGGQS

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain

Homologues:

Organism=Homo sapiens, GI191252797, Length=197, Percent_Identity=35.5329949238579, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI191252795, Length=197, Percent_Identity=35.5329949238579, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI110227607, Length=177, Percent_Identity=31.638418079096, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI110227605, Length=189, Percent_Identity=30.1587301587302, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI110227603, Length=189, Percent_Identity=30.1587301587302, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI110227601, Length=189, Percent_Identity=30.1587301587302, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI205277394, Length=189, Percent_Identity=30.1587301587302, Blast_Score=89, Evalue=3e-18,
Organism=Escherichia coli, GI1786292, Length=196, Percent_Identity=51.530612244898, Blast_Score=196, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17554944, Length=189, Percent_Identity=31.2169312169312, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6320402, Length=193, Percent_Identity=34.1968911917098, Blast_Score=101, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24658602, Length=193, Percent_Identity=27.979274611399, Blast_Score=98, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24644728, Length=178, Percent_Identity=33.1460674157303, Blast_Score=97, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAE_PSEPF (Q3K6P4)

Other databases:

- EMBL:   CP000094
- RefSeq:   YP_350551.1
- ProteinModelPortal:   Q3K6P4
- SMR:   Q3K6P4
- STRING:   Q3K6P4
- GeneID:   3717259
- GenomeReviews:   CP000094_GR
- KEGG:   pfo:Pfl01_4823
- eggNOG:   COG0237
- HOGENOM:   HBG650290
- OMA:   IIAREVV
- ProtClustDB:   PRK00081
- BioCyc:   PFLU205922:PFL_4823-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00376
- InterPro:   IPR001977
- TIGRFAMs:   TIGR00152

Pfam domain/function: PF01121 CoaE

EC number: =2.7.1.24

Molecular weight: Translated: 23027; Mature: 23027

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS51219 DPCK; PS01294 COAE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTPVEKPWILGLTGGIGSGKSAAAQHFIDLGIHVVDADHAARWVVEPGRPALAKIAEHF
CCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCEEEEECCCCCEEEECCCCHHHHHHHHHH
GPDVLQADGTLDRAALRKLIFEVPEQRRWLEALLHPLIAEEIAHHLALAKSPYAILVSPL
CCCCEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LIESGQYAMTQRILVIDAPQQLQIERTLQRDQTSEQQVQAILKAQSSREDRISRADDVVV
HHCCCCHHHHEEEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHCCCEEE
NDRDLAWLHSEVERLHHFYLTLSGGQS
CCCHHHHHHHHHHHHHHHEEEECCCCC
>Mature Secondary Structure
MNTPVEKPWILGLTGGIGSGKSAAAQHFIDLGIHVVDADHAARWVVEPGRPALAKIAEHF
CCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCEEEEECCCCCEEEECCCCHHHHHHHHHH
GPDVLQADGTLDRAALRKLIFEVPEQRRWLEALLHPLIAEEIAHHLALAKSPYAILVSPL
CCCCEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LIESGQYAMTQRILVIDAPQQLQIERTLQRDQTSEQQVQAILKAQSSREDRISRADDVVV
HHCCCCHHHHEEEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHCCCEEE
NDRDLAWLHSEVERLHHFYLTLSGGQS
CCCHHHHHHHHHHHHHHHEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA