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The map label for this gene is hmuU [H]

Identifier: 77461020

GI number: 77461020

Start: 5414352

End: 5415389

Strand: Reverse

Name: hmuU [H]

Synonym: Pfl01_4799

Alternate gene names: 77461020

Gene position: 5415389-5414352 (Counterclockwise)

Preceding gene: 77461021

Following gene: 77461019

Centisome position: 84.11

GC content: 64.35

Gene sequence:

>1038_bases
ATGACCACGCTGGTCAAGCCCCGTGGCTTGTTTATCGGCCTGATCTTGCTGTGTCTGCTGGCGATCTGGCTGTCGCTGGC
GTTGGGGCCGGTGAGTCTGCCGTTGTTCGATACCTTGCGCGCTGCCCTGCGCATGATCGGTGTGCCGCTGGCGCCGGACG
GGCTGGAGCAGGCTGAACTGATTCTCGGGCAGATTCGTCTGCCGCGTACGCTGCTCGGGTTGGCAGTTGGCGGTGTGCTG
GCGCTGTCCGGGGTGGCGATGCAGGGGCTGTTTCGCAATCCGCTGGCGGATCCAGGTTTGGTTGGCGTCTCGAGTGGAGC
GGCGTTGGGCGCGGCGGTGGCGATTGTCGGTGGTTCGTTTTTTGGCGGACTGCCAGAGTGGTTCGGGCCTTATCTGCTGT
CGGTTTGCGCGTTTCTCGGTGGCCTTGGCGTAACTGCGCTGGTCTATCGACTCGGCCGCCGTAACGGGCAGACCAATGTG
GCGACCATGTTGCTGGCGGGGATTGCCCTGACGGCGCTGGCCAGTTCGGCGGTGGGGCTGTTTACCTATCTGGCCGACGA
CGCGACATTGCGCACATTGACGTTCTGGAACCTGGGCAGCCTCAACGGTGCAAGTTATGCGCGATTGTGGCCGCTGCTGA
TCATCACCGCCGGTGTTGCACTTTGGCTCCCACGCCGAGCCAAGGCGTTGAATGCATTGCTGCTCGGCGAATCGGAAGCC
GGGCATCTGGGAATCGATGTCGAACGGCTCAAGCGTGAGCTGGTGTTCTGCACGGCGCTGGGCGTCGGTGCGGCGGTGGC
CGCGGCGGGCATGATCGGTTTTGTCGGGCTGGTGGTGCCACATCTGGTGCGCTTGCTCGTGGGGCCGGATCACCGGGTGT
TGCTGCCGGCATCGGTGCTGGCCGGAGCCAGTCTGTTGCTGTTGGCTGATCTGGTGGCGCGGCTGGCGCTGGCACCGGCG
GAGCTGCCGATCGGCATCGTCACCGCGTTCATCGGTGCGCCGTTCTTTCTTTATCTGTTGCTGCGAGGGCGTGCCTGA

Upstream 100 bases:

>100_bases
TGGAGCTGGACCCGACGCTGCTGGTCGGCGGGCTCGGGCCGCGTTTGCCGGCTGCGCTGAAGACCCTGTCTGAGGGGTTC
TATCCGGCCCAGAGCAGTCA

Downstream 100 bases:

>100_bases
TGCTGCGTGCGCACAACCTGCACATCCGTCGTGGCCGCAAGACCGTTCTGGCCGATGTCAGCCTGCAGCTCGAACCGGGC
GAAGTGCTTGGCGTGCTGGG

Product: transport system permease

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MTTLVKPRGLFIGLILLCLLAIWLSLALGPVSLPLFDTLRAALRMIGVPLAPDGLEQAELILGQIRLPRTLLGLAVGGVL
ALSGVAMQGLFRNPLADPGLVGVSSGAALGAAVAIVGGSFFGGLPEWFGPYLLSVCAFLGGLGVTALVYRLGRRNGQTNV
ATMLLAGIALTALASSAVGLFTYLADDATLRTLTFWNLGSLNGASYARLWPLLIITAGVALWLPRRAKALNALLLGESEA
GHLGIDVERLKRELVFCTALGVGAAVAAAGMIGFVGLVVPHLVRLLVGPDHRVLLPASVLAGASLLLLADLVARLALAPA
ELPIGIVTAFIGAPFFLYLLLRGRA

Sequences:

>Translated_345_residues
MTTLVKPRGLFIGLILLCLLAIWLSLALGPVSLPLFDTLRAALRMIGVPLAPDGLEQAELILGQIRLPRTLLGLAVGGVL
ALSGVAMQGLFRNPLADPGLVGVSSGAALGAAVAIVGGSFFGGLPEWFGPYLLSVCAFLGGLGVTALVYRLGRRNGQTNV
ATMLLAGIALTALASSAVGLFTYLADDATLRTLTFWNLGSLNGASYARLWPLLIITAGVALWLPRRAKALNALLLGESEA
GHLGIDVERLKRELVFCTALGVGAAVAAAGMIGFVGLVVPHLVRLLVGPDHRVLLPASVLAGASLLLLADLVARLALAPA
ELPIGIVTAFIGAPFFLYLLLRGRA
>Mature_344_residues
TTLVKPRGLFIGLILLCLLAIWLSLALGPVSLPLFDTLRAALRMIGVPLAPDGLEQAELILGQIRLPRTLLGLAVGGVLA
LSGVAMQGLFRNPLADPGLVGVSSGAALGAAVAIVGGSFFGGLPEWFGPYLLSVCAFLGGLGVTALVYRLGRRNGQTNVA
TMLLAGIALTALASSAVGLFTYLADDATLRTLTFWNLGSLNGASYARLWPLLIITAGVALWLPRRAKALNALLLGESEAG
HLGIDVERLKRELVFCTALGVGAAVAAAGMIGFVGLVVPHLVRLLVGPDHRVLLPASVLAGASLLLLADLVARLALAPAE
LPIGIVTAFIGAPFFLYLLLRGRA

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788004, Length=286, Percent_Identity=47.5524475524476, Blast_Score=186, Evalue=1e-48,
Organism=Escherichia coli, GI1790741, Length=299, Percent_Identity=36.7892976588629, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1790740, Length=292, Percent_Identity=36.986301369863, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1786805, Length=281, Percent_Identity=39.8576512455516, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1786804, Length=298, Percent_Identity=32.5503355704698, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1786347, Length=284, Percent_Identity=32.3943661971831, Blast_Score=95, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 35638; Mature: 35507

Theoretical pI: Translated: 10.11; Mature: 10.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLVKPRGLFIGLILLCLLAIWLSLALGPVSLPLFDTLRAALRMIGVPLAPDGLEQAEL
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHH
ILGQIRLPRTLLGLAVGGVLALSGVAMQGLFRNPLADPGLVGVSSGAALGAAVAIVGGSF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCHHHHHHHHHHCCHH
FGGLPEWFGPYLLSVCAFLGGLGVTALVYRLGRRNGQTNVATMLLAGIALTALASSAVGL
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
FTYLADDATLRTLTFWNLGSLNGASYARLWPLLIITAGVALWLPRRAKALNALLLGESEA
HHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCC
GHLGIDVERLKRELVFCTALGVGAAVAAAGMIGFVGLVVPHLVRLLVGPDHRVLLPASVL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHH
AGASLLLLADLVARLALAPAELPIGIVTAFIGAPFFLYLLLRGRA
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TTLVKPRGLFIGLILLCLLAIWLSLALGPVSLPLFDTLRAALRMIGVPLAPDGLEQAEL
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHH
ILGQIRLPRTLLGLAVGGVLALSGVAMQGLFRNPLADPGLVGVSSGAALGAAVAIVGGSF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCHHHHHHHHHHCCHH
FGGLPEWFGPYLLSVCAFLGGLGVTALVYRLGRRNGQTNVATMLLAGIALTALASSAVGL
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
FTYLADDATLRTLTFWNLGSLNGASYARLWPLLIITAGVALWLPRRAKALNALLLGESEA
HHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCC
GHLGIDVERLKRELVFCTALGVGAAVAAAGMIGFVGLVVPHLVRLLVGPDHRVLLPASVL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHH
AGASLLLLADLVARLALAPAELPIGIVTAFIGAPFFLYLLLRGRA
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]